Publication Date:
1983-01-14
Description:
Acetylcholine receptors are present in the sarcolemma of cultured skeletal muscle myotubes either as large clusters or in a diffuse distribution. Both the clustered and diffuse acetylcholine receptors are potentially removable from the membrane. Treatment of myotubes with globulin from patients with myasthenia gravis causes the loss of acetylcholine receptor clusters and the concomitant appearance of acetylcholine receptor microaggregates. The rate of acetylcholine receptor cluster loss is greater than the rate of acetylcholine receptor degradation, indicating that acetylcholine receptors are disrupted from clusters to form microaggregates before being removed from the plasma membrane.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Bursztajn, S -- McManaman, J L -- Elias, S B -- Appel, S H -- New York, N.Y. -- Science. 1983 Jan 14;219(4581):195-7.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/6849132" target="_blank"〉PubMed〈/a〉
Keywords:
*Autoantibodies
;
Cells, Cultured
;
Humans
;
Immunologic Capping
;
Macromolecular Substances
;
Membrane Proteins/metabolism
;
Myasthenia Gravis/*immunology
;
Pinocytosis
;
Receptors, Cholinergic/immunology/*metabolism
Print ISSN:
0036-8075
Electronic ISSN:
1095-9203
Topics:
Biology
,
Chemistry and Pharmacology
,
Computer Science
,
Medicine
,
Natural Sciences in General
,
Physics
