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  • Time Factors  (21)
  • Cell Line
  • American Association for the Advancement of Science (AAAS)  (34)
  • American Chemical Society
  • Oxford University Press
  • 1980-1984  (34)
  • 1925-1929
  • 1982  (34)
Collection
Keywords
Publisher
  • American Association for the Advancement of Science (AAAS)  (34)
  • American Chemical Society
  • Oxford University Press
Years
  • 1980-1984  (34)
  • 1925-1929
Year
  • 1
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    Rhodamine-123 selectively reduces clonal growth of carcinoma cells in vitro (1982)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1982-12-10
    Description: Rhodamine-123, a cationic laser dye, markedly reduced the clonal growth of carcinoma cells but had little effect on nontumorigenic epithelial cells in vitro. This selective inhibitory effect of Rhodamine-123 on some carcinomas is unusual since known anticancer drugs, such as arabinosyl cytosine and methotrexate, have not been shown to exhibit such selectivity in vitro.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Bernal, S D -- Lampidis, T J -- Summerhayes, I C -- Chen, L B -- New York, N.Y. -- Science. 1982 Dec 10;218(4577):1117-9.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/7146897" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; Carcinoma/*drug therapy ; Cell Line ; Cell Survival/drug effects ; Mice ; Mitochondria/metabolism ; Neoplasms, Experimental/drug therapy ; Rhodamine 123 ; Rhodamines/metabolism/therapeutic use ; Time Factors ; Urinary Bladder Neoplasms/drug therapy
    Print ISSN: 0036-8075
    Electronic ISSN: 1095-9203
    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
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  • 2
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    Reduced leucine-enkephalin--like immunoreactive substance in hamster basal ganglia after long-term ethanol exposure (1982)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1982-06-25
    Description: Golden Syrian hamsters were placed individually in cages with three drinking bottles--one empty, one containing water, and the third containing water and ethanol. Control hamsters received water only. After 1 year the experimental hamsters showed a significantly lower concentration of leucine-enkephalin-like immunoreactive substance in the basal ganglia than the control hamsters. This finding indicates that the action of ethanol involves endogenous peptidyl opiates.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Blum, K -- Briggs, A H -- Elston, S F -- DeLallo, L -- Sheridan, P J -- Sar, M -- New York, N.Y. -- Science. 1982 Jun 25;216(4553):1425-7.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/7089531" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; Basal Ganglia/*drug effects ; Cricetinae ; Endorphins/*analysis ; Enkephalin, Leucine ; Enkephalins/*analysis/metabolism ; Ethanol/metabolism/*pharmacology ; Mesocricetus ; Time Factors
    Print ISSN: 0036-8075
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  • 3
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    Measurement of intracellular free calcium in monkey kidney cells with aequorin (1982)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1982-07-16
    Description: A method has been developed for the measurement of intracellular free calcium in mammalian cells. The calcium-sensitive photoprotein aequorin can be incorporated into isolated cells by hypo-osmotic treatment without altering the cell viability, permeability, or metabolism. Intracellular calcium activity (Cai2+) was monitored in a perfusion system. In monkey kidney cells (LLC-MK2), Cai2+ is approximately 57 nanomoles per liter. Changes in Cai2+ with time can also be followed: exposure of the cells to anaerobiosis or the calcium ionophore A23187 reversibly increases Cai2+. The method has also been successfully tested in rat hepatocytes.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Borle, A B -- Snowdowne, K W -- New York, N.Y. -- Science. 1982 Jul 16;217(4556):252-4.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/6806904" target="_blank"〉PubMed〈/a〉
    Keywords: *Aequorin ; Anaerobiosis ; Animals ; Calcimycin/pharmacology ; Calcium/*metabolism ; Cell Line ; Kidney/drug effects/*metabolism ; Kinetics ; *Luminescent Proteins ; Macaca mulatta
    Print ISSN: 0036-8075
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  • 4
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    Long-term synaptic potentiation in the superior cervical ganglion (1982)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1982-03-12
    Description: Brief tetanic stimulation of the preganglionic nerves to the superior cervical ganglion enhances the postganglionic response to single preganglionic stimuli for 1 to 3 hours. This long-term potentiation of transmission through the ganglion is apparently not attributable to a persistent muscarinic action of the preganglionic neurotransmitter, acetylcholine, since neither the magnitude nor the time course of the phenomenon is reduced by atropine. The decay of long-term potentiation can be described by a first-order kinetic process with a mean time constant of 80 minutes. We conclude that long-term potentiation, once considered a unique property of the hippocampus, is in fact a more general feature of synaptic function. This form of synaptic memory may significantly influence information processing and control in other regions of the nervous system, including autonomic ganglia.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Brown, T H -- McAfee, D A -- 12116/PHS HHS/ -- NS 16576/NS/NINDS NIH HHS/ -- New York, N.Y. -- Science. 1982 Mar 12;215(4538):1411-3.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/6278593" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; Ganglia, Sympathetic/*physiology ; Kinetics ; Learning/*physiology ; Neuronal Plasticity ; Rats ; Synapses/*physiology ; *Synaptic Transmission ; Time Factors
    Print ISSN: 0036-8075
    Electronic ISSN: 1095-9203
    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
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  • 5
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    Evidence for the clonal origin of spontaneous metastases (1982)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1982-07-23
    Description: A cultured cell line of the K-1735 melanoma was x-irradiated to induce chromosome breakage and rearrangements and then was implanted into the footpads of syngenic C3H mice. Spontaneous lung metastases were isolated from different animals, established in culture as individual lines, and then karyotyped. Within certain metastases, the same chromosomal abnormality (or abnormalities) (recombinant chromosomes) was found in all the cells examined. Most metastases differed from one another in that they exhibited characteristic combinations of chromosomal markers. These findings indicated that the metastases were clonal and that they probably originated from different progenitor cells.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Talmadge, J E -- Wolman, S R -- Fidler, I J -- N01-CO-75380/CO/NCI NIH HHS/ -- New York, N.Y. -- Science. 1982 Jul 23;217(4557):361-3.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/6953592" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; Cell Line ; Chromosome Aberrations ; Genetic Markers ; Karyotyping ; Lung Neoplasms/secondary ; Melanoma ; Mice ; Mice, Inbred C3H ; Neoplasm Metastasis/*pathology ; Neoplasms, Experimental/pathology
    Print ISSN: 0036-8075
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    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
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  • 6
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    Breast-feeding patterns in low-income countries (1982)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1982-12-10
    Description: Breast-feeding is important to infant nutrition, morbidity, and mortality, and to postpartum amenorrhea (hence to birth intervals). Evidence on breast-feeding patterns in low-income countries from nationally representative World Fertility Surveys and secondary sources shows that in all but a few such countries most children are breast-fed for at least a few months. The limited evidence available on trends seems to indicate a decline in the duration of breast-feeding, but in most of Asia and Africa breast-feeding is almost universal during at least the first 6 months. Earlier weaning is common in Latin America.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Popkin, B M -- Bilsborrow, R E -- Akin, J S -- New York, N.Y. -- Science. 1982 Dec 10;218(4577):1088-93.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/7146896" target="_blank"〉PubMed〈/a〉
    Keywords: Africa ; Asia ; *Breast Feeding ; *Developing Countries ; Female ; Humans ; Rural Population ; South America ; Time Factors ; Urban Population
    Print ISSN: 0036-8075
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    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
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  • 7
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    Manipulation of event-related potential manifestations of information processing stages (1982)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1982-11-26
    Description: The timing of two event-related potential components was differentially affected by two experimental variables. The earlier component (NA) was affected by degradation of the stimuli and the later component (N2) by the nature of a classification task. The results support the hypothesis that NA and N2 reflect sequential stages of information processing, namely, pattern recognition and stimulus classification.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Ritter, W -- Simson, R -- Vaughan, H G Jr -- Macht, M -- HD 10804/HD/NICHD NIH HHS/ -- IF32 AGO-5193/AG/NIA NIH HHS/ -- MH 06723/MH/NIMH NIH HHS/ -- etc. -- New York, N.Y. -- Science. 1982 Nov 26;218(4575):909-11.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/7134983" target="_blank"〉PubMed〈/a〉
    Keywords: Action Potentials ; Adult ; Brain/*physiology ; Brain Mapping ; Cognition/*physiology ; Discrimination (Psychology)/physiology ; Evoked Potentials ; Humans ; Information Theory ; Perception/*physiology ; Time Factors
    Print ISSN: 0036-8075
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  • 8
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    Human fetal movement: spontaneous oscillations near one cycle per minute (1982)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1982-12-24
    Description: Spectral analysis of spontaneous fluctuations in human fetal movement revealed strong oscillations at frequencies between 0.24 and 0.90 cycle per minute, which are much higher than those of the cyclic alternation of quiet and active states in the fetus and neonate. Oscillations at frequencies up to 2.88 cycles per minute were also detected, but they were usually much weaker. The prominent peaks in the fetal movement spectra are in the frequency range of recently reported neonatal motor rhythms, and indicate the existence of a cyclic process controlling spontaneous motor output that oscillates near one cycle per minute and begins to function in utero.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Robertson, S S -- Dierker, L J -- Sorokin, Y -- Rosen, M G -- M01RR00210/RR/NCRR NIH HHS/ -- P50HD11089/HD/NICHD NIH HHS/ -- New York, N.Y. -- Science. 1982 Dec 24;218(4579):1327-30.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/7146916" target="_blank"〉PubMed〈/a〉
    Keywords: Female ; Fetus/*physiology ; Humans ; *Movement ; Pregnancy ; Pregnancy Trimester, Third ; Spectrum Analysis/methods ; Time Factors
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  • 9
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    Transformation of human leukocytes by cocultivation with an adult T cell leukemia virus producer cell line (1982)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1982-08-20
    Description: The transmission of adult T cell leukemia virus, a human retrovirus, into fresh leukocytes from normal humans was examined. One of three virus-carrying cell lines, tested after being subjected to lethal x-irradiation, consistently transformed leukocytes from adult peripheral blood and umbilical cord blood. All the transformed cell lines expressed adult T cell leukemia virus-associated antigen, but transformed lines originating from adult and umbilical cord blood exhibited T cell and non-T, non-B cell surface natures, respectively. Efforts to transform human leukocytes with cell-free virus were unsuccessful.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Yamamoto, N -- Okada, M -- Koyanagi, Y -- Kannagi, M -- Hinuma, Y -- New York, N.Y. -- Science. 1982 Aug 20;217(4561):737-9.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/6980467" target="_blank"〉PubMed〈/a〉
    Keywords: Antigens, Surface/immunology ; Antigens, Viral/immunology ; B-Lymphocytes/immunology ; Cell Line ; Fetal Blood ; Genes, Viral ; Humans ; Karyotyping ; Leukocytes/*physiology ; Retroviridae/*genetics ; T-Lymphocytes/immunology ; *Transformation, Genetic
    Print ISSN: 0036-8075
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  • 10
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    Anomalous patterns in cultured cell monolayers (1982)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1982-08-27
    Description: Gridlike patterns of differing cell density were observed in evenly seeded cell monolayers. Such patterns were obtained in five of six cell lines tested, suggesting widespread occurrence. The mechanism appears to involve small, transient temperature changes related to incubator tray structure. The very short time course of appearance of the patterns implicates attachment rather than growth as the critically affected factor. Impaired adhesion or directed sedimentation resulting from thermally induced microcurrents in the medium are the two most likely mechanisms.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Adler, E M -- Flunk, L J -- Mullin, J M -- Kleinzeller, A -- 2 T32 GM07229-07/GM/NIGMS NIH HHS/ -- AM 12619-13/AM/NIADDK NIH HHS/ -- HL07027-07/HL/NHLBI NIH HHS/ -- New York, N.Y. -- Science. 1982 Aug 27;217(4562):851-3.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/7048529" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; Cell Adhesion ; Cell Count ; Cell Line ; Cells, Cultured/*cytology ; Cricetinae ; *Cytological Techniques ; Dogs ; Mice ; Temperature
    Print ISSN: 0036-8075
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  • 11
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    Migration inhibition of endothelial cells by lymphokine-containing supernatants (1982)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1982-01-15
    Description: Many of the reactions of cellular immunity are mediated by soluble lymphocyte-derived factors (lymphokines). One important category of lymphokine action involves effects on cell motility. These effects have been described mainly with respect to inflammatory cells. In this report, we describe the ability of a lymphocyte product to inhibit the migration of endothelial cells in a system in vitro. The responsible factor is distinct from a previously described mediator that inhibits the migration of tumor cells. The ability of lymphocytes to influence the migration properties of endothelial cells is consistent with data of others showing a relation between the immune system and processes involving neovascularization.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Cohen, M C -- Picciano, P T -- Douglas, W J -- Yoshida, T -- Kreutzer, D L -- Cohen, S -- AI-12477/AI/NIAID NIH HHS/ -- HL-25015/HL/NHLBI NIH HHS/ -- New York, N.Y. -- Science. 1982 Jan 15;215(4530):301-3.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/6797069" target="_blank"〉PubMed〈/a〉
    Keywords: Cell Line ; Cell Migration Inhibition ; Cell Movement/drug effects ; Endothelium/cytology/*drug effects ; Humans ; Leukocyte Migration-Inhibitory Factors/pharmacology ; Lymphokines/*pharmacology ; Macrophages/drug effects ; Mast-Cell Sarcoma/physiopathology
    Print ISSN: 0036-8075
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  • 12
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    Coupling of histone and DNA synthesis in the somatic cell cycle (1982)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1982-01-01
    Description: The coupling of histone and DNA synthesis was examined in the temperature-sensitive hamster fibroblast cell line K12. By monitoring total cellular histone synthesis at various times after quiescent cells were stimulated to proliferate at permissive and nonpermissive temperatures, a direct correlation was found between the rates of DNA and histone synthesis. Furthermore, when DNA synthesis was blocked by the K12 mutation, histone synthesis was reduced to the basal rate.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Delegeane, A M -- Lee, A S -- 2S07RR05356/RR/NCRR NIH HHS/ -- CA27607/CA/NCI NIH HHS/ -- New York, N.Y. -- Science. 1982 Jan 1;215(4528):79-81.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/7053561" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; *Cell Cycle ; Cell Line ; Cricetinae ; DNA/biosynthesis ; *DNA Replication ; Histones/*biosynthesis ; Mutation
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  • 13
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    Biological diversity in metastatic neoplasms: origins and implications (1982)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1982-09-10
    Description: Whether neoplasms are unicellular or multicellular in their origin, the process of tumor evolution and progression can rapidly generate biological diversity. Metastases result from the survival and proliferation of specialized subpopulations of cells within the parent tumor. Metastases may have a clonal origin and different metastases may develop from different progenitor cells. However, as with the primary tumor, the origin of metastases is unimportant since the process of tumor evolution and progression can generate biological diversity within and among different metastatic foci.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Fidler, I J -- Hart, I R -- N01-CO-75380/CO/NCI NIH HHS/ -- New York, N.Y. -- Science. 1982 Sep 10;217(4564):998-1003.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/7112116" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; Cell Line ; Cell Transformation, Neoplastic/pathology ; Clone Cells ; Humans ; Immunity ; Melanoma/genetics/pathology ; Mice ; Mice, Inbred Strains ; Mutation ; Neoplasm Metastasis/*pathology ; Neoplasms, Experimental/pathology ; Phenotype ; Skin Neoplasms/genetics/pathology
    Print ISSN: 0036-8075
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    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
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  • 14
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    Intracellular pH of mitogen-stimulated lymphocytes (1982)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1982-05-28
    Description: Mitogenic stimulation of mouse lymphocytes results in two sequential intracellular alkalinizations. The first shift of intracellular pH from 7.18 to 7.35 coincides with early biochemical events following mitogenic stimulation. The second alkalinization begins 12 hours after stimulation and rises in parallel with the rate of thymidine incorporation. The results suggest that intracellular alkalinization following stimulation may play a key role in the enhancement of cellular activation and mitogenesis.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Gerson, D F -- Kiefer, H -- Eufe, W -- New York, N.Y. -- Science. 1982 May 28;216(4549):1009-10.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/6281887" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; B-Lymphocytes/physiology ; DNA Replication ; *Hydrogen-Ion Concentration ; *Lymphocyte Activation ; Lymphocytes/drug effects/*physiology ; Mice ; Mitogens/pharmacology ; Phosphotransferases/metabolism ; Spleen ; T-Lymphocytes/physiology ; Time Factors
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  • 15
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    Differential breakdown of phylogenetically diverse ribosomal RNA's inserted via liposomes into mammalian cells (1982)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1982-07-02
    Description: Liposomes were used to deliver ribosomal RNA's from the different organisms into cultivated mouse plasmacytoma cells. Ribosomal RNA from Escherichia coli was degraded intracellularly within 1 hour, whereas mouse and yeast ribosomal RNA's were degraded more slowly. This indicates that cells can discriminated between different ribosomal RNA's.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Lavelle, D -- Ostro, M J -- Giacomoni, D -- GM 27935/GM/NIGMS NIH HHS/ -- New York, N.Y. -- Science. 1982 Jul 2;217(4554):59-61.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/6178157" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; Cell Line ; Escherichia coli ; Kinetics ; *Liposomes ; Mice ; Molecular Weight ; Neoplasms, Experimental/metabolism ; Plasmacytoma/*metabolism ; RNA, Bacterial/metabolism ; RNA, Ribosomal/*metabolism ; Saccharomyces cerevisiae ; Species Specificity
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  • 16
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    Precipitated withdrawal by a benzodiazepine receptor antagonist (Ro 15-1788) after 7 days of diazepam (1982)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1982-09-17
    Description: Baboons implanted with intragastric catheters were given diazepam (10 milligrams per kilogram of body weight) twice daily for 45 consecutive days. On days 7 and 35, they were given intramuscular injections of the benzodiazepine receptor antagonist Ro 15-1788. Mild and intermediate withdrawal signs, including retching and vomiting, were observed after 7 days of diazepam, and more frequent and intense withdrawal signs, including tremor and convulsion, occurred after 35 days of diazepam. With the termination of the diazepam injections after 45 days, a mild to intermediate withdrawal syndrome was observed over the next 15-day period.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Lukas, S E -- Griffiths, R R -- DA-01147/DA/NIDA NIH HHS/ -- DA-05186/DA/NIDA NIH HHS/ -- New York, N.Y. -- Science. 1982 Sep 17;217(4565):1161-3.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/6287579" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; Benzodiazepinones/*pharmacology ; Diazepam/*pharmacology ; Flumazenil ; Humans ; Male ; Papio ; Receptors, Drug/*drug effects ; Receptors, GABA-A ; Receptors, Neurotransmitter/drug effects ; Substance Withdrawal Syndrome/*chemically induced ; Time Factors
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  • 17
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    Biosynthesis and processing of a human precursor complement protein, pro-C3, in a hepatoma-derived cell line (1982)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1982-01-22
    Description: A 180,000-dalton single-chain molecule (human pro-C3) is the precursor of the third component of human complement (C3), a disulfide-linked two-chain protein. The pro-C3 is converted by limited proteolysis to C3. The relationship between pro-C3 and C3 was established with the use of Hep G2, a cell line derived from a human hepatocellular carcinoma, which synthesizes at least 17 plasma proteins.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Morris, K M -- Goldberger, G -- Colten, H R -- Aden, D P -- Knowles, B B -- AM 16392/AM/NIADDK NIH HHS/ -- CA 18470/CA/NCI NIH HHS/ -- CA 25875/CA/NCI NIH HHS/ -- New York, N.Y. -- Science. 1982 Jan 22;215(4531):399-400.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/7199205" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; Cell Line ; Complement C3/*biosynthesis ; Humans ; Liver Neoplasms, Experimental/*metabolism ; Macromolecular Substances ; Molecular Weight ; Protein Precursors/metabolism
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  • 18
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    Cellular mechanism of neuronal synchronization in epilepsy (1982)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1982-05-14
    Description: Interictal spikes are a simple kind of epileptic neuronal activity. Field potentials and intracellular recordings observed during interictal spikes of penicillin-treated slices of the hippocampus were reproduced by a mathematical model of a network of 100 hippocampal neurons from the region including CA2 and CA3. The model shows that this form of neuronal synchronization arises because of mutual excitation between neurons, each of which is capable of intrinsic bursting in response to a brief input.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Traub, R D -- Wong, R K -- NS18464/NS/NINDS NIH HHS/ -- New York, N.Y. -- Science. 1982 May 14;216(4547):745-7.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/7079735" target="_blank"〉PubMed〈/a〉
    Keywords: Action Potentials/drug effects ; Epilepsy/*physiopathology ; Hippocampus/*physiopathology ; Models, Biological ; Neurons/physiology ; Penicillins/pharmacology ; Time Factors
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  • 19
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    Bronchoconstrictor effects of leukotriene C in humans (1982)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1982-04-09
    Description: Maximum expiratory flow rate at 30 percent of vital capacity above residual volume served as an index of airway obstruction in comparing the effects of leukotriene C and histamine administered by aerosol to five normal persons. Leukotriene C was 600 to 9500 times more potent than histamine on a molar basis in producing an equivalent decrement in the residual volume. The leukotriene C response was slow in onset and prolonged, reminiscent of the effects of aerosol allergen challenge in asthmatic allergic subjects.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Weiss, J W -- Drazen, J M -- Coles, N -- McFadden, E R Jr -- Weller, P F -- Corey, E J -- Lewis, R A -- Austen, K F -- AI-00399/AI/NIAID NIH HHS/ -- AI-07722/AI/NIAID NIH HHS/ -- AI-10356/AI/NIAID NIH HHS/ -- New York, N.Y. -- Science. 1982 Apr 9;216(4542):196-8.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/7063880" target="_blank"〉PubMed〈/a〉
    Keywords: Adult ; Airway Resistance/*drug effects ; Bronchi/*drug effects ; Dose-Response Relationship, Drug ; Female ; Histamine/pharmacology ; Humans ; Male ; Middle Aged ; Prostaglandins F/pharmacology ; SRS-A/*pharmacology ; Time Factors
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  • 20
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    Angiogenesis induced by "normal" human breast tissue: a probable marker for precancer (1982)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1982-10-15
    Description: Normal human breast lobules, freshly isolated by precision microdissection of tissue stained with methylene blue chloride, were assayed for their ability to induce neovascularization (angiogenesis) in rabbit irises. Histologically, normal lobules from cancerous breast induced angiogenesis twice as often as lobules from noncancerous breasts, suggesting that preneoplastic transformation is diffuse.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Jensen, H M -- Chen, I -- DeVault, M R -- Lewis, A E -- N01-CB-84316/CB/NCI NIH HHS/ -- New York, N.Y. -- Science. 1982 Oct 15;218(4569):293-5.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/6181563" target="_blank"〉PubMed〈/a〉
    Keywords: Age Factors ; Animals ; Breast/*physiology ; Female ; Humans ; Iris/*blood supply ; Middle Aged ; *Neovascularization, Pathologic ; Precancerous Conditions/*physiopathology ; Rabbits ; Time Factors
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  • 21
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    Mucus secretion-stimulating activity in human lymphoblastoid cells (1982)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1982-08-20
    Description: Two fractions isolated from cultured lymphoblastoid cells stimulated mucus secretion from the urn cell complex of the marine invertebrate Sipunculus nudus. The activity detected in the nuclear fraction was trypsin-sensitive, and it increased in response to specific nucleotides.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Kulemann-Kloene, H -- Krag, S S -- Bang, F B -- 5P50 HL-19157/HL/NHLBI NIH HHS/ -- CA-00640/CA/NCI NIH HHS/ -- New York, N.Y. -- Science. 1982 Aug 20;217(4561):736-7.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/6285469" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; Cell Fractionation ; Cell Line ; Cell Nucleus/analysis ; Cytoplasm/analysis ; Deoxyribonuclease I ; Deoxyribonucleases/pharmacology ; Endonucleases/pharmacology ; Humans ; Lymphocytes/*metabolism ; Mucus/*secretion ; Nematoda/*metabolism ; Temperature ; Trypsin/pharmacology
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  • 22
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    Virus-induced corticosterone in hypophysectomized mice: a possible lymphoid adrenal axis (1982)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1982-12-24
    Description: Infection of hypophysectomized mice with Newcastle disease virus caused a time-dependent increase in corticosterone and interferon production. Prior treatment with dexamethasone completely inhibited the virus-induced elevation in corticosterone concentration, but did not significantly alter the interferon response. Lymphocytes appear to be the most likely source of an adrenocorticotropin-like substance that is responsible for the increased corticosterone, since spleen cells from the virus-infected, but not from control or dexamethasone-treated, hypophysectomized mice showed positive immunofluorescence with antibody to adrenocorticotropin-(1-13 amide). Thus the adrenocorticotropin-like material and interferon appear to be coordinately induced the differentially controlled products of different genes. These findings strongly suggest the existence of a lymphoid-adrenal axis.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Smith, E M -- Meyer, W J -- Blalock, J E -- AM30046/AM/NIADDK NIH HHS/ -- HL20201/HL/NHLBI NIH HHS/ -- New York, N.Y. -- Science. 1982 Dec 24;218(4579):1311-2.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/6183748" target="_blank"〉PubMed〈/a〉
    Keywords: Adrenal Glands/*physiology ; Animals ; Corticosterone/*biosynthesis ; Dexamethasone/pharmacology ; *Hypophysectomy ; Interferons/biosynthesis ; Kinetics ; Lymph Nodes/*physiology ; Mice ; Newcastle Disease/*metabolism ; Time Factors
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  • 23
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    Excretion of beta-phenethylamine is elevated in humans after profound stress (1982)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1982-02-26
    Description: The urinary excretion rate of the endogenous, amphetamine-like substance beta-phenethylamine was markedly elevated in human subjects in association with an initial parachuting experience. The increases were delayed in most subjects and were not correlated with changes in urinary pH or creatinine excretion. The data suggest a stress-related role for beta-phenethylamine.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Paulos, M A -- Tessel, R E -- DA-01614/DA/NIDA NIH HHS/ -- GM-27430/GM/NIGMS NIH HHS/ -- RR-05606/RR/NCRR NIH HHS/ -- New York, N.Y. -- Science. 1982 Feb 26;215(4536):1127-9.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/7063846" target="_blank"〉PubMed〈/a〉
    Keywords: Adolescent ; Adult ; *Aerospace Medicine ; Creatinine/urine ; Female ; Humans ; Male ; Phenethylamines/*urine ; Stress, Physiological/*urine ; Time Factors
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  • 24
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    Hybridomas: the making of a revolution (1982)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1982-02-26
    Description: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Wade, N -- New York, N.Y. -- Science. 1982 Feb 26;215(4536):1073-5.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/7038873" target="_blank"〉PubMed〈/a〉
    Keywords: Allergy and Immunology/*history ; Animals ; Cell Line ; History, 20th Century ; Hybridomas/*immunology ; Mice
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  • 25
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    A specific and enduring improvement in visual motion discrimination (1982)
    American Association for the Advancement of Science (AAAS)
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    Publication Date: 1982-11-12
    Description: Training improves the ability of human observers to discriminate between two similar directions of motion. This gradual improvement is specific to the direction on which an observer is trained, and it endures for several months. Improvement does not affect motion perception generally, nor does it depend on recognition of details of the movement.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Ball, K -- Sekuler, R -- New York, N.Y. -- Science. 1982 Nov 12;218(4573):697-8.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/7134968" target="_blank"〉PubMed〈/a〉
    Keywords: Discrimination (Psychology)/*physiology ; Eye Movements ; Humans ; Motion Perception/*physiology ; Neuronal Plasticity ; Time Factors ; Visual Perception/*physiology
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  • 26
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    Experimental hepatic encephalopathy: changes in the binding of gamma-aminobutyric acid (1982)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1982-04-23
    Description: Two populations of receptors for gamma-aminobutyric acid, one with low- and the other with high-affinity characteristics, are detectable in frozen, thawed, Triton-treated synaptic membrane preparations from normal brain. It is now reported that membrane preparations from rats with mild galactosamine-induced hepatic encephalopathy show an increase in the number of low- and high-affinity gamma-aminobutyric acid binding sites, whereas those from rats with severe encephalopathy show only high-affinity binding sites. Thus, hepatic encephalopathy appears to involve partial degeneration of the gamma-aminobutyric acid-containing presynaptic nerve terminals.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Baraldi, M -- Zeneroli, Z L -- New York, N.Y. -- Science. 1982 Apr 23;216(4544):427-9.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/6280279" target="_blank"〉PubMed〈/a〉
    Keywords: Bicuculline/metabolism ; Binding, Competitive ; Brain/*metabolism ; Disease Models, Animal ; Galactosamine ; Hepatic Encephalopathy/*metabolism ; Humans ; Kinetics ; Receptors, Cell Surface/*metabolism ; Receptors, GABA-A ; Synaptic Membranes/metabolism ; Time Factors ; gamma-Aminobutyric Acid/*metabolism
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  • 27
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    Gestational zinc deprivation in mice: persistence of immunodeficiency for three generations (1982)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1982-10-29
    Description: Pregnant Swiss Webster mice were fed a diet moderately deficient in zinc from day 7 of gestation until parturition. Offspring of these mice showed depressed immune function through 6 months of age. In addition, the second and third filial generations, all of which were fed only the normal control diet, continued to manifest reduced immunocompetence, although not to the same degree as in the first generation.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Beach, R S -- Gershwin, M E -- Hurley, L S -- New York, N.Y. -- Science. 1982 Oct 29;218(4571):469-71.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/7123244" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; Antibody Formation ; Female ; Immune Tolerance ; Immunoglobulin M/analysis ; Immunologic Deficiency Syndromes/*embryology ; Mice ; Pregnancy ; Time Factors ; Zinc/*deficiency
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  • 28
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    Integrating visual information from successive fixations (1982)
    American Association for the Advancement of Science (AAAS)
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    Publication Date: 1982-01-08
    Description: One of the classic problems in perception is how visual information from successive fixations of a scene is integrated to form a coherent view of the scene. The results of this experiment implicate a process that integrates by summing information from successive fixations after spatially reconciling the information from each glimpse. The output of this process is a memory image that preserves the properly reconciled information from successive fixations.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Jonides, J -- Irwin, D E -- Yantis, S -- IR03 MH36869-01/MH/NIMH NIH HHS/ -- New York, N.Y. -- Science. 1982 Jan 8;215(4529):192-4.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/7053571" target="_blank"〉PubMed〈/a〉
    Keywords: Humans ; Memory/physiology ; Models, Biological ; Saccades ; Time Factors ; Visual Perception/*physiology
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  • 29
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    Cell biology yields clues to lung cancer (1982)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1982-10-01
    Description: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Kolata, G -- New York, N.Y. -- Science. 1982 Oct 1;218(4567):38-9.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/6289431" target="_blank"〉PubMed〈/a〉
    Keywords: Carcinoma, Small Cell/*physiopathology ; Cell Division ; Cell Line ; Humans ; Lung Neoplasms/*physiopathology
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  • 30
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    Adrenal medullary enkephalin-like peptides may mediate opioid stress analgesia (1982)
    American Association for the Advancement of Science (AAAS)
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    Publication Date: 1982-08-06
    Description: Different patterns of fact shock activate opioid and nonopioid mechanisms of stress analgesia in the rat. Opioid, but not nonopioid, stress analgesia is reduced by adrenal demedullation and denervation and is potentiated by reserpine, a drug known to increase concentrations of adrenal medullary enkephalin-like peptides. It is suggested that adrenal enkephalins mediate opioid stress analgesia.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Lewis, J W -- Tordoff, M G -- Sherman, J E -- Liebeskind, J C -- NS07628/NS/NINDS NIH HHS/ -- New York, N.Y. -- Science. 1982 Aug 6;217(4559):557-9.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/7089582" target="_blank"〉PubMed〈/a〉
    Keywords: Adrenal Medulla/*physiology ; Analgesia ; Animals ; Electroshock ; Endorphins/*physiology ; Enkephalins/*physiology ; Male ; Morphine/pharmacology ; Naltrexone/pharmacology ; Rats ; Reserpine/pharmacology ; Sodium Chloride/pharmacology ; Stress, Physiological/*physiopathology ; Time Factors
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    Monkey and human pictorial memory scanning (1982)
    American Association for the Advancement of Science (AAAS)
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    Publication Date: 1982-06-18
    Description: A rhesus monkey accurately recognized pictures in a Sternberg memory scanning experiment. When the monkey was tested with pictures that were reused during the same session, the monkey's performance was nearly identical to that of a human subject; this result demonstrates the monkeys are capable of some of the short-term retrieval mechanisms of humans.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Sands, S F -- Wright, A A -- EY-01256/EY/NEI NIH HHS/ -- MH35202/MH/NIMH NIH HHS/ -- New York, N.Y. -- Science. 1982 Jun 18;216(4552):1333-4.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/7079768" target="_blank"〉PubMed〈/a〉
    Keywords: Adult ; Animals ; Female ; Humans ; Macaca mulatta ; Male ; Memory/*physiology ; Species Specificity ; Time Factors ; *Visual Perception
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  • 32
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    Electric pulse-induced fusion of 3T3 cells in monolayer culture (1982)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1982-04-30
    Description: Swiss mouse 3T3-C2 fibroblasts, grown to confluence in monolayer culture, are shown to fuse when exposed to electric fields. Exposure to five repetitive electric pulses of about 1 kilovolt per centimeter with a duration of 50 microseconds caused approximately 20 percent of the cells to become fused (multinucleate) when 1 millimolar magnesium was present in the medium. The effects of minimum thresholds of field strength, pulse duration, and number of pulses were determined. Cell disruption was observed when the electric field exceeded 2.0 kilovolts per centimeter or the pulse was of longer duration than 120 microseconds.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Teissie, J -- Knutson, V P -- Tsong, T Y -- Lane, M D -- AM14574/AM/NIADDK NIH HHS/ -- GM28795/GM/NIGMS NIH HHS/ -- RR5378/RR/NCRR NIH HHS/ -- New York, N.Y. -- Science. 1982 Apr 30;216(4545):537-8.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/7071601" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; *Cell Fusion/drug effects ; *Electricity ; Magnesium/pharmacology ; Mice ; Time Factors
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  • 33
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    Impulse conduction in the mammalian brain: physiological properties of individual axons monitored for several months (1982)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1982-11-26
    Description: Microelectrode recordings were used in conjunction with antidromic activation to monitor impulse conduction along individual mammalian cerebral axons for periods of up to 165 days. Approximately half of the axons studied showed a stable conduction velocity and stable aftereffects of impulse activity. The remaining axons showed slow and progressive increases or decreases in conduction velocity overtime. In these latter axons, changes in the magnitude of the aftereffects of impulse conduction were far less pronounced than were changes in axonal conduction velocity.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Swadlow, H A -- New York, N.Y. -- Science. 1982 Nov 26;218(4575):911-3.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/7134984" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; Axons/*physiology ; Brain/*physiology ; Neural Conduction ; Rabbits ; Time Factors
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    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
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    Oncogenes (1982)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1982-12-10
    Description: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Pollack, R E -- New York, N.Y. -- Science. 1982 Dec 10;218(4577):1069-70.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/7146895" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; Cell Line ; Mice ; *Oncogenes
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    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
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