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  • Animals  (374)
  • 1995-1999
  • 1985-1989
  • 1975-1979  (374)
  • 1979  (374)
  • 1
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    Flatworm control of mosquito larvae in rice fields (1979)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1979-12-21
    Description: We describe some flatworms (some in the genus Mesostoma) that kill mosquito larvae and may account for the variability in the population densities of Culex tarsalis and Anopheles freeborni in rice fields. When mosquito larvae brush against these worms, the larvae immediately become paralyzed and die. When C. tarsalis larvae are placed inside floating cages that exclude flatworms (50-micromter mesh), there is a fourfold increase in the their survival. Rice fields that have abundant mosquito populations lack flatworms. Most such fields have only recently been turned over to rice production, suggesting that the flatworms have difficulty dispersing to new fields but, once established, are able to overwinter and control mosquitoes for the subsequent years of rice production.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Case, T J -- Washino, R K -- New York, N.Y. -- Science. 1979 Dec 21;206(4425):1412-4.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/41321" target="_blank"〉PubMed〈/a〉
    Keywords: Agriculture/*methods ; Animals ; Anopheles/physiology ; California ; Culex/physiology ; Culicidae/*physiology ; Insect Control/*methods ; Larva ; *Oryza ; Platyhelminths/*physiology
    Print ISSN: 0036-8075
    Electronic ISSN: 1095-9203
    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
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  • 2
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    A direct role of dopamine in the rat subthalamic nucleus and an adjacent intrapeduncular area (1979)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1979-12-21
    Description: The subthalamic nucleus, a clinically important component of the extrapyramidal motor system, and a lateral area extending into the peduncle contain catecholamine terminals and dopamine receptors coupled to adenylate cyclase. In addition, dopamine agonists administered in vivo enhance glucose utilization in the region. Thus, neuronal function in this region is directly affected by dopamine and dopaminergic drugs.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Brown, L L -- Markman, M H -- Wolfson, L I -- Dvorkin, B -- Warner, C -- Katzman, R -- New York, N.Y. -- Science. 1979 Dec 21;206(4425):1416-8.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/505015" target="_blank"〉PubMed〈/a〉
    Keywords: Adenylyl Cyclases/metabolism ; Animals ; Brain Mapping ; Catecholamines/pharmacology ; Dopamine/pharmacology ; Enzyme Activation/drug effects ; Extrapyramidal Tracts/*metabolism/ultrastructure ; Glucose/metabolism ; Male ; Mesencephalon/*metabolism ; Neurons/metabolism ; Rats ; Receptors, Dopamine/*metabolism
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  • 3
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    Chlorpromazine and its metabolites alter polymerization and gelation of actin (1979)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1979-12-21
    Description: Hepatic hydroxylated metabolites of chlorpromazine (10(-5)M to 10(-4)M), a frequently used phenothiazine tranquilizer, produce solid gel formation with filamentous actin, but the less toxic chlorpromazine sulfoxide metabolite does not. At higher concentrations (5 x 10(-4)M) chlorpromazine inhibits actin polymerization. These dose-response relationships parallel the drug's hepatic toxicity in vivo and suggest that interactions between chloropromazine or chlorpromazine metabolites and actin could be an underlying mechanism of cell injury.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Elias, E -- Boyer, J L -- New York, N.Y. -- Science. 1979 Dec 21;206(4425):1404-6.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/574316" target="_blank"〉PubMed〈/a〉
    Keywords: Actins/*metabolism ; Animals ; Chlorpromazine/*analogs & derivatives/*pharmacology ; Cytoskeleton/drug effects ; Dose-Response Relationship, Drug ; Gels ; Protein Binding/drug effects ; Rabbits ; Viscosity
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  • 4
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    Spontaneous diabetes mellitus: reversal and prevention in the BB/W rat with antiserum to rat lymphocytes (1979)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1979-12-21
    Description: Injections of rabbit antiserum to rat lymphocytes reversed hyperglycemia in 36 percent of spontaneously diabetic rats (Bio Breeding/Worcester) and prevented diabetes in susceptible nondiabetic controls. These findings strengthen the hypothesis that cell-mediated autoimmunity plays a role in the pathogenesis of diabetes in this animal model that mimics many morpholigic and physiologic characteristics of human insulin-dependent diabetes mellitus.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Like, A A -- Rossini, A A -- Guberski, D L -- Appel, M C -- Williams, R M -- New York, N.Y. -- Science. 1979 Dec 21;206(4425):1421-3.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/388619" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; Antilymphocyte Serum/*therapeutic use ; *Autoimmune Diseases ; Blood Glucose/metabolism ; Diabetes Mellitus, Experimental/*immunology/prevention & control/therapy ; Immunosuppression ; Islets of Langerhans/immunology ; Isoantibodies ; Lymphocytes/*immunology ; Rats
    Print ISSN: 0036-8075
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  • 5
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    Derived X chromosome in the turtle genus Staurotypus (1979)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1979-12-21
    Description: C-banding, G-banding, and silver (Ag-AS) staining techniques reveal a distinctive sex chromosome system in the turtle Staurotypus salvinii. Unlike previously described systems in most other vertebrate groups in which the Y or W is derived and the homogametic sex represents the primitive condition, the reverse is true for S. salvinii. The X chromosome is derived; thus the homogametic sex (female) is more derived than the heterogametic sex. The male is intermediate between the female and the ancestral condition observed in other turtle species. Staurotypus does not confirm to the general model of sex chromosome evolution for diploid dioecious organisms.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Sites, J W Jr -- Bickham, J W -- Haiduk, M W -- New York, N.Y. -- Science. 1979 Dec 21;206(4425):1410-2.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/92052" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; Biological Evolution ; Female ; Sex Chromosomes/*ultrastructure ; Silver ; Species Specificity ; Staining and Labeling ; Turtles/*anatomy & histology ; X Chromosome/*ultrastructure
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  • 6
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    Pyruvate dehydrogenase activation in adipocyte mitochondria by an insulin-generated mediator from muscle (1979)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1979-12-21
    Description: Material in a chromatographic fraction from an extract of insulin-treated muscle stimulated pyruvate dehydrogenase activity in addipocyte mitochondria. This action was similar to insulin's activation of the enzyme in a plasma membrane-mitochondria mixture. Neither the chromatographic fraction nor insulin required adenosine triphosphate or magnesium ion (Mg2+), suggesting that both agents acted through a calcium-sensitive phosphatase. This fraction may contain a chemical mediator of insulin action.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Jarett, L -- Seals, J R -- New York, N.Y. -- Science. 1979 Dec 21;206(4425):1407-8.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/505013" target="_blank"〉PubMed〈/a〉
    Keywords: Adenosine Triphosphate/pharmacology ; Adipose Tissue/*enzymology ; Animals ; Cell Membrane/drug effects ; Enzyme Activation/drug effects ; Insulin/*pharmacology ; Magnesium/pharmacology ; Mitochondria/enzymology ; Muscles/drug effects/*physiology ; Pyruvate Dehydrogenase Complex/*metabolism
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  • 7
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    Generation by insulin of a chemical mediator that controls protein phosphorylation and dephosphorylation (1979)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1979-12-21
    Description: Deproteinized skeletal muscle extracts free of major nucleotides from control and insulin-treated rats were fractionated and assayed for inhibition of protein phosphorylation by cyclic adenosine monophosphate (AMP)-dependent and -independent protein kinases. A differential effect of insulin on a particular fraction was observed on cyclic AMP-dependent protein kinase but not on cyclic AMP-independent protein kinases. This fraction that inhibited cyclic AMP-dependent protein kinase also stimulated glycogen synthase phosphoprotein phosphatase. It is proposed that this fraction may contain a mediator substance generateed in the presence of insulin.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Larner, J -- Galasko, G -- Cheng, K -- DePaoli-Roach, A A -- Huang, L -- Daggy, P -- Kellogg, J -- New York, N.Y. -- Science. 1979 Dec 21;206(4425):1408-10.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/228395" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; Cyclic AMP/metabolism ; Enzyme Activation/drug effects ; Glycogen-Synthase-D Phosphatase/*metabolism ; Insulin/*pharmacology ; Molecular Weight ; Muscle Proteins/isolation & purification/pharmacology ; Muscles/*drug effects ; Peptides/pharmacology ; Phosphoprotein Phosphatases/*metabolism ; *Protein Kinase Inhibitors ; Rats
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  • 8
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    Vascular smooth muscle: aerobic glycolysis linked to sodium and potassium transport processes (1979)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1979-12-21
    Description: Under aerobic conditions, glucose is primarily catabolized by vascular smooth muscle to lactate, in spite of an adequate oxidative capacity. Although this is often considered to be indicative of some nonspecific metabolic insufficiency, there is evidence that aerobic glycolysis is specifically coupled to sodium and potassium transport processes, whereas oxidative metabolism is couple to contracticle energy requirements.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Paul, R J -- Bauer, M -- Pease, W -- New York, N.Y. -- Science. 1979 Dec 21;206(4425):1414-6.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/505014" target="_blank"〉PubMed〈/a〉
    Keywords: Aerobiosis ; Animals ; Arteries/*metabolism ; Biological Transport, Active/drug effects ; *Glycolysis/drug effects ; Lactates/metabolism ; Muscle Contraction/drug effects ; Muscle, Smooth/*metabolism ; Ouabain/pharmacology ; Oxygen Consumption/drug effects ; Potassium/*metabolism/pharmacology ; Sodium/*metabolism
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  • 9
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    Clonal characteristics of experimentally induced "atherosclerotic" lesions in the hybrid hare (1979)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1979-12-21
    Description: The female hybrid hare (Lepus timidus x Lepus europaeus) is heterozygous for electrophoretically separable, X-linked isoenzymes of glucose-6-phosphate dehydrogenase. The isoenzymes of this animal have been used as cellular markers in the study of the clonal origins of experimentally induced atherosclerotic lesions. Aortic lesions produced in the hybrid hare by feeding cholesterol and injuring the aortic wall with a catheter have been shown to have polyclonal characteristics and in this way are fundamentally different from atherosclerotic fibrous plaques in man.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Pearson, T A -- Dillman, J -- Williams, K J -- Wolff, J A -- Adams, R -- Solez, K -- Heptinstall, R H -- Malmros, H -- Sternby, N -- New York, N.Y. -- Science. 1979 Dec 21;206(4425):1423-5.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/505016" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; Arteriosclerosis/enzymology/*pathology ; Catheterization/methods ; Clone Cells/enzymology/*pathology ; Diet, Atherogenic ; *Disease Models, Animal ; Glucosephosphate Dehydrogenase/metabolism ; Isoenzymes/metabolism ; Rabbits
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  • 10
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    Genetic mechanism accounting for precise immunoglobulin domain deletion in a variant of MPC 11 myeloma cells (1979)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1979-12-14
    Description: A variant of the MPC 11 cell line, M 311, produces a short immunoglobulin heavy chain. When compared with the parental gamma 2b heavy chain, M 311 was found to have a carboxyl terminal deletion comprising the CH3 domain. The COOH-terminal cyanogen bromide (CNBr) cleavage fragment of M 311 is identical to a corresponding segment ofa parental heavy chain CNBr fragment, with the exception of a substitution of asparagine for lysine at the COOH-terminal residue. This observation enabled prediction of both the parental DNA sequence in this region and the genetic mechanism which generated the variant, a frameshift followed by premature termination. This hypothesis is supported by studies of the DNA sequence of the MPC 11 gamma 2b constant region gene.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Kenter, A L -- Birshtein, B K -- R21 AI106328/AI/NIAID NIH HHS/ -- New York, N.Y. -- Science. 1979 Dec 14;206(4424):1307-9.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/117550" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; Cell Line ; Chromosome Deletion ; Genes ; Immunoglobulin G/*genetics ; Immunoglobulin gamma-Chains/genetics ; Macromolecular Substances ; Melphalan/pharmacology ; Mice ; Mutation ; Myeloma Proteins/*genetics ; Neoplasms, Experimental/genetics ; Peptide Chain Termination, Translational ; Plasmacytoma/genetics
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  • 11
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    Structure of the constant and 3' untranslated regions of the murine gamma 2b heavy chain messenger RNA (1979)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1979-12-14
    Description: The complete coding sequence for the constant region of the mouse gamma 2b immunoglobulin heavy chain and the 3' untranslated region has been determined. The coding portion of the sequence is 1008 nucleotides long (amino acid residues 114 to 449), and the 3' noncoding region contains 102 nucleotides preceeding the polyadenylate. An extra carboxyl-terminal lysine residue which had not been observed in the gamma 2b or other gamma subclass protein sequences occurs in the nucleotide sequence and is probably processed posttranslationally. A 17-nucleotide sequence occurs with slight variation twice in CH1 and once in CH2 domains in the same relative location but with different translational phase. This sequence may be the site of crossover in a gamma 2b . gamma 2a heavy chain variant, an indication of possible recombinational activity of some kind.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Tucker, P W -- Marcu, K B -- Slightom, J L -- Blattner, F R -- New York, N.Y. -- Science. 1979 Dec 14;206(4424):1299-303.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/117548" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; Base Sequence ; Biological Evolution ; Codon ; DNA, Recombinant ; Immunoglobulin Constant Regions/*genetics ; Immunoglobulin Heavy Chains/*genetics ; Immunoglobulin gamma-Chains/*genetics ; Immunoglobulins/*genetics ; Mice ; *Protein Biosynthesis ; RNA, Messenger/*genetics
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  • 12
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    Mercury in sperm whale meat (1979)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1979-12-14
    Description: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Beary, J F 3rd -- New York, N.Y. -- Science. 1979 Dec 14;206(4424):1260.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/515732" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; Cetacea/*metabolism ; Meat/*analysis ; Organomercury Compounds/*analysis ; Whales/*metabolism
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  • 13
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    Genetic resistance to aflatoxin in Japanese quail (1979)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1979-12-14
    Description: Progress was rapid in attempts to develop lines of quail resistant to acute aflatoxicosis induced by oral dosing with aflatoxin. After five generations of selection, 8- and 11-fold differences were present in mortality between two selected lines and their respective control lines. These quail lines should be of value in investigating the physiological basis of resistance to aflatoxin.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Marks, H L -- Wyatt, R D -- New York, N.Y. -- Science. 1979 Dec 14;206(4424):1329-30.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/515737" target="_blank"〉PubMed〈/a〉
    Keywords: Aflatoxins/*pharmacology ; Animals ; Coturnix/*genetics ; *Drug Resistance ; Female ; Genes ; Male ; Quail/*genetics ; Selection, Genetic
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  • 14
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    Sequence of the cloned gene for the constant region of murine gamma 2b immunoglobulin heavy chain (1979)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1979-12-14
    Description: The complete nucleotide sequence of the gamma 2b constant region gene cloned from BALB/c liver DNA is reported. The sequence of approximately 1870 base pairs includes the 5' flanking, 3' untranslated, and 3' flanking regions and three introns. The C gamma 2b coding region is divided by these introns into four segments corresponding to the homology domains and hinge region of the protein. The introns separating the hinge from the CH2 domain and the CH2 from the CH3 domain are small (106 and 119 base pairs). A larger intervening sequence of 314 base pairs separates the CH1 and hinge regions. The stretch of DNA comprising this large intron plus the hinge shows a strong homology with the other CH domains.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Tucker, P W -- Marcu, K B -- Newell, N -- Richards, J -- Blattner, F R -- New York, N.Y. -- Science. 1979 Dec 14;206(4424):1303-6.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/117549" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; Base Sequence ; Biological Evolution ; DNA, Recombinant ; *Genes ; Immunoglobulin Constant Regions/*genetics ; Immunoglobulin Heavy Chains/*genetics ; Immunoglobulin gamma-Chains/*genetics ; Immunoglobulins/*genetics ; Liver ; Mice ; Mice, Inbred BALB C ; Nucleic Acid Precursors/genetics ; RNA, Messenger/genetics ; Transcription, Genetic
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  • 15
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    Endocrine pancreas: three-dimensional reconstruction shows two types of islets of langerhans (1979)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1979-12-14
    Description: Three-dimensional reconstructions of islets of Langerhans, based on immunofluorescent staining of successive serial sections with antiserums to insulin, glucagon, somatostatin, and pancreatic polypeptide reveal a marked difference in the number of cells containing glucagon and pancreatic polypeptide depending on the anatomical location of the islet in the pancreas. The two types of islets are situated in regions of exocrine tissue that are drained by different excretory ducts. This demonstration contradicts the assumption that all islets in the pancreas are similar in their endocrine cell content.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Baetens, D -- Malaisse-Lagae, F -- Perrelet, A -- Orci, L -- New York, N.Y. -- Science. 1979 Dec 14;206(4424):1323-5.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/390711" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; Catheterization ; Glucagon/metabolism ; Insulin/metabolism ; Islets of Langerhans/*anatomy & histology/metabolism ; Pancreatic Polypeptide/metabolism ; Rats ; Somatostatin/metabolism
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  • 16
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    Cigarette smoke inhalation decreases alpha 1-antitrypsin activity in rat lung (1979)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1979-12-14
    Description: Brief inhalation exposure of rats to three or six puffs of cigarette smoke significantly decreases elastase inhibitory capacity per milligram of alpha 1-antitrypsin in lung lavage fluid. This effect is not observed in ozone-tolerant rats and can be reversed by treating the lung lavage fluid from smoke-exposed rats with reducing agents. Samples of human serum obtained immediately after smoking also show decreased elastase inhibitory capacity per milligram of alpha 1-antitrypsin. Again, elastase inhibitory capacity can be restored by treatment with a reducing agent. Cigarette smoking may cause emphysema by inactivating alpha 1-antitrypsin through oxidation.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Janoff, A -- Carp, H -- Lee, D K -- Drew, R T -- New York, N.Y. -- Science. 1979 Dec 14;206(4424):1313-4.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/316187" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; Drug Tolerance ; Lung/drug effects/*enzymology ; Male ; Oxidation-Reduction ; Ozone ; Pancreatic Elastase/metabolism ; Plants, Toxic ; Rats ; Smoke ; Smoking/*physiopathology ; Tobacco ; alpha 1-Antitrypsin/*metabolism
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  • 17
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    Choline excites cortical neurons (1979)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1979-12-14
    Description: In cats under halothane or methoxyflurane, iontophoretic applications of choline are only eight times weaker than applications of acetylcholine in evoking firing of neurons in the sensorimotor region of the cerebral cortex. The action of choline is suppressed by atropine but not by two agents that block choline uptake (hemicholinium-3 and triethylcholine), and is not potentiated by an anticholinesterase (physostigmine). Choline therefore appears to excite cortical neurons by a direct action, which may be a significant component of its beneficial therapeutic effects.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Krnjevic, K -- Reinhardt, W -- New York, N.Y. -- Science. 1979 Dec 14;206(4424):1321-3.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/515735" target="_blank"〉PubMed〈/a〉
    Keywords: Acetylcholine/pharmacology ; Action Potentials/drug effects ; Animals ; Cats ; Cerebral Cortex/*drug effects ; Choline/*pharmacology ; Drug Synergism ; Evoked Potentials ; Glutamates/pharmacology ; Hemicholinium 3/pharmacology ; Motor Cortex/physiology ; Physostigmine/pharmacology ; Receptors, Muscarinic/drug effects ; Stimulation, Chemical
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  • 18
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    Generation of unidirectionally propagated action potentials in a peripheral nerve by brief stimuli (1979)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1979-12-14
    Description: Single, unidirectionally propagated action potentials can be elicited in peripheral nerves by electrical stimuli of short duration. Propagation in one direction is blocked anodically by means of a quasi-trapezoidal stimulus wave form and a modified tripolar electrode configuration. Propagation in the other direction proceeds unhindered. This technique may be applicable to collision blocking of motor nerves for neural prostheses.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉van den Honert, C -- Mortimer, J T -- New York, N.Y. -- Science. 1979 Dec 14;206(4424):1311-2.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/515733" target="_blank"〉PubMed〈/a〉
    Keywords: *Action Potentials ; Animals ; Cats ; Electric Stimulation ; Electrodes ; Nerve Block/methods ; Peripheral Nerves/*physiology ; Sciatic Nerve/physiology
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    Target cells for 1,25-dihydroxyvitamin D3 in intestinal tract, stomach, kidney, skin, pituitary, and parathyroid (1979)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1979-12-07
    Description: After mature rats that had been fed on a vitamin D3-deficient diet were injected with tritium-labeled 1,25-dihydroxyvitamin D3, radioactivity became concentrated in nuclei of luminal and cryptal epithelium of the duodenum, jejunum, ileum, and colon; in nuclei of the epithelium of kidney distal tubules including the macula densa, and in podocytes of glomeruli; in nuclei of the epidermis including outer hairshafts and sebaceous glands; and in nuclei of certain cells of the stomach, anterior and posterior pituitary, and parathyroid. These results reveal cell types that contain receptors for 1,25-dihydroxyvitamin D3 or metabolites of this compound both in known or hypothesized target tissues and in tissues that were previously unknown to participate in vitamin D3 metabolism.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Stumpf, W E -- Sar, M -- Reid, F A -- Tanaka, Y -- DeLuca, H F -- New York, N.Y. -- Science. 1979 Dec 7;206(4423):1188-90.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/505004" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; Autoradiography ; Cell Nucleus/metabolism ; Cytoplasm/metabolism ; Digestive System/*metabolism ; Dihydroxycholecalciferols/*metabolism ; Hydroxycholecalciferols/*metabolism ; Intestinal Mucosa/metabolism ; Kidney/*metabolism ; Male ; Parathyroid Glands/*metabolism ; Pituitary Gland/*metabolism ; Rats ; Skin/*metabolism ; Stomach/metabolism
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    Temperature-dependent sex determination in turtles (1979)
    American Association for the Advancement of Science (AAAS)
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    Publication Date: 1979-12-07
    Description: The sex of hatchling map turtles is determined by incubation temperature of eggs in the laboratory as well as in nature. Temperature controls sex differentiation rather than causing a differential mortality of sexes. Temperature has no effect on sex determination in a soft-shelled turtle.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Bull, J J -- Vogt, R C -- New York, N.Y. -- Science. 1979 Dec 7;206(4423):1186-8.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/505003" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; Female ; Genotype ; Male ; *Sex Determination Analysis ; Species Specificity ; Temperature ; Turtles/*physiology
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  • 21
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    Microwaves: effect on thermoregulatory behavior in rats (1979)
    American Association for the Advancement of Science (AAAS)
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    Publication Date: 1979-12-07
    Description: Rats, with their fur clipped, pressed a lever to turn on an infrared lamp while in a cold chamber. When they were exposed to continuous-wave microwaves at 2450 megahertz for 15-minute periods, the rate at which they turned on the infrared lamp decreased as a function of the microwave power density, which ranged between 5 and 20 milliwatts per square centimeter. This result indicates that behaviorally significant levels of heating may occur at an exposure duration and intensities that do not produce measurable changes in many other behavioral measures or in colonic temperature. Further study of how microwaves affect thermoregulatory behavior may help us understand such phenomena as the reported "nonthermal" behavioral effects of microwaves.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Stern, S -- Margolin, L -- Weiss, B -- Lu, S T -- Michaelson, S M -- New York, N.Y. -- Science. 1979 Dec 7;206(4423):1198-201.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/505008" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; Behavior, Animal/*radiation effects ; Body Temperature Regulation/*radiation effects ; Male ; *Microwaves ; Rats
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  • 22
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    Dolphin lung collapse and intramuscular circulation during free diving: evidence from nitrogen washout (1979)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1979-12-07
    Description: Intramuscular nitrogen tensions in Tursiops truncatus after a schedule of repetitive ocean dives suggest a lung collapse depth of about 70 meters and suggest that intramuscular circulation is maintained during unrestrained diving in the open ocean. Therefore, the bottle-nosed dolphin is not protected by lung collapse from the decompression hazards of dives to depths shallower than 70 meters.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Ridgway, S H -- Howard, R -- New York, N.Y. -- Science. 1979 Dec 7;206(4423):1182-3.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/505001" target="_blank"〉PubMed〈/a〉
    Keywords: Adipose Tissue/metabolism ; Animals ; *Diving ; Dolphins/*physiology ; Lung/*physiology ; Muscles/*blood supply/metabolism ; Nitrogen/*metabolism ; Regional Blood Flow ; Respiration
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  • 23
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    Chimpanzee problem comprehension: insufficient evidence (1979)
    American Association for the Advancement of Science (AAAS)
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    Publication Date: 1979-12-07
    Description: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Savage-Rumbaugh, E S -- Rumbaugh, D M -- New York, N.Y. -- Science. 1979 Dec 7;206(4423):1201-2.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/505009" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; *Behavior, Animal ; Pan troglodytes/*physiology ; *Problem Solving ; Research Design
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  • 24
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    Neuronal chemotaxis: chick dorsal-root axons turn toward high concentrations of nerve growth factor (1979)
    American Association for the Advancement of Science (AAAS)
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    Publication Date: 1979-11-30
    Description: Micropipettes containing 2 to 50 biological units of beta growth factor (NGF) were placed near growing axons of chick dorsal-root ganglion neurons in tissue culture. The axons turned and grew toward the NGF source within 21 minutes. This turning response to elevated concentrations of NGF appears to represent chemotactic guidance rather than a general enhancement of growth rate.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Gundersen, R W -- Barrett, J N -- New York, N.Y. -- Science. 1979 Nov 30;206(4422):1079-80.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/493992" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; Axons/growth & development/*physiology ; Cells, Cultured ; *Chemotaxis/drug effects ; Chick Embryo ; Dose-Response Relationship, Drug ; Ganglia, Spinal/physiology ; Nerve Growth Factors/*pharmacology
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    Cortical plasticity in monocularly deprived immobilized kittens depends on eye movement (1979)
    American Association for the Advancement of Science (AAAS)
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    Publication Date: 1979-11-30
    Description: A marked reduction of binocular cells in striate cortex is found if 4-week-old kittens are visually stimulated monocularly while anesthetized and held in a stereotaxic apparatus. If the kittens are paralyzed and artificially respirated, changes are not found unless an eye is moved mechanically. It appears that eye movement and visual stimulation are necessary conditions for deactivation of binocular connections, but neither is sufficient to induce such changes alone.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Freeman, R D -- Bonds, A B -- New York, N.Y. -- Science. 1979 Nov 30;206(4422):1093-5.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/493996" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; Cats ; Evoked Potentials ; *Eye Movements ; Functional Laterality ; Immobilization ; Paralysis/physiopathology ; Visual Cortex/*growth & development/physiology ; Visual Pathways/*growth & development
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    A structural model for the kinetic behavior of hemoglobin (1979)
    American Association for the Advancement of Science (AAAS)
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    Publication Date: 1979-11-30
    Description: The tertiary structures of all liganded hemoglobins in the R state differ in detail. Steric hindrance arising from nonbonded ligand-globin interactions affects the binding of ligands such as CO and cyanide which preferentially form linear axial complexes to heme; these ligands bind in a strained off-axis configuration. Ligands such as O2 and NO, which preferentially form bent complexes, encounter less steric hindrance and can bind in their (preferred) unstrained configuration. Linear complexes distort the ligand pockets in the R state (and by inference, in the T state) more than bent complexes. These structural differences between linear and bent complexes are reflected in the kinetic behavior of hemoglobin. Structural interpretation of this kinetic behavior indicates that the relative contributions of nonbonded ligand-globin interactions and nonbonded heme interactions to transition state free energies differ for linear and bent ligands. The relative contributions of these interactions to the free energy of cooperativity may also differ for linear and bent ligands. Thus the detailed molecular mechanism by which the affinity of heme is regulated differs for different ligands.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Moffat, K -- Deatherage, J F -- Seybert, D W -- New York, N.Y. -- Science. 1979 Nov 30;206(4422):1035-42.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/493990" target="_blank"〉PubMed〈/a〉
    Keywords: Allosteric Regulation ; Animals ; Heme/*metabolism ; Hemoglobins/metabolism ; Horses ; Kinetics ; Ligands ; Oxygen/*metabolism ; Oxyhemoglobins/*metabolism ; Protein Conformation ; Stereoisomerism ; Structure-Activity Relationship
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    Elimination of metabolic cooperation in Chinese hamster cells by a tumor promoter (1979)
    American Association for the Advancement of Science (AAAS)
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    Publication Date: 1979-11-30
    Description: Wild-type Chinese hamster V79 cells (6-thioguanine-sensitive) reduce the recovery of 6-thioguanine-resistant cells when they are cultured together at high densities, through a form of intercellular communication (metabolic cooperation). Cooperation is inhibited by 12-O-tetradecanoyl phorbol-13-acetate, rescuing the 6-thioguanine-resistant cells. These results may be useful in the study of an aspect of the mechanism of tumor promotion and in assaying for promoters.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Yotti, L P -- Chang, C C -- Trosko, J E -- New York, N.Y. -- Science. 1979 Nov 30;206(4422):1089-91.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/493994" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; Cell Communication/*drug effects ; Cell Membrane/drug effects ; Cricetinae ; Dose-Response Relationship, Drug ; Drug Resistance ; Phorbol Esters/*pharmacology ; Phorbols/*pharmacology ; Structure-Activity Relationship ; Tetradecanoylphorbol Acetate/pharmacology ; Thioguanine/pharmacology
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    Physostigmine and recent memory: effects in young and aged nonhuman primates (1979)
    American Association for the Advancement of Science (AAAS)
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    Publication Date: 1979-11-30
    Description: The effect of physostigmine on recent memory was evaluated in young and aged rhesus monkeys. All aged monkeys had previously shown impaired memory. The performance of the young monkeys treated with physostigmine was similar to that recently reported for young humans--no effects at low doses, some improvement at a restricted range of doses, and deficits at the highest dose. Although the aged subjects also improved at the same general doses, their overall response as a group was much more variable than that of the younger subjects. The performance of some aged monkeys was impaired by low doses that did not affect young monkeys. Continued improvement was observed in some aged monkeys at the highest dose, which typically impaired young monkeys. These variable effects across aged subjects suggest that physostigmine cannot easily or reliably be used as an agent for treating geriatric cognition. Nevertheless, the differential age-related effects suggest that appropriate manipulation of the cholinergic system may eventually be developed to alleviate some of the cognitive impairments suffered by aged subjects.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Bartus, R T -- New York, N.Y. -- Science. 1979 Nov 30;206(4422):1087-9.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/227061" target="_blank"〉PubMed〈/a〉
    Keywords: Acetylcholine/physiology ; Aging ; Animals ; Cognition/physiology ; Female ; Haplorhini ; Humans ; Male ; Memory/*drug effects ; Memory Disorders/drug therapy ; Memory, Short-Term/drug effects ; Physostigmine/*pharmacology/therapeutic use ; Synaptic Transmission
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  • 29
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    Release of luteinizing hormone in male mice during exposure to females: habituation of the response (1979)
    American Association for the Advancement of Science (AAAS)
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    Publication Date: 1979-11-30
    Description: Male mice release luteinizing hormone when exposed for a short time to a female. In this experiment, multiple blood samples were withdrawn by atrial cannulas from tethered males during either continuous or intermittent exposure to nonreceptive females. After an immediate, transient release of luteinizing hormone, continuous exposure to the same female was accompanied by only random, spontaneous elevations in plasma levels of this hormone. Successive presentations of the same female at 2-hour intervals elicited gradually diminishing luteinizing hormone responses. Exposing such unresponsive males to novel, diestrous females, however, dramatically stimulated their release of the hormone. These results demonstrate habituation of a socially induced, neuroendocrine response involving reproductive hormones.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Coquelin, A -- Bronson, F H -- New York, N.Y. -- Science. 1979 Nov 30;206(4422):1099-101.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/573924" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; Arousal/physiology ; Diestrus ; Female ; Habituation, Psychophysiologic/*physiology ; Luteinizing Hormone/*metabolism ; Male ; Mice ; Pregnancy ; Sexual Behavior, Animal/physiology
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    Opiate (Enkephalin) receptors of neuroblastoma cells: occurrence in clusters on the cell surface (1979)
    American Association for the Advancement of Science (AAAS)
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    Publication Date: 1979-11-30
    Description: A bioactive, fluorescent derivative of enkephalin, Tyr-D-Ala-Gly-Phe-Leu-Lys-rhodamine, was used to determine the distribution of opiate receptors in living neuroblastoma cells. The receptors appeared in clusters on the cell surface, and no internalization was detected. No specific fluorescence or clusters were observed in the presence of [D-Ala2, Leu5]enkephalin or at 4 degrees C, and the clusters were much reduced under ionic conditions (that is, with 100 millimolars sodium) that specifically decrease the binding of opiate agonists.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Hazum, E -- Chang, K J -- Cuatrecasas, P -- New York, N.Y. -- Science. 1979 Nov 30;206(4422):1077-9.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/227058" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; Cell Line ; Endorphins/*metabolism ; Enkephalins/*metabolism ; Mice ; Microscopy, Fluorescence ; Neoplasms, Experimental/metabolism ; Neuroblastoma/*metabolism ; Receptors, Opioid/*metabolism ; Synaptic Membranes/metabolism
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    Prenatal stress reduces fertility and fecundity in female offspring (1979)
    American Association for the Advancement of Science (AAAS)
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    Publication Date: 1979-11-30
    Description: Female rats subjected to prenatal stress later experienced fewer conceptions, more spontaneous abortions and vaginal hemorrhaging, longer pregnancies, and fewer viable young than nonstressed rats. The offspring of the prenatally stressed rats were lighter in weight and less likely to survive the neonatal period. Prenatal stress may influence the balance of adrenal and gonadal hormones during a critical stage of fetal hypothalamic differentiation, thereby producing a variety of reproductive dysfunctions in adulthood.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Herrenkohl, L R -- New York, N.Y. -- Science. 1979 Nov 30;206(4422):1097-9.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/573923" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; Disorders of Sex Development/etiology ; Female ; Gestational Age ; Humans ; Infertility, Female/*etiology ; Lighting ; Litter Size ; Maternal Behavior ; Pregnancy ; Rats ; Reproduction ; Stress, Psychological/*complications
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    Conditioned tolerance to the hypothermic effect of ethyl alcohol (1979)
    American Association for the Advancement of Science (AAAS)
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    Publication Date: 1979-11-30
    Description: Results from experiments with rats support the proposition that tolerance to the hypothermic effect of alcohol involves the Pavlovian conditioning of compensatory responses. Tolerance was substantially reduced when alcohol was administered in an environment that had not been associated with alcohol. Direct evidence of a conditioned hyperthermic compensatory response was found.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Le, A D -- Poulos, C X -- Cappell, H -- New York, N.Y. -- Science. 1979 Nov 30;206(4422):1109-10.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/493999" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; Body Temperature Regulation/drug effects ; Conditioning (Psychology)/physiology ; Drug Tolerance ; Environment ; Ethanol/*pharmacology ; Hypothermia/chemically induced ; Male ; Rats
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    Differential competition with cytotoxic agents: an approach to selectivity in cancer chemotherapy (1979)
    American Association for the Advancement of Science (AAAS)
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    Publication Date: 1979-11-30
    Description: An approach to increasing the selectivity of cancer chemotherapeutic agents is presented in which noncytotoxic competitive substrates are used to discern the differences in structural requirements for transport of cytotoxic agents between tumor cells and a sensitive host tissue, the hematopoietic precursor cells of the bone marrow. Examples are given for two such systems, one responsible for the transport of nucleosides and another for the transport of amino acids. Cytidine is twice as effective in reducing the toxicity of showdomycin for murine bone marrow cells in culture as it is for murine L1210 leukemia cella. Conversely, homoleucine is twice as effective in reducing the toxicity of melphalan for L1210 cells as it is for bone marrow cells. These observations can serve as a basis for the development of bone marrow protective agents and for the design of cytotoxic agents that may be preferentially transported into tumor cells.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Rabinowitz, M -- Uehara, Y -- Vistica, D T -- New York, N.Y. -- Science. 1979 Nov 30;206(4422):1085-7.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/493993" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; Antibiotics, Antineoplastic/*metabolism ; Biological Transport ; Bone Marrow/drug effects ; Leukemia L1210/drug therapy ; Melphalan/metabolism/therapeutic use ; Mice ; Neoplasms/*drug therapy ; Showdomycin/*metabolism/therapeutic use ; Structure-Activity Relationship
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    Inbreeding and juvenile mortality in small populations of ungulates (1979)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1979-11-30
    Description: Juvenile mortality of inbred young was higher than that of noninbred young in 15 of 16 species of captive ungulates. In 19 of 25 individual females, belonging to ten species, a larger percentage of young died when the female was mated to a related male than when she was mated to an unrelated male.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Ralls, K -- Brugger, K -- Ballou, J -- New York, N.Y. -- Science. 1979 Nov 30;206(4422):1101-3.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/493997" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; Animals, Zoo/genetics/*physiology ; Artiodactyla/genetics/*physiology ; Fertility ; *Inbreeding ; Life Expectancy
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    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
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    Cerebral vessels have the capacity to transport sodium and potassium (1979)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1979-11-30
    Description: The activity of Na+, K+-activated adenosinetriphosphatase and the uptake of a potassium analog, rubidium, were found to be similar in cerebral microvessels and choroid plexus when measured in vitro. This similarity suggests that sodium and potassium concentrations in the nascent brain extracellular fluid are determined by the same active process that regulates their concentration in nascent cerebrospinal fluid. The brain microvessels may thereby play on active role in brain potassium homeostasis and brain extracellular fluid formation.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Eisenberg, H M -- Suddith, R L -- New York, N.Y. -- Science. 1979 Nov 30;206(4422):1083-5.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/227060" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; Biological Transport, Active ; Brain/blood supply/*metabolism ; Cerebrospinal Fluid/metabolism ; Choroid Plexus/metabolism ; Extracellular Space/metabolism ; Female ; Male ; Microcirculation/enzymology ; Potassium/*metabolism ; Rats ; Sodium/*metabolism ; Sodium-Potassium-Exchanging ATPase/*metabolism
    Print ISSN: 0036-8075
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    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
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    Can an ape create a sentence? (1979)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1979-11-23
    Description: More than 19,000 multisign utterances of an infant chimpanzee (Nim) were analyzed for syntactic and semantic regularities. Lexical regularities were observed in the case of two-sign combinations: particular signs (for example, more) tended to occur in a particular position. These regularities could not be attributed to memorization or to position habits, suggesting that they were structurally constrained. That conclusion, however, was invalidated by videotape analyses, which showed that most of Nim's utterances were prompted by his teacher's prior utterance, and that Nim interrupted his teachers to a much larger extent than a child interrupts an adult's speech. Signed utterances of other apes (as shown on films) revealed similar non-human patterns of discourse.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Terrace, H S -- Petitto, L A -- Sanders, R J -- Bever, T G -- New York, N.Y. -- Science. 1979 Nov 23;206(4421):891-902.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/504995" target="_blank"〉PubMed〈/a〉
    Keywords: *Animal Communication ; Animals ; Humans ; Language Development ; Male ; Pan troglodytes/*physiology ; Semantics ; Sign Language ; Time Factors
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    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
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    Tumor location detected with radioactively labeled monoclonal antibody and external scintigraphy (1979)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1979-11-16
    Description: Murine teratocarcinomas were located in mice by external gamma-ray scintigraphy with an iodine-125-labeled monoclonal antibody specific to the tumors. The specificity of the method was increased by subtracting the radiation produced by an iodine-125-labeled indifferent monoclonal antibody of the same immunoglobulin class as the tumor-specific antibody.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Ballou, B -- Levine, G -- Hakala, T R -- Solter, D -- New York, N.Y. -- Science. 1979 Nov 16;206(4420):844-7.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/493985" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; Antibodies, Neoplasm ; Clone Cells/immunology ; Mice ; Neoplasms, Experimental/diagnosis/immunology ; Radionuclide Imaging/*methods ; Teratoma/*diagnosis/immunology
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    Songbirds' brains: sexual dimorphism (1979)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1979-11-16
    Description: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Nottebohm, F -- Arnold, A P -- New York, N.Y. -- Science. 1979 Nov 16;206(4420):769.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/493981" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; Birds/*anatomy & histology ; Brain/*anatomy & histology ; Sex Differentiation ; Telencephalon/anatomy & histology
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    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
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  • 39
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    Calcitonin: inhibitory effect on eating in rats (1979)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1979-11-16
    Description: Subcutaneous and intracerebral injections of calcitonin inhibited feeding in rats. The anorectic activity of calcitonin was destroyed by exposing the hormone to heat, trypsin, or hydrogen peroxide. Calcitonin did not produce a conditioned taste aversion to saccharin, and maximum inhibition of feeding occurred 4.5 to 8.3 hours after subcutaneous administration. It is concluded that calcitonin inhibits feeding by acting directly on the central nervous system.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Freed, W J -- Perlow, M J -- Wyatt, R J -- New York, N.Y. -- Science. 1979 Nov 16;206(4420):850-2.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/493987" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; Brain/drug effects ; Calcitonin/administration & dosage/*pharmacology ; Depression, Chemical ; Diuresis/drug effects ; Dose-Response Relationship, Drug ; Feeding Behavior/*drug effects ; Injections, Intraventricular ; Rats
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    Lens epithelial cell elongation in the absence of microtubules: evidence for a new effect of colchicine (1979)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1979-11-16
    Description: Embryonic chick lens epithelial cells cultured in serum-supplemented medium elongated in the absence of microtubules after treatment with the antimicrotubule drug nocodazole. Colchicine, at concentrations lower than those that dissociate microtubules, blocks cell elongation and the associated increase in cell volume. These results indicate that an increase in cell volume, not microtubules, is responsible for lens cell elongation and suggest a previously undescribed effect of colchicine on cell volume regulation.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Beebe, D C -- Feagans, D E -- Blanchette-Mackie, E J -- Nau, M E -- New York, N.Y. -- Science. 1979 Nov 16;206(4420):836-8.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/493982" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; Benzimidazoles/pharmacology ; Carbamates/pharmacology ; Cells, Cultured ; Chick Embryo ; Colchicine/*pharmacology ; Epithelium/ultrastructure ; Lens, Crystalline/*cytology ; Microtubules/*drug effects
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    Fluidity of the rat liver microsomal membrane: increase at birth (1979)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1979-11-16
    Description: The lipid apparent microviscosity of the rat liver microsomal membrane on the first day after birth was found to be half of that observed on the last day of fetal life. This remarkable perinatal fluidization of the membrane resulted from a marked increase in the molar ratio of phospholipids to cholesterol.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Kapitulnik, J -- Tshershedsky, M -- Barenholz, Y -- New York, N.Y. -- Science. 1979 Nov 16;206(4420):843-4.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/493984" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; Animals, Newborn/*physiology ; Gestational Age ; Intracellular Membranes/*physiology ; Liver/*embryology ; Membrane Fluidity ; Microsomes, Liver/*physiology ; Rats ; Viscosity
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    Functional organization of lateral geniculate cells following removal of visual cortex in the newborn kitten (1979)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1979-11-09
    Description: When the visual cortex of a newborn kitten is removed, most neurons in the dorsal lateral geniculate nucleus degenerate, but a small population of large cells is spared. Electrophysiological recording revealed that detailed visual topography in the nucleus is abnormal and that single cells have unusually large receptive fields. These results suggest that optic axons deprived of their normal synaptic targets rearrange their connections to converge on local surviving neurons.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Murphy, E H -- Kalil, R -- New York, N.Y. -- Science. 1979 Nov 9;206(4419):713-6.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/493978" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; Animals, Newborn/anatomy & histology ; Cats ; Functional Laterality ; Geniculate Bodies/*cytology ; Nerve Degeneration ; Visual Cortex/*cytology ; Visual Pathways/*cytology/growth & development
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    Phenacetin studies (1979)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1979-11-09
    Description: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Vaught, J B -- King, C M -- New York, N.Y. -- Science. 1979 Nov 9;206(4419):637, 639.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/493967" target="_blank"〉PubMed〈/a〉
    Keywords: Acute Kidney Injury/chemically induced ; Animals ; Biotransformation ; *Carcinogens ; Humans ; Kidney Neoplasms/chemically induced ; Mice ; Mutation ; Phenacetin/*adverse effects/metabolism
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    Calcium dependence of toxic cell death: a final common pathway (1979)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1979-11-09
    Description: Primary cultures of adult rat hepatocytes were treated in the presence or absence of extracellular calcium with ten different membrane-active toxins. In all cases more than half the cells were killed in 1 to 6 hours in the presence but not in the absence of extracellular calcium. An effect of calcium on the primary mechanism of membrane injury by any of the agents cannot be implicated. Viability, as determined by trypan blue exclusion correlated well with other indices of viability such as plating efficiency and the hydrolysis of fluorescein diacetate. It is concluded that the cells are killed by processes that involve at least two steps. In each type of injury, disruption of the integrity of the plasma membrane by widely differing mechanisms is followed by a common functional consequence involving extracellular calcium, and most likely representing an influx of calcium across the damaged plasma membrane and down a steep concentration gradient. This later step represents, or at least initiates, a final common pathway for the toxic death of these cells.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Schanne, F A -- Kane, A B -- Young, E E -- Farber, J L -- New York, N.Y. -- Science. 1979 Nov 9;206(4419):700-2.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/386513" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; Calcimycin/pharmacology ; Calcium/*physiology ; Cell Membrane/drug effects ; Cell Membrane Permeability/drug effects ; *Cell Survival/drug effects ; Drug Interactions ; Liver/cytology ; Lysophosphatidylcholines/pharmacology ; Membrane Potentials/drug effects ; Rats ; Toxins, Biological/pharmacology
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    Xenopus liver: ontogeny of estrogen responsiveness (1979)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1979-11-09
    Description: Estradiol-17 beta stimulates the synthesis of numerous proteins exported into the culture medium by Xenopus tadpole liver tissue obtained after stage 50 and throughout metamorphosis to stage 66. Although estrogen-induced vitellogenin can be detected as early as stage 54, it is a minor percentage of the exported proteins until after the completion of metamorphosis. In hepatic tissue obtained after metamorphosis, the hormone evokes the synthesis of vitellogenin specifically without affecting the labeling of other secreted proteins.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Skipper, J K -- Hamilton, T H -- New York, N.Y. -- Science. 1979 Nov 9;206(4419):693-5.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/493974" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; Estradiol/pharmacology ; Estrogens/*pharmacology ; Larva ; Lipoproteins/*biosynthesis ; Liver/*growth & development ; Molecular Weight ; Protein Biosynthesis ; Vitellogenins/*biosynthesis
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    Endothermy and activity in vertebrates (1979)
    American Association for the Advancement of Science (AAAS)
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    Publication Date: 1979-11-09
    Description: Resting and maximal levels of oxygen consumption of endothermic vertebrates exceed those of ectotherms by an average of five- to tenfold. Endotherms have a much broader range of activity that can be sustained by this augmented aerobic metabolism. Ectotherms are more reliant upon, and limited by, anaerobic metabolism during activity. A principal factor in the evolution of endothermy was the increase in aerobic capacities to support sustained activity.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Bennett, A F -- Ruben, J A -- New York, N.Y. -- Science. 1979 Nov 9;206(4419):649-54.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/493968" target="_blank"〉PubMed〈/a〉
    Keywords: Adaptation, Biological ; Adenosine Triphosphate/biosynthesis ; Animals ; *Biological Evolution ; *Body Temperature Regulation ; *Energy Metabolism ; Locomotion ; Motor Activity ; Oxygen Consumption ; Selection, Genetic ; Vertebrates/*physiology
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    Phase resetting and annihilation of pacemaker activity in cardiac tissue (1979)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1979-11-09
    Description: Spontaneous rhythmic activity in isolated cardiac pacemaker cells can be terminated by a brief, subthreshold, depolarizing or hyperpolarizing perturbation of the proper magnitude applied at a specific point in the pacemaker cycle. Evidence is provided in support of a topological theory of the existence of a "singular" point in cardiac oscillators.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Jalife, J -- Antzelevitch, C -- New York, N.Y. -- Science. 1979 Nov 9;206(4419):695-7.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/493975" target="_blank"〉PubMed〈/a〉
    Keywords: Action Potentials ; Animals ; Cats ; Cattle ; Dogs ; Evaluation Studies as Topic ; Heart Conduction System/*physiology ; Membrane Potentials ; *Periodicity ; Purkinje Fibers/*physiology ; Sinoatrial Node/*physiology
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    Antennal hair erection in male mosquitoes: a new mechanical effector in insects (1979)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1979-11-02
    Description: Male Anopheles mosquitoes erect their antennal hairs prior to mating. The erectile mechanism resides in a unique annulus at the base of each hair whorl. It appears that the insect regulates the degree of hydration of this annulus. When the annulus is made to swell the attached hairs are pushed to their erect position.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Nijhout, H F -- Sheffield, H G -- New York, N.Y. -- Science. 1979 Nov 2;206(4418):595-6.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/40308" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; Anopheles/*physiology/ultrastructure ; Behavior, Animal/physiology ; Hair/physiology ; Hydrogen-Ion Concentration ; Male ; Microvilli/physiology ; Movement ; Proteins/physiology ; Water
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  • 49
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    End-capillary loops in the heart: an explanation for discrete myocardial infarctions without border zones (1979)
    American Association for the Advancement of Science (AAAS)
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    Publication Date: 1979-11-02
    Description: Separate perfusions of canine coronary arteries with colored silicone-rubber compound reveal that in the region where two microcirculations abut, capillaries derived from individual large vessels are discrete, with no interconnections. Terminal homologous capillaries from loops rather than anastomosing with heterologous capillaries. This anatomic arrangement may account for discrete myocardial infarctions without ischemic border zones.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Okun, E M -- Factor, S M -- Kirk, E S -- New York, N.Y. -- Science. 1979 Nov 2;206(4418):565-7.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/493960" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; *Coronary Circulation ; Coronary Vessels/*anatomy & histology ; Dogs ; Microcirculation ; Myocardial Infarction/*pathology
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  • 50
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    Intestinal absorption of immune complexes by neonatal rats: a route of antigen transfer from mother to young (1979)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1979-11-02
    Description: Horseradish peroxidase (HRP) in the presence of specific immunoglobulin G antibody to HRP is selectively absorbed from the gut lumen and transferred by intestinal epithelial cells to the lamina propria in newborn rats. The HRP is not transferred in detectable amounts in the absence of the antibody. Transport of maternally derived antigen via antigen-antibody complexes may have important influences on the developing immune system in young mammals.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Abrahamson, D R -- Powers, A -- Rodewald, R -- New York, N.Y. -- Science. 1979 Nov 2;206(4418):567-9.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/493961" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; Animals, Newborn/*immunology ; *Antigen-Antibody Complex ; *Antigens ; Biological Transport, Active ; Female ; Horseradish Peroxidase/immunology ; Immunoglobulin Fab Fragments ; Immunoglobulin Fc Fragments ; *Intestinal Absorption ; Jejunum/*immunology/metabolism ; Male ; Rats
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    Ethanol embryotoxicity: direct effects on mammalian embryos in vitro (1979)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1979-11-02
    Description: Exposure to ethanol retards growth and differentiation in cultured rat embryos during organogenesis. The development of untreated embryos is indistinguishable from growth in utero. These data suggest that the hypoplastic features of children born to chronically alcoholic mothers are due, at least in part, to a direct action of ethanol, which causes reduced embryonic cellular proliferation early in gestation.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Brown, N A -- Goulding, E H -- Fabro, S -- New York, N.Y. -- Science. 1979 Nov 2;206(4418):573-5.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/573922" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; Dose-Response Relationship, Drug ; Ectogenesis/*drug effects ; Embryo, Mammalian/*drug effects ; Ethanol/*toxicity ; Female ; Fetal Growth Retardation/chemically induced ; Pregnancy ; Rats ; *Teratogens
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    Response of cat inferior colliculus neurons to binaural beat stimuli: possible mechanisms for sound localization (1979)
    American Association for the Advancement of Science (AAAS)
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    Publication Date: 1979-11-02
    Description: The interaural phase sensitivity of neurons was studied through the use of binaural beat stimuli. The response of most cells was phase-locked to the beat frequency, which provides a possible neural correlate to the human sensation of binaural beats. In addition, this stimulus allowed the direction and rate of interaural phase change to be varied. Some neurons in our sample responded selectively to manipulations of these two variables, which suggests a sensitivity to direction or speed of movement.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Kuwada, S -- Yin, T C -- Wickesberg, R E -- New York, N.Y. -- Science. 1979 Nov 2;206(4418):586-8.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/493964" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; Auditory Perception/*physiology ; Cats ; Evoked Potentials ; Inferior Colliculi/*physiology ; Motion Perception/physiology ; Orientation/*physiology ; Periodicity
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    Effects of frontal eye field and superior colliculus ablations on eye movements (1979)
    American Association for the Advancement of Science (AAAS)
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    Publication Date: 1979-11-02
    Description: Two parallel neural pathways are primarily responsible for the control of saccadic eye movements--one mediated through the frontal eye fields and the other through the superior colliculus. When both pathways are disrupted, control of saccadic eye movements is lost. Disruption of either pathway alone produces only subtle deficits.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Schiller, P H -- True, S D -- Conway, J L -- New York, N.Y. -- Science. 1979 Nov 2;206(4418):590-2.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/115091" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; Brain Mapping ; *Eye Movements ; Frontal Lobe/*physiology ; Haplorhini ; Neural Pathways/physiology ; Reflex/physiology ; Saccades ; Superior Colliculi/*physiology ; Vestibule, Labyrinth/physiology
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    Strong electrical currents leave the primitive streak of chick embryos (1979)
    American Association for the Advancement of Science (AAAS)
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    Publication Date: 1979-11-02
    Description: The electrical fields above chick embryos were explored with a vibrating probe. These fields indicate that steady currents with exit densities of the order of 100 microamperes per square centimeter leave the whole streak and return elsewhere through the epiblast. The epicenter of these strong exit currents lies near Hensen's node. They are probably pumped into the intraembryonic space by the epiblast and then leak out of the streak because it is a zone of junctional disruption.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Jaffe, L F -- Stern, C D -- New York, N.Y. -- Science. 1979 Nov 2;206(4418):569-71.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/573921" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; Chick Embryo/*physiology ; Electric Conductivity ; Electricity ; Female ; Germ Layers/physiology ; Vitelline Membrane/physiology
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    Movement disorders of aged rats: reversal by dopamine receptor stimulation (1979)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1979-10-26
    Description: When placed in a tank of water, aged rats (24 to 27 months old) showed marked impairments in swimming. Compared with young adult rats (3 to 4 months old), the older animals moved their limbs less vigorously and were less successful in keeping their heads above water. The young, but not old, rats maintained a position nearly horizontal to the water surface and planed across it. These movement dysfunctions of aged rats resemble those seen in young adult animals that have sustained injury to brain dopamine-containing neurons. The swimming impairments of the aged rats were reversed by the dopamine receptor stimulant apomorphine and by the biosynthetic precursor of dopamine, L-dopa. Thus, age-related alterations in brain dopaminergic systems may be responsible for some of the movement disturbances associated with senescence.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Marshall, J F -- Berrios, N -- New York, N.Y. -- Science. 1979 Oct 26;206(4417):477-9.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/504992" target="_blank"〉PubMed〈/a〉
    Keywords: *Aging ; Animals ; Apomorphine/therapeutic use ; Levodopa/therapeutic use ; Male ; Movement Disorders/drug therapy/*physiopathology ; Rats ; Receptors, Dopamine/*physiology ; Swimming ; Time Factors
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    New information about the development of the autonomic nervous system (1979)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1979-10-26
    Description: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Marx, J L -- New York, N.Y. -- Science. 1979 Oct 26;206(4417):434-7.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/41320" target="_blank"〉PubMed〈/a〉
    Keywords: Acetylcholine/metabolism ; Adrenergic Fibers/growth & development ; Animals ; Autonomic Nervous System/*growth & development ; Cell Communication ; Cell Differentiation ; Cells, Cultured ; Cholinergic Fibers/growth & development ; Nerve Growth Factors/physiology ; Neural Crest/cytology ; Neural Pathways/growth & development ; Neurotransmitter Agents/*metabolism ; Synaptic Transmission
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    Intrathecal capsaicin depletes substance P in the rat spinal cord and produces prolonged thermal analgesia (1979)
    American Association for the Advancement of Science (AAAS)
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    Publication Date: 1979-10-26
    Description: A single intrathecal injection of capsaicin depletes substance P from primary sensory neurons and causes a prolonged increase in the thermal and chemical pain thresholds of the rat but no apparent change in responses to noxious mechanical stimuli.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Yaksh, T L -- Farb, D H -- Leeman, S E -- Jessell, T M -- New York, N.Y. -- Science. 1979 Oct 26;206(4417):481-3.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/228392" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; Capsaicin/*pharmacology ; Fatty Acids, Unsaturated/*pharmacology ; Hot Temperature ; Injections, Spinal ; Movement/drug effects ; Nociceptors/drug effects ; Pain/*physiopathology ; Rats ; Spinal Cord/*metabolism ; Substance P/administration & dosage/*metabolism ; Synaptic Transmission/drug effects
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    Experimental phenylketonuria: replacement of carboxyl terminal tyrosine by phenylalanine in infant rat brain tubulin (1979)
    American Association for the Advancement of Science (AAAS)
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    Publication Date: 1979-10-26
    Description: In the brains of newborn rats, about half of the tubulin molecules are modified posttranslationally by the addition of an aromatic amino acid at the carboxyl terminus of the alpha chain. Of the added residues, 96 percent are tyrosine and 4 percent are phenylalanine. After induction of hyperphenylalaninemia, the proportion of tubulin molecules containing carboxyl terminal phenylalanine increases up to eightfold and the pool of tyrosine-containing molecules decreases by an equivalent amount.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Rodriguez, J A -- Borisy, G G -- New York, N.Y. -- Science. 1979 Oct 26;206(4417):463-5.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/574315" target="_blank"〉PubMed〈/a〉
    Keywords: Amino Acid Sequence ; Animals ; Brain/*metabolism ; Cytoplasm/metabolism ; *Disease Models, Animal ; Humans ; Microtubules/metabolism ; Phenylalanine/*metabolism ; Phenylketonurias/*metabolism ; Protein Binding ; Rats ; Tubulin/*metabolism ; Tyrosine/metabolism
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    Classification of opioids on the basis of change in seizure threshold in rats (1979)
    American Association for the Advancement of Science (AAAS)
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    Publication Date: 1979-10-26
    Description: Twenty opioids have been subdivided into four classes by using flurothyl-induced seizures in rats to measure dose-response relationships, stereospecificity, naloxone sensitivity, and tolerance-cross-tolerance. The data support current theories of multiple opiate receptor types. Since the receptors involved mediate effects that are antagonized, enhanced, or unaffected by naloxone, the model is uniquely suitable for detecting novel narcotic antagonists that can then be used to differentiate opiate receptors in other systems.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Cowan, A -- Geller, E B -- Adler, M W -- New York, N.Y. -- Science. 1979 Oct 26;206(4417):465-7.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/504986" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; Drug Tolerance ; Flurothyl/antagonists & inhibitors ; Male ; Meperidine/classification/pharmacology ; Naloxone/pharmacology ; Narcotics/*classification/pharmacology ; Pentazocine/classification/pharmacology ; Rats ; Seizures/chemically induced ; Stereoisomerism
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    Cholecystokinin octapeptide: continuous picomole injections into the cerebral ventricles of sheep suppress feeding (1979)
    American Association for the Advancement of Science (AAAS)
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    Publication Date: 1979-10-26
    Description: Cholecystokinin octapeptide decreased food intake in a dose-related manner when injected continuously into the lateral cerebral ventricles of sheep that had been deprived of food for 2, 4, 8, or 24 hours. In sheep deprived of food for 2 hours, as little as 0.01 picomole per minute suppressed feeding 35 percent 1 hour after beginning injection. Pentagastrin also decreased feeding in the 2-hour group, but only at a much higher dose range. Secretin had no effect. These findings support the hypothesis that cholecystokinin octapeptide acts on central nervous system structures that are involved in control of food intake.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Della-Fera, M A -- Baile, C A -- New York, N.Y. -- Science. 1979 Oct 26;206(4417):471-3.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/504989" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; Brain/drug effects ; Cholecystokinin/administration & dosage/*pharmacology ; Depression, Chemical ; Feeding Behavior/*drug effects ; Injections, Intraventricular ; Pentagastrin/pharmacology ; Peptide Fragments/pharmacology ; Rats ; Secretin/pharmacology ; Sheep ; Species Specificity
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    Stimulation of abducens nucleus supports classical conditioning of the nictitating membrane response (1979)
    American Association for the Advancement of Science (AAAS)
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    Publication Date: 1979-10-26
    Description: The acquisition and terminal performance of a classical conditioning group compared with a control group indicated that extension of the nictitating membrane elicited by direct electrical stimulation of the abducens nucleus was successfully conditioned to a previously neutral stimulus. The conditioning so obtained was associative and not due to such nonassociative factors as sensitization, pseudo-conditioning, or alteration in base-rate responding.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Mis, F W -- Gormezano, I -- Harvey, J A -- New York, N.Y. -- Science. 1979 Oct 26;206(4417):473-5.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/504990" target="_blank"〉PubMed〈/a〉
    Keywords: Abducens Nerve/*physiology ; Animals ; Brain Stem/*physiology ; Conditioning, Eyelid/*physiology ; Electric Stimulation ; Motor Neurons/physiology ; Nictitating Membrane/*physiology ; Rabbits
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    Light and efferent activity control rhabdom turnover in Limulus photoreceptors (1979)
    American Association for the Advancement of Science (AAAS)
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    Publication Date: 1979-10-19
    Description: Photosensitive membrane structures in the retinular cells of the Limulus lateral eye are broken down and renewed daily. The first light onset causes a rapid, synchronous disassembly and buildup of the rhabdom in each photoreceptor cell. The entire process is complete within 30 minutes. Blocking the efferent input to the retina from the brain blocks the turnover of the rhabdom, and mimicking the efferent input by optic nerve stimulation restores it.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Chamberlain, S C -- Barlow, R B Jr -- New York, N.Y. -- Science. 1979 Oct 19;206(4416):361-3.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/482946" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; Efferent Pathways/physiology ; Electric Stimulation ; Horseshoe Crabs/*physiology ; *Light ; Optic Nerve/physiology ; Photoreceptor Cells/cytology/*physiology ; Regeneration ; Retina/cytology/physiology ; Time Factors
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    Erythrosin B inhibition of neurotransmitter accumulation by rat brain homogenate (1979)
    American Association for the Advancement of Science (AAAS)
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    Publication Date: 1979-10-19
    Description: A mixture of seven food dyes inhibited the accumulation of eight neurotransmitters or neurotransmitter precursors by rat brain homogenate. At a low concentration (1 microgram per milliliter), erythrosin B (FD&C red 3) was the only dye that inhibited dopamine accumulation. Erythrosin also was effective in decreasing the accumulation of all the other transmitter substances, suggesting that the inhibition is nonspecific and probably secondary to general membrane alteration.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Logan, W J -- Swanson, J M -- New York, N.Y. -- Science. 1979 Oct 19;206(4416):363-4.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/39341" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; Cell-Free System ; Depression, Chemical ; Dopamine/metabolism ; Erythrosine/adverse effects/*pharmacology ; Fluoresceins/*pharmacology ; Food Coloring Agents/adverse effects/*pharmacology ; Neurotransmitter Agents/*metabolism ; Rats ; Synapses/*drug effects
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    Developmental biology: where is it going (1979)
    American Association for the Advancement of Science (AAAS)
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    Publication Date: 1979-10-19
    Description: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Kolata, G B -- New York, N.Y. -- Science. 1979 Oct 19;206(4416):315-6.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/573497" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; Cell Division ; Cytoskeleton/physiology ; Embryology/*trends ; Forecasting ; Histones/metabolism ; Molecular Biology/trends
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    Neural axis representing target range in the auditory cortex of the mustache bat (1979)
    American Association for the Advancement of Science (AAAS)
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    Publication Date: 1979-10-19
    Description: In echolocating bats, the primary cue for determining distance to a target is the interval between an emitted orientation sound and its echo. Whereas frequency is represented by place in the bat cochlea, no anatomical location represents of primary range. Target range is coded by the time interval between grouped discharges of primary auditory neurons in response to both the emitted sound and its echo. In the frequency-modulated-signal processing area of the auditory cortex of the mustache bat (Pteronotus parnellii rubiginosus), neurons respond poorly or not at all to synthesized orientation sounds or echoes alone but respond vigorously to echoes following the emitted sound with a specific delay from targets at a specific range. These range-tuned neurons are systemically arranged along the rostrocaudal axis of the frequency-modulated-signal processing area according to the delays to which they best respond, and thus represent target range in terms of cortical organization. The frequency-modulated-signal processing area therefore shows odotopic representation.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Suga, N -- O'Neill, W E -- New York, N.Y. -- Science. 1979 Oct 19;206(4416):351-3.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/482944" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; Auditory Cortex/physiology ; Auditory Threshold ; Behavior, Animal/physiology ; Chiroptera/*physiology ; *Echolocation ; Evoked Potentials ; Neurons/physiology ; *Orientation
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    Comparison of total sequence of a cloned rabbit beta-globin gene and its flanking regions with a homologous mouse sequence (1979)
    American Association for the Advancement of Science (AAAS)
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    Publication Date: 1979-10-19
    Description: The nucleotide sequence of a cloned rabbit chromosomal DNA segment of 1620 nucleotides length which contains a beta-globin gene is presented. The coding regions are separated into three blocks by two intervening sequences of 126 and 573 base pairs, respectively. The rabbit sequence was compared with a homologous mouse sequence. The segments flanking the rabbit gene, as well as the coding regions, the 5' noncoding and part of the 3' noncoding messenger RNA sequences are similar to those of the mouse gene; the homologous introns, despite identical location, are distinctly dissimilar except for the junction regions. Homologous introns may be derived from common ancestral introns by large insertions and deletions rather than be multiple point mutations.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉van Ooyen, A -- van den Berg, J -- Mantei, N -- Weissmann, C -- New York, N.Y. -- Science. 1979 Oct 19;206(4416):337-44.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/482942" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; Base Sequence ; Biological Evolution ; Codon ; DNA, Recombinant ; Genetic Linkage ; Globins/*genetics ; Mice/*genetics ; Rabbits/*genetics
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    Synaptic regeneration in identified neurons of the lamprey spinal cords (1979)
    American Association for the Advancement of Science (AAAS)
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    Publication Date: 1979-10-19
    Description: Identified reticulospinal neurons whose giant axons were severed after spinal cord transection were filled with horseradish peroxidase. Whole mounts and serial-section light and electron micrographs show axon regeneration across the spinal lesion and the formation of new synapses. Normal swimming activity returns in the spinally transected animals, although the regenerated synapses are in atypical regions of the spinal cord.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Wood, M R -- Cohen, M J -- New York, N.Y. -- Science. 1979 Oct 19;206(4416):344-7.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/482943" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; Axons/physiology ; Fishes/*physiology ; Lampreys/*physiology ; Movement ; *Nerve Regeneration ; Spinal Cord/*physiology ; Synapses/physiology
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    Ciliary membrane alterations occurring in experimental Mycoplasma pneumoniae infection (1979)
    American Association for the Advancement of Science (AAAS)
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    Publication Date: 1979-10-19
    Description: Experimental infection of hamster ciliated tracheal epithelium in organ culture with virulent Mycoplasma pneumoniae resulted in the deterioration o ciliary necklaces and an altered distribution of membrane-associated particles on the shafts of the affected cilia. To our knowledge that is the first report of an altered disposition of ciliary membrane-associated particles in response to a specific infectious agent.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Carson, J L -- Collier, A M -- Clyde, W A Jr -- New York, N.Y. -- Science. 1979 Oct 19;206(4416):349-51.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/113877" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; Cell Membrane/ultrastructure ; Cilia/ultrastructure ; Cricetinae ; Culture Techniques ; Epithelium/ultrastructure ; Mycoplasma Infections/*pathology ; Mycoplasma pneumoniae ; Trachea/*pathology/ultrastructure
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    Monoclonal antibodies defining distinctive human T cell surface antigens (1979)
    American Association for the Advancement of Science (AAAS)
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    Publication Date: 1979-10-19
    Description: Three novel nonoclonal antibodies (designed OKT1, OKT3, and OKT4) were generated against surface determinants of human peripheral T cells. Both OKT1 and OKT3 reacted with all human peripheral T cells and 5 to 10 percent of thymocytes but differed in their reactivities with T cel- lines. By contrast, OKT4 reacted with 55 percent of human peripheral T cells and 80 percent of thymocyted in that they did not react with normal B cells, null cells, monocytes, or granulocytes.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Kung, P -- Goldstein, G -- Reinherz, E L -- Schlossman, S F -- New York, N.Y. -- Science. 1979 Oct 19;206(4416):347-9.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/314668" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; Antibody Specificity ; Antigens, Surface/*analysis ; Cells, Cultured/immunology ; Clone Cells/immunology ; Humans ; Leukemia, Experimental/immunology ; Mice ; Plasmacytoma/immunology ; T-Lymphocytes/*immunology
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    Hydrostatic pressure reversibly blocks membrane control of ciliary motility in Paramecium (1979)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1979-10-19
    Description: A hydrostatic pressure of only 68 atmospheres prevented swimming Paramecium caudatum from "avoiding" or reversing direction; 170 atmospheres stopped or decreased forward velocity by more than 75 percent. A decompression of 40 atmospheres invoked a single reversal, even at ,80 atmospheres. In contrast, 170 atmospheres did not significantly affect swimming behavior of paramecium "models" that were reactivated in a solution containing adenosine triphosphate and magnesium ions after their membrane had been disrupted by Triton X-100.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Otter, T -- Salmon, E D -- New York, N.Y. -- Science. 1979 Oct 19;206(4416):358-61.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/482945" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; Cell Membrane/physiology ; Cilia/physiology ; Hydrostatic Pressure ; Ion Channels/physiology ; Membrane Potentials ; Movement ; Mutation ; Paramecium/genetics/*physiology ; Polyethylene Glycols/pharmacology
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  • 71
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    Cerebellar plasticity: modification of Purkinje cell structure by differential rearing in monkeys (1979)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1979-10-12
    Description: Dendritic branching in Purkinje and granule cells and the diameters of Purkinje cell somas were compared in several cerebellar areas of monkeys reared in isolation, with social experience, or in a large colony. In the colony-reared monkeys, spiny branchlets of Purkinje cells were more extensive in the paraflocculus and the nodulus than they were in the other two groups. Granule cell dendritic branching in the paraflocculus and nodulus did not differ across groups. In addition, Purkinje cell somas were larger in the uvula and the nodulus of the colony animals than in the other groups. These data indicate that the social and physical environment during development influences the morphology of cerebellar Purkinje cells.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Floeter, M K -- Greenough, W T -- New York, N.Y. -- Science. 1979 Oct 12;206(4415):227-9.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/113873" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; Behavior, Animal/*physiology ; Cerebellum/*growth & development ; Dendrites/ultrastructure ; Environment ; Haplorhini ; Macaca fascicularis ; Movement ; Purkinje Cells/*cytology
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  • 72
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    Holographic assessment of a hypothesized microwave hearing mechanism (1979)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1979-10-12
    Description: Exposure of the head to pulse-modulated microwaves induces the perception of a sound. It has been hypothesized that the electromagnetic energy is converted to acoustic energy in the skull and then conducted through the bone. Dynamic time-averaged interferometric holography showed that the predicted motion of head tissue did not occur. An alternative locus for this hearing effect is suggested.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Frey, A H -- Coren, E -- New York, N.Y. -- Science. 1979 Oct 12;206(4415):232-4.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/482939" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; Auditory Perception/*physiology ; Bone and Bones/radiation effects ; Cochlea/physiology/radiation effects ; Guinea Pigs ; Hearing/*physiology ; Holography ; Humans ; *Microwaves ; Models, Biological ; Motion ; Rats ; Vibration
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  • 73
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    Calmodulin activation of adenylate cyclase in pancreatic islets (1979)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1979-10-12
    Description: Pancreatic islets contain calmodulin. The protein binds to a particulate fraction derived from the islets and stimulates adenylate cyclase activity in this subcellular fraction, both phenomena being activated by ionized calcium. A calcium-dependent stimulation of adenylate cyclase by endogenous calmodulin may contribute to the accumulation of adenosine 3',5'-monophosphate evoked by insulin releasing agents in the islet cells.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Valverde, I -- Vandermeers, A -- Anjaneyulu, R -- Malaisse, W J -- New York, N.Y. -- Science. 1979 Oct 12;206(4415):225-7.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/225798" target="_blank"〉PubMed〈/a〉
    Keywords: Adenylyl Cyclases/*metabolism ; Animals ; Calcium/*physiology ; Calcium-Binding Proteins/*metabolism ; Calmodulin/*metabolism ; Cell Membrane/metabolism ; Cyclic AMP/metabolism ; Egtazic Acid/metabolism ; Enzyme Activation ; Female ; Glucose/pharmacology ; Insulin/*secretion ; Islets of Langerhans/*enzymology ; Kinetics ; Rats
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  • 74
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    Human chorionic gonadotropin: induction of ovulation in the squirrel monkey (1979)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1979-10-12
    Description: The minimum dose of human chorionic gonadotropin that would cause ovulation in the squirrel monkey (Saimiri sciureus) was found to be between 100 and 250 international units.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Dukelow, W R -- New York, N.Y. -- Science. 1979 Oct 12;206(4415):234-5.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/113874" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; Chorionic Gonadotropin/administration & dosage/*pharmacology ; Dose-Response Relationship, Drug ; Female ; Follicle Stimulating Hormone/pharmacology ; Haplorhini/*physiology ; Ovulation/*drug effects ; Saimiri/*physiology
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  • 75
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    Exercise during development induces an increase in Purkinje cell dendritic tree size (1979)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1979-10-12
    Description: Mice allowed to exercise during the late postnatal period had Purkinje cells with larger dendritic trees and greater numbers of spines than littermates whose physical activity was severly restricted. These changes in Purkinje cells were accompanied by a selective reduction in the thickness of the cerebellar molecular layer. The data provide evidence for cerebellar plasticity during late development and demonstrate that physical activity can modify the development of Purkinje cell dendrites.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Pysh, J J -- Weiss, G M -- New York, N.Y. -- Science. 1979 Oct 12;206(4415):230-2.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/482938" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; Behavior, Animal/physiology ; Cell Differentiation ; Cerebellar Cortex/growth & development ; Cerebellum/*growth & development ; Dendrites/ultrastructure ; Female ; Male ; Mice ; Motor Activity/physiology ; Physical Exertion ; Purkinje Cells/*cytology
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  • 76
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    Calcification of differentiating skeletal mesenchyme in vitro (1979)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1979-10-12
    Description: Embryonic limb-bud mesenchyme was induced to calcify in culture by the addition of 3 mM inorganic phosphate to the medium. Phosphate enhanced calcification of the matrix produced by mesenchymal or fibroblast-like cells, whereas no calcification was evident in areas where cartilage had developed. However, calcification was induced throughout the cell layer by altering the cartilage matrix properties with certain enzymes or by changing the phenotypic expression of the cells with vitamin A.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Binderman, I -- Greene, R M -- Pennypacker, J P -- New York, N.Y. -- Science. 1979 Oct 12;206(4415):222-5.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/482937" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; *Bone Development/drug effects ; Bromodeoxyuridine/pharmacology ; *Calcification, Physiologic/drug effects ; Cell Differentiation ; Cells, Cultured ; Chick Embryo ; Collagen/physiology ; Fibroblasts/cytology ; Hyaluronoglucosaminidase/metabolism ; Mesoderm/cytology ; Phosphates/metabolism ; Proteoglycans/physiology ; Vitamin A/pharmacology
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  • 77
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    Effect of beta-endorphin on calcium uptake in the brain (1979)
    American Association for the Advancement of Science (AAAS)
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    Publication Date: 1979-10-05
    Description: The uptake of 45Ca2+ by nerve-ending fractions from brains of mice was inhibited in vitro by 10(-9)M concentrations of beta-endorphin and in mice injected intraventricularly with 7 picomoles of beta-endorphin. That the effect was a specific opiate agonist response of beta-endorphin was demonstrated by use of the opiate antagonist, naloxone, which reversed the action. A role for beta-endorphin in the regulation of calcium flux and neurotransmitter release should be considered.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Guerrero-Munoz, F -- de Lourdes Guerrero, M -- Way, E L -- Li, C H -- New York, N.Y. -- Science. 1979 Oct 5;206(4414):89-91.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/39340" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; Biological Transport/drug effects ; Calcium/*metabolism ; Dose-Response Relationship, Drug ; Drug Tolerance ; Endorphins/antagonists & inhibitors/*pharmacology ; Male ; Mice ; Naloxone/pharmacology ; Neurotransmitter Agents/metabolism ; Rats ; Synaptosomes/*drug effects/metabolism
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  • 78
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    Cerebral norepinephrine: influence on cortical oxidative metabolism in situ (1979)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1979-10-05
    Description: Unilateral lesion of the locus coeruleus and the resultant norepinephrine depletion in the ipsilateral cerebrum alters the relationship between cerebral metabolic demands and local delivery of oxygen and substrates. This effect of norepinephrine depletion is demonstrated by slower recovery of the redox ratio of cytochrome a,a3 during increased metabolic demands induced by local cortical stimulation.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Harik, S I -- LaManna, J C -- Light, A I -- Rosenthal, M -- New York, N.Y. -- Science. 1979 Oct 5;206(4414):69-71.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/482927" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; Cerebral Cortex/*metabolism ; Cytochromes/*metabolism ; Energy Metabolism ; Evoked Potentials ; Locus Coeruleus/*physiology ; Male ; Norepinephrine/*physiology ; Oxidation-Reduction ; Rats ; Spectrophotometry
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  • 79
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    Heterogeneity of vertebrate luteinizing hormone-releasing hormone (1979)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1979-10-05
    Description: Radioimmunoassay and chromatography analyses of hypothalamic luteinizing hormone-releasing hormone (LHRH) have demonstrated the presence of LHRH-like immunoreactive peptides in a wide range of vertebrates. Contrary to previous reports, the molecule differs in various vertebrates. Avian, reptilian, and teleostean LHRH's are chemically distinct from the mammalian peptide but are in themselves indistinguishable. However, amphibian LHRH appears to be identical to the mammalian peptide. These findings have interesting evolutionary implications.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉King, J A -- Millar, R P -- New York, N.Y. -- Science. 1979 Oct 5;206(4414):67-9.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/384514" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; *Biological Evolution ; Chromatography ; Gonadotropin-Releasing Hormone/*analysis/immunology ; Hypothalamus/analysis ; Radioimmunoassay ; Species Specificity ; Structure-Activity Relationship
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  • 80
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    Heavy metals affect rod, but not cone, photoreceptors (1979)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1979-10-05
    Description: Low concentrations of lead, mercury, or cadmium depress the amplitude of the rod receptor potential in the perfused bullfrog retina. Responses from the cones were not affected. The data implicate the rods as a lesion site in animals exhibiting scotopic vision deficits as a result of heavy metal poisoning.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Fox, D A -- Sillman, A J -- New York, N.Y. -- Science. 1979 Oct 5;206(4414):78-80.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/314667" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; Anura ; Cadmium/*pharmacology ; Cations, Divalent ; Evoked Potentials/drug effects ; In Vitro Techniques ; Lead/*pharmacology ; Mercury/*pharmacology ; Photoreceptor Cells/*drug effects/physiology ; Rana catesbeiana
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  • 81
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    Shark heart mitochondria: effects of external osmolality on respiration (1979)
    American Association for the Advancement of Science (AAAS)
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    Publication Date: 1979-10-05
    Description: Shark mitochondrial respiration was studied in media with osmolalities between 160 and 1500 milliosmoles. The respiratory control ratio, a marker for functional integrity of the isolated mitochondria, was maximal at 1000 millismoles and decreased during hypotonic or hypertonic exposure. Shark mitochondria function best at their native tonicity, a value that produces abnormal function in mammalian mitochondria.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Lewiston, N -- Newman, A -- Robin, E -- Holtzman, D -- New York, N.Y. -- Science. 1979 Oct 5;206(4414):75-6.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/482928" target="_blank"〉PubMed〈/a〉
    Keywords: Adenosine Diphosphate/metabolism ; Animals ; Mitochondria, Heart/*metabolism ; Mitochondria, Liver/metabolism ; *Osmolar Concentration ; *Oxygen Consumption ; Rats ; Sharks/*metabolism ; Species Specificity
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  • 82
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    Neonatal rat surgery: avoiding maternal cannibalism (1979)
    American Association for the Advancement of Science (AAAS)
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    Publication Date: 1979-10-05
    Description: A simple program of handling and care of pregnant rats before delivery makes it possible to carry out surgical procedures on newborn pups without resultant cannibalism or rejection of the operated animals by their mothers.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Libbin, R M -- Person, P -- New York, N.Y. -- Science. 1979 Oct 5;206(4414):66.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/482926" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; Animals, Laboratory/*physiology ; Animals, Newborn/*physiology ; *Behavior, Animal ; Handling (Psychology) ; *Maternal Behavior ; Rats
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  • 83
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    Correct axonal regeneration after target cell removal in the central nervous system of the leech (1979)
    American Association for the Advancement of Science (AAAS)
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    Publication Date: 1979-10-05
    Description: The unique target neuron of a severed axon in the leech was selectively eliminated by intracellular injection of protease. In the absence of the target, the severed axon regenerated normally along its original pathway to the usual site of synapse, where it stopped growing without forming alternative connections.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Muller, K J -- Scott, S A -- New York, N.Y. -- Science. 1979 Oct 5;206(4414):87-9.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/482931" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; Cell Communication ; Central Nervous System/growth & development/physiology ; Leeches/*physiology ; *Nerve Regeneration ; Synapses/physiology
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  • 84
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    Serotonin neurons project to small blood vessels in the brain (1979)
    American Association for the Advancement of Science (AAAS)
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    Publication Date: 1979-10-05
    Description: Electrolytic lesions of the nucleus raphe dorsalis and medianus reduce the concentration of serotonin (5-hydroxytryptamine) within rat brain intraparenchymal blood vessels. The concentration of serotonin within these vessels increases or decreases after the administration of drugs that modify the biosynthesis and degradation of serotonin or destroy nerve terminals by an uptake-dependent mechanism. These studies provide evidence for the existence of a serotonin-containing pathway seemingly analogous to the neuronal projection that terminates on small parenchymal blood vessels from noradrenergic neurons of the locus coeruleus.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Reinhard, J F Jr -- Liebmann, J E -- Schlosberg, A J -- Moskowitz, M A -- New York, N.Y. -- Science. 1979 Oct 5;206(4414):85-7.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/482930" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; Brain/*blood supply ; Brain Mapping ; Brain Stem/*physiology ; Cerebrovascular Circulation ; Microcirculation/*innervation ; Raphe Nuclei/cytology/*physiology ; Rats ; Serotonin/*physiology ; Tryptophan Hydroxylase/metabolism
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  • 85
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    4S RNA is present in regenerating optic axons of goldfish (1979)
    American Association for the Advancement of Science (AAAS)
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    Publication Date: 1979-10-05
    Description: Regenerating optic axons of goldfish were loaded with [3H]RNA by injecting [3H]uridine into the eye and allowing time for the radioactivity to be delivered to the optic tectum. The axons were subsequently removed from the tecta by cutting the optic nerve and allowing the optic axons in the tectum to degenerate. Analysis of tectal [3H]RNA by sodium dodecyl sulfate-polyacrylamide gel electrophoresis showed a selective loss of tritiated 4S RNA and not ribosomal RNA from the denervated tecta. These results support the hypothesis that regenerating optic axons of goldfish grow back into the tectum carrying 4C but not ribosomal RNA.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Ingoglia, N A -- New York, N.Y. -- Science. 1979 Oct 5;206(4414):73-5.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/90383" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; Axonal Transport ; Axons/*metabolism ; Goldfish ; Molecular Weight ; *Nerve Regeneration ; Optic Nerve/*metabolism/physiology ; RNA/*metabolism ; Superior Colliculi/metabolism
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  • 86
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    Long-term analgesic effects of inescapable shock and learned helplessness (1979)
    American Association for the Advancement of Science (AAAS)
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    Publication Date: 1979-10-05
    Description: Although exposure to inescapable shocks induced analgesia in rats, the analgesia was not manifest 24 hours later. A brief reexposure to shock, however, restored the analgesia. This reexposure to shock had an analgesic effect only if the rats had been shocked 24 hours previously. Further, long-term analgesic effects depended on the controllability of the original shocks and not on shock exposure per se. Implications of these results for learned helplessness and stress-induced analgesia are discussed.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Jackson, R L -- Maier, S F -- Coon, D J -- New York, N.Y. -- Science. 1979 Oct 5;206(4414):91-3.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/573496" target="_blank"〉PubMed〈/a〉
    Keywords: *Analgesia ; Animals ; *Avoidance Learning ; *Electroshock ; Humans ; Rats ; Stress, Psychological/*physiopathology ; Time Factors
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  • 87
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    Dopamine auto- and postsynaptic receptors: electrophysiological evidence for differential sensitivity to dopamine agonists (1979)
    American Association for the Advancement of Science (AAAS)
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    Publication Date: 1979-10-05
    Description: The responses of dopamine cells in the substantia nigra to iontophoretically administered dopamine and intravenous apomorphine were compared to the responses of spontaneously active neurons in the caudate nucleus. Dopaminergic cells were six to ten times more sensitive to dopamine and intravenous apomorphine than 86 percent of the caudate cells tested. This differential sensitivity of dopamine auto- and postsynaptic receptors may explain the apparently paradoxical behavioral effects induced by small compared to large doses of some dopamine agonists and may provide a means of developing new types of drugs to antagonize dopaminergic influence in the central nervous system.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Skirboll, L R -- Grace, A A -- Bunney, B S -- New York, N.Y. -- Science. 1979 Oct 5;206(4414):80-2.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/482929" target="_blank"〉PubMed〈/a〉
    Keywords: Action Potentials/drug effects ; Animals ; Apomorphine/*pharmacology ; Caudate Nucleus/drug effects ; Dendrites/drug effects ; Dopamine/*pharmacology ; Rats ; Receptors, Dopamine/*drug effects ; Substantia Nigra/drug effects ; Synaptic Membranes/drug effects
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  • 88
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    Angiogenesis in the mouse cornea (1979)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1979-09-28
    Description: We have developed a method that permits analysis of neovascular responses in the mouse cornea. Using this method we have demonstrated that both allogeneic lymphocytes and a variety of tumors can induce angiogenesis, but that only the latter appear capable of eliciting secondary capillary sprouting.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Muthukkaruppan, V -- Auerbach, R -- New York, N.Y. -- Science. 1979 Sep 28;205(4413):1416-8.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/472760" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; Cornea/*blood supply ; In Vitro Techniques ; Mice ; Mice, Inbred Strains ; Microcirculation ; Neoplasms, Experimental/*blood supply
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    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
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  • 89
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    Substance P: evidence for diverse roles in neuronal function from cultured mouse spinal neurons (1979)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1979-09-28
    Description: Mouse spinal neurons grown in tissue culture were used to examine the membrane mechanisms of action of the peptide substance P. Two functionally distinct actions were observed, one being a rapidly desensitizing excitation, and the other being a dose-dependent, reversible depression of excitatory responses to the putative amino acid neurotransmitter glutamate. These effects on excitability suggest that substance P may play more than one role in intercellular communication in the nervous system.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Vincent, J D -- Barker, J L -- New York, N.Y. -- Science. 1979 Sep 28;205(4413):1409-12.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/224464" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; Cell Communication ; Cells, Cultured ; Electric Conductivity ; Excitatory Amino Acid Antagonists ; Glutamates/pharmacology ; Membrane Potentials ; Mice ; Neural Inhibition ; Spinal Cord/cytology/*physiology ; Substance P/*physiology ; Synaptic Transmission
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    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
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  • 90
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    Pseudohermaphroditism in Ilyanassa obsoleta (Mollusca: Neogastropoda) (1979)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1979-09-28
    Description: Field studies, a rearing and maintenance program, and a transfer experiment have shown that anomalous male traits found in some female Ilyanassa obsoleta are an expression of environmentally controlled psuedohermaphroditism. The particular pattern of pseudohermaphroditism discovered in this species has not been reported previously from any other group, but may be characteristic of the Neogastropoda.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Jenner, M G -- New York, N.Y. -- Science. 1979 Sep 28;205(4413):1407-9.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/472758" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; Disorders of Sex Development/pathology/*physiopathology ; Female ; Male ; Sex Differentiation ; Snails/growth & development/*physiology
    Print ISSN: 0036-8075
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    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
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  • 91
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    Cyclic AMP receptor triggers nuclear protein phosphorylation in a hormone-dependent mammary tumor cell-free system (1979)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1979-09-28
    Description: Adenosine 3',5'-monophosphate (cyclic AMP) receptor protein of 56,000 daltons increases markedly in mammary tumors induced by 7,12-dimethylbenz[a]anthracene (DMBA) after incubation of tumor slices with cyclic AMP, benzamide, and arginine. Incubation of cytosol from these tumor slices with nuclei from unincubated tumors results in nuclear uptake of the 56,000-dalton cyclic AMP receptor and in phosphorylation of the 76,000-dalton nuclear protein. Binding of the 56,000-dalton receptor and phosphorylation of the 76,000-dalton protein also occur in DMBA tumor nuclei when protein kinase type II of bovine heart is used. The results suggest that cyclic AMP receptor is involved in the nuclear events of a hormone-dependent mammary tumor.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Cho-Chung, Y S -- Archibald, D -- Clair, T -- New York, N.Y. -- Science. 1979 Sep 28;205(4413):1390-2.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/224463" target="_blank"〉PubMed〈/a〉
    Keywords: 9,10-Dimethyl-1,2-benzanthracene ; Animals ; Cell Nucleus/metabolism ; Cell-Free System ; Chromosomal Proteins, Non-Histone/*metabolism ; Cyclic AMP/*metabolism ; Female ; Mammary Neoplasms, Experimental/*metabolism ; Neoplasm Proteins/metabolism ; Phosphorylation ; Protein Kinases/*metabolism ; Rats ; Receptors, Cyclic AMP/*metabolism
    Print ISSN: 0036-8075
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    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
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  • 92
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    Somatostatin cell processes as pathways for paracrine secretion (1979)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1979-09-28
    Description: Somatostatin is produced by gastrointestinal endocrine cells that have long, nonluminal, cytoplasmic processes. Such processes terminate on other cell types, including gastrin-producing and hydrochloric acid-producing cells, whose functions are profoundly affected by somatostatin. The findings suggest that somatostatin cells control the functions of other cells through local release of the peptide by way of cytoplasmic processes. Also, certain other types of gastrointestinal endocrine cells have similar cytoplasmic prolongations, which may have analogous local (paracrine) regulatory functions.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Larsson, L I -- Goltermann, N -- de Magistris, L -- Rehfeld, J F -- Schwartz, T W -- New York, N.Y. -- Science. 1979 Sep 28;205(4413):1393-5.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/382360" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; Gastric Juice/*secretion ; Gastrins/secretion ; Humans ; Immunoenzyme Techniques ; Pyloric Antrum/cytology/*metabolism ; Rats ; Somatostatin/*physiology
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    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
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  • 93
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    Morphine-naloxone interactions: a role for nonspecific morphine excitatory effects in withdrawal (1979)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1979-09-28
    Description: The opiate antagonist naloxone precipitates withdrawal when given either 15 minutes after or 1 minute before a single injection of morphine in drug-naive mice. We propose that withdrawal signs arise from a synergistic mixture of excitatory influences that are direct (agonistic action on nonspecific opiate receptors) and indirect (sensory and affective disorders, stress, hormonal and neurotransmitter dysfunction, and so forth). The predominant effects during precipitated withdrawal are assumed to be direct, whereas during abstinence in tolerant animals they are indirect.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Stevens, D R -- Klemm, W R -- New York, N.Y. -- Science. 1979 Sep 28;205(4413):1379-8.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/224462" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; Behavior, Animal/physiology ; Dose-Response Relationship, Drug ; Drug Interactions ; Drug Tolerance ; Female ; Humans ; Mice ; Morphine/*pharmacology ; Naloxone/*pharmacology ; Receptors, Opioid/*drug effects ; Stereotyped Behavior/physiology ; Substance Withdrawal Syndrome/*physiopathology
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    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
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  • 94
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    Perinatal exposure to cannabinoids alters male reproductive function in mice (1979)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1979-09-28
    Description: Oral administration of delta 9-tetrahydrocannabinol or cannabinol to female mice late in pregnancy and during early lactation alters body weight regulation and pituitary-gonadal function and suppresses adult copulatory activity in their male offspring. These findings suggest that both psychoactive and nonpsychoactive constituents of marihuana can affect the development of male reproductive functions in mice.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Dalterio, S -- Bartke, A -- New York, N.Y. -- Science. 1979 Sep 28;205(4413):1420-2.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/472762" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; Animals, Newborn ; Body Weight/drug effects ; Cannabinoids/*pharmacology ; Cannabinol/*pharmacology ; Copulation/drug effects ; Dronabinol/*pharmacology ; Male ; Mice ; Organ Size/drug effects ; Pituitary Hormones/blood ; Sex Differentiation/*drug effects ; Sexual Behavior, Animal/*drug effects ; Sexual Maturation/drug effects ; Testis/anatomy & histology ; Testosterone/blood
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  • 95
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    Meiotic maturation in Xenopus laevis oocytes initiated by insulin (1979)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1979-09-28
    Description: Insulin can induce meiotic division in Xenopus laevis oocytes. This effect shows the specificity expected of a receptor-mediated mechanism. It is potentiated by ethynylestradiol, a steroid antagonist of pregesterone (the natural hormone that provokes meiosis). The Xenopus laevis oocytes may serve as a model for the study of the poorly understood effect of insulin on cell division.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉El-Etr, M -- Schorderet-Slatkine, S -- Baulieu, E E -- New York, N.Y. -- Science. 1979 Sep 28;205(4413):1397-9.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/472755" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; Calcium/physiology ; Cholera Toxin/pharmacology ; Cycloheximide/pharmacology ; Ethinyl Estradiol/pharmacology ; Female ; Insulin/*pharmacology ; Kinetics ; Meiosis/*drug effects ; Oocytes/*drug effects ; Oogenesis/*drug effects ; Ovum/*drug effects ; Progesterone/pharmacology ; Receptor, Insulin/drug effects ; Xenopus
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  • 96
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    Baroreceptor activation reduces reactivity to noxious stimulation: implications for hypertension (1979)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1979-09-21
    Description: The hypothesis was tested that an acute rise of blood pressure may reduce reactivity to noxious stimuli through a baroreceptor-mediated reduction of cerebral arousal. When blood pressure was raised by an infusion of phenylephrine, rats showed less running to terminate or avoid noxious stimuli than during saline infusions. This effect was not seen in rats with denervated baroreceptors. The results suggest that a rise of blood pressure could have motivational consequences significant for human hypertension.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Dworkin, B R -- Filewich, R J -- Miller, N E -- Craigmyle, N -- Pickering, T G -- New York, N.Y. -- Science. 1979 Sep 21;205(4412):1299-301.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/472749" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; Avoidance Learning/drug effects/*physiology ; Blood Pressure/drug effects ; Heart Rate/drug effects ; Hypertension/*physiopathology ; Male ; Motivation/physiology ; Phenylephrine/pharmacology ; Pressoreceptors/*physiology ; Rats
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    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
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  • 97
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    DNA synthesis and mitosis in adult amphibian cardiac muscle cells in vitro (1979)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1979-09-21
    Description: High-resolution autoradiography and fine structural analysis of adult newt heart tissue in long-term culture revealed that tritiated thymidine was concentrated in the nuclei of dedifferentiated myocardial cells. Mitotic chromosomes were observed in some of these cells. This demonstrates that adult amphibian myocardial cells in vitro are capable of DNA synthesis and mitosis.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Nag, A C -- Healy, C J -- Cheng, M -- New York, N.Y. -- Science. 1979 Sep 21;205(4412):1281-2.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/472744" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; Cell Division ; Cells, Cultured ; DNA/*biosynthesis ; *Mitosis ; Muscle Proteins/metabolism ; Myocardial Contraction ; Myocardium/*metabolism ; Salamandridae ; Time Factors
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  • 98
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    Starvation-induced decreased sensitivity of resting metabolic rate to triiodothyronine (1979)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1979-09-21
    Description: The decrease in resting oxygen consumption induced by starvation was found to occur not only in euthyroid rats but also in hypothyroid and even in hypothyroid animals treated with triiodothyronine. Furthermore, the effectiveness of triiodothyronine was decreased when given to hypothyroid animals.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Wimpfheimer, C -- Saville, E -- Voirol, M J -- Danforth, E Jr -- Burger, A G -- New York, N.Y. -- Science. 1979 Sep 21;205(4412):1272-3.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/224460" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; Dose-Response Relationship, Drug ; Energy Metabolism/drug effects ; Hypothyroidism/metabolism ; Male ; Oxygen Consumption/*drug effects ; Rats ; Receptors, Cell Surface/drug effects ; Starvation/*metabolism ; Triiodothyronine/*pharmacology
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    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
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  • 99
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    Developmental fate of skeletal muscle satellite cells (1979)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1979-09-21
    Description: Radioisotopically labeled satellite cells from clonal cultures were implanted into normal muscle of the original donor. Implanted cells invariably retained their myogenic potential by participating in the regeneration of damaged myofibers or in the development of existing fibers.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Lipton, B H -- Schultz, E -- New York, N.Y. -- Science. 1979 Sep 21;205(4412):1292-4.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/472747" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; Cell Division ; Cells, Cultured ; Coturnix ; Muscles/cytology/*physiology/transplantation ; Rats ; *Regeneration ; Transplantation, Homologous
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    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
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  • 100
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    Thyrotropin-releasing hormone selectively depresses glutamate excitation of cerebral cortical neurons (1979)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1979-09-21
    Description: The microiontophoretic application of thyrotropin-releasing hormone causes a selective reduction in neuronal excitation evoked by L-glutamate but not by acetylcholine in rat cerebral cortex. Thyrotropin-releasing hormone has no influence on the activity of acetylcholinesterase or on choline uptake and release from cerebral synaptosomes. This evidence for a selective interaction between a centrally acting peptide and an excitatory amino acid neurotransmitter may indicate a specific locus of thyrotropin-releasing hormone action at glutamate-activated receptor sites.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Renaud, L P -- Blume, H W -- Pittman, Q J -- Lamour, Y -- Tan, A T -- New York, N.Y. -- Science. 1979 Sep 21;205(4412):1275-7.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/224461" target="_blank"〉PubMed〈/a〉
    Keywords: Acetylcholine/metabolism ; Action Potentials/drug effects ; Animals ; Aspartic Acid/antagonists & inhibitors ; Cerebral Cortex/*drug effects/physiology ; *Excitatory Amino Acid Antagonists ; Male ; Rats ; Receptors, Neurotransmitter/drug effects ; Synaptic Transmission/drug effects ; Thyrotropin-Releasing Hormone/*pharmacology
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    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
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