Publication Date:
1979-09-21
Description:
The microiontophoretic application of thyrotropin-releasing hormone causes a selective reduction in neuronal excitation evoked by L-glutamate but not by acetylcholine in rat cerebral cortex. Thyrotropin-releasing hormone has no influence on the activity of acetylcholinesterase or on choline uptake and release from cerebral synaptosomes. This evidence for a selective interaction between a centrally acting peptide and an excitatory amino acid neurotransmitter may indicate a specific locus of thyrotropin-releasing hormone action at glutamate-activated receptor sites.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Renaud, L P -- Blume, H W -- Pittman, Q J -- Lamour, Y -- Tan, A T -- New York, N.Y. -- Science. 1979 Sep 21;205(4412):1275-7.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/224461" target="_blank"〉PubMed〈/a〉
Keywords:
Acetylcholine/metabolism
;
Action Potentials/drug effects
;
Animals
;
Aspartic Acid/antagonists & inhibitors
;
Cerebral Cortex/*drug effects/physiology
;
*Excitatory Amino Acid Antagonists
;
Male
;
Rats
;
Receptors, Neurotransmitter/drug effects
;
Synaptic Transmission/drug effects
;
Thyrotropin-Releasing Hormone/*pharmacology
Print ISSN:
0036-8075
Electronic ISSN:
1095-9203
Topics:
Biology
,
Chemistry and Pharmacology
,
Computer Science
,
Medicine
,
Natural Sciences in General
,
Physics
