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  • Time Factors  (56)
  • American Association for the Advancement of Science (AAAS)  (56)
  • American Physical Society
  • Annual Reviews
  • 1980-1984  (24)
  • 1975-1979  (32)
  • 1983  (24)
  • 1979  (32)
Collection
Keywords
Publisher
  • American Association for the Advancement of Science (AAAS)  (56)
  • American Physical Society
  • Annual Reviews
Years
  • 1980-1984  (24)
  • 1975-1979  (32)
Year
  • 1
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    Light and efferent activity control rhabdom turnover in Limulus photoreceptors (1979)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1979-10-19
    Description: Photosensitive membrane structures in the retinular cells of the Limulus lateral eye are broken down and renewed daily. The first light onset causes a rapid, synchronous disassembly and buildup of the rhabdom in each photoreceptor cell. The entire process is complete within 30 minutes. Blocking the efferent input to the retina from the brain blocks the turnover of the rhabdom, and mimicking the efferent input by optic nerve stimulation restores it.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Chamberlain, S C -- Barlow, R B Jr -- New York, N.Y. -- Science. 1979 Oct 19;206(4416):361-3.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/482946" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; Efferent Pathways/physiology ; Electric Stimulation ; Horseshoe Crabs/*physiology ; *Light ; Optic Nerve/physiology ; Photoreceptor Cells/cytology/*physiology ; Regeneration ; Retina/cytology/physiology ; Time Factors
    Print ISSN: 0036-8075
    Electronic ISSN: 1095-9203
    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
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  • 2
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    Microsecond sensitivity of the human visual system to irregular flicker (1979)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1979-11-09
    Description: A flickering light presented to the eye produces a small alternating voltage at the scalp of a subject. This alternating voltage indicates the following response of the brain to the flicker. If every other flash in the flicker is displaced temporally by as little as 30 microseconds, an asymmetry appears in the brain's alternating voltage. The results suggest an underlying mechanism that may enhance visual detection of high-frequency flicker.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Diamond, A L -- New York, N.Y. -- Science. 1979 Nov 9;206(4419):708-10.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/493977" target="_blank"〉PubMed〈/a〉
    Keywords: Evoked Potentials ; Flicker Fusion/physiology ; Humans ; Time Factors ; *Vision, Ocular
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    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
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  • 3
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    Difference between postpartum and nutritional amenorrhea (1979)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1979-03-02
    Description: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Frisch, R E -- McArthur, J W -- New York, N.Y. -- Science. 1979 Mar 2;203(4383):921-3.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/419411" target="_blank"〉PubMed〈/a〉
    Keywords: Amenorrhea/*etiology/physiopathology ; Body Weight ; Female ; Humans ; Lactation ; Nutrition Disorders/complications ; Pregnancy ; Time Factors
    Print ISSN: 0036-8075
    Electronic ISSN: 1095-9203
    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
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  • 4
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    Movement disorders of aged rats: reversal by dopamine receptor stimulation (1979)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1979-10-26
    Description: When placed in a tank of water, aged rats (24 to 27 months old) showed marked impairments in swimming. Compared with young adult rats (3 to 4 months old), the older animals moved their limbs less vigorously and were less successful in keeping their heads above water. The young, but not old, rats maintained a position nearly horizontal to the water surface and planed across it. These movement dysfunctions of aged rats resemble those seen in young adult animals that have sustained injury to brain dopamine-containing neurons. The swimming impairments of the aged rats were reversed by the dopamine receptor stimulant apomorphine and by the biosynthetic precursor of dopamine, L-dopa. Thus, age-related alterations in brain dopaminergic systems may be responsible for some of the movement disturbances associated with senescence.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Marshall, J F -- Berrios, N -- New York, N.Y. -- Science. 1979 Oct 26;206(4417):477-9.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/504992" target="_blank"〉PubMed〈/a〉
    Keywords: *Aging ; Animals ; Apomorphine/therapeutic use ; Levodopa/therapeutic use ; Male ; Movement Disorders/drug therapy/*physiopathology ; Rats ; Receptors, Dopamine/*physiology ; Swimming ; Time Factors
    Print ISSN: 0036-8075
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  • 5
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    Pharmacologic effects in man of a potent, long-acting dopamine receptor agonist (1979)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1979-09-14
    Description: Single-dose administration of pergolide mesylate (100 to 400 micrograms) results in a dose-related inhibition of prolactin secretion which persists for more than 24 hours. During multiple-dose administration of pergolide, plasma prolactin concentrations remain markedly reduced (greater than 80 percnet) and gradually return to control levels several days after drug administration is discontinued.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Lemberger, L -- Crabtree, R E -- New York, N.Y. -- Science. 1979 Sep 14;205(4411):1151-3.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/382359" target="_blank"〉PubMed〈/a〉
    Keywords: Adult ; Clinical Trials as Topic ; Dose-Response Relationship, Drug ; Ergolines/*pharmacology/therapeutic use ; Humans ; Informed Consent ; Male ; Middle Aged ; Placebos ; Prolactin/blood ; Receptors, Dopamine/*drug effects ; Time Factors
    Print ISSN: 0036-8075
    Electronic ISSN: 1095-9203
    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
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  • 6
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    DNA synthesis and mitosis in adult amphibian cardiac muscle cells in vitro (1979)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1979-09-21
    Description: High-resolution autoradiography and fine structural analysis of adult newt heart tissue in long-term culture revealed that tritiated thymidine was concentrated in the nuclei of dedifferentiated myocardial cells. Mitotic chromosomes were observed in some of these cells. This demonstrates that adult amphibian myocardial cells in vitro are capable of DNA synthesis and mitosis.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Nag, A C -- Healy, C J -- Cheng, M -- New York, N.Y. -- Science. 1979 Sep 21;205(4412):1281-2.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/472744" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; Cell Division ; Cells, Cultured ; DNA/*biosynthesis ; *Mitosis ; Muscle Proteins/metabolism ; Myocardial Contraction ; Myocardium/*metabolism ; Salamandridae ; Time Factors
    Print ISSN: 0036-8075
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  • 7
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    Perception of echo phase information in bat sonar (1979)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1979-06-22
    Description: Echolocating bats (Eptesicus fuscus) can detect changes as small as 500 nanoseconds in the arrival time of sonar echoes when these changes appear as jitter or alternations in arrival time from one echo to the next. The psychophysical function relating the bat's performance to the magnitude of the jitter corresponds to the half-wave rectified cross-correlation function between the emitted sonar signals and the echoes. The bat perceives the phase or period structure of the sounds, which cover the 25- to 100-kilohertz frequency range, as these are represented in the auditory system after peripheral transformation. The acoustic image of a sonar target is apparently derived from time-domain or periodicity information processing by the nervous system.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Simmons, J A -- New York, N.Y. -- Science. 1979 Jun 22;204(4399):1336-8.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/451543" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; Auditory Perception/*physiology ; Chiroptera/*physiology ; Echolocation/*physiology ; Movement ; Orientation/*physiology ; Time Factors
    Print ISSN: 0036-8075
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  • 8
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    Harmonic-sensitive neurons in the auditory cortex of the mustache bat (1979)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1979-01-19
    Description: Human speech and animal sounds contain phonemes with prominent and meaningful harmonics. The biosonar signals of the mustache bat also contain up to four harmonics, and each consists of a long constant-frequency component followed by a short frequency-modulated component. Neurons have been found in a large cluster within auditory cortex of this bat whose responses are facilitated by combinations of two or more harmonically related tones. Moreover, the best frequencies for excitation of these neurons are closely associated with the constant-frequency components of the biosonar signals. The properties of these neurons make them well suited for identifying the signals produced by other echolocating mustache bats. They also show how meaningful components of sound are assembled by neural circuits in the central nervous system and suggest a method by which sounds with important harmonics (or formants) may be detected and recognized by the brain in other species, including humans.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Suga, N -- O'Neill, W E -- Manabe, T -- New York, N.Y. -- Science. 1979 Jan 19;203(4377):270-4.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/760193" target="_blank"〉PubMed〈/a〉
    Keywords: Action Potentials ; Animals ; Auditory Cortex/cytology/*physiology ; Auditory Pathways/physiology ; Auditory Perception/*physiology ; Chiroptera/*physiology ; Echolocation/physiology ; Neurons/physiology ; Time Factors
    Print ISSN: 0036-8075
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    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
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  • 9
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    Memory retrieval: a time-locked process in infancy (1983)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1983-12-23
    Description: Three-month-old infants learned to activate an overhead crib mobile by operant footkicking and received a visual reminder of the event (a "reactivation treatment") 2 weeks later, after forgetting had occurred. Subsequent manifestation of the association was a monotonic increasing function of time since the reactivation treatment, and performance of infants tested 8 hours after the remainder was related to the time spent sleeping in the interim (r = 0.75). These data demonstrate that normal retrieval is time-dependent. Moreover, individual data suggest that retrieval may be continuous rather than discontinuous.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Fagen, J W -- Rovee-Collier, C -- MH 32307/MH/NIMH NIH HHS/ -- New York, N.Y. -- Science. 1983 Dec 23;222(4630):1349-51.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/6658456" target="_blank"〉PubMed〈/a〉
    Keywords: Humans ; Infant ; *Memory ; Time Factors
    Print ISSN: 0036-8075
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  • 10
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    Expression of a cellular oncogene during liver regeneration (1983)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1983-02-04
    Description: The number of transcripts of the cellular oncogene ras, which is homologous to the transforming gene of Harvey sarcoma virus, increases during liver regeneration in rats. The increase in these transcripts in liver polysomal polyadenylated RNA occurs at the time of activation of DNA synthesis during the regenerative process induced by partial hepatectomy or carbon tetrachloride injury. The number of ras transcripts returns to basal levels within 72 hours. These observations show that transcription of a cellular oncogene increases in a regulated way in a nonneoplastic growth process.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Goyette, M -- Petropoulos, C J -- Shank, P R -- Fausto, N -- New York, N.Y. -- Science. 1983 Feb 4;219(4584):510-2.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/6297003" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; Carbon Tetrachloride Poisoning ; DNA/biosynthesis ; Hepatectomy ; *Liver Regeneration ; Nucleic Acid Hybridization ; *Oncogenes ; RNA, Messenger/biosynthesis ; Rats ; Sarcoma Viruses, Murine/genetics ; Time Factors ; *Transcription, Genetic
    Print ISSN: 0036-8075
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  • 11
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    Hand preference across time is related to intelligence in young girls, not boys (1983)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1983-09-09
    Description: Consistency of hand preference was examined in a longitudinal study of children between 18 and 42 months of age. Results showed a sex-specific relationship between hand consistency and intellectual development. Across a variety of intellectual abilities at all ages, females with consistency of handedness were precocious compared to females without such consistency. This relationship did not hold for males.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Gottfried, A W -- Bathurst, K -- New York, N.Y. -- Science. 1983 Sep 9;221(4615):1074-6.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/6879205" target="_blank"〉PubMed〈/a〉
    Keywords: Child, Preschool ; Female ; *Functional Laterality ; Humans ; Infant ; *Intelligence ; Intelligence Tests ; Male ; Sex Factors ; Time Factors
    Print ISSN: 0036-8075
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  • 12
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    Red/Green color opponency at detection threshold (1983)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1983-01-14
    Description: By means of visual stimnulus without temporal or spatial edges, we have achieved better isolation of chromatic signals at detection threshold than has been reported previously. Under various states of adaptation, the spectral sensitivity of the chromatic mechanism detecting middle- and long-wavelength lights corresponds with that deduced from suprathreshold red/green hue equilibriums.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Thornton, J E -- Pugh, E N Jr -- New York, N.Y. -- Science. 1983 Jan 14;219(4581):191-3.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/6849131" target="_blank"〉PubMed〈/a〉
    Keywords: Color Perception/*physiology ; Humans ; Spectrum Analysis ; Time Factors
    Print ISSN: 0036-8075
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  • 13
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    Human endothelial cells: use of heparin in cloning and long-term serial cultivation (1983)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1983-11-11
    Description: Endothelial cells from human blood vessels were cultured in vitro, with doubling times of 17 to 21 hours for 42 to 79 population doublings. Cloned human endothelial cell strains were established for the first time and had similar proliferative capacities. This vigorous cell growth was achieved by addition of heparin to culture medium containing reduced concentrations of endothelial cell growth factor. The routine cloning and long-term culture of human endothelial cells will facilitate studying the human endothelium in vitro.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Thornton, S C -- Mueller, S N -- Levine, E M -- AG-00839/AG/NIA NIH HHS/ -- T32-CA-09171/CA/NCI NIH HHS/ -- New York, N.Y. -- Science. 1983 Nov 11;222(4624):623-5.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/6635659" target="_blank"〉PubMed〈/a〉
    Keywords: Cell Division/drug effects ; Cells, Cultured ; Clone Cells/enzymology ; Endothelium/*cytology ; Growth Substances/pharmacology ; Heparin/*pharmacology ; Humans ; Time Factors
    Print ISSN: 0036-8075
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    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
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  • 14
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    Recovery of normal topography in the somatosensory cortex of monkeys after nerve crush and regeneration (1983)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1983-08-19
    Description: After median nerve fibers to glabrous skin on the hands of monkeys were crushed and allowed to regenerate, normal topographical organization was recovered in the representation of the hand in primary somatosensory cortex. Similar recovery of normal cortical organization may underlie the sensory restoration that usually follows nerve crush injury in humans.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Wall, J T -- Felleman, D J -- Kaas, J H -- New York, N.Y. -- Science. 1983 Aug 19;221(4612):771-3.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/6879175" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; Aotus trivirgatus/physiology ; Brain Mapping ; Hand/innervation ; *Nerve Crush ; *Nerve Regeneration ; Somatosensory Cortex/*physiology ; Time Factors
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  • 15
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    DNA methylation decreases in aging but not in immortal cells (1983)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1983-06-03
    Description: When normal diploid fibroblasts from mice, hamsters, and humans were grown in culture, the 5-methylcytosine content of their DNA's markedly decreased. The greatest rate of loss of 5-methylcytosine residues was observed in mouse cells, which survived the least number of division. Immortal mouse cell lines had more stable rates of methylation.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Wilson, V L -- Jones, P A -- 1-T32-CA09320/CA/NCI NIH HHS/ -- R01-GM30892/GM/NIGMS NIH HHS/ -- New York, N.Y. -- Science. 1983 Jun 3;220(4601):1055-7.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/6844925" target="_blank"〉PubMed〈/a〉
    Keywords: 5-Methylcytosine ; *Aging ; Animals ; Cell Division ; Cell Line ; Cricetinae ; Cytosine/analogs & derivatives/metabolism ; DNA/metabolism/*physiology ; Fibroblasts/metabolism ; Humans ; Mesocricetus ; Methylation ; Mice ; Time Factors
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  • 16
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    Temporal selectivity in the central auditory system of the leopard frog (1983)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1983-03-04
    Description: Amplitude modulation is a predominant temporal feature in many vocal signals. The leopard frog, Rana pipiens, has a class of neurons in the central auditory system that respond selectively to particular rates of amplitude modulation; these neurons can be characterized by a temporal tuning curve. Such selectivity is absent in the peripheral auditory system. This type of transformation may be fundamental in processing temporal information in the vertebrate sensory nervous system.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Rose, G -- Capranica, R R -- NS-09244/NS/NINDS NIH HHS/ -- New York, N.Y. -- Science. 1983 Mar 4;219(4588):1087-9.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/6600522" target="_blank"〉PubMed〈/a〉
    Keywords: Animal Communication ; Animals ; Auditory Pathways/*physiology ; Auditory Perception/*physiology ; Brain/physiology ; Rana pipiens/*physiology ; Time Factors
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  • 17
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    Effects of tyrosine administration on serum biopterin in normal controls and patients with Parkinson's disease (1983)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1983-01-07
    Description: After administration of tyrosine, total concentration of biopterin, the cofactor for tyrosine hydroxylase, was increased in the striatum, adrenal glands, and serum of rats, and in the serum of humans. Serum biopterin is lower in patients with Parkinson's disease than in normal controls. After oral administration of tyrosine, the increase in serum biopterin concentration was smaller in patients with Parkinson's disease (less than twofold) than in healthy controls (three-to sevenfold). These results suggest that tyrosine may have a regulatory role in biopterin biosynthesis and that patients with Parkinson's disease may have some abnormality in the regulation of biopterin biosynthesis.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Yamaguchi, T -- Nagatsu, T -- Sugimoto, T -- Matsuura, S -- Kondo, T -- Iizuka, R -- Narabayashi, H -- New York, N.Y. -- Science. 1983 Jan 7;219(4580):75-7.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/6849120" target="_blank"〉PubMed〈/a〉
    Keywords: Administration, Oral ; Adrenal Glands/metabolism ; Alanine/pharmacology ; Animals ; Biopterin/*blood ; Corpus Striatum/metabolism ; Humans ; Injections, Intraperitoneal ; Liver/metabolism ; Male ; Parkinson Disease/*blood ; Pteridines/*blood ; Rats ; Rats, Inbred Strains ; Time Factors ; Tyrosine/administration & dosage/*pharmacology
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  • 18
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    Delayed neurotoxicity of phenylphosphonothioate esters (1979)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1979-08-17
    Description: Administration of a single oral dose of five phenylphosphonothioate esters produced delayed neurotoxicity in hens; their potency was, in descending order, cyanofenphos, EPN, desbromoleptophos, leptophos, and EPBP (Seven). Histological examination showed that in some hens there was marked axonal and myelin degeneration in the spinal cord and peripheral nerves. The results suggest that delayed neurotoxicity may be a general feature of phenylphosphonothioate insecticides.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Abou-Donia, M B -- New York, N.Y. -- Science. 1979 Aug 17;205(4407):713-5.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/462181" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; Ataxia/chemically induced ; Chickens ; Demyelinating Diseases/chemically induced ; Dose-Response Relationship, Drug ; Female ; Insecticides/*toxicity ; Nerve Degeneration ; *Neurotoxins ; *Organothiophosphorus Compounds ; Time Factors
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  • 19
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    Nanosecond X-ray diffraction from biological samples with a laser-produced plasma source (1979)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1979-05-11
    Description: By using 4.45-angstrom radiation generated by Cl+15 ions in a laser plasma and nanosecond exposures, low-angle x-ray diffraction patterns were obtained from dried rat spinal nerves and a powder of cholesterol. Three to four 400-picosecond, 45-joule pulses were required for the exposure. This new technique should have wide application in structural kinetic studies.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Frankel, R D -- Forsyth, J M -- New York, N.Y. -- Science. 1979 May 11;204(4393):622-4.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/432665" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; *Cholesterol ; In Vitro Techniques ; *Lasers ; Neurons/*ultrastructure ; Rats ; Time Factors ; X-Ray Diffraction/*methods
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  • 20
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    Nonpneumonic, short-incubation-period Legionellosis (Pontiac fever) in men who cleaned a steam turbine condenser (1979)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1979-08-17
    Description: Pontiac fever affected ten men who had cleaned a steam turbine condenser with compressed air. Previous epidemics of Pontiac fever and Legionnaires' disease--both caused by Legionella Pneumophila (proposed sp. nov.)--involved "airborne spread" from air-conditioning cooling towers or evaporative condensers. Aerosols of contaminated water in heat-rejection systems appear to be important sources of epidemic legionellosis.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Fraser, D W -- Deubner, D C -- Hill, D L -- Gilliam, D K -- New York, N.Y. -- Science. 1979 Aug 17;205(4407):690-1.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/462175" target="_blank"〉PubMed〈/a〉
    Keywords: Adolescent ; Air Microbiology ; Humans ; Legionnaires' Disease/*etiology/microbiology/transmission ; Male ; Occupational Medicine ; Time Factors
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  • 21
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    Can an ape create a sentence? (1979)
    American Association for the Advancement of Science (AAAS)
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    Publication Date: 1979-11-23
    Description: More than 19,000 multisign utterances of an infant chimpanzee (Nim) were analyzed for syntactic and semantic regularities. Lexical regularities were observed in the case of two-sign combinations: particular signs (for example, more) tended to occur in a particular position. These regularities could not be attributed to memorization or to position habits, suggesting that they were structurally constrained. That conclusion, however, was invalidated by videotape analyses, which showed that most of Nim's utterances were prompted by his teacher's prior utterance, and that Nim interrupted his teachers to a much larger extent than a child interrupts an adult's speech. Signed utterances of other apes (as shown on films) revealed similar non-human patterns of discourse.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Terrace, H S -- Petitto, L A -- Sanders, R J -- Bever, T G -- New York, N.Y. -- Science. 1979 Nov 23;206(4421):891-902.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/504995" target="_blank"〉PubMed〈/a〉
    Keywords: *Animal Communication ; Animals ; Humans ; Language Development ; Male ; Pan troglodytes/*physiology ; Semantics ; Sign Language ; Time Factors
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  • 22
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    Ethanol modulation of opiate receptors in cultured neural cells (1983)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1983-12-16
    Description: The mouse neuroblastoma-rat glioma hybrid cell line NG108-15 was used to study the acute and chronic interaction of ethanol with intact neural cells. In the short term, ethanol inhibited opiate receptor binding, but after long-term exposure the cells exhibited an apparent adaptive increase in the number of opiate binding sites; this was reversible when ethanol was withdrawn. High concentrations of ethanol (200 mM) increased opiate binding after 18 to 24 hours, whereas lower concentrations (25 to 50 mM) produced similar changes after 2 weeks. This model system has potential for exploring the cellular and molecular mechanisms underlying ethanol intoxication, tolerance, and withdrawal.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Charness, M E -- Gordon, A S -- Diamond, I -- New York, N.Y. -- Science. 1983 Dec 16;222(4629):1246-8.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/6316506" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; Cell Line ; Dose-Response Relationship, Drug ; Enkephalin, Methionine/analogs & derivatives/metabolism ; Ethanol/*pharmacology ; Glioma ; Hybrid Cells ; Mice ; Neuroblastoma ; Neurons/*drug effects/metabolism ; Rats ; Receptors, Opioid/*drug effects/metabolism ; Time Factors
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  • 23
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    Taste flashes: reaction times, intensity, and quality (1983)
    American Association for the Advancement of Science (AAAS)
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    Publication Date: 1983-01-28
    Description: Human simple reaction times and magnitude estimates of taste intensity increased as the duration of 500-millimolar sodium chloride or 2-millimolar saccharin sodium pulses lengthened from 100 to 1000 milliseconds. Responses to "What was the taste?" ranged from 94 to 100 percent "sweet" for saccharin and 68 to 83 percent "salty" for salt across all pulse durations when both substances were randomized with water pulses.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Kelling, S T -- Halpern, B P -- New York, N.Y. -- Science. 1983 Jan 28;219(4583):412-4.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/6849142" target="_blank"〉PubMed〈/a〉
    Keywords: Humans ; Saccharin ; Sodium Chloride ; Taste/*physiology ; Time Factors
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  • 24
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    Immune response to hepatitis B surface antigen: enhancement by prior injection of antibodies to the idiotype (1983)
    American Association for the Advancement of Science (AAAS)
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    Publication Date: 1983-08-26
    Description: Anti-idiotype reagents that recognize a common idiotype associated with the combining site of antibodies to hepatitis B surface antigen (anti-HBs) were used to manipulate the immune response to hepatitis B surface antigen in BALB/c mice. The injection of antibodies to the idiotype before antigenic stimulation resulted in an increase in the number of cells secreting immunoglobulin M antibodies to hepatitis B surface antigen. Anti-HBs-secreting cells were also induced by administration of antibodies to the idiotype without subsequent antigen exposure. These findings indicate that the immune response to hepatitis B surface antigen in mice is regulated through an idiotype-anti-idiotype network.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Kennedy, R C -- Adler-Storthz, K -- Henkel, R D -- Sanchez, Y -- Melnick, J L -- Dreesman, G R -- New York, N.Y. -- Science. 1983 Aug 26;221(4613):853-5.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/6603657" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; Antibodies, Anti-Idiotypic/immunology ; Antibodies, Viral/*biosynthesis ; Hepatitis B Antibodies/*biosynthesis ; Hepatitis B Surface Antigens/*immunology ; Immunoglobulin G/biosynthesis ; Immunoglobulin Idiotypes/immunology ; Immunoglobulin M/biosynthesis ; Mice ; Spleen/immunology ; Time Factors
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  • 25
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    Vaginal stimulation: an important determinant of maternal bonding in sheep (1983)
    American Association for the Advancement of Science (AAAS)
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    Publication Date: 1983-01-07
    Description: The immediate induction of the full complement of maternal behavior in nonpregnant ewes primed with estrogen and progesterone has been obtained after 5 minutes of vaginal-cervical stimulation. A similar period of such stimulation given to recently parturient ewes, after the development of selective bonding to their own lambs, reversed their rejection behavior of alien lambs and produced a state of plasticity in maternal behavior, such that ewes receiving vaginal stimulation would accept and adopt alien lambs. These findings implicate vaginal-cervical stimulation as playing a role in the onset of maternal behavior.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Keverne, E B -- Levy, F -- Poindron, P -- Lindsay, D R -- New York, N.Y. -- Science. 1983 Jan 7;219(4580):81-3.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/6849123" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; Estradiol/pharmacology ; Female ; *Maternal Behavior ; Pregnancy ; Progesterone/pharmacology ; Sheep/*physiology ; Time Factors ; Vagina/*physiology
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  • 26
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    Pregnancy increases reactivity of mice to phenobarbital (1983)
    American Association for the Advancement of Science (AAAS)
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    Publication Date: 1983-04-29
    Description: Compared to nonpregnant controls, pregnant mice injected with phenobarbital had lower concentrations of the drug in the plasma but equivalent concentrations in the brain. In spite of the similar concentrations in the brain, the behavioral response to phenobarbital was greater for pregnant than nonpregnant mice. These results suggest that the concentration of phenobarbital in the plasma, which is commonly used as a basis for adjusting phenobarbital dosage during pregnancy, is not an appropriate indicator of the dynamics of the drug.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Middaugh, L D -- Zemp, J W -- Boggan, W O -- AA03532/AA/NIAAA NIH HHS/ -- DA00041/DA/NIDA NIH HHS/ -- DA01750/DA/NIDA NIH HHS/ -- New York, N.Y. -- Science. 1983 Apr 29;220(4596):534-6.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/6836299" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; Brain Chemistry ; Dose-Response Relationship, Drug ; Female ; Humans ; Mice ; Mice, Inbred C57BL ; Motor Activity/drug effects ; Phenobarbital/analysis/*metabolism/pharmacology ; *Pregnancy/drug effects ; Time Factors
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  • 27
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    Transported proteins in the regenerating optic nerve: regulation by interactions with the optic tectum (1983)
    American Association for the Advancement of Science (AAAS)
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    Publication Date: 1983-10-14
    Description: The transport of specific proteins in regenerating optic fibers of goldfish depends on the presence or absence of the optic tectum. When optic fibers were allowed to contact the tectum, amounts of rapidly transported proteins having molecular weights between 120,000 and 160,000 increased, and a species of molecular weight 26,000 reverted to normal levels. When nerves were prevented from contacting the tectum, the amount of the 26,000-molecular weight protein remained high for months. Amounts of other transported proteins, in particular a group of acidic components of molecular weight 44,000 to 49,000 that increase greatly at early stages of regeneration, proved to be independent of the tectum.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Benowitz, L I -- Yoon, M G -- Lewis, E R -- R01NS16943/NS/NINDS NIH HHS/ -- New York, N.Y. -- Science. 1983 Oct 14;222(4620):185-8.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/6194562" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; Axonal Transport ; Biological Transport ; Cell Communication ; Goldfish ; Isoelectric Point ; Molecular Weight ; *Nerve Regeneration ; Nerve Tissue Proteins/*metabolism ; Superior Colliculi/*physiology ; Time Factors ; Visual Pathways/*physiology
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  • 28
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    Clot-selective coronary thrombolysis with tissue-type plasminogen activator (1983)
    American Association for the Advancement of Science (AAAS)
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    Publication Date: 1983-06-10
    Description: Coronary thrombolysis, an intervention that can abort the sequelae of acute myocardial infarction, was accomplished within 10 minutes in dogs by intravenous administration of clot-selective, tissue-type plasminogen activator. In addition to inducing clot lysis, this promising fibrinolytic agent restored intermediary metabolism and nutritional myocardial blood flow, detectable noninvasively with positron tomography, without inducing a systemic fibrinolytic state.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Bergmann, S R -- Fox, K A -- Ter-Pogossian, M M -- Sobel, B E -- Collen, D -- HL 17646/HL/NHLBI NIH HHS/ -- New York, N.Y. -- Science. 1983 Jun 10;220(4602):1181-3.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/6602378" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; Coronary Disease/*drug therapy/radionuclide imaging ; Dogs ; Fibrinogen/analysis ; Infusions, Parenteral ; Injections ; Plasminogen Activators/administration & dosage/*therapeutic use ; Streptokinase/administration & dosage/therapeutic use ; Time Factors ; Tomography, Emission-Computed
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  • 29
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    Failure to integrate information from successive fixations (1983)
    American Association for the Advancement of Science (AAAS)
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    Publication Date: 1983-10-14
    Description: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Jonides, J -- Irwin, D E -- Yantis, S -- New York, N.Y. -- Science. 1983 Oct 14;222(4620):188.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/6623072" target="_blank"〉PubMed〈/a〉
    Keywords: Humans ; Research Design ; Time Factors ; Visual Perception/*physiology
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  • 30
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    Infants' discrimination of the duration of a rapid spectrum change in nonspeech signals (1983)
    American Association for the Advancement of Science (AAAS)
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    Publication Date: 1983-10-14
    Description: Two-month-old infants discriminated complex sinusoidal patterns that varied in the duration of their initial frequency transitions. Discrimination of these nonspeech sinusoidal patterns was a function of both the duration of the transitions and the total duration of the stimulus pattern. This contextual effect was observed even though the information specifying stimulus duration occurred after the transitional information. These findings parallel those observed with infants for perception of synthetic speech stimuli. Specialized speech processing capacities are thus not required to account for infants' sensitivity to contextual effects in acoustic signals, whether speech or nonspeech.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Jusczyk, P W -- Pisoni, D B -- Reed, M A -- Fernald, A -- Myers, M -- HD-11915/HD/NICHD NIH HHS/ -- HD-15795-02/HD/NICHD NIH HHS/ -- MH-24027/MH/NIMH NIH HHS/ -- New York, N.Y. -- Science. 1983 Oct 14;222(4620):175-7.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/6623067" target="_blank"〉PubMed〈/a〉
    Keywords: Humans ; *Infant ; Speech Perception/*physiology ; Time Factors
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  • 31
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    Rate of synaptic replacement in denervated rat hippocampus declines precipitously from the juvenile period to adulthood (1983)
    American Association for the Advancement of Science (AAAS)
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    Publication Date: 1983-08-05
    Description: Synaptic contacts per unit area in the rat dentate gyrus reach adult numbers by the end of the first month after birth and remain constant thereafter. This experiment demonstrated that the rate at which synapses were replaced by sprouting after a lesion declined dramatically from 35 to 90 days of age. Thus, the juvenile period of the rat's life is marked by a considerable change in neuronal plasticity. This may be related to age-dependent effects in recovery from brain damage.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉McWilliams, J R -- Lynch, G -- 5 F32 NS06821/NS/NINDS NIH HHS/ -- AG00538-06/AG/NIA NIH HHS/ -- New York, N.Y. -- Science. 1983 Aug 5;221(4610):572-4.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/6867730" target="_blank"〉PubMed〈/a〉
    Keywords: *Aging ; Animals ; Axons/physiology ; Denervation ; Hippocampus/*physiology ; Male ; Nerve Degeneration ; Neuronal Plasticity ; Rats ; Synapses/*physiology ; Time Factors
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  • 32
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    Very brief visual experience eliminates plasticity in the cat visual cortex (1983)
    American Association for the Advancement of Science (AAAS)
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    Publication Date: 1983-07-08
    Description: Rearing cats in the dark extends the critical period for development of visual cortical neurons, which indicates that the experience of visual input is necessary to begin the developmental process. A single brief pulse of visual input (6 hours) during a period of dark-rearing eliminates delayed development in the visual cortex. Light therefore seems to rapidly trigger the developmental process, and once triggered, that process runs to completion in the absence of further input.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Mower, G D -- Christen, W G -- Caplan, C J -- EY 03335/EY/NEI NIH HHS/ -- HD 06276/HD/NICHD NIH HHS/ -- New York, N.Y. -- Science. 1983 Jul 8;221(4606):178-80.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/6857278" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; Cats ; Darkness ; *Neuronal Plasticity ; Time Factors ; Vision, Ocular/physiology ; Visual Cortex/growth & development/*physiology
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  • 33
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    Visual sustained attention: image degradation produces rapid sensitivity decrement over time (1983)
    American Association for the Advancement of Science (AAAS)
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    Publication Date: 1983-04-15
    Description: Perceptual sensitivity to a visual target presented in a random continuous sequence of targets and nontargets decreased rapidly over time when stimuli were highly degraded visually but not when moderately degraded or undegraded. Large declines in sensitivity, independent of changes in response criterion, were found after only 5 minutes of observation. These rapid decrements of sensitivity to degraded targets seem to result from demands on the limited capacity of visual attention.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Nuechterlein, K H -- Parasuraman, R -- Jiang, Q -- 784040-29867-5/PHS HHS/ -- MH 30911/MH/NIMH NIH HHS/ -- New York, N.Y. -- Science. 1983 Apr 15;220(4594):327-9.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/6836276" target="_blank"〉PubMed〈/a〉
    Keywords: Adolescent ; Adult ; *Attention ; Child ; Discrimination (Psychology) ; Female ; Humans ; Male ; Memory ; Time Factors ; *Visual Perception
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  • 34
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    Physiological correlates of prolonged sleep deprivation in rats (1983)
    American Association for the Advancement of Science (AAAS)
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    Publication Date: 1983-07-08
    Description: The issue of whether sleep is physiologically necessary has been unresolved because experiments that reported deleterious effects of sleep deprivation did not control for the stimuli used to prevent sleep. In this experiment, however, experimental and control rats received the same relatively mild physical stimuli, but stimulus presentations were timed to reduce sleep severely in experimental rats but not in controls. Experimental rats suffered severe pathology and death; control rats did not.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Rechtschaffen, A -- Gilliland, M A -- Bergmann, B M -- Winter, J B -- MH-18428/MH/NIMH NIH HHS/ -- MH-4151/MH/NIMH NIH HHS/ -- New York, N.Y. -- Science. 1983 Jul 8;221(4606):182-4.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/6857280" target="_blank"〉PubMed〈/a〉
    Keywords: Adrenal Glands/pathology ; Animals ; Body Weight ; Electroencephalography ; Male ; Organ Size ; Rats ; Rats, Inbred Strains ; Sleep Deprivation/*physiology ; Time Factors
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  • 35
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    Tumor promotion by phorbol esters in skin: evidence for a memory effect (1983)
    American Association for the Advancement of Science (AAAS)
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    Publication Date: 1983-04-01
    Description: By means of a two-stage promotion protocol in mouse epidermis with 12-O-tetradecanoylphorbol-13-acetate as first-stage promoter and 12-O-retinoylphorbol-13-acetate as second-stage promoter, the effects of the former that are critical and obligatory for tumor promotion were shown to be irreversible in nature for at least 8 weeks. The reversibility of tumor promotion was related to the second stage of promotion, reflecting the reversibility of epidermal hyperplasia induced by 12-O-tetradecanoylphorbol-13-acetate.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Furstenberger, G -- Sorg, B -- Marks, F -- New York, N.Y. -- Science. 1983 Apr 1;220(4592):89-91.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/6828884" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; Carcinogens/*pharmacology ; Cell Line ; Epidermis/drug effects ; Female ; Hyperplasia/chemically induced ; Mice ; Mice, Inbred Strains ; Neoplasms, Experimental/chemically induced ; Phorbol Esters/*adverse effects ; Phorbols/*adverse effects ; Precancerous Conditions/chemically induced ; Skin Neoplasms/*chemically induced ; Tetradecanoylphorbol Acetate/*adverse effects ; Time Factors
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    Identifying environmental chemicals causing mutations and cancer (1979)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1979-05-11
    Description: Damage to DNA appears to be the major cause of most cancer and genetic birth defects and may contribute to aging and heart disease as well. The agents that cause this damage must be identified. Many of these agents are natural chemicals present in the human diet as complex mixtures. The tens of thousands of man-made chemicals that have been introduced into the environment in the last few decades must also be tested for their ability to damage DNA. Existing animal tests and human epidemiology alone are inadequate for this task because of time, expense, and the difficulty of dealing with complex mixtures, Newly developed short-term tests, most of them assaying for mutagenicity, are discussed as key tools in identifying environmental mutagens and carcinogens.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Ames, B N -- New York, N.Y. -- Science. 1979 May 11;204(4393):587-93.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/373122" target="_blank"〉PubMed〈/a〉
    Keywords: *Carcinogens ; DNA/genetics ; Disease Models, Animal ; Environmental Exposure ; Ethylene Dibromide ; Ethylene Dichlorides ; Flame Retardants ; Furylfuramide ; Hair Dyes ; Humans ; Hydrocarbons, Halogenated ; Maximum Allowable Concentration ; Microsomes, Liver/metabolism ; *Mutagens ; Neoplasms/*chemically induced ; Risk ; Salmonella/drug effects ; Smoking/complications ; Time Factors
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    "Sontaneous" neoplastic transformation in vitro: a form of foreign body (smooth surface) tumorigenesis (1979)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1979-04-13
    Description: Explants of subcutaneous connective tissue from adult BALB/c mice into plastic petri dishes were serially subcultured and tested for tumorigenicity in two ways: by the subcutaneous implantation of cells attached to plastic plates (1 by 5 by 10 millimeters), and by the subcutaneous injection of cells suspended in saline. Cells grown in vitro for 18 or more days before being implanted attached to a plastic plate (2.4 x 10(4) to 3.4 x 10(5) cells per plate) formed tumors after 24 to 79 weeks. The latent period before tumor appearance correlated inversely with the time spent by the cells in tissue culture. Cells inoculated in saline suspension (10 to 100 times the above number per plate) did not form tumors until after 84 days in vitro; plates alone did not induce tumor formation within more than 1 1/2 years of implantation. The tumors arising from the plate-attached cells were transplantable without plates and histologically appeared to be undifferentiated sarcomas. It is well established that smooth-surfaced foreign bodies, regardless of their chemical composition, will produce sarcomas when transplanted subcutaneously in rodents. We interpret our data, particularly the decrease in tumor latent period with time spent in tissue culture, as indicating that a smooth surface was acting as a carcinogen first in vitro (the surface of the tissue culture dish) and then in vivo (the surface of the plastic plate).〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Boone, C W -- Takeichi, N -- Eaton, S D -- Paranjpe, M -- New York, N.Y. -- Science. 1979 Apr 13;204(4389):177-9.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/373119" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; *Cell Transformation, Neoplastic/pathology ; Cells, Cultured ; Connective Tissue/pathology ; Female ; Foreign-Body Reaction/*complications ; Mice ; Neoplasms, Experimental/*etiology ; *Plastics ; Sarcoma, Experimental/etiology ; Time Factors
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    Feeding and behavioral activation in infant rats (1979)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1979-07-13
    Description: Three-day-old rats that were separated from their mothers and deprived of food were found to be capable of feeding either from small puddles of milk or when milk was infused into the front of their mouths. Such feeding was accompanied by a dramatic increase in behavioral activity and only occurred in a warm environment. These data demonstrate that neural systems for ingestive behavior are present at birth and suggest the existence of feeding-related arousal or motivational systems.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Hall, W G -- New York, N.Y. -- Science. 1979 Jul 13;205(4402):206-9.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/451591" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; Animals, Newborn/*physiology ; Behavior, Animal/*physiology ; Feeding Behavior/*physiology ; Food Deprivation ; Movement ; Rats ; Temperature ; Time Factors
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    Long-term choline treatment of memory-impaired elderly patients (1979)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1979-09-07
    Description: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Ferris, S H -- Sathananthan, G -- Reisberg, B -- Gershon, S -- New York, N.Y. -- Science. 1979 Sep 7;205(4410):1039-40.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/472728" target="_blank"〉PubMed〈/a〉
    Keywords: Aged ; Alzheimer Disease/drug therapy ; Dementia/drug therapy ; Humans ; Memory Disorders/*drug therapy ; Parasympathomimetics/*therapeutic use ; Time Factors
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    Testosterone reduces refractory period of stria terminalis neurons in the rat brain (1979)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1979-05-25
    Description: The absolute refractory period of neurons projecting from the corticomedial amygdala to the medial preoptic-anterior hypothalamic junction in rats was significantly increased by castration (from 1.01 to 1.61 milliseconds) and decreased again by testosterone (from 1.48 to 0.97 millisecond). Corticomedial amygdala neurons which projected to the capsule of the ventromedial nucleus of the hypothalamus were unaffected. These results demonstrate a specific, direct neuronal effect of testosterone.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Kendrick, K M -- Drewett, R F -- New York, N.Y. -- Science. 1979 May 25;204(4395):877-9.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/220709" target="_blank"〉PubMed〈/a〉
    Keywords: Action Potentials/drug effects ; Amygdala/drug effects ; Animals ; Brain/*drug effects ; Castration ; Electric Stimulation ; Evoked Potentials/drug effects ; Hypothalamus, Anterior/drug effects ; Male ; Preoptic Area/drug effects ; Rats ; Synaptic Transmission/drug effects ; Testosterone/*pharmacology ; Time Factors
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    Retrograde amnesia for old (reactivated) memory: some anomalous characteristics (1979)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1979-06-22
    Description: Old memory, when reactivated by cue exposure, was disrupted by mild or deep hypothermia treatments. New memory was impaired only by deep cooling. Moreover, old but not new learning showed spontaneous recovery. Old reactivated memory may be qualitatively different from newly acquired memory.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Mactutus, C F -- Riccio, D C -- Ferek, J M -- New York, N.Y. -- Science. 1979 Jun 22;204(4399):1319-20.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/572083" target="_blank"〉PubMed〈/a〉
    Keywords: Aging ; Amnesia/*physiopathology ; Amnesia, Retrograde/*physiopathology ; Animals ; Avoidance Learning/physiology ; Humans ; Hypothermia/*physiopathology ; Male ; Memory/*physiology ; Rats ; Time Factors
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    Low-level radiation: just how bad is it? (1979)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1979-04-13
    Description: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Marx, J L -- New York, N.Y. -- Science. 1979 Apr 13;204(4389):160-4.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/432638" target="_blank"〉PubMed〈/a〉
    Keywords: Dose-Response Relationship, Radiation ; Dust ; Environmental Exposure ; Leukemia, Radiation-Induced/etiology ; Maximum Allowable Concentration ; Neoplasms, Radiation-Induced/*etiology ; Occupational Diseases/etiology ; Plutonium ; Risk ; Time Factors
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  • 43
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    Watching fat digestion (1979)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1979-04-13
    Description: During fat digestion a number of physicochemical events can be seen directly by light microscopy. Under simulated physiological conditions, hydrolysis of emulsified fat droplets by human pancreatic lipase in the presence of colipase and bile salt micelles proceeds with the sequential formation of two visible product phases. A lamellar liquid crystalline or crystalline phase containing calcium and ionized fatty acid forms first; this is followed by the production of a "viscous isotropic" phase composed predominantly of monoglycerides and protonated fatty acids.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Patton, J S -- Carey, M C -- New York, N.Y. -- Science. 1979 Apr 13;204(4389):145-8.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/432636" target="_blank"〉PubMed〈/a〉
    Keywords: Bile Acids and Salts/physiology ; Chemistry, Physical ; Colipases/metabolism ; Crystallography ; *Digestion ; Lipase/*metabolism ; Models, Chemical ; Oils/*metabolism ; Physicochemical Phenomena ; Solubility ; Time Factors
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    Air is once again rent by drug lag claims (1979)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1979-07-20
    Description: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Smith, R J -- New York, N.Y. -- Science. 1979 Jul 20;205(4403):283.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/451599" target="_blank"〉PubMed〈/a〉
    Keywords: *Drug Evaluation ; Legislation, Drug ; Time Factors ; United States ; *United States Food and Drug Administration
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    Radiation from tritiated thymidine perturbs the cell cycle progression of stimulated lymphocytes (1979)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1979-03-09
    Description: Tritiated thymidine was found to affect the cell cycle progression of phytohemagglutinin-stimulated human lymphocytes. By means of flow cytometry a statistically significant increase in the G2 and M phases of the cell cycle was observed in cultures with low concentrations of tritiated thymidine added 18 hours before the cultures were harvested.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Pollack, A -- Bagwell, C B -- Irvin, G L 3rd -- New York, N.Y. -- Science. 1979 Mar 9;203(4384):1025-7.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/424727" target="_blank"〉PubMed〈/a〉
    Keywords: Cell Cycle/drug effects/*radiation effects ; Dose-Response Relationship, Radiation ; Humans ; Lymphocyte Activation/*radiation effects ; Lymphocytes/*radiation effects ; Mitosis/radiation effects ; Phytohemagglutinins/pharmacology ; Thymidine/pharmacology ; Time Factors ; *Tritium
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    A brain event related to the making of a sensory discrimination (1979)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1979-03-30
    Description: Event-related potentials associated with detected targets in a vigilance task were analyzed in two ways: (i) by sorting the potentials in terms of sequential reaction time bins of 50 milliseconds and (ii) by examining the single trial waveforms. A negative component (N2) covaried in latency with reaction time. These results support the hypothesis that N2 reflects a decision process which controls behavioral responses in sensory discrimination tasks.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Ritter, W -- Simson, R -- Vaughan, H G Jr -- Friedman, D -- New York, N.Y. -- Science. 1979 Mar 30;203(4387):1358-61.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/424760" target="_blank"〉PubMed〈/a〉
    Keywords: Behavior/physiology ; Brain/*physiology ; Cognition/physiology ; Discrimination (Psychology)/*physiology ; Evoked Potentials ; Humans ; Pitch Discrimination/physiology ; Time Factors
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    Long-term amphetamine treatment decreases brain serotonin metabolism: implications for theories of schizophrenia (1979)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1979-09-21
    Description: Long-term amphetamine administration to cats (a mean of 8.75 milligrams per kilogram twice daily for 10 days) produced large decreases (40 to 67 percent in serotonin and its major metabolite, 5-hydroxyindoleacetic acid, in all brain regions examined. This treatment also produced several behaviors that are dependent on depressed central serotonergic neurotransmission, and which normally are elicited exclusively by hallucinogenic drugs. Short-term amphetamine administration (15 mg/kg) did not produce these behaviors and resulted in small decreases in brain serotonin and no change in 5-hydroxyindoleacetic acid. These data are discussed in the context of monoamine theories of schizophrenia.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Trulson, M E -- Jacobs, B L -- New York, N.Y. -- Science. 1979 Sep 21;205(4412):1295-7.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/572992" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; Behavior, Animal/drug effects ; Brain/*metabolism ; Brain Chemistry/*drug effects ; Cats ; Dextroamphetamine/*pharmacology ; Disease Models, Animal ; Female ; Humans ; Hydroxyindoleacetic Acid/metabolism ; Schizophrenia/*physiopathology ; Serotonin/*metabolism ; Time Factors
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    Delay of constant light-induced persistent vaginal estrus by 24-hour time cues in rats (1979)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1979-04-20
    Description: The normal ovarian cycle of female rats is typically replaced by persistent estrus when these animals are housed under constant light. Evidence presented here shows that the maintenance of periodicity in the environment can at least delay (if not prevent) the photic induction of persistent vaginal estrus. Female rats in constant light were exposed to vaginal smearing at random times or at the same time every day. In another experiment, female rats were exposed to either constant bright light, constant dim light, or a 24-hour photic cycle of bright and dim light. The onset of persistent vaginal estrus was delayed in rats exposed to 24-hour time cues even though the light intensities were the same as or greater than those for the aperiodic control groups. The results suggest that the absence of 24-hour time cues in constant light contributes to the induction of persistent estrus.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Weber, A L -- Adler, N T -- New York, N.Y. -- Science. 1979 Apr 20;204(4390):323-5.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/571146" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; Biological Clocks ; Dose-Response Relationship, Radiation ; Estrus/*radiation effects ; Female ; *Light ; Periodicity/radiation effects ; Pregnancy ; Rats ; Time Factors
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    Antipsychotic drug action in schizophrenic patients: effect on cortical dopamine metabolism after long-term treatment (1979)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1979-09-28
    Description: In the brains of deceased schizophrenics who underwent long-term treatment with antipsychotic drugs, the concentration of homovanillic acid (a dopamine metabolite) was significantly increased in the orbital frontal, cingulate, and temporal tip areas of the cortex, but not in the putamen or the nucleus accumbens. The concentration of homovanillic acid was normal in the brains of schizophrenics who were not treated with drugs.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Bacopoulos, N C -- Spokes, E G -- Bird, E D -- Roth, R H -- New York, N.Y. -- Science. 1979 Sep 28;205(4413):1405-7.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/38504" target="_blank"〉PubMed〈/a〉
    Keywords: 3,4-Dihydroxyphenylacetic Acid/metabolism ; Antipsychotic Agents/therapeutic use ; Brain/*metabolism ; Cerebral Cortex/metabolism ; Dopamine/*metabolism ; Homovanillic Acid/metabolism ; Humans ; Nucleus Accumbens/metabolism ; Putamen/metabolism ; Schizophrenia/*drug therapy/metabolism ; Time Factors
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    Synaptic phosphoproteins: specific changes after repetitive stimulation of the hippocampal slice (1979)
    American Association for the Advancement of Science (AAAS)
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    Publication Date: 1979-01-05
    Description: Repetitive stimulation (100 pulses per second for 1 second) of the Schafer collateral-commissural system of the rat hippocampus induces long-term potentiation of synaptic strength and produces significant changes in the subsequent endogenous phosphorylation of a 40,000-dalton protein from synaptic plasma membranes. This effect is not observed after stimulation in calcium-deficient media or after simulation at the rate of one pulse per second for 100 seconds. These findings provide evidence that repetitive synaptic activation can alter the phosphorylation machinery of the synaptic region and suggest a biochemical process which may be involved in the production of neuronal plasticity.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Browning, M -- Dunwiddie, T -- Bennett, W -- Gispen, W -- Lynch, G -- New York, N.Y. -- Science. 1979 Jan 5;203(4375):60-2.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/214855" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; Calcium/metabolism ; Electric Stimulation ; Hippocampus/*metabolism ; In Vitro Techniques ; Membrane Proteins/*metabolism ; Molecular Weight ; Phosphoproteins/*metabolism ; Phosphorylation ; Rats ; Synaptic Membranes/*metabolism ; *Synaptic Transmission ; Time Factors
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    Neuronal supersensitivity to acetylcholine induced by kindling in the rat hippocampus (1979)
    American Association for the Advancement of Science (AAAS)
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    Publication Date: 1979-06-08
    Description: Kindling is an experimental model of epilepsy in which periodic brain stimulation induces the progressive development of electrical and behavioral seizures. A kindling-induced electrical seizure (afterdischarge) in the rat hippocampus produces prolonged neuronal supersensitivity to microiontophoretically applied acetylcholine after a latency of 40 to 60 minutes. Neuronal acetylcholine supersensitivity is correlated with the further progression of kindling. A larger hippocampal after-discharge is elicited by a subsequent kindling stimulus delivered in the presence of acetylcholine supersensitivity, but not by one delivered before the onset of the supersensitivity. The results suggest that alteration of synaptic sensitivity to acetylcholine may contribute to kindling and epileptogenesis.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Burchfiel, J L -- Duchowny, M S -- Duffy, F H -- New York, N.Y. -- Science. 1979 Jun 8;204(4397):1096-8.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/36660" target="_blank"〉PubMed〈/a〉
    Keywords: Acetylcholine/*pharmacology ; Animals ; Electric Stimulation ; Epilepsy/physiopathology ; Glutamates/pharmacology ; Hippocampus/drug effects/*physiology ; Neurotransmitter Agents/pharmacology ; Rats ; Synaptic Transmission ; Time Factors ; gamma-Aminobutyric Acid/pharmacology
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    Long-term analgesic effects of inescapable shock and learned helplessness (1979)
    American Association for the Advancement of Science (AAAS)
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    Publication Date: 1979-10-05
    Description: Although exposure to inescapable shocks induced analgesia in rats, the analgesia was not manifest 24 hours later. A brief reexposure to shock, however, restored the analgesia. This reexposure to shock had an analgesic effect only if the rats had been shocked 24 hours previously. Further, long-term analgesic effects depended on the controllability of the original shocks and not on shock exposure per se. Implications of these results for learned helplessness and stress-induced analgesia are discussed.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Jackson, R L -- Maier, S F -- Coon, D J -- New York, N.Y. -- Science. 1979 Oct 5;206(4414):91-3.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/573496" target="_blank"〉PubMed〈/a〉
    Keywords: *Analgesia ; Animals ; *Avoidance Learning ; *Electroshock ; Humans ; Rats ; Stress, Psychological/*physiopathology ; Time Factors
    Print ISSN: 0036-8075
    Electronic ISSN: 1095-9203
    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
    Published by American Association for the Advancement of Science (AAAS)
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  • 53
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    Synaptic proteins after electroconvulsive stimulation (1979)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1979-08-17
    Description: Quantitative immunoelectrophoresis of rat brain synaptic proteins following a series of electroconvulsive stimulations demonstrated changes suggestive of an increase in the number of synaptic vesicles, in a preparedness for glycolytic demands, and a delayed development of a certain area in the brain. The increased synaptic remodeling may be important for the action of electroconvulsive therapy.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Jorgensen, O S -- Bolwig, T G -- New York, N.Y. -- Science. 1979 Aug 17;205(4407):705-7.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/462178" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; Brain/*metabolism ; Cerebral Cortex/metabolism ; Electric Stimulation ; *Electroconvulsive Therapy ; Membrane Proteins/metabolism ; Nerve Tissue Proteins/*metabolism ; Occipital Lobe/metabolism ; Rats ; Synaptic Membranes/*metabolism ; Time Factors
    Print ISSN: 0036-8075
    Electronic ISSN: 1095-9203
    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
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  • 54
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    Prolongation of islet allograft survival following in vitro culture (24 degrees C) and a single injection of ALS (1979)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1979-04-20
    Description: Isolated rat islets remain morphologically and functionally intact during a 7-day period of in vitro culture at 24 degrees C. In vitro culture of islets at 24 degrees C for 7 days prior to transplantation, in conjunction with a single injection of antiserum to lymphocytes into the diabetic recipient, results in islet allograft survival of 100 days when the islets are transplanted across a major histocompatibility barrier.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Lacy, P E -- Davie, J M -- Finke, E H -- New York, N.Y. -- Science. 1979 Apr 20;204(4390):312-3.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/107588" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; *Antilymphocyte Serum ; Culture Techniques ; Diabetes Mellitus, Experimental/therapy ; Graft Survival ; Histocompatibility Antigens ; *Islets of Langerhans Transplantation ; Male ; Rats ; Time Factors ; Transplantation, Homologous
    Print ISSN: 0036-8075
    Electronic ISSN: 1095-9203
    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
    Published by American Association for the Advancement of Science (AAAS)
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  • 55
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    Memory load and event rate control sensitivity decrements in sustained attention (1979)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1979-08-31
    Description: The capacity to sustain attention at an efficient level deteriorates over time in discrimination and monitoring tasks. This "vigilance decrement" results from a decrement in perceptual sensitivity only if (i) target discrimination loads memory and (ii) stimulus events occur rapidly; otherwise, the decrement reflects temporal changes in response criteria. These results provide a basis for distinguishing between the perceptual and response processes underlying the vigilance decrement that may be generalized across a range of tasks.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Parasuraman, R -- New York, N.Y. -- Science. 1979 Aug 31;205(4409):924-7.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/472714" target="_blank"〉PubMed〈/a〉
    Keywords: Attention/*physiology ; Cognition/physiology ; Discrimination (Psychology)/*physiology ; Humans ; Memory/*physiology ; Time Factors
    Print ISSN: 0036-8075
    Electronic ISSN: 1095-9203
    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
    Published by American Association for the Advancement of Science (AAAS)
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  • 56
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    Differential effects of classical and atypical antipsychotic drugs on A9 and A10 dopamine neurons (1983)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1983-09-09
    Description: Prolonged treatment with classical antipsychotic drugs decreased the number of spontaneously active dopamine neurons in both the substantia nigra (A9) and the ventral tegmental area (A10) of the rat brain. In contrast, treatment with atypical antipsychotic drugs selectively decreased the number of A10 dopamine neurons. Related drugs lacking antipsychotic efficacy failed to decrease dopamine activity. These findings suggest that the inability of atypical antipsychotic drugs to decrease A9 dopamine neuronal activity may be related to their lower potential for causing tardive dyskinesia and that the inactivation of A10 neurons may be involved in the delayed onset of therapeutic effects during treatment.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉White, F J -- Wang, R Y -- MH 00378/MH/NIMH NIH HHS/ -- MH-34424/MH/NIMH NIH HHS/ -- New York, N.Y. -- Science. 1983 Sep 9;221(4615):1054-7.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/6136093" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; Antipsychotic Agents/*pharmacology ; Dopamine/*metabolism ; Male ; Metoclopramide/pharmacology ; Mice ; Neurons/metabolism ; Pons/*metabolism ; Rats ; Rats, Inbred Strains ; Substantia Nigra/*metabolism ; Time Factors
    Print ISSN: 0036-8075
    Electronic ISSN: 1095-9203
    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
    Published by American Association for the Advancement of Science (AAAS)
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