Publication Date:
1983-08-05
Description:
Synaptic contacts per unit area in the rat dentate gyrus reach adult numbers by the end of the first month after birth and remain constant thereafter. This experiment demonstrated that the rate at which synapses were replaced by sprouting after a lesion declined dramatically from 35 to 90 days of age. Thus, the juvenile period of the rat's life is marked by a considerable change in neuronal plasticity. This may be related to age-dependent effects in recovery from brain damage.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉McWilliams, J R -- Lynch, G -- 5 F32 NS06821/NS/NINDS NIH HHS/ -- AG00538-06/AG/NIA NIH HHS/ -- New York, N.Y. -- Science. 1983 Aug 5;221(4610):572-4.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/6867730" target="_blank"〉PubMed〈/a〉
Keywords:
*Aging
;
Animals
;
Axons/physiology
;
Denervation
;
Hippocampus/*physiology
;
Male
;
Nerve Degeneration
;
Neuronal Plasticity
;
Rats
;
Synapses/*physiology
;
Time Factors
Print ISSN:
0036-8075
Electronic ISSN:
1095-9203
Topics:
Biology
,
Chemistry and Pharmacology
,
Computer Science
,
Medicine
,
Natural Sciences in General
,
Physics
