Publikationsdatum:
1991-12-13
Beschreibung:
The current view of how steroid hormone receptors affect gene transcription is that these receptors, on binding ligand, change to a state in which they can interact with chromatin and regulate transcription of target genes. Receptor activation is believed to be dependent only on this ligand-binding event. Selected steroid hormone receptors can be activated in a ligand-independent manner by a membrane receptor agonist, the neurotransmitter dopamine. In vitro, dopamine faithfully mimicked the effect of progesterone by causing a translocation of chicken progesterone receptor (cPR) from cytoplasm to nucleus. Dual activation by progesterone and dopamine was dissociable, and a serine residue in the cPR was identified that is not necessary for progesterone-dependent activation of cPR, but is essential for dopamine activation of this receptor.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Power, R F -- Mani, S K -- Codina, J -- Conneely, O M -- O'Malley, B W -- New York, N.Y. -- Science. 1991 Dec 13;254(5038):1636-9.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Department of Cell Biology, Baylor College of Medicine, Houston, TX 77030.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/1749936" target="_blank"〉PubMed〈/a〉
Schlagwort(e):
2,3,4,5-Tetrahydro-7,8-dihydroxy-1-phenyl-1H-3-benzazepine/pharmacology
;
Adenylyl Cyclases/physiology
;
Animals
;
Cell Line
;
Cercopithecus aethiops
;
Dopamine/*pharmacology
;
Epinephrine/pharmacology
;
Ergolines/pharmacology
;
Ethers, Cyclic/pharmacology
;
Gene Expression Regulation/drug effects
;
In Vitro Techniques
;
Isoproterenol/pharmacology
;
Ligands
;
Norepinephrine/pharmacology
;
Okadaic Acid
;
Promoter Regions, Genetic
;
Quinpirole
;
Receptors, Dopamine/*physiology
;
Receptors, Steroid/*physiology
;
Regulatory Sequences, Nucleic Acid
;
Signal Transduction
;
Transcription Factors/physiology
;
Transcription, Genetic/drug effects
Print ISSN:
0036-8075
Digitale ISSN:
1095-9203
Thema:
Biologie
,
Chemie und Pharmazie
,
Informatik
,
Medizin
,
Allgemeine Naturwissenschaft
,
Physik
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