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  • Articles  (84)
  • Adult  (84)
  • American Association for the Advancement of Science (AAAS)  (83)
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  • Articles  (84)
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  • American Association for the Advancement of Science (AAAS)  (83)
  • Springer  (1)
  • American Geophysical Union
  • American Meteorological Society
  • American Physical Society (APS)
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  • 2010-2014  (31)
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  • 1
    Electronic Resource
    Electronic Resource
    Changed pharmacokinetics under the influence of age (1987)
    Springer
    Pharmacy world & science 9 (1987), S. 50-55 
    Details
    ISSN: 1573-739X
    Keywords: Absorption ; Adult ; Aged ; Child ; Clearance ; Metabolism ; Pharmacokinetics ; Protein binding
    Source: Springer Online Journal Archives 1860-2000
    Topics: Chemistry and Pharmacology
    Notes: Abstract Age significantly affects therapeutics in both general and specific ways. In newborns and in infants various physiological processes are still developing, whereas in elderly there may be decreased efficiency or capacity of physiological processes. Unexpected or ‘idiosyncratic’ responses to drugs in the very old or in the very young often can be explained by age-related changes in absorption, distribution, metabolism, end-organ responsiveness and excretion. Adolescence is often associated with rapid growth and changing body composition. Special problems with adolescents are poor compliance and drug abuse. Adults show a rather stable pharmacokinetic profile, although the cardiac output diminishes and the peripheral resistance increases about 1% annually. Exposure to enzyme-inducing agents (nicotine, cimetidine) influences the pharmacokinetic parameters of both adolescents and adults.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01960735
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  • 2
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    Little emperors: behavioral impacts of China's One-Child Policy (2013)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 2013-01-12
    Description: We document that China's One-Child Policy (OCP), one of the most radical approaches to limiting population growth, has produced significantly less trusting, less trustworthy, more risk-averse, less competitive, more pessimistic, and less conscientious individuals. Our data were collected from economics experiments conducted with 421 individuals born just before and just after the OCP's introduction in 1979. Surveys to elicit personality traits were also used. We used the exogenous imposition of the OCP to identify the causal impact of being an only child, net of family background effects. The OCP thus has significant ramifications for Chinese society.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Cameron, L -- Erkal, N -- Gangadharan, L -- Meng, X -- New York, N.Y. -- Science. 2013 Feb 22;339(6122):953-7. doi: 10.1126/science.1230221. Epub 2013 Jan 10.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Department of Econometrics, Monash University, Clayton, Victoria 3800, Australia. lisa.cameron@monash.edu〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/23306438" target="_blank"〉PubMed〈/a〉
    Keywords: Adult ; Altruism ; Anxiety Disorders ; *Attitude ; *Behavior ; China ; Competitive Behavior ; Family ; *Family Planning Policy ; Female ; Games, Experimental ; Humans ; Male ; Only Child/*psychology ; *Personality ; Risk-Taking ; Trust ; Urban Population
    Print ISSN: 0036-8075
    Electronic ISSN: 1095-9203
    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
    Published by American Association for the Advancement of Science (AAAS)
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  • 3
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    Global epigenomic reconfiguration during mammalian brain development (2013)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 2013-07-06
    Description: DNA methylation is implicated in mammalian brain development and plasticity underlying learning and memory. We report the genome-wide composition, patterning, cell specificity, and dynamics of DNA methylation at single-base resolution in human and mouse frontal cortex throughout their lifespan. Widespread methylome reconfiguration occurs during fetal to young adult development, coincident with synaptogenesis. During this period, highly conserved non-CG methylation (mCH) accumulates in neurons, but not glia, to become the dominant form of methylation in the human neuronal genome. Moreover, we found an mCH signature that identifies genes escaping X-chromosome inactivation. Last, whole-genome single-base resolution 5-hydroxymethylcytosine (hmC) maps revealed that hmC marks fetal brain cell genomes at putative regulatory regions that are CG-demethylated and activated in the adult brain and that CG demethylation at these hmC-poised loci depends on Tet2 activity.〈br /〉〈br /〉〈a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3785061/" target="_blank"〉〈img src="https://static.pubmed.gov/portal/portal3rc.fcgi/4089621/img/3977009" border="0"〉〈/a〉   〈a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3785061/" target="_blank"〉This paper as free author manuscript - peer-reviewed and accepted for publication〈/a〉〈br /〉〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Lister, Ryan -- Mukamel, Eran A -- Nery, Joseph R -- Urich, Mark -- Puddifoot, Clare A -- Johnson, Nicholas D -- Lucero, Jacinta -- Huang, Yun -- Dwork, Andrew J -- Schultz, Matthew D -- Yu, Miao -- Tonti-Filippini, Julian -- Heyn, Holger -- Hu, Shijun -- Wu, Joseph C -- Rao, Anjana -- Esteller, Manel -- He, Chuan -- Haghighi, Fatemeh G -- Sejnowski, Terrence J -- Behrens, M Margarita -- Ecker, Joseph R -- AI44432/AI/NIAID NIH HHS/ -- CA151535/CA/NCI NIH HHS/ -- HD065812/HD/NICHD NIH HHS/ -- HG006827/HG/NHGRI NIH HHS/ -- K99NS080911/NS/NINDS NIH HHS/ -- MH094670/MH/NIMH NIH HHS/ -- R01 AI044432/AI/NIAID NIH HHS/ -- R01 CA151535/CA/NCI NIH HHS/ -- R01 HD065812/HD/NICHD NIH HHS/ -- R01 HG006827/HG/NHGRI NIH HHS/ -- R01 MH094670/MH/NIMH NIH HHS/ -- R01 MH094774/MH/NIMH NIH HHS/ -- Howard Hughes Medical Institute/ -- New York, N.Y. -- Science. 2013 Aug 9;341(6146):1237905. doi: 10.1126/science.1237905. Epub 2013 Jul 4.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Genomic Analysis Laboratory, The Salk Institute for Biological Studies, La Jolla, CA 92037, USA. ryan.lister@uwa.edu.au〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/23828890" target="_blank"〉PubMed〈/a〉
    Keywords: 5-Methylcytosine/metabolism ; Adult ; Animals ; Base Sequence ; Conserved Sequence ; Cytosine/*analogs & derivatives/metabolism ; *DNA Methylation ; *Epigenesis, Genetic ; Epigenomics ; Frontal Lobe/*growth & development ; *Gene Expression Regulation, Developmental ; Genome-Wide Association Study ; Humans ; Longevity ; Mice ; Mice, Inbred C57BL ; X Chromosome Inactivation/genetics
    Print ISSN: 0036-8075
    Electronic ISSN: 1095-9203
    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
    Published by American Association for the Advancement of Science (AAAS)
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  • 4
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    IBI series winner. Exploring the evolution of human mate preference (2013)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 2013-11-30
    Description: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Foster, Valerie -- New York, N.Y. -- Science. 2013 Nov 29;342(6162):1060-1. doi: 10.1126/science.1230005.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Natural Sciences Division, Pasadena City College, 1570 East Colorado Boulevard, Pasadena, CA 91106, USA.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/24288326" target="_blank"〉PubMed〈/a〉
    Keywords: Adult ; Courtship/*psychology ; Female ; Humans ; Male ; Marriage/*psychology ; Personality ; Problem-Based Learning/*methods ; Selection, Genetic ; Voice Quality ; Young Adult
    Print ISSN: 0036-8075
    Electronic ISSN: 1095-9203
    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
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  • 5
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    Poverty impedes cognitive function (2013)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 2013-08-31
    Description: The poor often behave in less capable ways, which can further perpetuate poverty. We hypothesize that poverty directly impedes cognitive function and present two studies that test this hypothesis. First, we experimentally induced thoughts about finances and found that this reduces cognitive performance among poor but not in well-off participants. Second, we examined the cognitive function of farmers over the planting cycle. We found that the same farmer shows diminished cognitive performance before harvest, when poor, as compared with after harvest, when rich. This cannot be explained by differences in time available, nutrition, or work effort. Nor can it be explained with stress: Although farmers do show more stress before harvest, that does not account for diminished cognitive performance. Instead, it appears that poverty itself reduces cognitive capacity. We suggest that this is because poverty-related concerns consume mental resources, leaving less for other tasks. These data provide a previously unexamined perspective and help explain a spectrum of behaviors among the poor. We discuss some implications for poverty policy.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Mani, Anandi -- Mullainathan, Sendhil -- Shafir, Eldar -- Zhao, Jiaying -- New York, N.Y. -- Science. 2013 Aug 30;341(6149):976-80. doi: 10.1126/science.1238041.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Department of Economics, University of Warwick, Coventry, UK.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/23990553" target="_blank"〉PubMed〈/a〉
    Keywords: Adult ; Agriculture ; *Cognition ; Female ; Financial Management ; Humans ; Male ; Poverty/*psychology ; Public Policy
    Print ISSN: 0036-8075
    Electronic ISSN: 1095-9203
    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
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  • 6
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    Genomics. Initiative aims to minister to Mexico's unique genetic heritage (2013)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 2013-11-16
    Description: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Wade, Lizzie -- New York, N.Y. -- Science. 2013 Nov 15;342(6160):788. doi: 10.1126/science.342.6160.788.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/24233700" target="_blank"〉PubMed〈/a〉
    Keywords: Adult ; Alleles ; Diabetes Mellitus/epidemiology/genetics ; Female ; Genetic Predisposition to Disease/*genetics ; Genetic Variation ; Genome, Human/*genetics ; Humans ; Male ; Mexico/epidemiology ; Pedigree ; Population/*genetics
    Print ISSN: 0036-8075
    Electronic ISSN: 1095-9203
    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
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  • 7
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    Standing up for GMOs (2013)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 2013-09-21
    Description: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Alberts, Bruce -- Beachy, Roger -- Baulcombe, David -- Blobel, Gunter -- Datta, Swapan -- Fedoroff, Nina -- Kennedy, Donald -- Khush, Gurdev S -- Peacock, Jim -- Rees, Martin -- Sharp, Phillip -- New York, N.Y. -- Science. 2013 Sep 20;341(6152):1320. doi: 10.1126/science.1245017.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/24052276" target="_blank"〉PubMed〈/a〉
    Keywords: Adult ; Carotenoids/chemistry/genetics/metabolism ; Child, Preschool ; Female ; Humans ; Infant ; Infant, Newborn ; *Oryza ; Philippines ; *Plants, Genetically Modified ; Seeds/chemistry/genetics ; Violence/*prevention & control ; Vitamin A/metabolism ; Vitamin A Deficiency/*prevention & control
    Print ISSN: 0036-8075
    Electronic ISSN: 1095-9203
    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
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  • 8
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    Protection against malaria by intravenous immunization with a nonreplicating sporozoite vaccine (2013)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 2013-08-10
    Description: Consistent, high-level, vaccine-induced protection against human malaria has only been achieved by inoculation of Plasmodium falciparum (Pf) sporozoites (SPZ) by mosquito bites. We report that the PfSPZ Vaccine--composed of attenuated, aseptic, purified, cryopreserved PfSPZ--was safe and well tolerated when administered four to six times intravenously (IV) to 40 adults. Zero of six subjects receiving five doses and three of nine subjects receiving four doses of 1.35 x 10(5) PfSPZ Vaccine and five of six nonvaccinated controls developed malaria after controlled human malaria infection (P = 0.015 in the five-dose group and P = 0.028 for overall, both versus controls). PfSPZ-specific antibody and T cell responses were dose-dependent. These data indicate that there is a dose-dependent immunological threshold for establishing high-level protection against malaria that can be achieved with IV administration of a vaccine that is safe and meets regulatory standards.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Seder, Robert A -- Chang, Lee-Jah -- Enama, Mary E -- Zephir, Kathryn L -- Sarwar, Uzma N -- Gordon, Ingelise J -- Holman, LaSonji A -- James, Eric R -- Billingsley, Peter F -- Gunasekera, Anusha -- Richman, Adam -- Chakravarty, Sumana -- Manoj, Anita -- Velmurugan, Soundarapandian -- Li, MingLin -- Ruben, Adam J -- Li, Tao -- Eappen, Abraham G -- Stafford, Richard E -- Plummer, Sarah H -- Hendel, Cynthia S -- Novik, Laura -- Costner, Pamela J M -- Mendoza, Floreliz H -- Saunders, Jamie G -- Nason, Martha C -- Richardson, Jason H -- Murphy, Jittawadee -- Davidson, Silas A -- Richie, Thomas L -- Sedegah, Martha -- Sutamihardja, Awalludin -- Fahle, Gary A -- Lyke, Kirsten E -- Laurens, Matthew B -- Roederer, Mario -- Tewari, Kavita -- Epstein, Judith E -- Sim, B Kim Lee -- Ledgerwood, Julie E -- Graham, Barney S -- Hoffman, Stephen L -- VRC 312 Study Team -- 3R44AI055229-06S1/AI/NIAID NIH HHS/ -- 4R44AI055229-08/AI/NIAID NIH HHS/ -- 5R44AI058499-05/AI/NIAID NIH HHS/ -- N01-AI-40096/AI/NIAID NIH HHS/ -- Intramural NIH HHS/ -- Howard Hughes Medical Institute/ -- New York, N.Y. -- Science. 2013 Sep 20;341(6152):1359-65. doi: 10.1126/science.1241800. Epub 2013 Aug 8.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Vaccine Research Center, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20852, USA. rseder@mail.nih.gov〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/23929949" target="_blank"〉PubMed〈/a〉
    Keywords: Administration, Intravenous ; Adult ; Animals ; Cytokines/immunology ; Female ; Humans ; Immunity, Cellular ; Malaria Vaccines/*administration & dosage/adverse effects/*immunology ; Malaria, Falciparum/*prevention & control ; Male ; Mice ; Plasmodium falciparum/*immunology ; Sporozoites/immunology ; T-Lymphocytes/immunology ; Vaccination/adverse effects/methods
    Print ISSN: 0036-8075
    Electronic ISSN: 1095-9203
    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
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  • 9
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    Point-counterpoint. Ethics and genomic incidental findings (2013)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 2013-05-21
    Description: 〈br /〉〈br /〉〈a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3772710/" target="_blank"〉〈img src="https://static.pubmed.gov/portal/portal3rc.fcgi/4089621/img/3977009" border="0"〉〈/a〉   〈a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3772710/" target="_blank"〉This paper as free author manuscript - peer-reviewed and accepted for publication〈/a〉〈br /〉〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉McGuire, Amy L -- Joffe, Steven -- Koenig, Barbara A -- Biesecker, Barbara B -- McCullough, Laurence B -- Blumenthal-Barby, Jennifer S -- Caulfield, Timothy -- Terry, Sharon F -- Green, Robert C -- CA154517/CA/NCI NIH HHS/ -- HG003178/HG/NHGRI NIH HHS/ -- HG005092/HG/NHGRI NIH HHS/ -- HG006485/HG/NHGRI NIH HHS/ -- HG006492/HG/NHGRI NIH HHS/ -- HG006500/HG/NHGRI NIH HHS/ -- HG006612-02/HG/NHGRI NIH HHS/ -- HG006615/HG/NHGRI NIH HHS/ -- HG02213/HG/NHGRI NIH HHS/ -- P20 HG007243/HG/NHGRI NIH HHS/ -- R01 CA154517/CA/NCI NIH HHS/ -- R01 HG002213/HG/NHGRI NIH HHS/ -- R01 HG003178/HG/NHGRI NIH HHS/ -- R01 HG005092/HG/NHGRI NIH HHS/ -- R01-CA154517/CA/NCI NIH HHS/ -- U01 HG006485/HG/NHGRI NIH HHS/ -- U01 HG006492/HG/NHGRI NIH HHS/ -- U01 HG006500/HG/NHGRI NIH HHS/ -- Intramural NIH HHS/ -- New York, N.Y. -- Science. 2013 May 31;340(6136):1047-8. doi: 10.1126/science.1240156. Epub 2013 May 16.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Center for Medical Ethics and Health Policy, Baylor College of Medicine, Houston, TX 77030, USA. amcguire@bcm.edu〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/23686340" target="_blank"〉PubMed〈/a〉
    Keywords: Adult ; Child ; Disease/*genetics ; *Genetic Predisposition to Disease ; Genetic Testing/ethics/standards ; Genome-Wide Association Study/ethics/standards ; Genomics/*ethics/*standards ; Humans ; *Incidental Findings ; Laboratories/ethics/standards/statistics & numerical data ; Mutation/ethics ; Neoplasms/genetics ; *Practice Guidelines as Topic ; Sequence Analysis, DNA/ethics
    Print ISSN: 0036-8075
    Electronic ISSN: 1095-9203
    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
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  • 10
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    Neural decoding of visual imagery during sleep (2013)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 2013-04-06
    Description: Visual imagery during sleep has long been a topic of persistent speculation, but its private nature has hampered objective analysis. Here we present a neural decoding approach in which machine-learning models predict the contents of visual imagery during the sleep-onset period, given measured brain activity, by discovering links between human functional magnetic resonance imaging patterns and verbal reports with the assistance of lexical and image databases. Decoding models trained on stimulus-induced brain activity in visual cortical areas showed accurate classification, detection, and identification of contents. Our findings demonstrate that specific visual experience during sleep is represented by brain activity patterns shared by stimulus perception, providing a means to uncover subjective contents of dreaming using objective neural measurement.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Horikawa, T -- Tamaki, M -- Miyawaki, Y -- Kamitani, Y -- New York, N.Y. -- Science. 2013 May 3;340(6132):639-42. doi: 10.1126/science.1234330. Epub 2013 Apr 4.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉ATR Computational Neuroscience Laboratories, Kyoto 619-0288, Japan.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/23558170" target="_blank"〉PubMed〈/a〉
    Keywords: Adult ; Artificial Intelligence ; Brain/*physiology ; Brain Mapping ; Databases, Factual ; Dreams/*physiology ; Electroencephalography ; Humans ; Magnetic Resonance Imaging ; Male ; Photic Stimulation ; Sleep/*physiology ; Sleep Stages ; *Support Vector Machine ; Visual Cortex/*physiology ; Visual Perception ; Wakefulness
    Print ISSN: 0036-8075
    Electronic ISSN: 1095-9203
    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
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