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  • Chemistry  (93.258)
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  • 1
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    American Association for the Advancement of Science (AAAS)
    Publikationsdatum: 1978-10-13
    Beschreibung: Picosecond spectroscopy is a relatively new field of science that utilizes ultrashort laser pulses to monitor events taking place in the 10(-12) second regime. The continuing development of picosecond spectroscopy has made possible the detection and measurement of the primary events in many physical and tiological processes. This article describes a currently used picosecond spectroscopy system that is capable of reliably recording picosecond events. Two areas of picosecond research are discussed; one concerns the interaction of electrons in fluids, and the second the primary events in vision.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Rentzepis, P M -- New York, N.Y. -- Science. 1978 Oct 13;202(4364):174-82.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/694523" target="_blank"〉PubMed〈/a〉
    Schlagwort(e): Chemical Phenomena ; Chemistry ; Electrons ; *Kinetics ; Lasers ; Protons ; *Retinal Pigments ; *Rhodopsin ; Spectrum Analysis/*methods ; Temperature ; *Vision, Ocular
    Print ISSN: 0036-8075
    Digitale ISSN: 1095-9203
    Thema: Biologie , Chemie und Pharmazie , Informatik , Medizin , Allgemeine Naturwissenschaft , Physik
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  • 2
    Publikationsdatum: 1979-12-14
    Beschreibung: The structure and absolute stereoconfigurations of four adenosine adducts with (+/-)-7 alpha,8 beta-dihydroxy-9 beta, 10 beta-epoxy-7,8,9,10-tetrahydrobenzo(a)pyrene (BPDE) and their deoxyadenosine analogs have been determined. They result from both cis and trans addition of the N6 amino group of ademine to the 10 position of both enantiomers of BDPE. This was determined from studies of the nuclear magnetic resonance spectra, mass spectra, and circular dichroism spectra, as well as from their pKa values and chemical reactivities.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Jeffrey, A M -- Grzeskowiak, K -- Weinstein, I B -- Nakanishi, K -- Roller, P -- Harvey, R G -- New York, N.Y. -- Science. 1979 Dec 14;206(4424):1309-11.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/316186" target="_blank"〉PubMed〈/a〉
    Schlagwort(e): *Benzopyrenes ; Chemical Phenomena ; Chemistry ; Circular Dichroism ; Dna ; *Deoxyadenosines/analogs & derivatives ; Magnetic Resonance Spectroscopy ; Mass Spectrometry ; Molecular Conformation ; Mutation ; Stereoisomerism
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    Thema: Biologie , Chemie und Pharmazie , Informatik , Medizin , Allgemeine Naturwissenschaft , Physik
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  • 3
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    American Association for the Advancement of Science (AAAS)
    Publikationsdatum: 1981-08-14
    Beschreibung: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Klotz, I M -- Haney, D N -- King, L C -- New York, N.Y. -- Science. 1981 Aug 14;213(4509):724-31.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/7256275" target="_blank"〉PubMed〈/a〉
    Schlagwort(e): Anemia, Sickle Cell/*drug therapy ; Aspirin/analogs & derivatives/therapeutic use ; Chemical Phenomena ; Chemistry ; *Hemoglobin, Sickle ; Humans ; Protein Binding/drug effects ; Protein Conformation ; Salicylates/*therapeutic use ; Solubility ; Structure-Activity Relationship
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    Thema: Biologie , Chemie und Pharmazie , Informatik , Medizin , Allgemeine Naturwissenschaft , Physik
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  • 4
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    Unbekannt
    American Association for the Advancement of Science (AAAS)
    Publikationsdatum: 1982-09-10
    Beschreibung: Alkyl-Substituted gamma-butyrolactones were synthesized and tested for their convulsant and anticonvulsant actions in mice and guinea pigs. The alpha-substituted compounds, alpha, alpha-dimethyl-, and alpha-ethyl-alpha-methyl-gamma-butyrolactone were anticonvulsant compounds with a spectrum of activity similar to that of ethosuximide. In contrast, beta-substituted compounds were convulsant agents similar to picrotoxinin. The alpha-substituted-gama-butyrolactones represent a new class of anticonvulsant drug with experimental and clinical potential.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Klunk, W E -- McKeon, A -- Covey, D F -- Ferrendelli, J A -- GM-07200/GM/NIGMS NIH HHS/ -- GM-24483/GM/NIGMS NIH HHS/ -- NS-14834/NS/NINDS NIH HHS/ -- etc. -- New York, N.Y. -- Science. 1982 Sep 10;217(4564):1040-2.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/6810462" target="_blank"〉PubMed〈/a〉
    Schlagwort(e): *4-Butyrolactone/analogs & derivatives/*therapeutic use/toxicity ; Animals ; *Anticonvulsants ; Chemical Phenomena ; Chemistry ; Convulsants ; Drug Evaluation, Preclinical ; Electroencephalography ; Epilepsy, Absence/drug therapy ; Ethosuximide/pharmacology ; *Furans/*therapeutic use ; Guinea Pigs ; Mice ; Structure-Activity Relationship ; Trimethadione/pharmacology
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    Thema: Biologie , Chemie und Pharmazie , Informatik , Medizin , Allgemeine Naturwissenschaft , Physik
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  • 5
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    American Association for the Advancement of Science (AAAS)
    Publikationsdatum: 1983-05-06
    Beschreibung: Crystalline cholesterol undergoes a phase transition a few degrees below human body temperature. The high-temperature form has an unusually complex structure with 16 independent molecules. In the transition two molecules change side chain conformation, four reorient about their long axes, and ten remain unchanged. The transition mechanism implies relatively nonspecific intermolecular interactions, qualitatively consistent with the behavior of cholesterol in biomembranes. The transition preserves a remarkably closely obeyed pseudosymmetry present in the structure.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Hsu, L Y -- Nordman, C E -- GM15259/GM/NIGMS NIH HHS/ -- New York, N.Y. -- Science. 1983 May 6;220(4597):604-6.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/6836303" target="_blank"〉PubMed〈/a〉
    Schlagwort(e): Body Temperature ; Chemical Phenomena ; Chemistry ; *Cholesterol ; Crystallization ; Humans ; Magnetic Resonance Spectroscopy ; Molecular Conformation
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    Thema: Biologie , Chemie und Pharmazie , Informatik , Medizin , Allgemeine Naturwissenschaft , Physik
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  • 6
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    American Association for the Advancement of Science (AAAS)
    Publikationsdatum: 1984-07-20
    Beschreibung: The iron-carbon monoxide stretching mode and the iron-carbon-oxygen bending mode in carbon monoxide-bound cytochrome oxidase have been assigned at 520 and 578 cm-1, respectively. The frequencies, widths, and intensities of these modes show that the Fe-C-O grouping in carbon monoxide-cytochrome a3 is linear but tilted from the normal to the heme plane; that the iron-histidine bond in both five- and six-coordinate cytochrome a3 is strained; and that the carbon monoxide and the proximal histidine each have characteristic, well-defined orientations in all molecules. These data can account for the binding affinities of carbon monoxide and dioxygen under physiological conditions.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Argade, P V -- Ching, Y C -- Rousseau, D L -- New York, N.Y. -- Science. 1984 Jul 20;225(4659):329-31.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/6330890" target="_blank"〉PubMed〈/a〉
    Schlagwort(e): Animals ; Carbon Monoxide/metabolism ; Cattle ; Chemical Phenomena ; Chemistry ; Electron Transport Complex IV/*metabolism ; Myoglobin/metabolism ; Oxidation-Reduction ; Oxygen/metabolism ; Spectrum Analysis, Raman
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    Thema: Biologie , Chemie und Pharmazie , Informatik , Medizin , Allgemeine Naturwissenschaft , Physik
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  • 7
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    American Association for the Advancement of Science (AAAS)
    Publikationsdatum: 1983-05-06
    Beschreibung: Arachidonic acid plays a central role in a biological control system where such oxygenated derivatives as prostaglandins, thromboxanes, and leukotrienes are mediators. The leukotrienes are formed by transformation of arachidonic acid into an unstable epoxide intermediate, leukotriene A4, which can be converted enzymatically by hydration to leukotriene B4, and by addition of glutathione to leukotriene C4. This last compound is metabolized to leukotrienes D4 and E4 by successive elimination of a gamma-glutamyl residue and glycine. Slow-reacting substance of anaphylaxis consists of leukotrienes C4, D4, and E4. The cysteinyl-containing leukotrienes are potent bronchoconstrictors, increase vascular permeability in postcapillary venules, and stimulate mucus secretion. Leukotriene B4 causes adhesion and chemotactic movement of leukocytes and stimulates aggregation, enzyme release, and generation of superoxide in neutrophils. Leukotrienes C4, D4, and E4, which are released from the lung tissue of asthmatic subjects exposed to specific allergens, seem to play a pathophysiological role in immediate hypersensitivity reactions. These leukotrienes, as well as leukotriene B4, have pro-inflammatory effects.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Samuelsson, B -- New York, N.Y. -- Science. 1983 May 6;220(4597):568-75.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/6301011" target="_blank"〉PubMed〈/a〉
    Schlagwort(e): Animals ; Arachidonic Acids/metabolism/pharmacology/physiology ; Bronchi/drug effects ; Cats ; Chemical Phenomena ; Chemistry ; Cricetinae ; Guinea Pigs ; Haplorhini ; Humans ; Hypersensitivity, Immediate/*physiopathology ; Inflammation/*physiopathology ; Leukocytes/drug effects/metabolism ; Leukotriene B4/pharmacology/*physiology ; Mice ; Microcirculation/drug effects ; Rabbits ; Rats ; SRS-A/*physiology
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    Thema: Biologie , Chemie und Pharmazie , Informatik , Medizin , Allgemeine Naturwissenschaft , Physik
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  • 8
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    American Association for the Advancement of Science (AAAS)
    Publikationsdatum: 1984-01-20
    Beschreibung: Peptide synthesis can be used for elucidating the roles of secondary structures in the specificity of hormones, antigens, and toxins. Intermediate sized peptides with these activities assume amphiphilic secondary structures in the presence of membranes. When models are designed to optimize the amphiphilicity of the secondary structure, stronger interactions can be observed with the synthetic peptides than with the naturally occurring analogs.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Kaiser, E T -- Kezdy, F J -- HL-18577/HL/NHLBI NIH HHS/ -- New York, N.Y. -- Science. 1984 Jan 20;223(4633):249-55.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/6322295" target="_blank"〉PubMed〈/a〉
    Schlagwort(e): Amino Acid Sequence ; Apolipoprotein A-I ; Apolipoproteins ; Binding Sites ; Calcitonin ; Chemical Phenomena ; Chemistry ; Corticotropin-Releasing Hormone ; Endorphins ; Glucagon ; Growth Hormone-Releasing Hormone ; *Hormones/pharmacology ; Lipoproteins, HDL ; Melitten ; Models, Structural ; *Peptides/chemical synthesis/metabolism/pharmacology ; Protein Conformation ; Structure-Activity Relationship ; beta-Endorphin
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    Thema: Biologie , Chemie und Pharmazie , Informatik , Medizin , Allgemeine Naturwissenschaft , Physik
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  • 9
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    American Association for the Advancement of Science (AAAS)
    Publikationsdatum: 1984-10-19
    Beschreibung: Fourier transform mass spectrometry will play an important role in the future because of its unique combination of high mass resolution, high upper mass limit, and multichannel advantage. These features have already found application in gas chromatography-mass spectrometry, multiphoton ionization, laser desorption, and secondary ion mass spectrometry. However, its most notable feature is the ability to store ions. This characteristic, when combined with the others, will allow expeditious study of the interaction of gas-phase ions with both photons (photodissociation) and neutral molecules, and the convenient application of this fundamental information for chemical analysis.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Gross, M L -- Rempel, D L -- 2-8423576/PHS HHS/ -- New York, N.Y. -- Science. 1984 Oct 19;226(4672):261-8.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/6385250" target="_blank"〉PubMed〈/a〉
    Schlagwort(e): Chemical Phenomena ; Chemistry ; *Fourier Analysis ; Ions ; Lasers ; *Mass Spectrometry/instrumentation/methods
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    Thema: Biologie , Chemie und Pharmazie , Informatik , Medizin , Allgemeine Naturwissenschaft , Physik
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  • 10
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    American Association for the Advancement of Science (AAAS)
    Publikationsdatum: 1984-08-31
    Beschreibung: High-resolution carbon-13 nuclear magnetic resonance (NMR) spectra of enzyme-inhibitor and enzyme-substrate complexes provide detailed structural and stereochemical information on the mechanism of enzyme action. The proteases trypsin and papain are shown to form tetrahedrally coordinated complexes and acyl derivatives with a variety of compounds artificially enriched at the site or sites of interest. These results are compared with the structural information derived from x-ray diffraction. Detailed NMR studies have provided a clearer picture of the ionization state of the residues participating in enzyme-catalyzed processes than other more classical techniques. The dynamics of enzymic catalysis can be observed at sub-zero temperatures by a combination of cryoenzymology and carbon-13 NMR spectroscopy. With these powerful techniques, transient, covalently bound intermediates in enzyme-catalyzed reactions can be detected and their structures rigorously assigned.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Mackenzie, N E -- Malthouse, J P -- Scott, A I -- New York, N.Y. -- Science. 1984 Aug 31;225(4665):883-9.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/6433481" target="_blank"〉PubMed〈/a〉
    Schlagwort(e): Binding Sites ; Carbon Isotopes ; Carboxypeptidases/metabolism ; Carboxypeptidases A ; Catalysis ; Chemical Phenomena ; Chemistry ; Coenzymes/*metabolism ; Endopeptidases/metabolism ; Enzymes/*metabolism ; Freezing ; Fructose-Bisphosphate Aldolase/metabolism ; Magnetic Resonance Spectroscopy ; Papain/metabolism ; Pepsin A/metabolism ; Peptide Hydrolases/*metabolism ; Protease Inhibitors ; Pterins/metabolism ; Pyridoxal Phosphate/metabolism ; Serine Endopeptidases
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    Thema: Biologie , Chemie und Pharmazie , Informatik , Medizin , Allgemeine Naturwissenschaft , Physik
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  • 11
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    American Association for the Advancement of Science (AAAS)
    Publikationsdatum: 1984-03-09
    Beschreibung: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Maugh, T H 2nd -- New York, N.Y. -- Science. 1984 Mar 9;223(4640):1051-2.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/6695193" target="_blank"〉PubMed〈/a〉
    Schlagwort(e): *Air Pollutants ; *Atmosphere ; Carbon Tetrachloride ; Chemical Phenomena ; Chemistry ; *Chlorofluorocarbons, Methane ; Free Radicals ; Nitrogen Dioxide ; Nitrous Oxide ; Oxygen ; *Ozone ; Photochemistry ; Risk ; Singlet Oxygen ; Trichloroethanes ; Ultraviolet Rays
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    Thema: Biologie , Chemie und Pharmazie , Informatik , Medizin , Allgemeine Naturwissenschaft , Physik
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  • 12
    Publikationsdatum: 1984-10-19
    Beschreibung: Pyrolysis mass spectrometry in combination with computerized multivariate statistical analysis enables qualitative and quantitative analysis of nonvolatile organic materials containing molecular assemblies of a complexity and size far beyond the capabilities of direct mass spectrometry. The state of the art in pyrolysis mass spectrometry techniques is illustrated through specific applications, including structural determination and quality control of synthetic polymers, quantitative analysis of polymer mixtures, classification and structural characterization of fossil organic matter, and nonsupervised numerical extraction of component patterns from complex biological samples.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Meuzelaar, H L -- Windig, W -- Harper, A M -- Huff, S M -- McClennen, W H -- Richards, J M -- New York, N.Y. -- Science. 1984 Oct 19;226(4672):268-74.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/6484572" target="_blank"〉PubMed〈/a〉
    Schlagwort(e): Biochemical Phenomena ; Biochemistry ; Chemical Phenomena ; Chemistry ; Coal ; Enterobacteriaceae/analysis/isolation & purification ; Hot Temperature ; Mass Spectrometry/*methods ; Polymers
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    Thema: Biologie , Chemie und Pharmazie , Informatik , Medizin , Allgemeine Naturwissenschaft , Physik
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  • 13
    Publikationsdatum: 1984-08-31
    Beschreibung: The splicing of messenger RNA precursors in vitro proceeds through an intermediate that has the 5' end of the intervening sequence joined to a site near the 3' splice site. This lariat structure, which has been characterized for an adenovirus 2 major late transcript, has a branch point, with 2'-5' and 3'-5' phosphodiester bonds emanating from a single adenosine residue. The excised intervening sequence retains the branch site and terminates in a guanosine residue with a 3' hydroxyl group. The phosphate group at the splice junction between the two exons originates from the 3' splice site at the precursor.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Padgett, R A -- Konarska, M M -- Grabowski, P J -- Hardy, S F -- Sharp, P A -- P01-CA14051/CA/NCI NIH HHS/ -- P01-CA26717/CA/NCI NIH HHS/ -- R01-GM32467/GM/NIGMS NIH HHS/ -- New York, N.Y. -- Science. 1984 Aug 31;225(4665):898-903.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/6206566" target="_blank"〉PubMed〈/a〉
    Schlagwort(e): Adenoviruses, Human/metabolism ; Base Sequence ; Chemical Phenomena ; Chemistry ; Nucleic Acid Conformation ; Nucleic Acid Precursors/analysis/*metabolism ; Oligoribonucleotides/metabolism ; Phosphates/metabolism ; RNA/analysis/*metabolism ; RNA Precursors ; *RNA Splicing ; RNA, Messenger/analysis/*metabolism ; RNA, Viral/analysis/*metabolism
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    Thema: Biologie , Chemie und Pharmazie , Informatik , Medizin , Allgemeine Naturwissenschaft , Physik
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  • 14
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    American Association for the Advancement of Science (AAAS)
    Publikationsdatum: 1984-05-11
    Beschreibung: The mechanism of lipid peroxidation and the manner in which antioxidants function is reviewed. beta-Carotene is a purported anticancer agent, which is believed by some to have antioxidant action of a radical-trapping type. However, definitive experimental support for such action has been lacking. New experiments in vitro show that beta-carotene belongs to a previously unknown class of biological antioxidants. Specifically, it exhibits good radical-trapping antioxidant behavior only at partial pressures of oxygen significantly less than 150 torr, the pressure of oxygen in normal air. Such low oxygen partial pressures are found in most tissues under physiological conditions. At higher oxygen pressures, beta-carotene loses its antioxidant activity and shows an autocatalytic, prooxidant effect, particularly at relatively high concentrations. Similar oxygen-pressure-dependent behavior may be shown by other compounds containing many conjugated double bonds.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Burton, G W -- Ingold, K U -- New York, N.Y. -- Science. 1984 May 11;224(4649):569-73.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/6710156" target="_blank"〉PubMed〈/a〉
    Schlagwort(e): Antioxidants/*metabolism ; Carotenoids/*metabolism ; Chemical Phenomena ; Chemistry ; Free Radicals ; Humans ; Linoleic Acids/metabolism ; *Lipid Metabolism ; Oxidation-Reduction ; Oxygen/metabolism ; Partial Pressure ; Peroxides/metabolism ; Tetrahydronaphthalenes/metabolism ; beta Carotene
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    Thema: Biologie , Chemie und Pharmazie , Informatik , Medizin , Allgemeine Naturwissenschaft , Physik
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  • 15
    Publikationsdatum: 1983-12-16
    Beschreibung: Aplysiatoxin and debromoaplysiatoxin, which are isolated from the seaweed, Lyngbya gracilis, differ in their chemical structure only by the presence or absence of a bromine residue in the hydrophilic region. The function and the structure-activity relation of the hydrophilic region are not known. Aplysiatoxin increased malignant transformation, stimulated DNA synthesis, and inhibited the binding of phorbol-12,13-dibutyrate and epidermal growth factor to cell receptors. Debromoaplysiatoxin inhibited the binding of these two substances as strongly as aplysiatoxin but did not increase malignant transformation or stimulate DNA synthesis. These results indicate that a slight change in the chemical structure of the hydrophilic region of aplysiatoxin affects its abilities to increase cell transformation and stimulate DNA synthesis and that the abilities of the tumor promoters to inhibit the binding of phorbol-12,13-dibutyrate and epidermal growth factor are dissociable from their abilities to increase cell transformation and stimulate DNA synthesis under some circumstances.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Shimomura, K -- Mullinix, M G -- Kakunaga, T -- Fujiki, H -- Sugimura, T -- New York, N.Y. -- Science. 1983 Dec 16;222(4629):1242-4.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/6316505" target="_blank"〉PubMed〈/a〉
    Schlagwort(e): Animals ; *Caenorhabditis elegans Proteins ; Carcinogens/*pharmacology ; Carrier Proteins ; Cell Line ; Cell Transformation, Neoplastic/*drug effects ; Chemical Phenomena ; Chemistry ; DNA/biosynthesis ; Epidermal Growth Factor/metabolism ; Lactones/analysis/*pharmacology ; *Lyngbya Toxins ; Mice ; Phorbol 12,13-Dibutyrate ; Phorbol Esters/metabolism ; *Protein Kinase C ; Receptor, Epidermal Growth Factor ; Receptors, Cell Surface/metabolism ; *Receptors, Drug ; Structure-Activity Relationship
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    Thema: Biologie , Chemie und Pharmazie , Informatik , Medizin , Allgemeine Naturwissenschaft , Physik
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  • 16
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    American Association for the Advancement of Science (AAAS)
    Publikationsdatum: 1984-03-16
    Beschreibung: Yeast phenylalanine transfer RNA was subjected to a 12-picosecond molecular dynamics simulation. The principal features of the x-ray crystallographic analysis are reproduced, and the amplitudes of atomic displacements appear to be determined by the degree of exposure of the atoms. An analysis of the hydrogen bonds shows a correlation between the average length of a bond and the fluctuation in that length and reveals a rocking motion of bases in Watson-Crick guanine X cytosine base pairs. The in-plane motions of the bases are generally of larger amplitude than the out-of-plane motions, and there are correlations in the motions of adjacent bases.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Harvey, S C -- Prabhakaran, M -- Mao, B -- McCammon, J A -- New York, N.Y. -- Science. 1984 Mar 16;223(4641):1189-91.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/6560785" target="_blank"〉PubMed〈/a〉
    Schlagwort(e): Chemical Phenomena ; Chemistry ; Computers ; Cytosine ; Guanine ; Hydrogen Bonding ; Nucleic Acid Conformation ; *RNA, Fungal ; *RNA, Transfer, Amino Acyl ; Yeasts/analysis
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    Thema: Biologie , Chemie und Pharmazie , Informatik , Medizin , Allgemeine Naturwissenschaft , Physik
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  • 17
    Publikationsdatum: 1984-11-16
    Beschreibung: Sequence-dependent variations in DNA revealed by x-ray crystallographic studies have suggested that certain DNA-reactive drugs may react preferentially with defined sequences in DNA. Drugs that wind around the helix and reside within one of the grooves of DNA have perhaps the greatest chance of recognizing sequence-dependent features of DNA. The antitumor antibiotic CC-1065 covalently binds through N-3 of adenine and resides within the minor groove of DNA. This drug overlaps with five base pairs for which a high sequence specificity exists.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Hurley, L H -- Reynolds, V L -- Swenson, D H -- Petzold, G L -- Scahill, T A -- New York, N.Y. -- Science. 1984 Nov 16;226(4676):843-4.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/6494915" target="_blank"〉PubMed〈/a〉
    Schlagwort(e): Antibiotics, Antineoplastic/*metabolism ; *Base Sequence ; Binding Sites ; Chemical Phenomena ; Chemistry ; DNA/*metabolism ; *Indoles ; Leucomycins/*metabolism ; Molecular Conformation ; X-Ray Diffraction
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    Thema: Biologie , Chemie und Pharmazie , Informatik , Medizin , Allgemeine Naturwissenschaft , Physik
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  • 18
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    American Association for the Advancement of Science (AAAS)
    Publikationsdatum: 1984-06-15
    Beschreibung: A new class of synthetic antifungal agents, the allylamines , has been developed by modification of naftifine , a topical antimycotic. SF 86-327, the most effective of these compounds so far, is highly active in vitro against a wide range of fungi and exceeds clinical standards in the oral and topical treatment of guinea pig dermatophytoses. SF 86-327 is a powerful specific inhibitor of fungal squalene epoxidase, a key enzyme in sterol biosynthesis.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Petranyi, G -- Ryder, N S -- Stutz, A -- New York, N.Y. -- Science. 1984 Jun 15;224(4654):1239-41.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/6547247" target="_blank"〉PubMed〈/a〉
    Schlagwort(e): Allylamine/analogs & derivatives/*chemical synthesis/pharmacology ; Amines/*chemical synthesis ; Animals ; Antifungal Agents/*chemical synthesis/pharmacology ; Chemical Phenomena ; Chemistry ; Dermatomycoses/drug therapy ; Fungi/*drug effects/enzymology ; Guinea Pigs ; Naphthalenes/chemical synthesis/pharmacology ; Oxygenases/*antagonists & inhibitors ; Squalene Monooxygenase
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    Thema: Biologie , Chemie und Pharmazie , Informatik , Medizin , Allgemeine Naturwissenschaft , Physik
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  • 19
    facet.materialart.
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    American Association for the Advancement of Science (AAAS)
    Publikationsdatum: 1984-11-02
    Beschreibung: By recombinant DNA techniques, a disulfide bond was introduced at a specific site in T4 lysozyme, a disulfide-free enzyme. This derivative retained full enzymatic activity and was more stable toward thermal inactivation than the wild-type protein. The derivative, T4 lysozyme (Ile3----Cys), was prepared by substituting a Cys codon for an Ile codon at position 3 in the cloned lysozyme gene by means of oligonucleotide-dependent, site-directed mutagenesis. The new gene was expressed in Escherichia coli under control of the (trp-lac) hybrid tac promoter, and the protein was purified. Mild oxidation generated a disulfide bond between the new Cys3 and Cys97, one of the two unpaired cysteines of the native molecule. Oxidized T4 lysozyme (Ile3----Cys) exhibited specific activity identical to that of the wild-type enzyme when measured at 20 degrees C in a cell-clearing assay. The cross-linked protein was more stable than the wild type during incubation at elevated temperatures as determined by recovered enzymatic activity at 20 degrees C.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Perry, L J -- Wetzel, R -- New York, N.Y. -- Science. 1984 Nov 2;226(4674):555-7.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/6387910" target="_blank"〉PubMed〈/a〉
    Schlagwort(e): Chemical Phenomena ; Chemistry ; DNA, Recombinant/metabolism ; Escherichia coli/enzymology ; *Genetic Engineering ; Kinetics ; Muramidase/*genetics/metabolism ; Protein Denaturation
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    Thema: Biologie , Chemie und Pharmazie , Informatik , Medizin , Allgemeine Naturwissenschaft , Physik
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  • 20
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    American Association for the Advancement of Science (AAAS)
    Publikationsdatum: 1983-09-09
    Beschreibung: The structures of three proteins that regulate gene expression have been determined recently and suggest how these proteins may bind to their specific recognition sites on the DNA. One protein (Cro) is a repressor of gene expression, the second (CAP) usually stimulates gene expression, and the third (lambda repressor) can act as either a repressor or an activator. The three proteins contain a substructure consisting of two consecutive alpha helices that is virtually identical in each case. Structural and amino acid sequence comparisons suggest that this bihelical fold occurs in a number of proteins that regulate gene expression, and is an intrinsic part of the DNA-protein recognition event. The modes of repression and activation by Cro and lambda repressor are understood reasonably well, but the mode of action of CAP is still unclear.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Takeda, Y -- Ohlendorf, D H -- Anderson, W F -- Matthews, B W -- GM20066/GM/NIGMS NIH HHS/ -- GM28138/GM/NIGMS NIH HHS/ -- GM30894/GM/NIGMS NIH HHS/ -- New York, N.Y. -- Science. 1983 Sep 9;221(4615):1020-6.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/6308768" target="_blank"〉PubMed〈/a〉
    Schlagwort(e): Amino Acid Sequence ; Chemical Phenomena ; Chemistry ; *DNA Helicases ; DNA-Binding Proteins ; Escherichia coli/genetics ; Gene Expression Regulation ; Models, Chemical ; Protein Conformation
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    Thema: Biologie , Chemie und Pharmazie , Informatik , Medizin , Allgemeine Naturwissenschaft , Physik
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  • 21
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    American Association for the Advancement of Science (AAAS)
    Publikationsdatum: 1984-06-08
    Beschreibung: The effect of a partial pressure of nitrogen of 50 atmospheres (5065 kilopascals ) on the hydrogen evolution reaction of nitrogenase has been investigated. Evolution of hydrogen was not blocked completely by 50 atmospheres of nitrogen in any of four experiments; rather, 27.3 +/- 2.4 percent of the total electron flux through nitrogenase was directed toward production of hydrogen. The ratio of hydrogen evolved to nitrogen fixed was close to 1:1, which implies that hydrogen evolution is obligatory in the fixation of molecular nitrogen by nitrogenase.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Simpson, F B -- Burris, R H -- AI-00848/AI/NIAID NIH HHS/ -- New York, N.Y. -- Science. 1984 Jun 8;224(4653):1095-7.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/6585956" target="_blank"〉PubMed〈/a〉
    Schlagwort(e): Chemical Phenomena ; Chemistry ; *Hydrogen ; *Nitrogen ; Nitrogen Fixation ; *Nitrogenase ; Partial Pressure
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    Thema: Biologie , Chemie und Pharmazie , Informatik , Medizin , Allgemeine Naturwissenschaft , Physik
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  • 22
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    American Association for the Advancement of Science (AAAS)
    Publikationsdatum: 1978-03-17
    Beschreibung: The history of U.S. foreign aid support of science and technology in Latin America is examined and an attempt is made to evaluate the scientific and economic growth of that area in relation to the total foreign aid effort.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Szmant, H H -- New York, N.Y. -- Science. 1978 Mar 17;199(4334):1173-82.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/415363" target="_blank"〉PubMed〈/a〉
    Schlagwort(e): Chemistry ; Cost-Benefit Analysis ; Education ; History, 20th Century ; International Educational Exchange ; Latin America ; *Research Support as Topic ; *Science/history ; United States
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    Thema: Biologie , Chemie und Pharmazie , Informatik , Medizin , Allgemeine Naturwissenschaft , Physik
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  • 23
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    American Association for the Advancement of Science (AAAS)
    Publikationsdatum: 1980-01-04
    Beschreibung: In concentrates of water produced in a laboratory simulation of a drinking water treatment process, direct-acting, nonvolatile mutagens were readily detected by means of the Ames Salmonella test. The mutagens were shown to be produced by the chlorination process. Treatment of the water with chloramine resulted in less mutagenic activity than treatment with free chlorine. Dechlorination of drinking water with sulfite sharply reduced the mutagenic activity. Treatment with sulfur dioxide is proposed as an effective, inexpensive method of reducing the direct-acting mutagenic activity of drinking water and of aqueous industrial effluents.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Cheh, A M -- Skochdopole, J -- Koski, P -- Cole, L -- New York, N.Y. -- Science. 1980 Jan 4;207(4426):90-2.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/6985746" target="_blank"〉PubMed〈/a〉
    Schlagwort(e): Chemical Phenomena ; Chemistry ; Chloramines ; Chlorine ; Mutagens/*analysis ; Salmonella typhimurium/genetics ; Sulfites ; Water Pollutants/*analysis ; Water Pollutants, Chemical/*analysis ; Water Supply/*analysis
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    Thema: Biologie , Chemie und Pharmazie , Informatik , Medizin , Allgemeine Naturwissenschaft , Physik
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  • 24
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    American Association for the Advancement of Science (AAAS)
    Publikationsdatum: 1981-10-16
    Beschreibung: The DNA/RNA Synthesizer provides a complete and automated procedure for the synthesis of DNA sequences. Each base unit is added in a 30-minute cycle, permitting a tetradecamer to be constructed in 6 1/2 hours. The complete procedure is described, including a practical procedure for isolation and purification of the desired DNA sequence.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Alvarado-Urbina, G -- Sathe, G M -- Liu, W C -- Gillen, M F -- Duck, P D -- Bender, R -- Ogilvie, K K -- New York, N.Y. -- Science. 1981 Oct 16;214(4518):270-4.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/6169150" target="_blank"〉PubMed〈/a〉
    Schlagwort(e): Automation ; Chemical Phenomena ; Chemistry ; DNA/*chemical synthesis ; *Genes, Synthetic ; RNA/*chemical synthesis ; Solubility
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    Thema: Biologie , Chemie und Pharmazie , Informatik , Medizin , Allgemeine Naturwissenschaft , Physik
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  • 25
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    American Association for the Advancement of Science (AAAS)
    Publikationsdatum: 1981-05-15
    Beschreibung: Research on chitin as a marine resource is pointing to novel applications for this cellulose-like biopolymer. Discovery of nondegrading solvent systems has permitted the spinning of filaments, for example, for use as surgical sutures. New methods for preparing the bioactive alkyl glycoside of N-acetyl-D-glucosamine (the monomer unit of chitin) and a microcrystalline chitin has encouraged their use as promoters for growth of bifidobacteria and as an aid in digestion of high-lactose cheese whey by domestic animals. Chitin-protein complexes of several crustacean species show great variability in ratios of chitin to covalently bound protein and in residual protein in the "purified" chitins.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Austin, P R -- Brine, C J -- Castle, J E -- Zikakis, J P -- New York, N.Y. -- Science. 1981 May 15;212(4496):749-53.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/7221561" target="_blank"〉PubMed〈/a〉
    Schlagwort(e): Animal Feed ; Animals ; Cheese ; Chemical Phenomena ; Chemistry ; Chickens ; *Chitin ; Crystallography ; Lactose/metabolism ; Proteins/analysis ; Sutures ; *Technology
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    Thema: Biologie , Chemie und Pharmazie , Informatik , Medizin , Allgemeine Naturwissenschaft , Physik
    Standort Signatur Erwartet Verfügbarkeit
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  • 26
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    American Association for the Advancement of Science (AAAS)
    Publikationsdatum: 1981-12-18
    Beschreibung: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Gilbert, W -- New York, N.Y. -- Science. 1981 Dec 18;214(4527):1305-12.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/7313687" target="_blank"〉PubMed〈/a〉
    Schlagwort(e): Base Sequence ; Chemical Phenomena ; Chemistry ; DNA/*genetics ; Eukaryotic Cells/physiology ; *Genes ; Hydrazines ; Lac Operon ; Methylation ; Prokaryotic Cells/physiology ; Sulfuric Acid Esters
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    Thema: Biologie , Chemie und Pharmazie , Informatik , Medizin , Allgemeine Naturwissenschaft , Physik
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  • 27
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    American Association for the Advancement of Science (AAAS)
    Publikationsdatum: 1982-07-09
    Beschreibung: A new process has been developed which is called "Boradeption" to signify boronic acid--dependent phase transfer of water-insoluble agents. Highly fluorescent boronic acid dervatives, FluoroBoras, are solubilized with a physiologically compatible carrier buffer containing a receptor group for boronate adduct formation. The system can be used to stain living cells. In another variation of the Boradeption concept, an insoluble reporter molecule containing a boronate receptor is solubilized with a carrier buffer containing a boronic acid functional group. The boronate-receptor complexes, which are in dynamic equilibrium, can be designed as vital stains and reagents for a variety of biological and medical applications.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Gallop, P M -- Paz, M A -- Henson, E -- AG-00376-07/AG/NIA NIH HHS/ -- HL-20764-04A1/HL/NHLBI NIH HHS/ -- New York, N.Y. -- Science. 1982 Jul 9;217(4555):166-9.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/6178158" target="_blank"〉PubMed〈/a〉
    Schlagwort(e): Animals ; *Biological Transport ; *Boron Compounds/therapeutic use ; *Boronic Acids/therapeutic use ; *Cell Membrane Permeability ; Cells, Cultured ; Chemical Phenomena ; Chemistry ; Chromogenic Compounds/metabolism ; Cricetinae ; Fibroblasts ; Fluorescent Dyes/metabolism ; Humans ; Rats ; Staining and Labeling
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    Thema: Biologie , Chemie und Pharmazie , Informatik , Medizin , Allgemeine Naturwissenschaft , Physik
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  • 28
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    American Association for the Advancement of Science (AAAS)
    Publikationsdatum: 1981-12-11
    Beschreibung: The scrapie agent causes a degenerative nervous system disease in sheep and goats. Studies with extensively purified preparations demonstrated that the agent contains a protein that is required for infectivity. Chemical modification of the scrapie agent by diethyl pyrocarbonate reduced the titer 1000-fold. Exposure of the inactivated agent to hydroxylamine, a strong nucleophile, resulted in complete restoration of infectivity. Presumably, nucleophilic residues within a scrapie agent protein undergo carbethoxylation on reaction with diethyl pyrocarbonate, and subsequent addition of hydroxylamine displaces these carbethoxy groups.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉McKinley, M P -- Masiarz, F R -- Prusiner, S B -- NS14069/NS/NINDS NIH HHS/ -- New York, N.Y. -- Science. 1981 Dec 11;214(4526):1259-61.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/6795721" target="_blank"〉PubMed〈/a〉
    Schlagwort(e): Animals ; Biological Assay ; Brain/microbiology ; Chemical Phenomena ; Chemistry ; Cricetinae ; Diethyl Pyrocarbonate/pharmacology ; Histidine/pharmacology ; *Prions ; Ribonucleases/pharmacology ; Serum Albumin, Bovine/pharmacology ; Viral Proteins/*isolation & purification/pharmacology
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    Thema: Biologie , Chemie und Pharmazie , Informatik , Medizin , Allgemeine Naturwissenschaft , Physik
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  • 29
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    American Association for the Advancement of Science (AAAS)
    Publikationsdatum: 1981-01-30
    Beschreibung: The incubation of lens proteins with reducing sugars leads to the formation of fluorescent yellow pigments and cross-like similar to those reported in aging and cataractous human lenses. Called nonenzymatic browning or the Maillard reaction, this aging process also occurs in stored foods. Reducing sugars condense with the free amino group of proteins, then rearrange and dehydrate to form unsaturated pigments and cross-linked products. Although most proteins in living systems turn over with sufficient rapidity to avoid nonenzymatic browning, some, such as lens crystallins and skin collagen, are exceptionally long-lived and may be vulnerable.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Monnier, V M -- Cerami, A -- AM 19655/AM/NIADDK NIH HHS/ -- New York, N.Y. -- Science. 1981 Jan 30;211(4481):491-3.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/6779377" target="_blank"〉PubMed〈/a〉
    Schlagwort(e): *Aging ; Animals ; Cattle ; Chemical Phenomena ; Chemistry ; *Crystallins ; Diabetes Mellitus/physiopathology ; Glucose ; Glucosephosphates ; In Vitro Techniques ; Lysine ; *Proteins ; Spectrophotometry, Ultraviolet
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    Thema: Biologie , Chemie und Pharmazie , Informatik , Medizin , Allgemeine Naturwissenschaft , Physik
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  • 30
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    American Association for the Advancement of Science (AAAS)
    Publikationsdatum: 1981-03-13
    Beschreibung: Great advances have been made in fundamental scientific research in recent years. The new knowledge gathered, in addition to deepening our understanding of the physical universe, contributes a range of abilities and opportunities to society that would not otherwise be available. Much research that may be called applied because it addresses needs of society is quite fundamental in character, and support of such research at the National Science Foundation is to be handled in tandem by the research directorates. Other areas that require a refocusing of support are engineering science and education, at all levels, in science and engineering. Increasing our strength in these areas is essential to achieve our national economic, social, and political goals. Steps are being taken by the National Science Foundation to make its structure better able to deal with engineering and applied research and to provide greater mutual reinforcement between applied and basic research.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Slaughter, J B -- New York, N.Y. -- Science. 1981 Mar 13;211(4487):1131-6.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/7466384" target="_blank"〉PubMed〈/a〉
    Schlagwort(e): Cell Biology ; Chemical Phenomena ; Chemistry ; *Forecasting ; Geological Phenomena ; Geology ; *Government Agencies ; Molecular Biology ; Neurochemistry ; Physical Phenomena ; Physics ; Research Support as Topic ; United States
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    Thema: Biologie , Chemie und Pharmazie , Informatik , Medizin , Allgemeine Naturwissenschaft , Physik
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  • 31
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    American Association for the Advancement of Science (AAAS)
    Publikationsdatum: 1982-12-10
    Beschreibung: The discovery that cis-diamminedichloroplatinum(II) (cis-DDP) has clinically useful antitumor properties and can form platinum blues spawned an extensive investigation of its chemistry in water. Several new molecules have been synthesized, some rather old ones have been characterized for the first time, and clues have begun to emerge about the chemical interaction of cis-DDP with its likely biological target, DNA.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Lippard, S J -- New York, N.Y. -- Science. 1982 Dec 10;218(4577):1075-82.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/6890712" target="_blank"〉PubMed〈/a〉
    Schlagwort(e): Chemical Phenomena ; Chemistry ; *Cisplatin ; *Dna ; Hydrolysis ; Pigments, Biological
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    Thema: Biologie , Chemie und Pharmazie , Informatik , Medizin , Allgemeine Naturwissenschaft , Physik
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  • 32
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    American Association for the Advancement of Science (AAAS)
    Publikationsdatum: 1982-12-03
    Beschreibung: The visual response is initiated by light reception and transduction into chemical and electrical energy in the outer-segment membranes of rod and cone cells. Recent research on the molecular events controlled by light has clarified the roles of some of the rod outer-segment biomolecules. These developments and the current unresolved questions are described.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉O'Brien, D F -- New York, N.Y. -- Science. 1982 Dec 3;218(4576):961-6.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/6291153" target="_blank"〉PubMed〈/a〉
    Schlagwort(e): Animals ; Blood Proteins/metabolism ; Calcium/metabolism ; Chemical Phenomena ; Chemistry ; Enzyme Activation ; Enzymes/metabolism ; GTP-Binding Proteins ; Light ; Membranes/metabolism ; Models, Biological ; Phosphoric Diester Hydrolases/biosynthesis ; Photoreceptor Cells/*metabolism ; Receptors, Cell Surface/metabolism ; Rhodopsin/metabolism ; Rod Cell Outer Segment/*metabolism ; Vision, Ocular/*physiology
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    Thema: Biologie , Chemie und Pharmazie , Informatik , Medizin , Allgemeine Naturwissenschaft , Physik
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  • 33
    facet.materialart.
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    American Association for the Advancement of Science (AAAS)
    Publikationsdatum: 1983-06-10
    Beschreibung: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Krenitsky, T A -- Beauchamp, L -- New York, N.Y. -- Science. 1983 Jun 10;220(4602):1106.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/6857236" target="_blank"〉PubMed〈/a〉
    Schlagwort(e): Acyclovir/metabolism ; *Antiviral Agents/metabolism ; Chemical Phenomena ; Chemistry ; Humans ; Vidarabine/metabolism
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    Thema: Biologie , Chemie und Pharmazie , Informatik , Medizin , Allgemeine Naturwissenschaft , Physik
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  • 34
    Publikationsdatum: 1983-05-06
    Beschreibung: Resonance Raman spectra of photolyzed carbonmonoxyhemoglobin obtained with 10-nanosecond pulses are compared with the spectra of photolyzed carbonmonoxyhemoglobin stabilized at 80 K. In comparing the deoxy with the photodissociated species, the changes in the Raman spectra are the same for these two experimental regimes. These results show that at ambient and cryogenic temperatures the heme pocket in liganded hemoglobin is significantly different from that of deoxyhemoglobin. It is concluded that measurements of the properties of intermediate species from photodissociated hemoglobin stabilized at low temperatures can be used to probe the short-lived metastable forms of hemoglobin present after photodissociation under biologically relevant solution conditions.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Ondrias, M R -- Friedman, J M -- Rousseau, D L -- New York, N.Y. -- Science. 1983 May 6;220(4597):615-7.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/6836305" target="_blank"〉PubMed〈/a〉
    Schlagwort(e): Carboxyhemoglobin ; Chemical Phenomena ; Chemistry ; Freezing ; *Hemoglobins ; Humans ; Ligands ; Spectrum Analysis, Raman ; Temperature
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    Thema: Biologie , Chemie und Pharmazie , Informatik , Medizin , Allgemeine Naturwissenschaft , Physik
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  • 35
    Publikationsdatum: 1983-04-15
    Beschreibung: Alkylating agents that display strong selectivity for opiate receptor types delta or mu were prepared by appropriate modification of the structures of the strong analgesics fentanyl, etonitazene, and endoethenotetrahydrooripavine. The availability of these substances should facilitate studies of the structural basis of receptor specificity and of the physiologic roles of these receptors.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Rice, K C -- Jacobson, A E -- Burke, T R Jr -- Bajwa, B S -- Streaty, R A -- Klee, W A -- New York, N.Y. -- Science. 1983 Apr 15;220(4594):314-6.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/6132444" target="_blank"〉PubMed〈/a〉
    Schlagwort(e): Alkylation ; Animals ; Benzimidazoles/analogs & derivatives/metabolism ; Brain/physiology ; Cells, Cultured ; Chemical Phenomena ; Chemistry ; Enkephalin, Methionine/analogs & derivatives/metabolism ; Fentanyl/analogs & derivatives/metabolism ; *Isothiocyanates ; Ligands ; Rats ; Receptors, Opioid/*metabolism/physiology ; Thebaine/analogs & derivatives/pharmacology
    Print ISSN: 0036-8075
    Digitale ISSN: 1095-9203
    Thema: Biologie , Chemie und Pharmazie , Informatik , Medizin , Allgemeine Naturwissenschaft , Physik
    Standort Signatur Erwartet Verfügbarkeit
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  • 36
    facet.materialart.
    Unbekannt
    American Association for the Advancement of Science (AAAS)
    Publikationsdatum: 1978-04-07
    Beschreibung: Glucose reacts nonenzymatically with the NH2-terminal amino acid of the beta chain of human hemoglobin by way of a ketoamine linkage, resulting in the formation of hemoglobin AIc. Other minor components appear to be adducts of glucose 6-phosphate and fructose 1,6-diphosphate. These hemoglobins are formed slowly and continuously throughout the 120-day life-span of the red cell. There is a two- to threefold increase in hemoglobin AIc in the red cells of patients with diabetes mellitus. By providing an integrated measurement of blood glucose, hemoglobin AIc is useful in assessing the degree of diabetic control. Furthermore, this hemoglobin is a useful model of nonenzymatic glycosylation of other proteins that may be involved in the long-term complications of the disease.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Bunn, H F -- Gabbay, K H -- Gallop, P M -- New York, N.Y. -- Science. 1978 Apr 7;200(4337):21-7.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/635569" target="_blank"〉PubMed〈/a〉
    Schlagwort(e): Blood Glucose/metabolism ; Chemical Phenomena ; Chemistry ; Diabetes Complications ; Diabetes Mellitus/*blood/diagnosis ; Diphosphoglyceric Acids/blood ; Glycosides/blood ; Glycosuria/etiology ; Hemoglobin A/*metabolism ; Hemoglobins/*analysis/*metabolism ; Humans ; Kinetics ; Oxygen/blood ; Structure-Activity Relationship
    Print ISSN: 0036-8075
    Digitale ISSN: 1095-9203
    Thema: Biologie , Chemie und Pharmazie , Informatik , Medizin , Allgemeine Naturwissenschaft , Physik
    Standort Signatur Erwartet Verfügbarkeit
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  • 37
    facet.materialart.
    Unbekannt
    American Association for the Advancement of Science (AAAS)
    Publikationsdatum: 1979-06-08
    Beschreibung: It has been proposed that nitrilotriacetic acid be substituted for trisodium polyphosphates in detergents as a way to reduce the rate of eutrophication in the Great Lake Basin. The reaction of nitrilotriacetic acid with chlorine-containing solutions produces a hitherto unknown degradation production, N-formyliminodiacetic acid, in high yield. The toxicological and environmental implications of this reaction are unclear.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Spanggord, R J -- Tyson, C A -- New York, N.Y. -- Science. 1979 Jun 8;204(4397):1081-2.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/36659" target="_blank"〉PubMed〈/a〉
    Schlagwort(e): *Acetates ; Chemical Phenomena ; Chemistry ; *Chlorine ; Dicarboxylic Acids ; Environmental Pollutants ; Hydrogen-Ion Concentration ; *Imino Acids ; Mutagens ; *Nitrilotriacetic Acid
    Print ISSN: 0036-8075
    Digitale ISSN: 1095-9203
    Thema: Biologie , Chemie und Pharmazie , Informatik , Medizin , Allgemeine Naturwissenschaft , Physik
    Standort Signatur Erwartet Verfügbarkeit
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  • 38
    facet.materialart.
    Unbekannt
    American Association for the Advancement of Science (AAAS)
    Publikationsdatum: 1979-03-16
    Beschreibung: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Ferris, J P -- New York, N.Y. -- Science. 1979 Mar 16;203(4385):1135-7.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/218287" target="_blank"〉PubMed〈/a〉
    Schlagwort(e): Chemical Phenomena ; Chemistry ; *Hydrogen Cyanide ; *Peptides
    Print ISSN: 0036-8075
    Digitale ISSN: 1095-9203
    Thema: Biologie , Chemie und Pharmazie , Informatik , Medizin , Allgemeine Naturwissenschaft , Physik
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  • 39
    Publikationsdatum: 1980-10-01
    Beschreibung: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Bumb, R R -- Crummett, W B -- Cutie, S S -- Gledhill, J R -- Hummel, R H -- Kagel, R O -- Lamparski, L L -- Luoma, E V -- Miller, D L -- Nestrick, T J -- Shadoff, L A -- Stehl, R H -- Woods, J S -- New York, N.Y. -- Science. 1980 Oct;210(4468):385-90.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/6159682" target="_blank"〉PubMed〈/a〉
    Schlagwort(e): Air Pollutants/analysis ; Chemical Phenomena ; Chemistry ; Chromatography, High Pressure Liquid ; *Dioxins/analysis ; *Fires ; Power Plants ; Smoke/analysis ; Soil Pollutants/analysis ; Tetrachlorodibenzodioxin/analysis ; Vehicle Emissions/analysis ; Water Pollutants, Chemical/analysis
    Print ISSN: 0036-8075
    Digitale ISSN: 1095-9203
    Thema: Biologie , Chemie und Pharmazie , Informatik , Medizin , Allgemeine Naturwissenschaft , Physik
    Standort Signatur Erwartet Verfügbarkeit
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  • 40
    facet.materialart.
    Unbekannt
    American Association for the Advancement of Science (AAAS)
    Publikationsdatum: 1984-05-25
    Beschreibung: Polypeptide analogs of the known members of the corticotropin-releasing factor (CRF) family were synthesized and tested in vitro and in vivo for enhanced potency or competitive antagonism. Predictive methods and physicochemical measurements had suggested an internal secondary alpha-helical conformation spanning about 25 residues for at least three members of the CRF family. Maximization of alpha-helix-forming potential by amino acid substitutions from the native known sequences (rat/human and ovine CRF, sauvagine, and carp and sucker urotensin 1) led to the synthesis of an analog that was found to be more than twice as potent as either of the parent peptides in vitro. In contrast, certain amino-terminally shortened fragments, such as alpha-helical CRF or ovine CRF residues 8 to 41, 9 to 41, and 10 to 41, were found to be competitive inhibitors in vitro. Selected antagonists were examined and also found to be active in vivo.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Rivier, J -- Rivier, C -- Vale, W -- AA03504/AA/NIAAA NIH HHS/ -- AM20917/AM/NIADDK NIH HHS/ -- AM26741/AM/NIADDK NIH HHS/ -- etc. -- New York, N.Y. -- Science. 1984 May 25;224(4651):889-91.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/6326264" target="_blank"〉PubMed〈/a〉
    Schlagwort(e): Adrenocorticotropic Hormone/secretion ; Animals ; Binding, Competitive ; Chemical Phenomena ; Chemistry ; Corticotropin-Releasing Hormone/*antagonists & inhibitors ; Rats
    Print ISSN: 0036-8075
    Digitale ISSN: 1095-9203
    Thema: Biologie , Chemie und Pharmazie , Informatik , Medizin , Allgemeine Naturwissenschaft , Physik
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  • 41
    facet.materialart.
    Unbekannt
    In:  CASI
    Publikationsdatum: 2004-12-03
    Beschreibung: Projections of technological advances to the year 2000 have suggested a number of possible conceptual types of air vehicles. For convenience, these have been grouped according to speed, increasing from below Mach 1 (including hovering flight) through various Mach ranges to orbital flight. The potential performance capabilities that could be realized for each of these types of aircraft provide exciting prospects for the years beyond 2000. It is clear that the greater design flexibilities provided by the projected technology advances will permit significant improvements in performance, economy, and safety and allow the design and development of aircraft systems that current technology will not support. In the following sections, each vehicle type is discussed, noting design features and significant advances. Where related aircraft exist, the significant economic and performance factors are compared. In addition, for each concept, the technology developments considered essential for the advanced concept are identified. The types of aircraft described are examples of what advances in the technology projected for the year 2000 could provide. They are by no means all that would be possible. The panel's views on the current state of knowledge of systems intergration as a discipline and the need for advancement in this area presented in the concluding section of this report.
    Schlagwort(e): Aircraft Design, Testing and Performance
    Materialart: Aeronautics Technology Possibilities for 2000: Report of a Workshop; 195-213; NASA-CR-205283
    Format: text
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  • 42
    facet.materialart.
    Unbekannt
    In:  CASI
    Publikationsdatum: 2004-12-03
    Beschreibung: Over the last 50 years, aeronautical structures have evolved from the wood, fabric, and wire of low-speed biplanes to supersonic aircraft fabricated with advanced metallic and nonmetallic materials. The advances made in structures technology have had significant impact on aircraft design and performance. An example is the large weight reductions being realized from the utilization of composite materials for secondary and primary structures. However, structural advances have been evolutionary, not revolutionary. Through the year 2000, there are opportunities to obtain significant new advancements in structural technology. These advances could result in considerable performance and capability payoffs such as increased payload, range, speed, maneuverability, fuel efficiency, and safety through reductions in weight, increases in strength, and the ability to make structures pliable. Also, with new manufacturing processes it is possible that reductions in production costs will be realized. Some of the structural technology areas where future major advances could be made are adaptive structures, thermal structures, damage tolerant structures, propulsion system structures, and new structural concepts.
    Schlagwort(e): Aircraft Design, Testing and Performance
    Materialart: Aeronautics Technology Possibilities for 2000: Report of a Workshop; 71-98; NASA-CR-205283
    Format: text
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  • 43
    facet.materialart.
    Unbekannt
    In:  Other Sources
    Publikationsdatum: 2011-08-23
    Beschreibung: An overview of the technical development of hingeless and bearingless rotors is given, with emphasis on aeroelastic and aeromechanical stability characteristics. Important considerations for theoretical analysis are discussed. Theoretical and experimental investigations of isolated blade flap-lag and flap-lag-torsion stability, and coupled rotor-body aeromechanical stability are described. Physical interpretation and important rotor system design parameters are emphasized. An overview of bearingless rotor dynamics is also included.
    Schlagwort(e): Aircraft Design, Testing and Performance
    Materialart: Vertica (ISSN 0360-5450); Volume 7; No. 2; 143-181
    Format: text
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  • 44
    facet.materialart.
    Unbekannt
    In:  CASI
    Publikationsdatum: 2018-06-09
    Beschreibung: Raisbeck Mark Five Sabreliner 60A is a modernized, higher performance version of the Sabreliner business jet designed more than 20 years ago. Rockwell decided to update the design to incorporate NASA's computational fluid dynamics technology, thereby insuring continuing production of a competitive new airplane and protecting Sabreliner owners' investments by allowing them to convert to the update configuration. Redesign of the airplane involved extensive changes in aerodynamics structure and on-board systems. Key to Mark Five design is a new wing which has greater fuel capacity, increased span and improved airfoils to reduce fuel consumption.
    Schlagwort(e): Aircraft Design, Testing and Performance
    Materialart: Spinoff 1980; 61
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  • 45
    facet.materialart.
    Unbekannt
    In:  CASI
    Publikationsdatum: 2018-06-09
    Beschreibung: Rohr Industries, Inc. specializes in the manufacturing of nacelles, thrust reversers, and other engine components, has made use of the COSMIC program in nacelle work for aircraft like the McDonnell Douglas DC-10, the French/German Airbus and the Boeing 727, 737 and 747 jetliners. They also manufacture complete nacelles for military and business aircraft and are supplying nacelle components for the Boeing 757. The nacelle requires research and development for each type of airplane because of complex airflows around the engine inlet and high pressures on the nacelle skin. The use of the computer program defines the airflow field around turbofan engine nacelle inlet and cowls. Pressures on the nacelle skin are estimated for various flight conditions and structural integrity of the nacelle design. Rohr estimates that use of this program saved six man-months of programmer time necessary to develop alternative software.
    Schlagwort(e): Aircraft Design, Testing and Performance
    Materialart: Spinoff 1982; 71
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  • 46
    facet.materialart.
    Unbekannt
    In:  CASI
    Publikationsdatum: 2018-06-09
    Beschreibung: Hang gliding is growing rapidly. Free Flight produces 1,000 gliders a month and other companies are entering the field. Wing is simple to control, pulling back on control bar allows you to pick up speed and at the same time lowers your altitude. Pushing forward slows your speed and levels you off. Birdmen can choose from prone, upright or swing seat harnesses in either kits or ready-to-fly gliders.
    Schlagwort(e): Aircraft Design, Testing and Performance
    Materialart: Spinoff 1976; 82
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  • 47
    facet.materialart.
    Unbekannt
    In:  CASI
    Publikationsdatum: 2018-06-09
    Beschreibung: Farmers are increasingly turning to aerial applications of pesticides, fertilizers and other materials. Sometimes uneven distribution of the chemicals is caused by worn nozzles, improper alignment of spray nozzles or system leaks. If this happens, job must be redone with added expense to both the pilot and customer. Traditional pattern analysis techniques take days or weeks. Utilizing NASA's wind tunnel and computer validation technology, Dr. Roth, Oklahoma State University (OSU), developed a system for providing answers within minutes. Called the Rapid Distribution Pattern Evaluation System, the OSU system consists of a 100-foot measurement frame tied in to computerized analysis and readout equipment. System is mobile, delivered by trailer to airfields in agricultural areas where OSU conducts educational "fly-ins." A fly-in typically draws 50 to 100 aerial applicators, researchers, chemical suppliers and regulatory officials. An applicator can have his spray pattern checked. A computerized readout, available in five to 12 minutes, provides information for correcting shortcomings in the distribution pattern.
    Schlagwort(e): Aircraft Design, Testing and Performance
    Materialart: Spinoff 1982; 114-115
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  • 48
    facet.materialart.
    Unbekannt
    In:  CASI
    Publikationsdatum: 2019-06-28
    Beschreibung: Seamless steel tubing is today the principal material of construction for aircraft. The commercial grade of tubing containing about 0.10 to 0.20% carbon at first used is being superseded by two grades which are approved by the army and navy, and which are also becoming standard for commercial airplanes.
    Schlagwort(e): Aircraft Design, Testing and Performance
    Materialart: AD-B204801 , NASA-TM-111285 , NACA-TN-342 , NAS 1.15:111285
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  • 49
    Publikationsdatum: 2019-06-28
    Beschreibung: A stiffened composite panel has been designed that is representative of the fuselage structure of existing wide bodied aircraft. The panel is a minimum weight design, based on the current level of technology and realistic loads and criteria. Several different stiffener configurations were investigated in the optimization process. The final configuration is an all graphite epoxy J-stiffened design in which the skin between adjacent stiffeners is permitted to buckle under design loads. Fail-safe concepts typically employed in metallic fuselage structure have been incorporated in the design. A conservative approach has been used with regard to structural details such as skin frame and stringer frame attachments and other areas where sufficient design data was not available.
    Schlagwort(e): Aircraft Design, Testing and Performance
    Materialart: NASA-CR-159302 , NAS 1.26:159302 , AD-A301599 , LG80ER0137
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  • 50
    Publikationsdatum: 2019-05-11
    Beschreibung: The Ryan VZ-3RY V/STOL test vehicle was flight tested over the airspeed range from 80 knots to below 6 knots. The deflected slipstream concept proved to be better suited to STOL than VTOL operation. Adverse ground effects prevented operation close to the ground at speeds less than 20 knots and below approximately 15 feet altitude. Steep glide slopes to landing (up to -16 deg) at approximately 40 knots were achieved, but steep, slow, descending flight did not appear feasible. Full-span leading-edge slats markedly increased the descent capability and reduced the minimum level flight speed.
    Schlagwort(e): Aircraft Design, Testing and Performance
    Materialart: NASA-TN-D-1891
    Format: application/pdf
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  • 51
    Publikationsdatum: 2019-06-28
    Beschreibung: A survey of methods and equipment used in the riveting of German aircraft. Includes descriptions and illustrations.
    Schlagwort(e): Aircraft Design, Testing and Performance
    Materialart: NACA-TM-596
    Format: application/pdf
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  • 52
    facet.materialart.
    Unbekannt
    In:  CASI
    Publikationsdatum: 2019-06-28
    Beschreibung: This report describes the Bucharest wind tunnel and presents numerous photographs and diagrams. The wind tunnel is of the closed- circuit type, the return being symmetrical with respect t o the longitudinal axis of the tunnel. Th e tunnel is of the horizontal type with a diameter of 3. 2 m (10. 5-ft.) a t the beginning of the entrance cone, and 1.5 m ( 4,92 ft.) at the entrance to the test chamber. The latter, 2 m (6.56 ft.) long, may be either of the open-jet type or enclosed in a cylindrical housing.
    Schlagwort(e): Aircraft Design, Testing and Performance
    Materialart: NACA-TM-651
    Format: application/pdf
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  • 53
    facet.materialart.
    Unbekannt
    In:  CASI
    Publikationsdatum: 2019-06-28
    Beschreibung: No abstract available
    Schlagwort(e): Aircraft Design, Testing and Performance
    Materialart: NASA-CR-52817 , NAS 1.26:52817 , LRP-297-VOL-1
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  • 54
    Publikationsdatum: 2019-06-28
    Beschreibung: A 60' delta-wing airplane model was oscillated in roll for several frequencies and amplitudes of oscillation to determine the effects of the oscillatory motion on the roll-stability derivatives for the model. The derivatives were measured at a Reynolds number of 1,600,000 for the wing alone, the wing-fuselage combination, and the complete model which included a triangular-plan-form vertical tail. Both rolling and yawing moments due to rolling velocity exhibited large frequency effects for angles of attack higher than 16 degrees. Variations in these derivatives were measured for the lowest frequencies of oscillation; as the frequency increased, the derivatives because more nearly linear with angle of attack. Both velocity derivatives were considerably different at high angles of attack from the corresponding derivatives measured by the steady-state rolling-flow technique. Rolling and yawing moments due to rolling acceleration were measured and similarly found to be highly dependent on frequency at high angles of attack. Some period and time-to-damp computations, which were made to reveal the significance of the acceleration derivatives, indicated that inclusion of the measured derivatives in the equations of motion lengthened the period of the lateral oscillation by 10 percent for a typical delta-wing airplane and increased the time to damp to one-half amplitude by 50 percent.
    Schlagwort(e): Aircraft Design, Testing and Performance
    Materialart: NASA-TN-D-232
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  • 55
    facet.materialart.
    Unbekannt
    In:  Other Sources
    Publikationsdatum: 2019-06-27
    Beschreibung: An experimental investigation has been conducted to evaluate a unique engine-over-wing propulsive-life scheme for providing maneuver improvement in the subsonic-transonic speed regime. The concept combines the benefits of vectored thrust for added circulation and spanwise blowing for leading-edge-vortex augmentation so as to provide full angle-of-attack aerodynamic improvements. Results of a series of wind tunnel tests employing a powered research model illustrate the propulsive/aerodynamic features of the concept.
    Schlagwort(e): Aircraft Design, Testing and Performance
    Materialart: AIAA PAPER 76-917
    Format: text
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  • 56
    Publikationsdatum: 2019-07-13
    Beschreibung: A new formulation of helicopter rotor thickness, noise for hover and forward flight, is discussed. The parameters required for this formulation are rotor motion, planform and airfoil thickness distribution. A computer program has been developed to calculate the pressure signature due to blade thickness for a helicopter in arbitrary motion. Comparison with high-speed helicopter tests shows good agreement with calculations when the observer is in or near the horizontal plane in which the rotor disc lies. Characteristics of thickness noise are illustrated by numerical examples indicating strongly that the high-speed blade slap may be due primarily to the thickness effect. The methods of Deming and Arnoldi are discussed as the special cases of this technique.
    Schlagwort(e): Aircraft Design, Testing and Performance
    Materialart: AIAA Paper 75-453 , AIAA 2nd Aero-Acoustics Conference; Mar 24, 1975 - Mar 26, 1975; Hampton, VA; United States
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  • 57
    Publikationsdatum: 2019-07-13
    Beschreibung: Results of recent wind tunnel tests and analyses are described which are aimed at helping to prevent spin entry after a stall by modifications to the aircraft wing. Simple add-on devices were utilized which modify the shape of the lift curve after stall, making it essentially flat to 30- 40 degree angle of attack. It is hypothesized that his will greatly reduce the danger of spin entry. Further research will be aimed at laying a firmer theoretical and analytical basis for the approach and at incorporating the complete full scale airplane and its dynamics into the problem.
    Schlagwort(e): Aircraft Design, Testing and Performance
    Materialart: Rept-760481 , NASA-TM-208064 , Business Aircraft Meeting; Apr 06, 1976 - Apr 09, 1976; Wichita, KS; United States
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  • 58
    Publikationsdatum: 2019-07-13
    Beschreibung: The pressure recovery of incoming cooling air and the drag associated with engine cooling of a typical general aviation twin-engine aircraft was Investigated experimentally. The semispan model was mounted vertically in the 40 x 80-Foot Wind Tunnel at Ames Research Center. The propeller was driven by an electric motor to provide thrust with low vibration levels for the cold-now configuration. It was found that the propeller slip-stream reduces the frontal air spillage around the blunt nacelle shape. Consequently, this slip-stream effect promotes flow reattachment at the rear section of the engine nacelle and improves inlet pressure recovery. These effects are most pronounced at high angles of attack; that is, climb condition. For the cruise condition those improvements were more moderate.
    Schlagwort(e): Aircraft Design, Testing and Performance
    Materialart: NASA/TM-1980-208075 , NAS 1.15:208075 , AIAA Paper 80-1872 , Aircraft Systems and Technology Meeting; Aug 04, 1980 - Aug 06, 1980; Anaheim, CA; United States|Journal of Aircraft; 19; 3; 193-197
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  • 59
    facet.materialart.
    Unbekannt
    In:  CASI
    Publikationsdatum: 2019-07-12
    Beschreibung: Investigations with a view to increasing the lift coefficient of a wing, without greatly increasing the C(sub x min), are chiefly related to the important question of the maximum speed range.
    Schlagwort(e): Aircraft Design, Testing and Performance
    Materialart: NACA Misc. Paper No. 37
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  • 60
    Publikationsdatum: 2019-08-16
    Beschreibung: An experimental investigation has been conducted at Mach numbers of 0.6 to 1.4 to determine the base pressures on several cylindrical afterbody configurations having two propulsive nozzles and to determine the effect on base pressure of stabilizing fins and the canting outward of the propulsive nozzles. Nozzle design Mach numbers of 2.0 and 3.43 were employed in this investigation and cold air at total pressures up to 120 times the free-stream static pressure was used to simulate nozzle flow. The results show that canting the nozzles outward 11 degrees was effective in increasing base pressures at supersonic speeds and that stabilizing fins caused a decrease in base pressure. The magnitudes of base pressure coefficients obtained in this investigation were consistent with those obtained on similar configurations in previous jet-effect investigations.
    Schlagwort(e): Aircraft Design, Testing and Performance
    Materialart: NASA/TN-D-544 , L-861
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  • 61
    Publikationsdatum: 2019-08-16
    Beschreibung: An investigation has been made in the Langley 16-foot transonic tunnel to determine the aerodynamic loading characteristics of a 3-percent-thick, aspect-ratio - 2.06, 60 deg delta-wing-body combination. The Mach number range was from 0.80 t o 1.05 and the average Reynolds number based on wing mean aerodynamic chord was 10 x 10(exp 6). The angle-of-attack range was from 0 deg to 26 deg but was limited at the highest Mach numbers by tunnel drive power. Pressure distributions, spanwise loadings, integrated wing coefficients, and tabulated pressure coefficients are presented for the range of Mach numbers and angles of attack. The results indicate that a free leading-edge separation vortex is the dominant flow-field phenomenon at all Mach numbers and that, consequently, there are only slight changes in the spanwise loadings with Mach number. There is a slight outboard shift in center of pressure with an increase in Mach number. The chord-wise position of the center of pressure varies from 46 t o 55 percent of the mean aerodynamic chord when the Mach number i s increased from 0.80 to l.05.
    Schlagwort(e): Aircraft Design, Testing and Performance
    Materialart: NASA-TN-D-830 , L-1543
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  • 62
    Publikationsdatum: 2019-07-10
    Beschreibung: Results of an investigation in the Langley full-scale tunnel of the hovering performance of large-scale twin-rotor-helicopter models are presented. Measurements of thrust, torque, and rotor flapping are given for overlapped (approximately 76 percent of blade radius) and nonoverlapped configurations and for two different rotor solidities. The measured performance is compared with single-rotor measurements and with available rotor theory. These tests show that the hovering performance of a single rotor and of two rotors without overlap or vertical offset are the same and hence may be calculated by single-rotor theory. These tests in conjunction with results of previous coaxial-rotor tests show that the performance of highly overlapped rotors can be reasonably predicted by available rotor theory.
    Schlagwort(e): Aircraft Design, Testing and Performance
    Materialart: NASA-TN-D-534 , L-95399
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  • 63
    facet.materialart.
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    In:  CASI
    Publikationsdatum: 2019-08-14
    Beschreibung: Recent research on pneumatic tire hydroplaning has been collected and summarized with the aim of describing what is presently known about the phenomena of tire hydroplaning. A physical description of tire hydroplaning is given along with formulae for estimating the ground speed at which it occurs. Eight manifestations of tire hydroplaning which have been experimentally observed are presented and discussed. These manifestations are: detachment of tire footprint, hydrodynamic ground pressure, spin-down of wheel, suppression of tire bow wave, scouring action of escaping fluid in tire-ground footprint region, peaking of fluid displacement drag, loss in braking traction, and loss of tire directional stability. The vehicle, pavement, tire, and fluid parameters of importance to tire hydroplaning are listed and described. Finally, the hazards of tire hydroplaning to ground and air-vehicle-ground performance are listed, and procedures are given to minimize these effects.
    Schlagwort(e): Aircraft Design, Testing and Performance
    Materialart: NASA-TN-D-2056
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  • 64
    Publikationsdatum: 2019-08-14
    Beschreibung: An investigation was conducted in the Langley 20-foot free-spinning tunnel on a 1/20-scale model of an unswept-wing, twin-engine, observation airplane. The effects of control settings and movements on the erect spin and recovery characteristics for the normal loading and the most rearward center-of-gravity loading (external wing tanks full) were determined. Also, tests were made to determine the effect on the spin and recovery characteristics of a large radar store, of empty and full external wing tanks, and of an asymmetrical condition when one empty or one full external wing tank is carried. Spin-recovery parachute tests were also performed. The results of the tests indicate that erect spins obtained on the airplane for the normal loading should be satisfactorily terminated by rudder reversal to full against the spin, ailerons moved to with the spin, followed one-half turn later by forward movement of the stick to neutral. With the radar store, with wing tanks empty, or with an asymmetrical condition when one empty tank is on either wing, satisfactory recoveries can be obtained by using the same technique as for the normal loading. Recoveries for the model with a rearward center-of-gravity loading (external wing tanks full) or with a full tank on the wing inboard of the spin axis will be slow to unsatisfactory with rudder reversal to full against the spin followed by brisk forward stick movement. With a full tank on the wing outboard of the spin axis, the recoveries will be satisfactory. Spins in the landing configuration should be terminated by first retracting the flaps, slats, and landing gear, after which recovery should be attempted immediately by using the recovery technique recommended for the normal loading condition. Inverted spins can be satisfactorily terminated by rudder reversal to full against the spin followed by neutralization of the longitudinal and lateral controls. A 12.7-foot-diameter tail parachute with a towline length of 21.7 feet and a drag coefficient of 0.65 should be satisfactory for recoveries from erect and inverted demonstration spins when used simultaneously with movement of rudder to neutral.
    Schlagwort(e): Aircraft Design, Testing and Performance
    Materialart: NASA-TN-D-1516
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  • 65
    Publikationsdatum: 2019-08-17
    Beschreibung: On August 12, 1960, an X-15 flight was made to achieve essentially the maximum altitude expected to be possible with the interim rocket engines. N l y corrected altitude measurements showed that the maxhum geometric altitude was 136,500 feet k600 and the maximum pressure altitude, referred to the tables of the 0. S . Extension to the ICAO Standard Atmosphere, was indicated to be 133,900 feet.
    Schlagwort(e): Aircraft Design, Testing and Performance
    Materialart: NASA-TN-D-623 , H-206
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  • 66
    Publikationsdatum: 2019-08-17
    Beschreibung: An investigation has been conducted in the Langley 4- by 4-foot supersonic pressure tunnel to determine the aerodynamic characteristics in pitch of a two-stage-rocket model configuration which simulated the last two stages of the launching vehicle for an inflatable sphere. Tests were made through an angle-of-attack range from -6 deg to 18 deg at dynamic pressures of 102 and 255 pounds per square foot with corresponding Mach numbers of 1.89 and 1.98 for the model both with and without a bumper arrangement designed to protect the rocket casing from the outer shell of the vehicle.
    Schlagwort(e): Aircraft Design, Testing and Performance
    Materialart: NASA-TN-D-640 , L-911
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  • 67
    Publikationsdatum: 2019-08-17
    Beschreibung: An investigation was made in the Langley 300-MPH 7- by 10-foot tunnel with a conventional ground-board setup and in the Langley tank no. 1 by using the tow carriage to move the model over a ground board to evaluate the simulation of flight conditions in ground influence with a conventional ground-board setup. The 12-percent-thick airfoil was unswept and untapered with an aspect ratio of 6.0 and had a 10 percent- chord jet-augmented flap. From this investigation it appears that the loss in lift of an airfoil with a jet-augmented flap in ground influence as determined in a wind tunnel with a conventional ground-board setup is considerably larger than would be obtained in free flight.
    Schlagwort(e): Aircraft Design, Testing and Performance
    Materialart: NASA-TN-D-658 , L-1199
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  • 68
    Publikationsdatum: 2019-08-17
    Beschreibung: Wind-tunnel tests have been conducted on a large-scale model of a swept-wing jet transport type airplane to study the factors affecting exhaust gas ingestion into the engine inlets when thrust reversal is used during ground roll. The model was equipped with four small jet engines mounted in nacelles beneath the wing. The tests included studies of both cascade and target type reversers. The data obtained included the free-stream velocity at the occurrence of exhaust gas ingestion in the outboard engine and the increment of drag due to thrust reversal for various modifications of thrust reverser configuration. Motion picture films of smoke flow studies were also obtained to supplement the data. The results show that the free-stream velocity at which ingestion occurred in the outboard engines could be reduced considerably, by simple modifications to the reversers, without reducing the effective drag due to reversed thrust.
    Schlagwort(e): Aircraft Design, Testing and Performance
    Materialart: NASA-TN-D-686 , A-445
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  • 69
    Publikationsdatum: 2019-08-17
    Beschreibung: An investigation has been made to determine the thrust characteristics within ground proximity of a series of models which might represent vertical take-off-and-landing (VTOL) aircraft with multiple exit jet engines exhausting vertically downward beneath a lifting surface. Variations in simulated engine configurations were provided by a series of nozzle insert plugs in which the number of jet exits, located symmetrically on a fixed circle, was varied, or the diameter of the circle was varied for a given number of jet exits. represent lifting surfaces, and high-pressure air was used to simulate jet-engine exhaust. Plywood plates were used to The results of the investigation showed that increasing the number of exits, such that an annular jet configuration was approached, provided more favorable thrust characteristics within ground proximity than any other variation in the geometry of these multiple jets. Tests of a configuration with two nozzles approximating a fan-in-wing VTOL aircraft with fans located at different spanwise locations indicated that the augmentation in thrust within ground proximity was greater for the arrangement with the more inboard location of the nozzles.
    Schlagwort(e): Aircraft Design, Testing and Performance
    Materialart: NASA-TN-D-513 , L-868
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  • 70
    Publikationsdatum: 2019-08-17
    Beschreibung: An investigation has been made by the NASA to obtain statistical measurements of landing-contact conditions for a large turbojet transport in commercial airline operations. The investigation was conducted at the Los Angeles International Airport in Los Angeles, California. Measurements were taken photographically during routine daylight operations. The quantities determined were vertical velocity, horizontal velocity, rolling velocity, bank angle, and distance from runway threshold, just prior to ground contact. The results indicated that the mean vertical velocity for the turbojet-transport landings was 1.62 feet per second and that 1 landing out of 100 would be expected to equal or exceed about 4.0 feet per second. The mean airspeed at contact was 132.0 knots, with 1 landing in 100 likely to equal or exceed about 153.0 knots. The mean rolling velocity was about 1.6 deg per second. One lending in 100 would probably equal or exceed a rolling velocity of about 4.0 deg. per second in the direction of the first wheel to touch. The mean bank angle for the turbojet transports was 1.04 deg, and right and left angles of bank were about evenly divided. One lending in 100 would be likely to equal or exceed a bank angle of about 3.5 deg. The mean value of distance to touchdown from the runway threshold was 1,560 feet. One lending in 100 would be expected to touchdown at or beyond about 2,700 feet from the runway threshold. The mean values for vertical velocity, airspeed, and distance t o touch-down for the turbojet transports were somewhat higher than those found previously for piston-engine transports. No significant differences were found for values of rolling velocity and bank angle.
    Schlagwort(e): Aircraft Design, Testing and Performance
    Materialart: NASA-TN-D-527 , L-1009
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  • 71
    Publikationsdatum: 2019-08-17
    Beschreibung: An investigation has been made to determine the effects of nose bluntness on boundary-layer transition for a cone with an included angle of 10 degrees and for a hollow cylinder. The tests were conducted at Mach numbers of 1.41 and 2.01 for free-stream Reynolds numbers per foot ranging from 1 x 10(exp 6) to 9 x 10(exp 6). The investigation was made with the use of schlieren photography for which the models were aligned with the free stream. For the 10 degree cone, the favorable effects of nose blunting were so small at both test Mach numbers as to be lost within the experimental accuracy. For small amounts of nose blunting on the hollow cylinder, for which the ratio of bluntness height to transition distance for the sharp-leading-edge cylinder was relatively small, there was little, if any, effect of blunting on transition. For somewhat larger values of this ratio, nose blunting had a favorable effect on transition. The magnitude of the favorable effect was dependent upon the size and the shape of the bluntness, and the maximum increase in transition distance relative to the sharp-leading-edge cylinder is in good agreement with the theoretical predictions of NACA Technical Report 1312. For relatively large values of the ratio of nose bluntness to transition distance, the effects of nose blunting were adverse for both the cone and the cylinder. In general, adverse effects due to blunting were larger for the flat bluntness than for the hemispherical or the round bluntness of equal bluntness height. Increasing the Mach number increased the size of bluntness required to induce adverse effects at constant free-stream Reynolds number per foot, delayed the adverse effects to higher values of Reynolds number per foot for constant nose bluntness, and reduced the abruptness of the transition decrease.
    Schlagwort(e): Aircraft Design, Testing and Performance
    Materialart: NASA-TN-D-717 , L-762
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  • 72
    Publikationsdatum: 2019-08-17
    Beschreibung: An investigation has been made to determine the low-subsonic-speed static stability characteristics of several right-triangular-pyramid and half-cone configurations. Also studied were the effects of various modifications, such as base extensions, nose shape, nose incidence, and ridge-line shape. The investigation showed that, in general, the models had satisfactory longitudinal and lateral stability. The basic pyramid model and the conical ridge-line model with or without a rounded nose had almost identical longitudinal and lateral stability characteristics and lift-drag ratios. The lift-drag ratios of the cylindrical ridge-line and half-cone models were considerably lower than those of the conical ridge-line model. The addition of a 20 degree boattail to the models increased the lift-drag ratios but decreased the directional stability, whereas a streamwise base extension was more effective in increasing the lift-drag ratios and increased the directional stability.
    Schlagwort(e): Aircraft Design, Testing and Performance
    Materialart: NASA-TN-D-646 , L-1242
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  • 73
    Publikationsdatum: 2019-08-17
    Beschreibung: This paper presents the analysis of the flapwise natural bending frequencies and mode shapes of rotor blades with two flapping hinges located at arbitrary blade radii. The equations of motion are derived for a blade of variable mass and stiffness distribution. Solutions to the equations (natural frequencies and mode shapes) are presented for a typical blade of constant cross section having a wide range of hinge locations. The results show that the natural frequencies of the blades can be changed appreciably by varying the locations of the blade hinges, and that with two properly located flapping hinges, blade designs are possible which eliminate or greatly reduce conditions of resonance between the blade natural frequencies and the frequencies of the harmonic air loads. The results also show that ratios of natural frequency to rotor speed below a value of 6.0 are essentially constant for variations in rotor speed consistent with helicopter and VTOL applications.
    Schlagwort(e): Aircraft Design, Testing and Performance
    Materialart: NASA-TN-D-633
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  • 74
    Publikationsdatum: 2019-08-17
    Beschreibung: An investigation was conducted at the request of the U.S. Air Force Avionics Laboratory to analyze the flight characteristics of a small uncontrolled glider with folding wings. The study consisted of wind-tunnel tests of an actual glider and a theoretical analysis of the performance, stability, and trimmability of the configuration.
    Schlagwort(e): Aircraft Design, Testing and Performance
    Materialart: NASA-TM-SX-3205 , L-10031
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  • 75
    Publikationsdatum: 2019-08-17
    Beschreibung: During the first powered flight of the North American X-15 research airplane on September 17, 1959, a Mach number of 2.1 and an altitude of 52,000 feet were attained. Static and dynamic maneuvers were performed to evaluate the characteristics of the airplane at subsonic and supersonic speeds. Data from these maneuvers as well as from the launch and landing phases are presented, discussed, and compared with predicted values. The rate of separation of the X-15 from the B-52 carrier airplane at launch was less than that predicted by wind-tunnel studies and was less rapid than in the lightweight condition of the initial glide flight. In addition, the angular motions and bank angle attained following the launch were of lesser magnitude than in the glide flight. Stable longitudinal-stability trends were apparent during the acceleration to maximum speed, and the pilot reported experiencing little or no transonic trim excursions. An inexplicable high-frequency vibration, which occurred at Mach numbers above 1.4, is being investigated further. Essentially linear lift and stability characteristics were indicated within the limited ranges of angle of attack and angle of sideslip investigated. The dynamic longitudinal and lateral-directional stability and control-effectiveness characteristics appeared satisfactory to the pilot. Although the longitudinal- and lateral-directional-damping ratios showed no significant change from subsonic to supersonic speeds, on the basis of time to damp, the damping characteristics at supersonic speeds appeared to the pilot to be somewhat improved over those at subsonic speeds.
    Schlagwort(e): Aircraft Design, Testing and Performance
    Materialart: NASA-TM-X-269
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  • 76
    Publikationsdatum: 2019-08-17
    Beschreibung: The take-off distances over a 35-foot obstacle have been determined for a supersonic transport configuration characterized by a low maximum lift coefficient at a high angle of attack and by high drag due to lift. These distances were determined analytically by means of an electronic digital computer. The effects of rotation speed, rotation angle, and rotation time were determined. A few configuration changes were made to determine the effects of thrust-weight ratio, wing loading, maximum lift coefficient, and induced drag on the take-off distance. The required runway lengths based on Special Civil Air Regulation No. SR-422B were determined for various values of rotation speed and compared with those based on full engine power. Increasing or decreasing the rotation speed as much as 5 knots from the value at which the minimum take-off distance occurred increased the distance only slightly more than 1 percent for the configuration studied. Under-rotation by 1 deg to 1.5 deg increased the take-off distance by 9 to 15 percent. Increasing the time required for rotation from 3 to 5 seconds had a rather small effect on the take-off distance when the values of rotation speed were near the values which result in the shortest take-off distance. When the runway length is based on full engine power rather than on SR-422B, the rotation speed which results in the shortest required runway length is 10 knots lower and the runway length is 4.3 percent less.
    Schlagwort(e): Aircraft Design, Testing and Performance
    Materialart: NASA-TN-D-982 , L-1728
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  • 77
    Publikationsdatum: 2019-08-17
    Beschreibung: An investigation has been conducted at low subsonic speeds to study the effects of canard planform and wing-leading-edge modification on the longitudinal aerodynamic characteristics of a general research canard airplane configuration. The basic wing of the model had a trapezoidal planform, an aspect ratio of 3.0, a taper ratio of 0.143, and an unswept 80-percent-chord line. Modifications to the wing included addition of full-span and partial-span leading-edge chord-extensions. Two canard planforms were employed in the study; one was a 60 deg sweptback delta planform and the other was a trapezoidal planform similar to that of the basic wing. Modifications to these canards included addition of a full-span leading-edge chord-extension to the trapezoidal planform and a fence to the delta planform. For the basic-wing-trapezoidal-canard configuration, rather abrupt increases in stability occurred at about 12 deg angle of attack. A slight pitch-up tendency occurred for the delta-canard configuration at approximately 8 deg angle of attack. A comparison of the longitudinal control effectiveness for the basic-wing-trapezoidal-canard combination and for the basic-wing-delta-canard combination indicates higher values of control effectiveness at law angles of attack for the trapezoidal canard. The control effectiveness for the delta-canard configuration, however, is seen to hold up for higher canard deflections and to higher angles of attack. Use of a full-span chord-extension deflected approximately 30 deg on the trapezoidal canard greatly improved the control characteristics of this configuration and enabled a sizeable increase in trim lift to be realized.
    Schlagwort(e): Aircraft Design, Testing and Performance
    Materialart: NASA-TN-D-958 , L-1372
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  • 78
    Publikationsdatum: 2019-08-17
    Beschreibung: General equations are developed for the design of efficient structures protected from thermal environments typical of those encountered in boost-glide or atmospheric-reentry conditions. The method is applied to insulated heat-sink stressed-skin structures and to internally cooled insulated structures. Plates loaded in compression are treated in detail. Under limited conditions of plate buckling, high loading, and short flight periods, and for aluminum structures only, the weights of both configurations are nearly equal. Load parameters are found and are similar to those derived in previous investigations for the restricted case of a constant equilibrium temperature at the outside surface of the insulation.
    Schlagwort(e): Aircraft Design, Testing and Performance
    Materialart: NASA-TN-D-990 , L-991
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  • 79
    Publikationsdatum: 2019-08-17
    Beschreibung: The model was tested at two different elevations with the wing pivot at 1.008 and 2.425 propeller diameters above the ground. The slipstream of the propellers was deflected by tilting the wing and propellers, by deflections of large-chord trailing-edge flaps, and by combinations of flap deflection and wing tilt. Tests were conducted over a range of propeller disk loadings from 7.41 to 29.70 pounds per square foot. Force data for the complete model and pressure distributions for the wing and flaps behind one propeller were recorded and are presented in tabular form without analysis.
    Schlagwort(e): Aircraft Design, Testing and Performance
    Materialart: NASA-TN-D-397 , L-987
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  • 80
    Publikationsdatum: 2019-08-17
    Beschreibung: A numerical study was made of the effects of blade cutout on the power required by a sample helicopter rotor traveling at tip-speed ratios of 0.3, 0.4, and 0.5. The amount of cutout varied from 0 to 0.5 of the rotor radius and the calculations were carried out for a thrust coefficient-solidity ratio of 0.04. In these calculations the blade within the cutout radius was assumed to have zero chord. The effect of such cutout on profile-drag power ranged from almost no effect at a tip-speed ratio of 0.3 to as much as a 60 percent reduction at a tip-speed ratio of 0.5. Optimum cutout was about 0.3 of the rotor radius. Part of the large power reduction at a tip-speed ratio of 0.5 resulted from a reduction in tip-region stall, brought about by cutout. For tip-speed ratios greater than 0.3, cutout also effected a significant increase in the ability of the rotor to overcome helicopter parasite drag. It is thus seen that the adverse trends (at high tip-speed ratios) indicated by the uniform-chord theoretical charts are caused in large measure by the center portion of the rotor. The extent to which a modified-design rotor can actually be made more efficient at high speeds than a uniform-chord rotor will depend in practice on the degree of success in minimizing the blade plan form near the center and on special modifications in center-section profiles. A few suggestions and estimates in regard to such modifications are included herein.
    Schlagwort(e): Aircraft Design, Testing and Performance
    Materialart: NASA-TN-D-382 , L-696
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  • 81
    facet.materialart.
    Unbekannt
    In:  CASI
    Publikationsdatum: 2019-08-17
    Beschreibung: A free-flight investigation of two radio-controlled models with parawings, a glider configuration and an airplane (powered) configuration, was made to evaluate the performance, stability, and methods of controlling parawing vehicles. The flight tests showed that the models were stable and could be controlled either by shifting the center of gravity or by using conventional elevator and rudder control surfaces. Static wind-tunnel force-test data were also obtained.
    Schlagwort(e): Aircraft Design, Testing and Performance
    Materialart: NASA-TN-D-927 , L-1374
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  • 82
    Publikationsdatum: 2019-08-17
    Beschreibung: The aerodynamic characteristics of a hypersonic glider configuration, consisting of a slender ogive cylinder with three highly swept wings, spaced 120 apart, with the wing chord equal to the body length, were investigated experimentally at a Mach number of 6 and at Reynolds numbers from 6 to 16 million. The objectives were to evaluate the theoretical procedures which had been used to estimate the performance of the glider, and also to evaluate the characteristics of the glider itself. A principal question concerned the viscous drag at full-scale Reynolds number, there being a large difference between the total drags for laminar and turbulent boundary layers. It was found that the procedures which had been applied for estimating minimum drag, drag due to lift, lift curve slope, and center of pressure were generally accurate within 10 percent. An important exception was the non-linear contribution to the lift coefficient which had been represented by a Newtonian term. Experimentally, the lift curve was nearly linear within the angle-of-attack range up to 10 deg. This error affected the estimated lift-drag ratio. The minimum drag measurements indicated that substantial amounts of turbulent boundary layer were present on all models tested, over a range of surface roughness from 5 microinches maximum to 200 microinches maximum. In fact, the minimum drag coefficients were nearly independent of the surface smoothness and fell between the estimated values for turbulent and laminar boundary layers, but closer to the turbulent value. At the highest test Reynolds numbers and at large angles of attack, there was some indication that the skin friction of the rough models was being increased by the surface roughness. At full-scale Reynolds number, the maximum lift-drag ratio with a leading edge of practical diameter (from the standpoint of leading-edge heating) was 4.0. The configuration was statically and dynamically stable in pitch and yaw, and the center of pressure was less than 2-percent length ahead of the centroid of plan-form area.
    Schlagwort(e): Aircraft Design, Testing and Performance
    Materialart: NASA-TN-D-341
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  • 83
    Publikationsdatum: 2019-08-17
    Beschreibung: An aircraft configuration, previously conceived as a means to achieve favorable aerodynamic stability characteristics., high lift-drag ratio, and low heating rates at high supersonic speeds., was modified in an attempt to increase further the lift-drag ratio without adversely affecting the other desirable characteristics. The original configuration consisted of three identical triangular wing panels symmetrically disposed about an ogive-cylinder body equal in length to the root chord of the panels. This configuration was modified by altering the angular disposition of the wing panels, by reducing the area of the panel forming the vertical fin, and by reshaping the body to produce interference lift. Six-component force and moment tests of the modified configuration at combined angles of attack and sideslip were made at a Mach number of 3.3 and a Reynolds number of 5.46 million. A maximum lift-drag ratio of 6.65 (excluding base drag) was measured at a lift coefficient of 0.100 and an angle of attack of 3.60. The lift-drag ratio remained greater than 3 up to lift coefficient of 0.35. Performance estimates, which predicted a maximum lift-drag ratio for the modified configuration 27 percent greater than that of the original configuration, agreed well with experiment. The modified configuration exhibited favorable static stability characteristics within the test range. Longitudinal and directional centers of pressure were slightly aft of the respective centroids of projected plan-form and side area.
    Schlagwort(e): Aircraft Design, Testing and Performance
    Materialart: NASA-TN-D-330
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  • 84
    facet.materialart.
    Unbekannt
    In:  CASI
    Publikationsdatum: 2019-08-16
    Beschreibung: After studying three Tech Briefs reports on NASA submerged duct technology developed for high performance aircraft, Wilhelm Cashen was able to adapt the technology to the induction intercooler system of turbocharged lightplanes. In lightplane installations, the submerged ducts introduce cool "ram" air to the propulsion system for greater operating efficiency.
    Schlagwort(e): Aircraft Design, Testing and Performance
    Materialart: Spinoff 1984; 95
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  • 85
    Publikationsdatum: 2019-08-16
    Beschreibung: Near-field and far-field noise surveys were made of the supersonic The exhaust jet of the Langley 9- by 6-foot thermal structures tunnel. The jet had a thrust rating of approximately 475,000 pounds. The sound power radiated was found to be about 3.6 x 10(exp 6) watts, and on an acoustical-mechanical efficiency basis this value is in reasonable agreement with data for smaller supersonic jets and for rocket engines of other investigations. Octave-band analyses of the near-field noise show that the maximum sound pressure levels in the low-frequency bands are greatest downstream, whereas maximum sound pressure levels in the high-frequency bands were greatest near the jet exit. A comparison of near-field noise measurements is made with data previously obtained for rocket engines. Noise survey measurements of the original jet are compared with similar data obtained after the addition of a 97-foot-long exit diffuser section, and an example of the application of this facility to the problem of acoustic environmental testing of a large space capsule is cited.
    Schlagwort(e): Aircraft Design, Testing and Performance
    Materialart: NASA-TN-D-517 , L-499
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  • 86
    Publikationsdatum: 2019-08-16
    Beschreibung: An experimental investigation was conducted to evaluate the heat-transfer rates at the apex of two 60 degree sweptback delta wings (panel semi-apex angle of 30 degrees) having cylindrical leading edges and 0 degrees and 45 degree positive dihedral. The models tested might correspond to the first several feet of a hypersonic reentry vehicle. The tests were conducted at a Mach number of 4.95 and a stagnation temperature of 400 F. nominal test-section unit Reynolds numbers varied from 2 x 10(exp 6) to 12 x 10(exp 6) per foot. The results of the investigation indicated that the laminar heat-transfer distributions (ratio of local to stagnation-line heating rate) about the models normal to the leading edges were in close agreement with two-dimensional blunt-body theory. The three-dimensional stagnation point heat-transfer rate on the 0 degree dihedral model was in excellent agreement with theory and the stagnation-line heat transfer on the straight portion of the leading edge of both models approached a constant level 12 percent above the theoretical stagnation-line level on an isolated swept infinite cylinder. When the heating rates on the 45 degree dihedral model (planform sweep of 69.3 degree) were compared with those on the 0 degree dihedral model (planform sweep of 60 degrees) at equal angles of attack and equal lifts greater than zero, the stagnation-line heating rates on the 45 degrees dihedral model were, in general, considerably lower as a result of the difference in effective sweeps of the leading edges. On the wing panels inboard from the stagnation lines, the differences in heating were very small. The stagnation-line heat-transfer variation with angle of attack, the shift in stagnation-line location, and the reduction in stagnation-line heat transfer resulting from the increase in effective sweep when positive dihedral is incorporated into a constant-panel 0 degree dihedral wing, all agreed with the results of a theoretical study made of highly swept delta wings with large positive dihedral.
    Schlagwort(e): Aircraft Design, Testing and Performance
    Materialart: NASA-TN-D-550 , L-963
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  • 87
    Publikationsdatum: 2019-08-16
    Beschreibung: An approximate method for the estimation of laminar heat transfer to blunt bodies with gaseous film cooling i s developed. Attention is focused on the parameters which are important for the design of an attractive heat protection system. Application of the analysis is made to calculate the approximate coolant weight requirement for both a circular and a parabolic entry.
    Schlagwort(e): Aircraft Design, Testing and Performance
    Materialart: NASA-TN-D-861 , A-499
    Format: application/pdf
    Standort Signatur Erwartet Verfügbarkeit
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  • 88
    Publikationsdatum: 2019-08-16
    Beschreibung: A series of semispan wing models having various spanwise distributions of both thickness ratio and chord but having the same effective thickness ratio was tested in the Langley 4-by 4-foot supersonic pressure tunnel at Mach number 2.03 and Reynolds numbers from 1.9 x 10(exp 6) to 6.5 x 10(exp 6) complex wing forms with thickened roots, extended root chords, and higher volumes show appreciably lower zero-lift wave drag coefficients than the plain swept wings. A calculative technique for the determination of wave drag has been applied to one of the complex wings of the series and good agreement is shown with experimental results. The complex wing forms showed higher drags due to lift than the plain swept wings.
    Schlagwort(e): Aircraft Design, Testing and Performance
    Materialart: NASA-TN-D-631
    Format: text
    Standort Signatur Erwartet Verfügbarkeit
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  • 89
    Publikationsdatum: 2019-08-16
    Beschreibung: The experimental wing buffet response of a transport-type airplane model with and without wing bodies, fences, flaps, and a fuselage addition has been investigated at Mach numbers from 0.20 to 1.03. The wing had NACA 64A-series airfoil sections inclined 5 degrees to the free-stream direction. The quarter-chord line of the wing was swept back 45 degrees, the aspect ratio was 7, the taper ratio was 0.3, and the thickness ratio varied from 0.115 at the root to 0.074 at the midsemispan and was constant from that station to the tip. The wing was twisted and cambered for a design lift coefficient of 0.3. The results of the investigation indicated that a marked reduction of buffet intensity and a delay of buffet onset at transonic speeds were achieved by the addition to the wing of special bodies designed to reduce shock-induced separation. The further addition of wing fences and wing trailing-edge flaps deflected 30 degrees increased the lift coefficients at which low-speed stall buffeting occurred. An addition to the fuselage near the upper forward portion produced no consistent change in the buffet characteristics.
    Schlagwort(e): Aircraft Design, Testing and Performance
    Materialart: NASA-TN-D-637
    Format: application/pdf
    Standort Signatur Erwartet Verfügbarkeit
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  • 90
    Publikationsdatum: 2019-08-16
    Beschreibung: Data obtained with NASA VGH and V-G recorders installed on three types of turboprop and one type of turbojet commercial transport air- plane have been analyzed to determine the relation of the maximum operational speeds to the placard normal-operating and never-exceed speeds. The frequency of exceeding the placard speeds is compared with corresponding results for past operations with piston-powered transports. In addition, data pertaining to the operational altitudes and the average airspeeds in rough and smooth air for the turbine-powered transports are presented.
    Schlagwort(e): Aircraft Design, Testing and Performance
    Materialart: NASA-TN-D-744
    Format: text
    Standort Signatur Erwartet Verfügbarkeit
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  • 91
    Publikationsdatum: 2019-08-16
    Beschreibung: An experimental investigation has been made to determine the dynamic stability and control characteristics of a 1/6-scale flying model of the Hawker P lIP7 jet vertical-take-off-and-landing (VTOL) airplane in hovering and transition flight. The model was powered by a counter-rotating ducted fan driven by compressed-air jets at the tips of the fan blades. In hovering flight the model was controlled by jet-reaction controls which consisted of yaw and pitch jets at the extremities of the fuselage and a roll jet on each wing tip. In forward flight the model was controlled by conventional ailerons and rudder and an all-movable horizontal tail. In hovering flight the model could be flown smoothly and easily, but the roll control was considered too weak for rapid maneuvering or hovering in gusty air. Transitions from hovering to normal forward flight and back to hovering could be made smoothly and consistently and with only moderate changes in longitudinal trim. The model had a static longitudinal instability or pitch-up tendency throughout the transition range, but the rate of divergence in the pitch-up was moderate and the model could be controlled easily provided the angle of attack was not allowed to become too high. In both the transition and normal forward flight conditions the lateral motions of the model were difficult to control at high angles of attack, apparently because of low directional stability at small angles of sideslip. The longitudinal stability of the model in normal forward flight was generally satisfactory, but there was a decided pitch-up tendency for the flap-down condition at high angles of attack. In the VTOL landing approach condition, with the jets directed straight down or slightly forward, the nose-down pitch trim required was greater than in the transitions from hovering to forward flight, but the longitudinal instability was about the same. Take-offs and landings in still air could be made smoothly although there was a slight unfavorable ground effect on lift and a nose-down change in pitch trim near the ground. Short take-offs and landings could be made smoothly and consistently although the model experienced a decided nose-up change in pitching moment as it climbed out of ground effect.
    Schlagwort(e): Aircraft Design, Testing and Performance
    Materialart: NASA-TM-SX-531 , L-1484
    Format: application/pdf
    Standort Signatur Erwartet Verfügbarkeit
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  • 92
    Publikationsdatum: 2019-08-16
    Beschreibung: The lift and drag characteristics of a Boeing KC-135 airplane were determined during maneuvering flight over the Mach number range from 0.70 to 0.85 for the airplane in the clean configuration at an altitude of 26,000 feet. Data were also obtained over the speed range of 130 knots to 160 knots at 9,000 feet for various flap deflections with gear down.
    Schlagwort(e): Aircraft Design, Testing and Performance
    Materialart: NASA-TN-D-30 , H-119
    Format: application/pdf
    Standort Signatur Erwartet Verfügbarkeit
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  • 93
    Publikationsdatum: 2019-08-16
    Beschreibung: An analytical investigation is made of a precession-type instability which can occur in a flexibly supported aircraft-engine-propeller combination. By means of an idealized mathematical model which is comprised of a rigid power-plant system flexibly mounted in pitch and yaw to a fixed backup structure, the conditions required for neutral stability are determined. The paper also examines the sensitivity of the stability boundaries to changes in such parameters as stiffness, damping, and asymmetries in the engine mount, propeller speed, airspeed, Mach number, propeller thrust, and location of pitch and yaw axes. Stability is found to depend strongly on the damping and stiffness in the system. With the use of nondimensional charts, theoretical stability boundaries are compared with experimental results obtained in wind-tunnel tests of an aeroelastic airplane model. In general, the theoretical results, which do not account for wing response, show the same trends as observed experimentally; however, for a given set of conditions calculated airspeeds for neutral stability are consistently lower than the measured values. Evidently, this result is due to the fact that wing response tends to add damping to the system.
    Schlagwort(e): Aircraft Design, Testing and Performance
    Materialart: NASA-TN-D-659
    Format: application/pdf
    Standort Signatur Erwartet Verfügbarkeit
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  • 94
    Publikationsdatum: 2019-08-13
    Beschreibung: This note discusses the limitations of the conventional tank test of a seaplane model. The advantages of a complete test, giving the characteristics of the model at all speeds, loads, and trim angles in the useful range are pointed out. The data on N.A.C.A. Model No.11, obtained from a complete test, are presented and discussed. The results are analyzed to determine the best trim angle for each speed and load. The data for the best angles are reduced to non-dimensional form for ease of comparison and application. A practical problem using the characteristics of model no.11 is presented to show the method of calculating the take-off time and run of a seaplane from these data.
    Schlagwort(e): Aircraft Design, Testing and Performance
    Materialart: NACA-TN-464
    Format: application/pdf
    Standort Signatur Erwartet Verfügbarkeit
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  • 95
    facet.materialart.
    Unbekannt
    In:  CASI
    Publikationsdatum: 2019-08-14
    Beschreibung: This catalog gives the selenographic coordinates of all craters observable on a selected portion of the moon's surface. The diameter of the crater together with comments on shape are also given. Approximately 25 per cent of the craters have been measured previously by other observers. The catalog gives the position found in the present series of measurements and the name adopted by the International Astronomical Union.
    Schlagwort(e): Aircraft Design, Testing and Performance
    Materialart: HQ-E-DAA-TN50637
    Format: application/pdf
    Standort Signatur Erwartet Verfügbarkeit
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  • 96
    facet.materialart.
    Unbekannt
    In:  CASI
    Publikationsdatum: 2019-08-13
    Beschreibung: The interpretation of the take-off resistance of seaplane floats by model test involves a problem in mechanics, the solution of which forms the basis of this report. The comparison of three float forms is confined to an angle = 5 degree trim run in order to preserve the clearness of the arrangement. But for complete comparison the corresponding curves for several trim runs should be included.
    Schlagwort(e): Aircraft Design, Testing and Performance
    Materialart: NACA-TM-621 , Zeitschrift fur Flugtechnik und Motorluftschiffahrt; 22; 8-12; 1
    Format: text
    Standort Signatur Erwartet Verfügbarkeit
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  • 97
    Publikationsdatum: 2019-08-15
    Beschreibung: Brief dynamic-model tests have been made at the request of the Federal Aviation Agency to investigate the use of a shallow pond of water at the end of a runway as a means of arresting jet-transport aircraft when they are forced to abort on take-off or overrun on landing. Such a scheme is of particular interest for civil aircraft because it requires no modifications or attachments to the airplane and no mechanical devices in the arresting system. A modification of this scheme that uses a flexible plastic cover over the water surface has also been tested. The purpose of this paper is to present the results of a dynamic model investigation which would aid in determining whether the water-pond arresting system could be used as a means of arresting airplane overrun.
    Schlagwort(e): Aircraft Design, Testing and Performance
    Materialart: NASA-TN-D-732 , L-1318
    Format: text
    Standort Signatur Erwartet Verfügbarkeit
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  • 98
    Publikationsdatum: 2019-08-15
    Beschreibung: An investigation at low subsonic speeds has been conducted in the Langley 300-MPH 7- by 10-foot tunnel. The basic wing had a trapezoidal planform, an aspect ratio of 3.0., a taper ratio of 0.143, and an unswept 80-percent-chord line. Modifications to the basic wing included deflectable full-span and partial-span leading-edge chord-extensions. A trapezoidal horizontal control similar in planform to the basic wing and a 60 deg sweptback delta horizontal control were tested in conjunction with the wing. The total planform area of each horizontal control was 16 percent of the total basic-wing area. Modifications to these horizontal controls included addition of a full-span chord-extension to the trapezoidal planform and a fence to the delta planform.
    Schlagwort(e): Aircraft Design, Testing and Performance
    Materialart: NASA-TM-X-549 , L-1372
    Format: application/pdf
    Standort Signatur Erwartet Verfügbarkeit
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  • 99
    Publikationsdatum: 2019-08-15
    Beschreibung: An attempt has been made to determine the importance of rolling performance and other factors in the design of an interceptor which uses collision-course tactics. A graphical method is presented for simple visualization of attack situations. By means of diagrams showing vectoring limits, that is, the ranges of interceptor position and heading from which attacks may be successfully completed, the relative importance of rolling performance and normal-acceleration capability in determining the success of attacks is illustrated. The results indicate that the reduction in success of attacks due to reduced rolling performance (within the limits generally acceptable from the pilots' standpoint) is very small, whereas the benefits due to substantially increasing the normal-acceleration capability are large. Additional brief analyses show that the optimum speed for initiating a head-on attack is often that corresponding to the upper left-hand corner of the V-g diagram. In these cases, increasing speed beyond this point for given values of normal acceleration and radar range rapidly decreases the width of the region from which successful attacks can be initiated. On the other hand, if the radar range is increased with a variation somewhere between the first and second power of the interceptor speed, the linear dimensions of the region from which successful attacks can be initiated vary as the square of the interceptor speed.
    Schlagwort(e): Aircraft Design, Testing and Performance
    Materialart: NASA-TN-D-952
    Format: application/pdf
    Standort Signatur Erwartet Verfügbarkeit
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  • 100
    Publikationsdatum: 2019-08-15
    Beschreibung: Incipient- and developed-spin and recovery characteristics of a modern high-speed fighter design with low aspect ratio have been investigated by means of dynamic model tests. A 1/7-scale radio-controlled model was tested by means of drop tests from a helicopter. Several 1/25-scale models with various configuration changes were tested in the Langley 20-foot free-spinning tunnel. Model results indicated that generally it would be difficult to obtain a developed spin with a corresponding airplane and that either the airplane would recover of its own accord from any poststall motion or the poststall motion could be readily terminated by proper control technique. On occasion, however, the results indicated that if a post-stall motion were allowed to continue, a fully developed spin might be obtainable from which recovery could range from rapid to no recovery at all, even when optimum control technique was used. Satisfactory recoveries could be obtained with a proper-size tail parachute or strake, application of pitching-, rolling-, or yawing-moment rockets, or sufficient differential deflection of the horizontal tail.
    Schlagwort(e): Aircraft Design, Testing and Performance
    Materialart: NASA-TN-D-956 , L-1662
    Format: application/pdf
    Standort Signatur Erwartet Verfügbarkeit
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