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  • Articles  (133)
  • Rats  (133)
  • American Association for the Advancement of Science (AAAS)  (133)
  • 2025-2025
  • 1990-1994
  • 1980-1984  (133)
  • 1980  (133)
  • 1929
  • Chemistry and Pharmacology  (133)
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  • Process Engineering, Biotechnology, Nutrition Technology
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  • Articles  (133)
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Keywords
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  • American Association for the Advancement of Science (AAAS)  (133)
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  • 2025-2025
  • 1990-1994
  • 1980-1984  (133)
Year
Journal
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  • 101
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    New techniques for selective immune suppression increase transplant odds (1980)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1980-10-03
    Description: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Maugh, T A 2nd -- New York, N.Y. -- Science. 1980 Oct 3;210(4465):44-6.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/6774417" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; Antilymphocyte Serum/therapeutic use ; Blood Transfusion ; Bone Marrow Transplantation ; Cyclosporins ; Drainage ; *Graft Survival/drug effects ; Haplorhini ; Heart Transplantation ; Humans ; Immunosuppression/*methods ; Immunosuppressive Agents/therapeutic use ; Infection Control ; Kidney Transplantation ; Lung Transplantation ; Lymphatic System/radiation effects ; Lymphocyte Depletion ; Mice ; Peptides, Cyclic/therapeutic use ; Rats ; T-Lymphocytes/drug effects/immunology ; Thoracic Duct/surgery ; Transplantation, Homologous
    Print ISSN: 0036-8075
    Electronic ISSN: 1095-9203
    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
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  • 102
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    Evidence for L-glutamate as the neurotransmitter of baroreceptor afferent nerve fibers (1980)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1980-08-15
    Description: Microinjection of L-glutamate into the intermediate nucleus tractus solitarii in anesthetized rats elicits hypotension, bradycardia, and apnea, simulating baroreceptor reflexes. Ablation of the nodose ganglion results in selective reduction of high-affinity uptake of L-glutanate in the nucleus tractus solitarii. L-Glutamate may be the neurotransmitter of afferent nerve fibers from arterial baroreceptors.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Talman, W T -- Perrone, M H -- Reis, D J -- New York, N.Y. -- Science. 1980 Aug 15;209(4458):813-5.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/6105709" target="_blank"〉PubMed〈/a〉
    Keywords: Afferent Pathways/physiology ; Animals ; Blood Pressure/drug effects ; Brain Mapping ; Glutamates/pharmacology/*physiology ; Heart Rate/drug effects ; Kainic Acid/pharmacology ; Medulla Oblongata/*physiology ; Neurotransmitter Agents/*physiology ; Pressoreceptors/*physiology ; Rats ; Reflex/drug effects ; Respiration/drug effects
    Print ISSN: 0036-8075
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    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
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  • 103
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    Insulin binding sites localized to nerve terminals in rat median eminence and arcuate nucleus (1980)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1980-03-07
    Description: Specific binding sites for blood-borne insulin were determined to be selectively localized on axons and axon terminals in the external median eminence and the hypothalamic arcuate nucleus by means of quantitative fine structural radioautography. This localization suggests that discrete populations of hypothalamic nerve terminals are potential targets for the direct effects of insulin and that insulin may act through synaptic mechanisms to influence hypothalamic circuits regulating energy balance and hypophyseal function.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉van Houten, M -- Posner, B I -- Kopriwa, B M -- Brawer, J R -- New York, N.Y. -- Science. 1980 Mar 7;207(4435):1081-3.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/6986652" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; Autoradiography ; Axons/metabolism ; Hypothalamo-Hypophyseal System/*metabolism ; Hypothalamus/blood supply/cytology/*metabolism ; Insulin/blood/*metabolism ; Median Eminence/*metabolism ; Microcirculation ; Nerve Endings/metabolism ; Rats ; Receptor, Insulin/*metabolism ; Synapses/metabolism
    Print ISSN: 0036-8075
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    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
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  • 104
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    Evidence for homologous actions of pro-opiocortin products (1980)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1980-12-12
    Description: alpha-Melanocyte-stimulating hormone (alpha-MSH), a modified fragment of adrenocorticotropic hormone, derives from the same biosynthetic route as beta-endorphin and is stored by the same arcuate neurons. Microinjection of alpha-melanocyte-stimulating hormone and several related peptides into the periaqueductal gray matter significantly reduced responsiveness to pain and had a behavioral profile similar to that produced by beta-endorphin.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Walker, J M -- Akil, H -- Watson, S J -- 1F32DAO5183/DA/NIDA NIH HHS/ -- New York, N.Y. -- Science. 1980 Dec 12;210(4475):1247-9.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/6254152" target="_blank"〉PubMed〈/a〉
    Keywords: Adrenocorticotropic Hormone/*pharmacology ; Analgesia ; Animals ; Brain/*drug effects ; Cerebral Aqueduct ; Endorphins/*pharmacology ; Male ; Melanocyte-Stimulating Hormones/*pharmacology ; Pain/*physiopathology ; Pituitary Hormones, Anterior/*metabolism ; Pro-Opiomelanocortin ; Protein Precursors/*pharmacology ; Rats
    Print ISSN: 0036-8075
    Electronic ISSN: 1095-9203
    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
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  • 105
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    Maternal stress alters plasma testosterone in fetal males (1980)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1980-01-18
    Description: Titers of testosterone in plasma were determined by radioimmunoassay in male rat fetuses of stressed and control mothers on days 17, 18, 19, 21, and 23 (the day of birth) after conception. In fetuses of stressed mothers, testosterone concentrations were highest on day 17, declined on days 18 and 19, and then remained unchanged. In the control fetuses, testosterone increased from relatively low concentrations on day 17 to the highest amounts on days 18 and 19, and then declined. Thus, the persistence of feminine and impaired masculine sexual behavior in male offspring of stressed mothers could be due to the absence of a surge of circulating testosterone during days 18 and 19 after conception, a period postulated to be critical in the development of the central nervous system in the rat.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Ward, I L -- Weisz, J -- New York, N.Y. -- Science. 1980 Jan 18;207(4428):328-9.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/7188648" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; Disorders of Sex Development/embryology ; Female ; Fetal Blood/*analysis ; Gestational Age ; Humans ; Male ; Pregnancy ; Rats ; *Sex Differentiation ; Stress, Psychological/blood/*physiopathology ; Testosterone/*blood
    Print ISSN: 0036-8075
    Electronic ISSN: 1095-9203
    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
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  • 106
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    Glucose suppresses basal firing and haloperidol-induced increases in the firing rate of central dopaminergic neurons (1980)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1980-12-12
    Description: In the rat, doses of glucose sufficient to raise glucose concentrations in the blood to levels equivalent to those produced by a meal or stress suppress the firing of dopamine-containing neurons located within the substantia nigra. Glucose also prevents or reverses the increase in discharge rates of dopaminergic cells normally elicited by the antipsychotic agent haloperidol.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Saller, C F -- Chiodo, L A -- 5T 32-MH14634/MH/NIMH NIH HHS/ -- MH 16581/MH/NIMH NIH HHS/ -- New York, N.Y. -- Science. 1980 Dec 12;210(4475):1269-71.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/6254155" target="_blank"〉PubMed〈/a〉
    Keywords: Action Potentials/drug effects ; Animals ; Dopamine/*physiology ; Fructose/pharmacology ; Glucose/*pharmacology ; Haloperidol/*antagonists & inhibitors ; Male ; Rats ; Substantia Nigra/*drug effects/physiology ; Synaptic Transmission/*drug effects
    Print ISSN: 0036-8075
    Electronic ISSN: 1095-9203
    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
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  • 107
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    Environmental influences on serotonin and cyclic nucleotides in rat cerebral cortex (1980)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1980-11-07
    Description: The response to different environmental conditions and negative air ions was investigated on cerebral cortical serotonin and cyclic nucleotides. The results indicated that negative air ions alter the weight of the cerebral cortex and that concentrations of serotonin and cyclic nucleotides can be altered both by different environments and by negative air ions. The data stress the importance of the role of the environment when studying the structure and chemistry of the cerebral cortex.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Diamond, M C -- Connor, J R Jr -- Orenberg, E K -- Bissell, M -- Yost, M -- Krueger, A -- New York, N.Y. -- Science. 1980 Nov 7;210(4470):652-4.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/6254145" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; Anions ; Atmosphere ; Brain/growth & development ; Cerebral Cortex/*metabolism ; Crowding ; Cyclic AMP/metabolism ; Cyclic GMP/metabolism ; *Environment ; Male ; Nucleotides, Cyclic/*metabolism ; Rats ; Serotonin/*metabolism
    Print ISSN: 0036-8075
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  • 108
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    Stimulation of DNA and collagen synthesis by autologous growth factor in cultured fetal rat calvaria (1980)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1980-11-28
    Description: Conditioned medium derived from organ or cell cultures prepared from 19- to 21-day fetal rat calvaria stimulated the incorporation of [3H]proline collagen and of [3H]thymidine into DNA in organ cultures of the same tissue. Addition of cortisol enhanced the effect on collagen but not on DNA synthesis. These effects appeared to be due to a nondialyzable and heat-stable growth factor.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Canalis, E -- Peck, W A -- Raisz, L G -- AM-18063/AM/NIADDK NIH HHS/ -- AM-19855/AM/NIADDK NIH HHS/ -- New York, N.Y. -- Science. 1980 Nov 28;210(4473):1021-3.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/7434011" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; *Bone Development ; Bone and Bones/*physiology ; Collagen/*biosynthesis ; Culture Techniques ; DNA/biosynthesis ; Growth Substances/isolation & purification/*physiology ; Hydrocortisone/pharmacology ; Rats ; Skull
    Print ISSN: 0036-8075
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  • 109
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    Long-lasting depletion of striatal dopamine by a single injection of amphetamine in iprindole-treated rats (1980)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1980-07-11
    Description: A single injection of amphetamine given to rats treated concurrently with iprindole so that they could not metabolize the amphetamine by para-hydroxylation resulted in a decrease in the concentration of striatal dopamine 1 week later. The decrease was antagonized by amfonelic acid, an inhibitor of uptake into dopamine neurons. The long-lasting depletion of cerebral dopamine by amphetamine may be analogous to the depletion of cerebral serotonin by halogenated derivatives of amphetamine.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Fuller, R W -- Hemrick-Luecke, S -- New York, N.Y. -- Science. 1980 Jul 11;209(4453):305-7.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/7384808" target="_blank"〉PubMed〈/a〉
    Keywords: Amphetamine/*pharmacology ; Animals ; Brain/drug effects/metabolism ; Corpus Striatum/drug effects/*metabolism ; Dopamine/*metabolism ; Epinephrine/metabolism ; Indoles/*pharmacology ; Iprindole/*pharmacology ; Male ; Naphthyridines/pharmacology ; Norepinephrine/metabolism ; Organ Specificity ; Rats ; p-Chloroamphetamine/pharmacology
    Print ISSN: 0036-8075
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  • 110
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    Nigral dopamine neurons: intracellular recording and identification with L-dopa injection and histofluorescence (1980)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1980-11-07
    Description: Intracellular recordings in vivo were obtained from dopamine-containing neurons of the rat substantia nigra. These neurons were identified electrophysiologically by antidromic activation and histochemically by L-dopa injection and subsequent fluorescence histochemistry. Extracellular spikes and antidromic conduction velocity of the neurons were identical to those previously described for putative dopaminergic neurons. Spontaneous intracellular fast potentials, slow depolarizations during burst firing, and spike prepotentials were observed.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Grace, A A -- Bunney, B S -- MH-25642/MH/NIMH NIH HHS/ -- MH-28849/MH/NIMH NIH HHS/ -- New York, N.Y. -- Science. 1980 Nov 7;210(4470):654-6.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/7433992" target="_blank"〉PubMed〈/a〉
    Keywords: Action Potentials ; Animals ; Dopamine/*metabolism ; Hippocampus/physiology ; Levodopa/metabolism ; Membrane Potentials ; Microscopy, Fluorescence ; Neurons/physiology ; Rats ; Substantia Nigra/*cytology/physiology
    Print ISSN: 0036-8075
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  • 111
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    Alterations in brain norepinephrine metabolism induced by environmental stimuli previously paired with inescapable shock (1980)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1980-09-05
    Description: Footshock stress produced an immediate increase in brain concentrations of 3-methoxy-4-hydroxyphenylglycol sulfate (MHPG-SO4), a major metabolite of the neurotransmitter norepinephrine, in the rat brain. Twenty-four hours after footshock stress, when concentrations had returned to baseline, increases in MHPG-SO4 and emotional behavior could be elicited by previously neutral environmental stimuli that had been paired with the stress.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Cassens, G -- Roffman, M -- Kuruc, A -- Orsulak, P J -- Schildkraut, J J -- New York, N.Y. -- Science. 1980 Sep 5;209(4461):1138-40.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/7403874" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; Behavior, Animal/physiology ; Brain/*metabolism ; *Conditioning (Psychology) ; Electroshock ; Environment ; Male ; Methoxyhydroxyphenylglycol/metabolism ; Norepinephrine/*metabolism ; Posture ; Rats ; Stress, Physiological/*metabolism ; Sulfates
    Print ISSN: 0036-8075
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  • 112
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    Functional development of grafted vasopressin neurons (1980)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1980-12-19
    Description: Vasopressin neurons, transplanted from normal rat fetuses into the third ventricle of adult Brattleboro rats, alleviate the polydipsia and polyuria of the hosts. Determination of the antidiuretic activity of grafted neurons in hosts with congenital diabetes insipidus provides a convenient model for analyzing the development, plasticity, and function of transplanted central nervous system neurons in mammals.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Gash, D -- Sladek, J R Jr -- Sladek, C D -- AM 16166/AM/NIADDK NIH HHS/ -- NS 15109/NS/NINDS NIH HHS/ -- New York, N.Y. -- Science. 1980 Dec 19;210(4476):1367-9.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/7434031" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; Diabetes Insipidus/physiopathology/*therapy ; Disease Models, Animal ; Drinking Behavior/physiology ; Hypothalamus/cytology/embryology/*transplantation ; Kidney Concentrating Ability ; Rats ; Transplantation, Homologous ; Vasopressins/*physiology
    Print ISSN: 0036-8075
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    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
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  • 113
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    Successful culture of rat embryos on human serum: use in the detection of teratogens (1980)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1980-03-28
    Description: Growth of head-fold-stage rat embryos cultured with human serum for 48 hours was enhanced by supplementation with glucose. Embryo growth (protein and DNA contents) varied with the source of the serum. Serum from 16 of 19 untreated subjects produced normal embryos. Serum from five subjects undergoing cancer chemotherapy and six subjects receiving anticonvulsants was either lethal or teratogenic.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Chatot, C L -- Klein, N W -- Piatek, J -- Pierro, L J -- New York, N.Y. -- Science. 1980 Mar 28;207(4438):1471-3.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/7361097" target="_blank"〉PubMed〈/a〉
    Keywords: Adult ; Animals ; Anticonvulsants/pharmacology ; Antineoplastic Agents/pharmacology ; Blood ; Culture Media ; *Culture Techniques ; Drug Evaluation, Preclinical/*methods ; *Embryo, Mammalian/drug effects ; Female ; Glucose ; Humans ; Male ; Rats ; *Teratogens
    Print ISSN: 0036-8075
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    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
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  • 114
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    Sodium-induced elevation of blood pressure in the anephric state (1980)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1980-08-22
    Description: Normotensive anephric rats infused with 2 milliliters of a hyperosmolar solution of either sodium chloride or mannitol showed an increase in arterial pressure that was very pronounced with the sodium chloride and that could be partly abolished by administration of an antagonist to the vasopressor action of antidiuretic hormone (ADH). Rats with congenital ADH deficiency subjected to the same treatment showed smaller increments in arterial pressure that remained unchanged after administration of the ADH antagonist. Expansion of intravascular fluid volume was similar in all four groups and bore no correlation to the change in arterial pressure. It is concluded that about half of the increase in blood pressure induced by saline was attributable to the vasopressor effect of stimulated ADH and the remainder to an additional sodium-related factor, since it was more pronounced in the saline-infused than in the mannitol-infused groups. Expansion of the intravascular volume per se could only account for a minimal part of the increment in pressure.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Hatzinikolaou, P -- Gavras, H -- Brunner, H R -- Gavras, I -- New York, N.Y. -- Science. 1980 Aug 22;209(4459):935-6.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/7403861" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; Blood Pressure ; *Blood Volume ; Disease Models, Animal ; Hypertension/*etiology/physiopathology ; Male ; *Nephrectomy ; Rats ; Sodium/*blood ; Vasoconstriction ; Vasopressins/antagonists & inhibitors/deficiency/physiology
    Print ISSN: 0036-8075
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  • 115
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    Male contraception; synergism of gonadotropin-releasing hormone analog and testosterone in suppressing gonadotropin (1980)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1980-08-22
    Description: Long-term administration of either superactive analog's of gonadotropin-releasing hormone or of testosterone suppresses gonadotropin secretion in male animals and humans. Testosterone administered in combination with gonadotropin-releasing hormone analog further suppresses serum gonadotropin levels in male rats. This observation indicates synergistic activity and suggests that the gonadotropin-releasing hormone analog and testosterone act at independent sites within the hypothalamic-pituitary axis. The primary actions of superactive analog are probably mediated by changes at a postreceptor site in the pituitary gonadotropin-secreting cells.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Heber, D -- Swerdloff, R S -- New York, N.Y. -- Science. 1980 Aug 22;209(4459):936-8.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/6773142" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; *Contraceptive Agents, Male/pharmacology ; Dose-Response Relationship, Drug ; Drug Synergism ; Follicle Stimulating Hormone/*secretion ; Gonadotropin-Releasing Hormone/*analogs & derivatives/pharmacology ; Luteinizing Hormone/*secretion ; Male ; Rats ; Spermatogenesis/*drug effects ; Testosterone/*pharmacology
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  • 116
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    Alcoholic rhabdomyolysis: an experimental model in the rat (1980)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1980-04-25
    Description: The main features of alcoholic rhabdomyolysis-skeletal muscle necrosis, marked elevation of serum creatine phosphokinase, and myoglobinuria-were produced in rats by a combination of relatively prolonged (2 to 4 weeks) exposure to ethanol and a brief period of food deprivation. This observation suggests that fasting may similarly trigger muscle injury during binge drinking in man. The effect of fasting is in part related to an increase in blood alcohol due to reduced alcohol clearance and in part caused by a fasting-induced potentiation of the toxic effects of high concentrations of alcohol of skeletal muscle.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Haller, R G -- Drachman, D B -- New York, N.Y. -- Science. 1980 Apr 25;208(4442):412-5.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/7189294" target="_blank"〉PubMed〈/a〉
    Keywords: Alcoholism/*complications ; Animals ; Creatine Kinase/blood ; *Disease Models, Animal ; Female ; *Food Deprivation ; Humans ; Muscular Diseases/blood/complications/*etiology/pathology ; Myoglobinuria/etiology ; Phosphates/blood ; Potassium/blood ; Rats ; Sodium/blood
    Print ISSN: 0036-8075
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  • 117
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    Increased dopamine receptor sensitivity after estrogen treatment using the rat rotation model (1980)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1980-06-27
    Description: Estrogen was administered to male rats that had received unilateral injections of 6-hydroxydopamine into the striatum. Following this treatment, their duration of rotation increased in response to amphetamine. Estrogen treatment resulted in a corresponding increase in the number of striatal dopamine receptors. Therefore, both behavioral and biochemical evidence suggests that striatal dopamine function is influenced by peripherally administered estrogens. These results are relevant to the clinical cases of chorea associated with elevated concentrations of estrogen, which occur in pregnancy and during oral contraceptive use.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Hruska, R E -- Silbergeld, E K -- New York, N.Y. -- Science. 1980 Jun 27;208(4451):1466-8.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/7189902" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; Apomorphine/pharmacology ; Corpus Striatum/drug effects/*metabolism ; Dextroamphetamine/pharmacology ; Estradiol/*pharmacology ; Humans ; Hydroxydopamines/*pharmacology ; Male ; Rats ; Receptors, Dopamine/drug effects/*metabolism ; Rotation ; Spiperone/metabolism ; Stereotyped Behavior
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    Prenatal exposure to diazepam alters behavioral development in rats (1980)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1980-01-11
    Description: Characteristic potentiation of rat locomotion responses and acoustic startle reflexes that normally appear in the third postnatal week was absent in rats exposed to diazepam during the third week of gestation. Loss of these behaviors suggests a long-term effect that may result from changes in cellular development. Tissue undergoing neuronal differentation may be especially sensitive to drugs that act on the central nervous system, and the period in which differentiation occurs is perhaps critical for the induction of changes that are later expressed as altered behavior.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Kellogg, C -- Tervo, D -- Ison, J -- Parisi, T -- Miller, R K -- New York, N.Y. -- Science. 1980 Jan 11;207(4427):205-7.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/7350658" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; Auditory Perception/drug effects ; Behavior, Animal/*drug effects ; Diazepam/*pharmacology ; Female ; Fetus/*drug effects ; Gestational Age ; Motor Activity/drug effects ; Pregnancy ; Rats ; Reflex, Startle/drug effects ; Sound
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    Choline acetyltransferase-containing neurons in rodent brain demonstrated by immunohistochemistry (1980)
    American Association for the Advancement of Science (AAAS)
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    Publication Date: 1980-05-30
    Description: Choline acetyltransferase was demonstrated in neuronal structures of the rodent central nervous system by immunohistochemistry through the application of Fab fragments obtained from monospecific antiserums to human choline acetyltransferase. The specificity of the antiserum for the enzyme was confirmed by the staining of both the ventral horn motor neurons in the rat spinal cord and the neuromuscular junction of the guinea pig diaphragm. Enzyme-containing cell bodies were observed in frontal sections of rat and guinea pig brain in the neostriatum, accumbens, nucleus of the diagonal band, medial septum, and olfactory tubercle. Positively staining fibers and probable nerve terminals were also found in the olfactory tubercle field and other areas of the basal forebrain. The results provide information on the distribution of the cholinergic systems in the rostral forebrain of the rodent.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Kimura, H -- McGeer, P L -- Peng, F -- McGeer, E G -- New York, N.Y. -- Science. 1980 May 30;208(4447):1057-9.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/6990490" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; Brain/cytology/*enzymology ; Brain Mapping ; Choline O-Acetyltransferase/*metabolism ; Cholinergic Fibers/cytology ; Corpus Striatum/enzymology ; Guinea Pigs ; Hippocampus/enzymology ; Immunoenzyme Techniques ; Nucleus Accumbens/enzymology ; Olfactory Bulb/enzymology ; Rats ; Spinal Cord/enzymology
    Print ISSN: 0036-8075
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    Anesthetics as teratogens: nitrous oxide is fetotoxic, xenon is not (1980)
    American Association for the Advancement of Science (AAAS)
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    Publication Date: 1980-11-21
    Description: Exposure of pregnant rats to the anesthetic nitrous oxide on the ninth day of gestation causes fetal resorption, skeletal anomalies, and macroscopic lesions including encephalocele, anophthalmia, microphthalmia, and gastroschisis. The inert gas xenon, which has anesthetic properties similar to those of nitrous oxide, does not cause teratogenic effects under the same experimental conditions.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Lane, G A -- Nahrwold, M L -- Tait, A R -- Taylor-Busch, M -- Cohen, P J -- Beaudoin, A R -- New York, N.Y. -- Science. 1980 Nov 21;210(4472):899-901.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/7434002" target="_blank"〉PubMed〈/a〉
    Keywords: Anesthetics/*adverse effects ; Animals ; Female ; Nitrous Oxide/*toxicity ; Pregnancy ; Rats ; Structure-Activity Relationship ; *Teratogens ; Xenon/*toxicity
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    High-affinity [3H]imipramine binding in rat hypothalamus: association with uptake of serotonin but not of norepinephrine (1980)
    American Association for the Advancement of Science (AAAS)
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    Publication Date: 1980-12-05
    Description: Inhibition of the binding of [3H]imipramine and inhibition of the uptake of [3H]serotonin and [3H]norepinephrine by a series of antidepressants and other drugs were studied in the rat hypothalamus. No correlation was found between the potencies of these drugs for the inhibition of [3H]imipramine binding and the inhibition of [3H]norepinephrine uptake. There was, however, a highly significant correlation between the potencies of these drugs for the inhibition of [3H]serotonin uptake. These results suggest that high-affinity [3H]imipramine binding might be associated with the mechanism of serotonin uptake in the brain.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Langer, S Z -- Moret, C -- Raisman, R -- Dubocovich, M L -- Briley, M -- New York, N.Y. -- Science. 1980 Dec 5;210(4474):1133-5.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/7444441" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; Antidepressive Agents/pharmacology ; Biological Transport/drug effects ; *Carrier Proteins ; Hypothalamus/*metabolism ; Imipramine/*metabolism ; Norepinephrine/*metabolism ; Rats ; Receptors, Drug/*metabolism ; Serotonin/*metabolism ; Structure-Activity Relationship
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    Intensity fluctuation spectroscopy monitors contractile activation in "resting" cardiac muscle (1980)
    American Association for the Advancement of Science (AAAS)
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    Publication Date: 1980-03-21
    Description: Intensity fluctuations in a laser beam scattered by nonbeating isolated rat cardiac muscle varied directly with the calcium concentrations in the bathing fluid. The steady-state level of these fluctuations varied directly with calcium-dependent force suggesting that the intensity fluctuations reflect an interaction of calcium ions with the myofilaments. The demonstration that both a portion of resting force and the frequency of intensity fluctuations vary directly with calcium even in quiescent conditions indicates that some contractile activation is present in the resting muscle.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Lappe, D L -- Lakatta, E G -- New York, N.Y. -- Science. 1980 Mar 21;207(4437):1369-71.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/7355295" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; Calcium/*pharmacology ; Heart/*physiology ; Lasers ; Muscle Proteins/physiology ; *Myocardial Contraction/drug effects ; Rats ; Scattering, Radiation ; Spectrum Analysis
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    Erythrosine (Red No. 3) and its nonspecific biochemical actions: what relation to behavioral changes? (1980)
    American Association for the Advancement of Science (AAAS)
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    Publication Date: 1980-02-01
    Description: Biochemical studies have shown that the ability of erythrosine to inhibit dopamine uptake into brain synaptosomal preparations is dependent on the concentration of tissue present in the assay mixture. Thus, the finding that erythrosine inhibits dopamine uptake (which, if true, would provide a plausible explanation of the Feingold hypothesis of childhood hyperactivity) may simply be an artifact that results from nonspecific interactions with brain membranes. In addition, although erythrosine given parenterally (50 milligrams per kilogram) did not alter locomotor activity of control of 6-hydroxydopamine-treated rats, erythrosine (50 to 300 milligrams per kilogram) attenuated the effect of punishment in a "conflict" paradigm.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Mailman, R B -- Ferris, R M -- Tang, F L -- Vogel, R A -- Kilts, C D -- Lipton, M A -- Smith, D A -- Mueller, R A -- Breese, G R -- New York, N.Y. -- Science. 1980 Feb 1;207(4430):535-7.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/7352264" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; Behavior, Animal/*drug effects ; Biological Transport/drug effects ; Brain/*drug effects/metabolism ; Dopamine/*metabolism ; Food Coloring Agents/*pharmacology ; Hydroxydopamines/pharmacology ; Male ; Motor Activity/drug effects ; Nerve Tissue Proteins/metabolism ; Rats ; Synaptosomes/metabolism
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    Regeneration in the central nervous system (1980)
    American Association for the Advancement of Science (AAAS)
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    Publication Date: 1980-07-18
    Description: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Marx, J L -- New York, N.Y. -- Science. 1980 Jul 18;209(4454):378-80.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/6155701" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; Axonal Transport ; Axons/physiology ; Brain/*physiology ; Humans ; Nerve Growth Factors/physiology ; *Nerve Regeneration ; Neurons/*physiology/transplantation ; Rats ; Sciatic Nerve/transplantation ; Spinal Cord/*physiology ; Transplantation, Homologous
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    Electrical stimulation of the midbrain mediates metastatic tumor growth (1980)
    American Association for the Advancement of Science (AAAS)
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    Publication Date: 1980-09-05
    Description: Pulmonary metastases were counted 10 days after female rats received tail-vein injections of Walker-256 carcinosarcoma cells. Previous observations that halothane anesthesia plus hind-limb amputation increases the number of metastases were confirmed. Amputation under the analgesia of electrical stimulation of the midbrain was found to increase metastatic activity. However, the stimulus-produced analgesia alone also increased the number of metastases. Systemically administered naloxone blocked the analgesic effect of midbrain stimulation but did not block the increase in the number of pulmonary metastases.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Simon, R H -- Lovett, E J 3rd -- Tomaszek, D -- Lundy, J -- New York, N.Y. -- Science. 1980 Sep 5;209(4461):1132-3.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/6250220" target="_blank"〉PubMed〈/a〉
    Keywords: *Anesthesia ; Animals ; Carcinoma 256, Walker/*pathology ; Cerebral Aqueduct ; Electric Stimulation ; Immune Tolerance ; Lung Neoplasms/*secondary ; Mesencephalon/*physiology ; Naloxone/pharmacology ; *Neoplasm Metastasis ; Rats ; Receptors, Opioid/drug effects ; Stress, Physiological/physiopathology
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    The testicular feminized rat: a naturally occurring model of androgen independent brain masculinization (1980)
    American Association for the Advancement of Science (AAAS)
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    Publication Date: 1980-07-18
    Description: Although genotypically male (XY), the testicular feminized rat develops as an anatomic female because of an inherited deficiency in intracellular androgen receptors that prevents androgen imprinting of sexual primordia. However, the ability of testicular feminized rats to exhibit male-like sexual behavior and little feminine sexual behavior suggests that the brain can be masculinized without androgens.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Shapiro, B H -- Levine, D C -- Adler, N T -- New York, N.Y. -- Science. 1980 Jul 18;209(4454):418-20.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/7384816" target="_blank"〉PubMed〈/a〉
    Keywords: Androgen-Insensitivity Syndrome/*physiopathology ; Animals ; Brain/*physiopathology ; Castration ; Estradiol/pharmacology ; Female ; Male ; Posture ; Rats ; Sex Factors ; *Sexual Behavior, Animal/drug effects ; Testosterone/pharmacology
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    Progesterone administration in vivo stimulates release of luteinizing hormone-releasing hormone in vitro (1980)
    American Association for the Advancement of Science (AAAS)
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    Publication Date: 1980-05-30
    Description: The release of luteinizing hormone-releasing hormone (LHRH) from tissue from the mediobasal hypothalamic-anterior hypothalamic-preoptic area of prepuberal female rats was measured in a perfusion system. Measurements were also made of the concentrations of LHRH in these tissue fragments and of luteinizing hormone in serum obtained when the rats were killed. Four groups of immature rats were studied: intact, ovariectomized, ovariectomized and implanted with estradiol-containing capsules, and ovariectomized rats primed with estradiol and injected with progesterone. The release of LHRH from the tissue of ovariectomized animals was significantly less than that of intact females and was not modified when the ovariectomized rats received estradiol. However, there was a four- to fivefold increase in LHRH release from tissue of ovariectomized rats primed with estradiol when they were killed 6 hours after they received an injection of progesterone. The concentrations of LHRH in tissue and of luteinizing hormone in serum varied among groups and with the time of day that the animals were killed. The interactions among luteinizing hormone, gonadal steroids, and the photoperiod seem to set the appropriate conditions for neural processes triggering a complete and normal release of luteinizing hormone.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Ramirez, V D -- Dluzen, D -- Lin, D -- New York, N.Y. -- Science. 1980 May 30;208(4447):1037-9.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/6990489" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; Castration ; Circadian Rhythm ; Estradiol/pharmacology ; Female ; Gonadotropin-Releasing Hormone/*metabolism ; Hypothalamus/*metabolism ; Hypothalamus, Anterior/metabolism ; Light ; Luteinizing Hormone/blood ; Preoptic Area/metabolism ; Progesterone/*pharmacology ; Rats
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    Aryl hydrocarbon hydroxylase is inhibited by antibody to rat liver cytochrome P-450 (1980)
    American Association for the Advancement of Science (AAAS)
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    Publication Date: 1980-05-30
    Description: Antibody to the major purified cytochrome P-450 induced by 3-methylcholanthrene in rat liver strongly inhibits aryl hydrocarbon hydroxylase activity of uninduced and benz[a]anthracene-induced human monocytes and lymphocytes. Antibody to the cytochrome P-450 induced by phenobarbital has relatively little or no effect on the aryl hydrocarbon hydroxylase activity of the same human cells.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Robie-Suh, K -- Robinson, R -- Gelboin, H V -- Guengerich, F P -- New York, N.Y. -- Science. 1980 May 30;208(4447):1031-3.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/7375915" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; Antigen-Antibody Reactions ; Aryl Hydrocarbon Hydroxylases/*antagonists & inhibitors/immunology ; Benz(a)Anthracenes/pharmacology ; Cytochrome P-450 Enzyme System/*immunology ; Enzyme Induction/drug effects ; Humans ; Lymphocytes/*enzymology ; Methylcholanthrene/pharmacology ; Monocytes/*enzymology ; Pentobarbital/pharmacology ; Rats
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    Gastrin injected into the lateral hypothalamus stimulates secretion of gastric acid in rats (1980)
    American Association for the Advancement of Science (AAAS)
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    Publication Date: 1980-09-05
    Description: Intrahypothalamic injections of 100 picomoles of pentagastrin or natural gastrin promptly increased secretion of gastric acid in conscious rats. The response was blocked by atropine and by vagotomy. The same doses, injected intravenously or into other forebrain sites, did not increase secretion, nor did intrahypothalamic injections of other peptides common to the gut and brain.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Tepperman, B L -- Evered, M D -- New York, N.Y. -- Science. 1980 Sep 5;209(4461):1142-3.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/7403876" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; Gastric Juice/*secretion ; Gastrins/*pharmacology ; Hypothalamus/*drug effects/*physiology ; Male ; Pentagastrin/blood/pharmacology ; Rats ; Stimulation, Chemical
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    Gonadal steroids: effects on excitability of hippocampal pyramidal cells (1980)
    American Association for the Advancement of Science (AAAS)
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    Publication Date: 1980-08-29
    Description: Electrophysiological field potentials from hippocampal slices of rat brain show sex-linked differences in response to 1 X 10(-10)M concentrations of estradiol and testosterone added to the incubation medium. Slices from male rats show increased excitability to estradiol and not to testosterone. Slices from female rats are not affected by estradiol, but slices from female rats in diestrus show increased excitability in response to testosterone whereas slices from females in proestrus show decreased excitability.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Teyler, T J -- Vardaris, R M -- Lewis, D -- Rawitch, A B -- New York, N.Y. -- Science. 1980 Aug 29;209(4460):1017-8.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/7190730" target="_blank"〉PubMed〈/a〉
    Keywords: Action Potentials/drug effects ; Animals ; Biotransformation ; Diestrus ; Estradiol/metabolism/*pharmacology ; *Estrus ; Female ; Hippocampus/*drug effects ; Male ; Membrane Potentials/drug effects ; Pregnancy ; Proestrus ; Pyramidal Tracts/*drug effects ; Rats ; Sex Differentiation ; Testosterone/*pharmacology
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    Antiallergic drug cromolyn may inhibit histamine secretion by regulating phosphorylation of a mast cell protein (1980)
    American Association for the Advancement of Science (AAAS)
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    Publication Date: 1980-01-04
    Description: Cromolyn inhibited histamine release from mast cells that was induced by a classic secretagogue and correspondingly increased incorporation of radioactive phosphate into a 78,000-dalton protein. These effects on histamine secretion and on protein phosphorylation were rapid in onset and both showed tachyphylaxis. Cromolyn may therefore act by altering the phosphorylation of a protein involved in the regulation of secretion.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Theoharides, T C -- Sieghart, W -- Greengard, P -- Douglas, W W -- New York, N.Y. -- Science. 1980 Jan 4;207(4426):80-2.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/6153130" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; Calcium/physiology ; Cromolyn Sodium/*pharmacology ; Histamine Release/*drug effects ; Kinetics ; Mast Cells/*drug effects/immunology/metabolism ; Molecular Weight ; Phosphoproteins/*metabolism ; Phosphorylation ; Rats ; p-Methoxy-N-methylphenethylamine/antagonists & inhibitors
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    Neuronal loss in hippocampus induced by prolonged ethanol consumption in rats (1980)
    American Association for the Advancement of Science (AAAS)
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    Publication Date: 1980-08-08
    Description: Quantitative neurohistological techniques were used to examine the hippocampal complex of laboratory rats maintained on ethanol-containing or control diets for 5 months followed by a 2-month alcohol-free period. Chronic ethanol consumption resulted in a significant loss of hippocampal pyramidal and dentate gyrus granule cells. This study provides direct evidence that long-term ethanol consumption, in the absence of malnutrition, produces neuronal loss in the central nervous system.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Walker, D W -- Barnes, D E -- Zornetzer, S F -- Hunter, B E -- Kubanis, P -- New York, N.Y. -- Science. 1980 Aug 8;209(4457):711-3.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/7394532" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; Ethanol/*pharmacology ; Hippocampus/drug effects/*physiology ; Male ; Neurons/drug effects/*physiology ; Pyramidal Tracts/drug effects/physiology ; Rats ; Time Factors
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    Cholecystokinin receptors in the brain: characterization and distribution (1980)
    American Association for the Advancement of Science (AAAS)
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    Publication Date: 1980-06-06
    Description: Specific cholecystokinin binding sites in particulate fractions of rat brain were measured with iodine 125-labeled Bolton-Hunter cholecystokinin, a cholecystokinin analog that has full biological activity. Binding was detected in brain regions known to contain immunoreactive cholecystokinin. Binding was saturable, reversible, of high affinity (dissociation constant, 1.7 x 10(-9) M), and was inhibited by cholecystokinin analogs but not by unrelated hormones.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Saito, A -- Sankaran, H -- Goldfine, I D -- Williams, J A -- New York, N.Y. -- Science. 1980 Jun 6;208(4448):1155-6.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/6246582" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; Binding, Competitive ; Brain/*metabolism ; Brain Mapping ; Cerebral Cortex/metabolism ; Cholecystokinin/*metabolism ; Gastrins/metabolism ; Kinetics ; Male ; Olfactory Bulb/metabolism ; Pancreas/metabolism ; Rats ; Receptors, Cell Surface/*metabolism
    Print ISSN: 0036-8075
    Electronic ISSN: 1095-9203
    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
    Published by American Association for the Advancement of Science (AAAS)
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