Abstract
A single injection of amphetamine given to rats treated concurrently with iprindole so that they could not metabolize the amphetamine by para-hydroxylation resulted in a decrease in the concentration of striatal dopamine 1 week later. The decrease was antagonized by amfonelic acid, an inhibitor of uptake into dopamine neurons. The long-lasting depletion of cerebral dopamine by amphetamine may be analogous to the depletion of cerebral serotonin by halogenated derivatives of amphetamine.
MeSH terms
-
Amphetamine / pharmacology*
-
Animals
-
Brain / drug effects
-
Brain / metabolism
-
Corpus Striatum / drug effects
-
Corpus Striatum / metabolism*
-
Dopamine / metabolism*
-
Epinephrine / metabolism
-
Indoles / pharmacology*
-
Iprindole / pharmacology*
-
Male
-
Nalidixic Acid / analogs & derivatives
-
Naphthyridines / pharmacology
-
Norepinephrine / metabolism
-
Organ Specificity
-
Rats
-
p-Chloroamphetamine / pharmacology
Substances
-
Indoles
-
Naphthyridines
-
Nalidixic Acid
-
p-Chloroamphetamine
-
Iprindole
-
Amphetamine
-
amfonelic acid
-
Dopamine
-
Norepinephrine
-
Epinephrine