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  • 1
    Publication Date: 2013-09-20
    Description: Mitochondria are intracellular organelles where oxidative phosphorylation is carried out to complete ATP synthesis. Mitochondria have their own genome; in metazoans, this is a small, circular molecule encoding 13 electron transport proteins, 22 tRNAs, and 2 rRNAs. In invertebrates, mitochondrial gene rearrangement is common, and it is correlated with increased substitution rates. In vertebrates, mitochondrial gene rearrangement is rare, and its relationship to substitution rate remains unexplored. Mitochondrial genes can also show spatial variation in substitution rates around the genome due to the mechanism of mtDNA replication, which produces a mutation gradient. To date, however, the strength of the mutation gradient and whether movement along the gradient in rearranged (or otherwise modified) genomes impacts genic substitution rates remain unexplored in the majority of vertebrates. Salamanders include both normal mitochondrial genomes and independently derived rearrangements and expansions, providing a rare opportunity to test the effects of large-scale changes to genome architecture on vertebrate mitochondrial gene sequence evolution. We show that: 1) rearranged/expanded genomes have higher substitution rates; 2) most genes in rearranged/expanded genomes maintain their position along the mutation gradient, substitution rates of the genes that do move are unaffected by their new position, and the gradient in salamanders is weak; and 3) genomic rearrangements/expansions occur independent of levels of selective constraint on genes. Together, our results demonstrate that large-scale changes to genome architecture impact mitochondrial gene evolution in predictable ways; however, despite these impacts, the same functional constraints act on mitochondrial protein-coding genes in both modified and normal genomes.
    Electronic ISSN: 1759-6653
    Topics: Biology
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  • 2
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    In:  Bull. Seism. Soc. Am., Dordrecht, Netherlands, Dr. W. Junk, vol. 61, no. 35, pp. 1675-1692, pp. L08304, (ISSN: 1340-4202)
    Publication Date: 1971
    Keywords: Seismology ; Nuclear explosion ; Scaling ; Spectrum ; Muller ; BSSA
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  • 3
    Publication Date: 2015-12-02
    Description: Author(s): R. A. Müller, A. Desilets-Benoit, N. Gauthier, L. Lapointe, A. D. Bianchi, T. Maris, R. Zahn, R. Beyer, E. Green, J. Wosnitza, Z. Yamani, and M. Kenzelmann Single-crystal neutron diffraction and various bulk probes are used to investigate the magnetic structure and properties of the rare-earth half-Heusler antiferromagnet NdBiPt. While the family of compounds R BiPt ( R =Ce–Lu) have been suggested as candidates for a new family of antiferromagnetic topological insulators, the magnetic structure for the Nd compound, as determined in this report, seems to exclude it from this distinction. [Phys. Rev. B 92, 184432] Published Mon Nov 30, 2015
    Keywords: Magnetism
    Print ISSN: 1098-0121
    Electronic ISSN: 1095-3795
    Topics: Physics
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  • 4
    Publication Date: 2015-12-02
    Description: The Precordillera terrane in northwestern Argentina is interpreted to be an exotic (Laurentian) continental fragment that was accreted to western Gondwana during the Ordovician. One prominent manifestation of the subduction and collision process is a Middle–Upper Ordovician clastic wedge, which overlies a passive-margin carbonate-platform succession in the Precordillera. U/Pb ages of detrital zircons from sandstones within the clastic wedge, as well as zircons from clasts within conglomerates, provide documentation for the composition of the sediment provenance. The ages of detrital zircons are consistent vertically through the succession, as well as laterally along and across strike of the Precordillera, indicating a single, persistent sediment source throughout deposition of the clastic wedge. The dominant mode (~1350–1000 Ma) of the detrital-zircon ages corresponds to the ages of basement rocks in the Western Sierras Pampeanas along the eastern side of the Precordillera. A secondary mode (1500–1350 Ma) corresponds in age to the Granite-Rhyolite province of Laurentia, an age range which is not known in ages of basement rocks of the Western Sierras Pampeanas; however, detritus from Granite-Rhyolite-age rocks in the basement of the Precordillera was available through recycling of synrift and passive-margin cover strata. Igneous clasts in the conglomerates have ages (647–614 Ma) that correspond to the ages of minor synrift igneous rocks in the nearby basement massifs; the same ages are represented in a minor mode (~750–570 Ma) of detrital-zircon ages. A quartzite clast in a conglomerate, as well as parts of the population of detrital zircons, indicates the importance of a source in the metasedimentary cover of the leading edge of the Precordillera. The Famatina continental-margin magmatic arc reflects pre-collision subduction of Precordillera lithosphere beneath the western Gondwana margin; however, no detrital zircons have ages that correspond to Famatina arc magmatism, indicating that sedimentary detritus from the arc may have been trapped in a forearc basin and did not reach the foreland. The indicators of sedimentary provenance for the foreland deposits are consistent with subduction of the Precordillera beneath western Gondwana, imbrication of basement rocks from either the Precordillera or Gondwana into an accretionary complex, and recycling of deformed Precordillera cover rocks.
    Electronic ISSN: 1553-040X
    Topics: Geosciences
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  • 5
    Publication Date: 1979-08-17
    Description: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Mailman, R B -- Breese, G R -- Krigman, M R -- Mushak, P -- Mueller, R A -- New York, N.Y. -- Science. 1979 Aug 17;205(4407):726.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/17781262" target="_blank"〉PubMed〈/a〉
    Print ISSN: 0036-8075
    Electronic ISSN: 1095-9203
    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
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  • 6
    Publication Date: 1980-02-01
    Description: Biochemical studies have shown that the ability of erythrosine to inhibit dopamine uptake into brain synaptosomal preparations is dependent on the concentration of tissue present in the assay mixture. Thus, the finding that erythrosine inhibits dopamine uptake (which, if true, would provide a plausible explanation of the Feingold hypothesis of childhood hyperactivity) may simply be an artifact that results from nonspecific interactions with brain membranes. In addition, although erythrosine given parenterally (50 milligrams per kilogram) did not alter locomotor activity of control of 6-hydroxydopamine-treated rats, erythrosine (50 to 300 milligrams per kilogram) attenuated the effect of punishment in a "conflict" paradigm.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Mailman, R B -- Ferris, R M -- Tang, F L -- Vogel, R A -- Kilts, C D -- Lipton, M A -- Smith, D A -- Mueller, R A -- Breese, G R -- New York, N.Y. -- Science. 1980 Feb 1;207(4430):535-7.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/7352264" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; Behavior, Animal/*drug effects ; Biological Transport/drug effects ; Brain/*drug effects/metabolism ; Dopamine/*metabolism ; Food Coloring Agents/*pharmacology ; Hydroxydopamines/pharmacology ; Male ; Motor Activity/drug effects ; Nerve Tissue Proteins/metabolism ; Rats ; Synaptosomes/metabolism
    Print ISSN: 0036-8075
    Electronic ISSN: 1095-9203
    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
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  • 7
    Publication Date: 1978-08-18
    Description: Lead (200 milligrams per kilogram) was administered daily by intubation to Long-Evans rats on days 3 through 30 of life. Thirty to 180 days after cessation of lead administration, the lead-treated rats were consistently more polydipsic after lithium administration (2 millimoles per kilogram per day) than were pair-treated controls. Lithium increased the plasma renin activity equally in both the lead treated and the control groups. These data are evidence that there may be permanent neural changes induced by postnatal exposure to lead that are manifested by pharmacological challenge with lithium.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Mailman, R B -- Krigman, M R -- Mueller, R A -- Mushak, P -- Breese, G R -- New York, N.Y. -- Science. 1978 Aug 18;201(4356):637-9.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/675249" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; Animals, Newborn ; *Drinking Behavior/drug effects ; Female ; Lead Poisoning/*physiopathology ; Lithium/pharmacology ; Male ; Rats ; Renin/blood
    Print ISSN: 0036-8075
    Electronic ISSN: 1095-9203
    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
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  • 8
    Publication Date: 2014-07-29
    Description: Author(s): R. A. Müller, N. R. Lee-Hone, L. Lapointe, D. H. Ryan, T. Pereg-Barnea, A. D. Bianchi, Y. Mozharivskyj, and R. Flacau A topological insulator is a state of matter which does not break any symmetry and is characterized by topological invariants, the integer expectation values of nonlocal operators. Antiferromagnetism, on the other hand, is a broken symmetry state in which the translation symmetry is reduced and time... [Phys. Rev. B 90, 041109] Published Mon Jul 28, 2014
    Keywords: Electronic structure and strongly correlated systems
    Print ISSN: 1098-0121
    Electronic ISSN: 1095-3795
    Topics: Physics
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  • 9
    Publication Date: 2018-10-09
    Description: Author(s): A. V. Maiorova, S. Fritzsche, R. A. Müller, and A. Surzhykov The elastic scattering of twisted electrons by diatomic molecules is studied within the framework of the nonrelativistic first Born approximation. In this process, the coherent interaction of incident electrons with two molecular centers may cause interference patterns in the angular distributions o... [Phys. Rev. A 98, 042701] Published Mon Oct 08, 2018
    Keywords: Atomic and molecular collisions and interactions
    Print ISSN: 1050-2947
    Electronic ISSN: 1094-1622
    Topics: Physics
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  • 10
    Publication Date: 2016-11-24
    Description: Author(s): D. Seipt, R. A. Müller, A. Surzhykov, and S. Fritzsche The two-color above-threshold ionization (ATI) of atoms and ions is investigated for a vortex Bessel beam in the presence of a strong near-infrared (NIR) light field. While the photoionization is caused by the photons from the weak but extreme ultraviolet (XUV) vortex Bessel beam, the energy and ang… [Phys. Rev. A 94, 053420] Published Wed Nov 23, 2016
    Keywords: Atomic and molecular processes in external fields, including interactions with strong fields and short pulses
    Print ISSN: 1050-2947
    Electronic ISSN: 1094-1622
    Topics: Physics
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