Publication Date:
1980-07-11
Description:
A single injection of amphetamine given to rats treated concurrently with iprindole so that they could not metabolize the amphetamine by para-hydroxylation resulted in a decrease in the concentration of striatal dopamine 1 week later. The decrease was antagonized by amfonelic acid, an inhibitor of uptake into dopamine neurons. The long-lasting depletion of cerebral dopamine by amphetamine may be analogous to the depletion of cerebral serotonin by halogenated derivatives of amphetamine.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Fuller, R W -- Hemrick-Luecke, S -- New York, N.Y. -- Science. 1980 Jul 11;209(4453):305-7.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/7384808" target="_blank"〉PubMed〈/a〉
Keywords:
Amphetamine/*pharmacology
;
Animals
;
Brain/drug effects/metabolism
;
Corpus Striatum/drug effects/*metabolism
;
Dopamine/*metabolism
;
Epinephrine/metabolism
;
Indoles/*pharmacology
;
Iprindole/*pharmacology
;
Male
;
Naphthyridines/pharmacology
;
Norepinephrine/metabolism
;
Organ Specificity
;
Rats
;
p-Chloroamphetamine/pharmacology
Print ISSN:
0036-8075
Electronic ISSN:
1095-9203
Topics:
Biology
,
Chemistry and Pharmacology
,
Computer Science
,
Medicine
,
Natural Sciences in General
,
Physics
