ALBERT

Note: Preface -- Acknowledgments -- Executive Summary -- Part One - C’mon! Don’t tell me the current trends are sustainable! -- 1.1 Introduction: The World in Disarray -- 1.2 Limits to Growth - how relevant was its message?- 1.3 Planetary Boundaries -- 1.4 The Anthropocene -- 1.5 The Climate Challenge -- 1.6 Other disasters ahead -- 1.7 Unsustainable population growth - and urbanization -- 1.8 Unsustainable agriculture and food system -- 1.9 Trade versus environment -- 1.10 The 2030 Agenda - the devil is in implementation -- 1.11 Do we like disruptions? The case of the digital revolution -- 1.12 From Empty World to Full World -- Part Two - C’mon! Don’t stick to outdated philosophies! -- 2.1 Laudato Sí: The Pope raises His voice -- 2.2 Change the Story, Change the Future -- 2.3 1991: „The First Global Revolution“ -- 2.4 Capitalism got arrogant -- 2.5 The failure of the market doctrine -- 2.6 Philosophical errors of the market doctrine -- 2.7 Reductionist philosophy is shallow and inadequate -- 2.8 Gaps between Theory, Education and Social Reality -- 2.9 Tolerance and long-term perspectives -- 2.10 We may need a New Enlightenment -- Part Three Come On! Join us on an exciting journey towards a sustainable world! .- 3.1 A regenerative economy -- 3.2 Development Alternatives -- 3.3 The Blue Economy -- 3.4 Decentralized energy -- 3.5 Some agricultural success stories -- 3.6 Regenerative urbanization: Ecopolis -- 3.7 Climate: Some good news, but bigger challenges -- 3.8 Circular economy requires a new economic logic -- 3.9 Five-fold resource productivity -- 3.10 Healthy disruption -- 3.11 Reform of the financial sector -- 3.12 Reform of the economic set-up -- 3.13 Benign investment -- 3.14 Measuring well-being rather than GDP -- 3.15 Civil Society, Social Capital and Collective Leadership -- 3.16 Global Governance -- 3.17 National level action: China and Bhutan -- 3.18 Education for a sustainable civilization -- Conclusion: We invite readers to ‘come on’

Note: Contents: Part I: Understanding the resource nexus: Setting scenes ; 1 The Resource Nexus: Preface and Introduction ; 2 Appreciating wider environmental angles; 3 Scales and the resource nexus ; 4 Security, climate change and the resource nexus ; Part II: Analysing the resource nexus: Tools and metrics 5 Life Cycle Assessment for resource nexus analysis ; 6 Linking society and nature: material flows and the resource nexus ; 7 Resource footprints ; 8 Input-Output analysis and resource nexus assessment ; 9 Material criticality assessment and resource nexus analysis ; 10 Industrial Ecology Methods and the Resource Nexus ; Part III: Resource nexus modelling: Practices and future transformations ; 11 Integrating environmental and social impacts with Ecosystem services analysis ; 12 Modelling practices from local to global ; 13 Global change and K-waves: exploring nexus patterns ; 14 Foresight and scenarios: modelling practices and resource nexus assessment ; 15 Extending macro-economic modelling into the resource nexus ; 16 The five-node resource nexus dynamics: an integrated modelling approach ; Part IV: International political economy and the resource nexus ; 17 The resource nexus in an uncertain world: a non-equilibrium perspective ; 18 Mining and the resource nexus ; 19 Scarcities, supply and new resource curses? ; 20 The international commodity trade: Stylized facts ; 21 Rare Earth Elements and a resource nexus perspective ; 22 Governing land in the Global South ; Part V: Applying the resource nexus: Regional and Global Scale ; 23 Elements of the Water-Energy-Food nexus in China ; 24 The Energy-Materials nexus: the case of metals ; 25 Unconventional oil and gas production meets the resource nexus ; 26 Feeding Africa: Nexus-related opportunities, challenges and policy options ; 27 The five node resource nexus at sea ; Part VI: Governing the resource nexus: Emerging responses ; 28 Urban metabolism and new urban governance ; 29 Eco-innovation and resource nexus challenges: Ambitions and evidence ; 30 Green Chemistry: Opportunities, waste and food supply chains ; 31 California Innovations @ WEN ; 32 The UN, Global Governance and the SDGs

Note: Contents Part I Challenges 1 Factor X – 25 Years – “Factor X Concept” Is Essential for Achieving Sustainable Development / Harry Lehmann, Friedrich Schmidt-Bleek, and Christopher Manstein 2 Necessities for a Resource Efficient Europe / Leida Rijnhout, Magda Stoczkiewicz, and Meadhbh Bolger 3 Global Megatrends and Resource Use – A Systemic Reflection / Ullrich Lorenz, Harald Ulrik Sverdrup, and Kristin Vala Ragnarsdottir 4 Data, Indicators and Targets for Comprehensive Resource Policies / Stephan Lutter, Stefan Giljum, and Martin Bruckner 5 The Critical Raw Materials Concept: Subjective, Multifactorial and Ever-Developing / Jan Kosmol, Felix Müller, and Hermann Keßler 6 Equitable, Just Access to Natural Resources: Environmental Narratives during Worsening Climate Crises / Patrick Bond Part II Implementation Strategies 7 Circular Economy: Origins and Future Orientations / Riina Antikainen, David Lazarevic, and Jyri Seppälä 8 Financial System, and Energy and Resource Husbandry / R. Andreas Kraemer 9 Developing Resource Competence – Anchoring Resource Conservation and Efficiency in the German Education System / Carolin Baedeker, Holger Rohn, Michael Scharp, and Jaya Bowry 10 The Way from Problem Scope Towards the Vision of a Low Resource Society – The First Working Period of the Resources Commission at the German Environment Agency (KRU) / Sascha Hermann and Christa Liedtke 11 Implementing Resource Efficiency in Europe – Overview of Policies, Instruments and Targets in 32 European Countries / Paweł Kaźmierczyk 12 The Resource Nexus and Resource Efficiency: What a Nexus Perspective Adds to the Story / Raimund Bleischwitz and Michal Miedzinski 13 Germany’s Resource Efficiency Agenda: Driving Momentum on the National Level and Beyond / Reinhard Kaiser 14 Results of Three Cost-Effective, Innovative and Transferable Resource-Efficiency Instruments for Industries in the Basque Country / Ander Elgorriaga Kunze and Ignacio Quintana San Miguel 15 The Circular Economy Package of the European Union / Joachim Wuttke 16 Saving Natural Resources Through Conversion and Constructional Densification in Urban Areas: Ecological Potentials and Limits / Daniel Reißmann and Matthias Buchert 17 The Path to Degrowth for a Sustainable Society / Serge Latouche Part III Examples of Good Practice 18 Social Innovation Repair – The R.U.S.Z Case: A Systemic Approach Contributing to the Unplanned Obsolescence of Capitalism / Sepp Eisenriegler and Greta Sparer 19 Resource Efficiency in the Building Sector / Klaus Dosch 20 Eco Efficiency and Circular Production: Cases from the Netherlands’ Eastern Region / Frank A.G. den Butter and Harry A.A.M. Webers 21 An Approach to Identify Resource Patterns on a Neighborhood Level / Magnus Österbring, Leonardo Rosado, Holger Wallbaum, and Paul Gontia 22 Strategic Business Examples from Finland: The Growth of the Smartup Industry / Tuuli Kaskinen, Satu Lähteenoja, Mikael Sokero, and Iiris Suomela 23 Circular Flanders: Adaptive Policy for a Circular Economy / Sam Deckmyn 24 The 100 Companies Project Resource Efficient Practice Cases from Producing Industry / Mario Schmidt 25 Lifestyle Material Footprint of Finnish Households – Insights, Targets, Transitions / Michael Lettenmeier 26 Construction 4.0: The LifeCycle Tower and Digitalised Timber Construction / Hubert Rhomberg 27 Protect Resources, Strengthen the Economy: Good Examples for Resource Efficiency in Industry and Handicraft Businesses / Peter Jahns 28 Chemical Leasing: A Business Model to Drive Resource Efficiency in the Supply Chain / Reinhard Joas, Veronika Abraham, and Anke Joas 29 Resource Efficiency for the Manufacturing Industries – A Holistic Approach / Werner Maass, Christof Oberender, and Martin Vogt 30 Towards a Resource Efficient and Greenhouse Gas Neutral Germany 2050 / Jens Günther, Harry Lehmann, Ullrich Lorenz, David Pfeiffer, and Katja Purr 31 Pope Francis’ Encyclical Laudato Si’ as a Catalyst for Societal Transformation? Critical Remarks and Presentation of an Inspired Exemplary Project as a Driver for Sustainability / Ulrich Bartosch, Christian Meier, and Till Weyers Index

Note: Hydrocarbon systems, by nature, are a complex interplay of elements that must be spatially and temporally aligned to result in the generation and preservation of subsurface hydrocarbon accumulations. To meet the increasing challenges of discovering hydrocarbon resources, it is essential that we advance our understanding of these systems through new geochemical approaches and analytical developments. Such development requires that academic- and industry-led research efforts converge in ways that are unique to the geosciences. The aim of this volume is to bring together a multidisciplinary geochemical community from industry and academia working in hydrocarbon systems to publish recent advances and state-of-the-art approaches to resolve the many remaining questions in hydrocarbon systems analysis. From Source to Seep presents geochemical and isotopic studies that are grouped into three themes: (1) source-rock identification and the temperature/timing of hydrocarbon generation; (2) mechanisms and time-scales associated with hydrocarbon migration, trapping, storage and alteration; and (3) the impact of fluid flow on reservoir properties. | Contents: Geochemical applications in petroleum systems analysis: new constraints and the power of integration / M. Lawson, M. J. Formolo, L. Summa and J. M. Eiler / Geological Society, London, Special Publications, 468, 1-21, 19 February 2018, https://doi.org/10.1144/SP468.6 --- Source-rock identification and the temperature/timing of hydrocarbon generation --- The utility of methane clumped isotopes to constrain the origins of methane in natural gas accumulations / Daniel A. Stolper, Michael Lawson, Michael J. Formolo, Cara L. Davis, Peter M. J. Douglas and John M. Eiler / Geological Society, London, Special Publications, 468, 23-52, 14 December 2017, https://doi.org/10.1144/SP468.3 --- The isotopic structures of geological organic compounds / John M. Eiler, Matthieu Clog, Michael Lawson, Max Lloyd, Alison Piasecki, Camilo Ponton and Hao Xie / Geological Society, London, Special Publications, 468, 53-81, 14 December 2017, https://doi.org/10.1144/SP468.4 --- Vanadium isotope composition of crude oil: effects of source, maturation and biodegradation / Yongjun Gao, John F. Casey, Luis M. Bernardo, Weihang Yang and K. K. (Adry) Bissada / Geological Society, London, Special Publications, 468, 83-103, 14 December 2017, https://doi.org/10.1144/SP468.2 --- Carbon and hydrogen isotopic compositions of n-alkanes as a tool in petroleum exploration / Nikolai Pedentchouk and Courtney Turich / Geological Society, London, Special Publications, 468, 105-125, 14 December 2017, https://doi.org/10.1144/SP468.1 --- Mechanisms and time-scales associated with hydrocarbon migration, trapping, storage and alteration --- Noble gases in conventional and unconventional petroleum systems / David J. Byrne, P. H. Barry, M. Lawson and C. J. Ballentine / Geological Society, London, Special Publications, 468, 127-149, 14 December 2017, https://doi.org/10.1144/SP468.5 --- Differentiating between biogenic and thermogenic sources of natural gas in coalbed methane reservoirs from the Illinois Basin using noble gas and hydrocarbon geochemistry / Myles T. Moore, David S. Vinson, Colin J. Whyte, William K. Eymold, Talor B. Walsh and Thomas H. Darrah / Geological Society, London, Special Publications, 468, 151-188, 18 January 2018, https://doi.org/10.1144/SP468.8 --- The impact of fluid flow on reservoir properties --- Testing clumped isotopes as a reservoir characterization tool: a comparison with fluid inclusions in a dolomitized sedimentary carbonate reservoir buried to 2–4 km / John M. MacDonald, Cédric M. John and Jean-Pierre Girard / Geological Society, London, Special Publications, 468, 189-202, 14 December 2017, https://doi.org/10.1144/SP468.7

Note: Gondwana, comprising more than 64% of the present day continental mass, is home to 33% of large igneous provinces (LIPs) and key to understanding the lithosphere–atmosphere system and related tectonics that influenced global climate and sediment production on Earth. Gondwana has many of the largest LIPs, with areas of 200 000 to 2 000 000 km2. Several Gondwana LIPs erupted near active continental margins as well as within continents. The rifting of continents continued even after LIP emplacement or was aborted by a coeval compression and did not open into an ocean. Important contemporary frontiers include understanding significant amounts of synchronous silicic volcanic rocks in mafic LIPs, bringing better stratigraphic constraints supported by precise age dating and volume estimation of LIPs, the possible link between LIP emplacement and biotic crisis, refinement of the existing petrogenetic models and assessing large eruptions and associated societal risk. This volume covers topics on magma emplacements, petrology and geochemistry, source characteristics, flood basalt–carbonatite linkage, tectonics and geochronology of LIPs distributed in Gondwana continents. | Contents: Gondwana Large Igneous Provinces (LIPs): distribution, diversity and significance / Sarajit Sensarma, Bryan C. Storey and Vivek P. Malviya / Geological Society, London, Special Publications, 463, 1-16, 27 November 2017, https://doi.org/10.1144/SP463.11 --- Gondwana Large Igneous Provinces: plate reconstructions, volcanic basins and sill volumes / H. H. Svensen, T. H. Torsvik, S. Callegaro, L. Augland, T. H. Heimdal, D. A. Jerram, S. Planke and E. Pereira / Geological Society, London, Special Publications, 463, 17-40, 30 August 2017, https://doi.org/10.1144/SP463.7 --- The Ferrar Large Igneous Province: field and geochemical constraints on supra-crustal (high-level) emplacement of the magmatic system / David H. Elliot and Thomas H. Fleming / Geological Society, London, Special Publications, 463, 41-58, 10 July 2017, https://doi.org/10.1144/SP463.1 --- The Panjal Traps / J. Gregory Shellnutt / Geological Society, London, Special Publications, 463, 59-86, 6 July 2017, https://doi.org/10.1144/SP463.4 --- Mantle source heterogeneity in continental mafic Large Igneous Provinces: insights from the Panjal, Rajmahal and Deccan basalts, India / K. Vijaya Kumar, More B. Laxman and K. Nagaraju / Geological Society, London, Special Publications, 463, 87-116, 11 July 2017, https://doi.org/10.1144/SP463.5 --- Imprints of modal metasomatism in the post-Deccan subcontinental lithospheric mantle: petrological evidence from an ultramafic xenolith in an Eocene lamprophyre, NW India / Rohit Pandey, N. V. Chalapathi Rao, Dinesh Pandit, Samarendra Sahoo and Prashant Dhote / Geological Society, London, Special Publications, 463, 117-136, 5 July 2017, https://doi.org/10.1144/SP463.6 --- Origin of the Amba Dongar carbonatite complex, India and its possible linkage with the Deccan Large Igneous Province / Jyoti Chandra, Debajyoti Paul, Shrinivas G. Viladkar and Sarajit Sensarma / Geological Society, London, Special Publications, 463, 137-169, 10 July 2017, https://doi.org/10.1144/SP463.3 --- Mineralogy, geochemistry and geochronology of mafic magmatic enclaves and their significance in evolution of Nongpoh granitoids, Meghalaya, NE India / Mohd. Sadiq, Ravi K. Umrao, B. B. Sharma, S. Chakraborti, S. Bhattacharyya and A. Kundu / Geological Society, London, Special Publications, 463, 171-198, 6 July 2017, https://doi.org/10.1144/SP463.2 --- Regional volcanism of northern Zealandia: post-Gondwana break-up magmatism on an extended, submerged continent / N. Mortimer, P. B. Gans, S. Meffre, C. E. Martin, M. Seton, S. Williams, R. E. Turnbull, P. G. Quilty, S. Micklethwaite, C. Timm, R. Sutherland, F. Bache, J. Collot, P. Maurizot, P. Rouillard and N. Rollet / Geological Society, London, Special Publications, 463, 199-226, 16 August 2017, https://doi.org/10.1144/SP463.9 --- Modelling basalt weathering at elevated CO2 concentrations: implications for terminal to post-magmatic rifting in the Deccan Traps, Kachchh, India / Kaushik Mitra, Souvik Mitra, Saibal Gupta, Satadru Bhattacharya, Prakash Chauhan and Nirmala Jain / Geological Society, London, Special Publications, 463, 227-241, 17 July 2017, https://doi.org/10.1144/SP463.8 --- Geochemical and Sm–Nd isotopic constraints on the petrogenesis and tectonic setting of the Proterozoic mafic magmatism of the Gwalior Basin, central India: the influence of Large Igneous Provinces on Proterozoic crustal evolution / Jwellys D. Samom, Talat Ahmad and A. K. Choudhary / Geological Society, London, Special Publications, 463, 243-268, 10 July 2017, https://doi.org/10.1144/SP463.10

Note: Contents: 1. Introduction ; Part I. Background and Fundamentals: 2. Regional climate ; 3. History of downscaling ; 4. Rationale of downscaling ; 5. User needs ; 6. Mathematical and statistical methods ; 7. Reference observations ; 8. Climate modelling ; 9. Uncertainties ; Part II. Statistical Downscaling Concepts and Methods: 10. Structure of statistical downscaling methods ; 11. Perfect prognosis ; 12. Model output statistics ; 13. Weather generators ; 14. Other approaches ; Part III. Downscaling in Practice and Outlook: 15. Evaluation ; 16. Performance of statistical downscaling ; 17. A regional modelling debate ; 18. Use of downscaling in practice ; 19. Outlook ; Appendix A ; Appendix B

Note: Contents: Part 1: Crisis ; 1 The new anxieties ; Part 2: Restoring Ethics ; 2 The foundations of morality: from the selfish gene to the ethical group ; 3 The ethicla state ; 4 The ethical firm ; 5 The ethical family ; 6 The ethical world ; Part 3: Restoring the Inclusive Society ; 7 The geographic divide: booming metropolis, broken cities ; 8 The class divide: having it all, falling apart ; 9 The global divide: winners, and the left behind ; Part 4: Restoring Inclusive Politics ; 10 Breaking the extremes

Note: CONTENTS: PREFACE. - 1 IASC Internal Development. - IASC Organization. - IASC Council. - IASC Executive Committee. - IASC Secretariat. - ISIRA. - IASC Medal 2018. - 2 IASC Working Groups. - Cross-Cutting Activities. - Atmosphere Working Group (AWG). - Cryosphere Working Group (CWG). - Marine Working Group (MWG). - Social and Human Working Group (SHWG). - Terrestrial Working Group (TWG). - 3 Arctic Science Summit Week 2017. - Upcoming ASSWs. - 4 Data and Observations. - Arctic Data Committee (ADC). - Sustaining Arctic Observing Networks (SAON). - 5 Partnerships. - Arctic Council. - Asian Forum for Polar Sciences (AFoPS). - Association of Polar Early Career Scientists (APECS). - Circumpolar Health Research Network (CirchNet). - European Polar Board (EPB). - Forum of Arctic Research Operators (FARO). - International Arctic Social Sciences Association (IASSA). - International Association of Cryospheric Sciences (IACS). - International Council for the Exploration of the Sea (ICES). - The International Permafrost Association (IPA). - The Pacific Arctic Group (PAG). - The Scientific Committee on Antarctic Research (SCAR). - University of the Arctic (UArctic). - WCRP Climate and Cryosphere (CliC). - 6 Capacity Building. - IASC Fellowship Program. - CAFF-IASC Fellowship. - Fellows’ Voices. - Overview of Supported Early Career Scientists.

Note: Contents ISOLA Code for Multiple-Point Source Modeling—Review / Jiří Zahradník and Efthimios Sokos Seismic Moment Tensors in Anisotropic Media: A Review / Václav Vavryčuk The Frequency-Domain Moment-Tensor Inversion: Retrieving the Complete Source Moment-Tensor Spectra and Time Histories / Xiaoning Yang, Brian W. Stump and Mason D. Macphail Berkeley Seismic Moment Tensor Method, Uncertainty Analysis, and Study of Non-double-couple Seismic Events / Douglas S. Dreger Estimating Stability and Resolution of Waveform Inversion Focal Mechanisms / S. Scolaro, C. Totaro, D. Presti, Sebastiano D’Amico, G. Neri and B. Orecchio The Method of Cataclastic Analysis of Discontinuous Displacements / Yu. L. Rebetsky and A. Yu. Polets Challenges in Regional Moment Tensor Resolution and Interpretation / Simone Cesca and Sebastian Heimann The Role of Moment Tensors in the Characterization of Hydraulic Stimulations / Ismael Vera Rodriguez, James Rutledge and Sergey Stanchits Constrained Moment Tensors: Source Models and Case Studies / Jan Šílený Seismic Deformation Derived from Moment Tensor Summation: Application Along the Hellenic Trench / Anastasia Kiratzi, Christoforos Benetatos and Filippos Vallianatos Estimation of Empirical Green’s Tensor Spatial Derivative Elements: A Preliminary Study Using Strong Motion Records in Southern Fukui Prefecture, Japan / Michihiro Ohori Retrieval of the Seismic Moment Tensor from Joint Measurements of Translational and Rotational Ground Motions: Sparse Networks and Single Stations / Stefanie Donner, Heiner Igel, Céline Hadziioannou and the Romy group Overview of Moment Tensor Analysis in New Zealand / John Ristau Applications of Moment Tensor Solutions to the Assessment of Earthquake Hazard in Canada / J. F. Cassidy, H. Kao, John Ristau and A. Bent Intraplate Earthquakes in Europe—Source Parameters from Regional Moment Tensor Analysis / Jochen Braunmiller Source Characteristics of the January 8, 2013 (M W = 5.7) and May 24, 2014 (M W = 6.8) North Aegean Earthquakes Sequence / Doğan Kalafat, Kıvanç Kekovalı and Ali Pınar Investigating the Focal Mechanisms of the August 4th, 2003, Mw 7.6, South Orkney Islands Earthquake and its Aftershocks Sequence / M. P. Plasencia Linares, M. Guidarelli, M. Russi and G. F. Panza Waveform Modelling of 2009 Bhutan Earthquake of Magnitude 6.1 (Mw) Using Local Network Data of North East India / Santanu Baruah and Midusmita Boruah Resolving the Tectonic Stress by the Inversion of Earthquake Focal Mechanisms. Application in the Region of Greece. A Tutorial / Ioannis G. Kassaras and Vasilis Kapetanidis Relative Locations of Clustered Earthquakes in the Sea of Marmara and States of Local Stresses in the East of the Central Marmara Basin / Yasemin Korkusuz Öztürk and Nurcan Meral Özel Focal Mechanisms of Earthquakes and Stress Field of the Earth Crust in Azerbaijan / G. J. Yetirmishli and S. E. Kazimova Seismotectonic Crustal Strains of the Mongol-Baikal Seismic Belt from Seismological Data / Alena Seredkina and Valentina Melnikova The Stress State of Seismic Areas of the Central and East Asia / Yu. L. Rebetsky, A. Yu. Polets, O. A. Kuchay and N. A. Sycheva The Significance of Crustal Velocity Model in Moment Tensor Solutions: A Case Study of Yedisu Earthquakes / Fatih Turhan, Musavver Didem Cambaz and Jiří Zahradník An Overview of the Seismicity and Tectonics of the Black Sea / Doğan Kalafat Coulomb Stress Changes in the Area of December 2013–January 2014 Sannio-Matese Seismic Sequence (Southern Italy) / Santanu Baruah and Sebastiano D’Amico Active Faulting in the Earth’s Crust of the Baikal Rift System Based on the Earthquake Focal Mechanisms / Vladimir A. Sankov and Anna A. Dobrynina Quaternary Stress Field and Faulting in the Western Part of the Catanzaro Trough (Calabria, Southern Italy) / F. Brutto, F. Muto, M. F. Loreto, Sebastiano D’Amico, N. De Paola, V. Tripodi and S. Critelli A Seismogenic Zone Model for Seismic Hazard Studies in Northwestern Africa / J. A. Peláez, J. Henares, M. Hamdache and C. Sanz de Galdeano A Trial Modeling of Perturbed Repeating Earthquakes Combined by Mathematical Statics, Numerical Modeling and Seismological Observations / Keisuke Ariyoshi, Shunichi Nomura, Naoki Uchida and Toshihiro Igarashi Getting Started with GMT: An Introduction for Seismologists / Matthew R. Agius Devices for a Rotational Ground Motion Measurement / Leszek R. Jaroszewicz and Anna Kurzych

Note: Contents: Cover -- Title -- Copyright -- Contents -- Foreword by Robert McLeman and FranÃois Gemenne -- Foreword by Mary Robinson -- Acknowledgements -- List of figures -- List of tables -- List of boxes -- List of contributors -- Part I Existing knowledge, theories and methods -- 1 Environmental migration research: evolution and current state of the science -- 2 Theories of voluntary and forced migration -- 3 Mobility, displacement and migration, and their interactions with vulnerability and adaptation to environmental risks -- 4 Environmental change and international migration: a review -- 5 Immobility -- 6 Geospatial modeling and mapping -- 7 Modeling migration and population displacement in response to environmental and climate change: multilevel event history models -- 8 Estimating the population impacts of sea level rise -- 9 Qualitative research techniques: itâs a case-studies world -- 10 Incorporating Indigenous knowledge in research -- 11 Gender, migration and (global) environmental change -- 12 Environmental migrants, climate ârefugeesâ and sun-seeking expats: capturing the larger context of migration in a changing climate through appropriate and effective behavioural research -- Part II Empirical evidence from regions -- 13 Environmental change and migration: a review of West African case studies -- 14 Burkina Faso: the adaptation-migration policy nexus in a drying climate -- 15 Fleeing from arid lands: pastoralism in the context of climate change -- 16 Climate and risk of migration in South Africa -- 17 Deforestation, drought and environmental migration in Brazil: an overview -- 18 Internal migration in Bangladesh: a comparative analysis of coastal, environmentally challenged, and other districts -- 19 Environmental stressors and population mobility in China: causes, approaches and consequences -- 20 Environmental migration in Mexico -- 21 Transnational approaches to remittances, risk reduction, and disaster relief: evidence from post-Typhoon Haiyan experiences of Filipino immigrants in Canada -- 22 Population displacements and migration patterns in response to Hurricane Katrina -- 23 A community-based model for resettlement: lessons from coastal Louisiana -- 24 Social and cultural dimensions of environment-related mobility and planned relocations in the South Pacific -- Part III Legal and policy considerations -- 25 Definitions and concepts -- 26 Human rights, environmental displacement and migration -- 27 Climate, migration and displacement: exploring the politics of preventative action -- 28 Environmental migration and international political security: rhetoric, reality and questions -- 29 Green grabbing-induced displacement -- 30 Climate-induced community relocations: institutional challenges and human rights protections -- 31 UNHCRâs perspectives and activities on displacement in the context of climate change -- 32 Environmental change and human mobility: perspectives from the World Bank -- 33 Human mobility in the Anthropocene: perspectives from UN Environment -- 34 Platform on Disaster Displacement, follow-up to the Nansen Initiative: addressing the protection needs of persons displaced across borders in the context of disasters and climate change -- 35 A moment of opportunity to define the global governance of environmental migration: perspectives from the International Organization for Migration -- 36 Where do we go from here? Reflections on the future of environmental migration and displacement research -- Index

Note: Contents: 1. Introduction; 2. Steam-engine economics; 3. Beyond homo economicus; 4. Big and dirty; 5. Pictures of improbability; 6. Trillions, or only hundreds?; 7. Zipf’s law and other stories; 8. Ants and traders; 9. Too big to ignore; 10. Climate tipping points and known unknowns; 11. Predators and prey; 12. Good enough for government work; 13. Fat tails and the failure of forecasting; 14. Misunderstanding risk; 15. Choices beyond calculation; 16. Who won World War II?; 17. Conclusion

Note: Contents: Preface - The strongman economy? ; 1 - Putin's economic inheritance ; 2 - Reforging the Russian state ; 3 - Rise of the energy giants ; 4 - Stabilizing Russia's finances ; 5 - Restructuring Russian industry ; 6 - Wages and welfare ; 7 From crisis to crisis ; 8 - Putinomics under pressure ; Postscript - Can Putinomics survive?

Note: Dissertation, Universität Potsdam, 2018 , Contents Acknowledgements Abstract (English/Deutsch/Français) List of figures List of tables 1 Introduction 1.1 Scientic background 1.1.1 The Arctic coast, permafrost and climate change 1.1.2 Organic carbon in permafrost soils 1.1.3 Hillslope thermokarst processes 1.2 Aims 1.3 Study region 1.4 Methods 1.4.1 Mapping 1.4.2 Spline interpolation and volumes estimations 1.4.3 Fieldwork 1.4.4 Geochemical analyses 1.4.5 Statistical analyses 1.5 Thesis outline 1.6 Authors’ contributions 2 Synthesis 2.1 Retrogressive thaw slumps are widely spread in ice-rich permafrost areas 2.2 Retrogressive thaw slumps contribute signicantly to the nearshore or-ganic carbon 2.3 Thermokarst impacts the distribution of soil organic carbon along hill-slopes 2.4 Outlook . 3 Terrain Controls on the Occurrence of Coastal RTSs 3.1 Abstract 3.2 Introduction 3.3 Study area 3.4 Methods 3.4.1 Mapping of retrogressive thaw slumps and landform classication 3.4.2 Environmental variables 3.4.3 Univariate regression trees 3.5 Results 3.5.1 Characteristics of retrogressive thaw slumps 3.5.2 Density and areal coverage of retrogressive thaw slumps 3.6 Discussion 3.6.1 Characteristics and distribution of retrogressive thaw slumps 3.6.2 Terrain factors explaining retrogressive thaw slump occurrence 3.6.3 Coastal Processes 3.7 Conclusion 4 RTSs release sediments and organic carbon into the Arctic Ocean 4.1 Abstract 4.2 Introduction 4.3 Study Area 4.4 Methods 4.4.1 Evolution of retrogressive thaw slumps 4.4.2 Volume Estimations 4.4.3 Estimates of soil and dissolved organic carbon values 4.5 Results 4.5.1 Evolution of retrogressive thaw slumps between 1952 and 2011 4.5.2 Eroded material and estimated amount of mobilized SOC and DOC 4.6 Discussion 4.6.1 Increase in slump activity 4.6.2 Eroded material from retrogressive thaw slumps and organic car-bon uxes 4.6.3 Impact of retrogressive thaw slumps on the coastal ecosystem 4.7 Conclusion 5 Snapshot of carbon and nitrogen distribution in Arctic valleys 5.1 Abstract 5.2 Introduction 5.3 Study Area 5.4 Methods 5.4.1 Spatial analyses 5.4.2 Sampling Scheme 5.4.3 Geochemical analyses 5.4.4 Environmental variables and statistical analyses 5.5 Results 5.5.1 Geomorphology of the valleys 5.5.2 Spatial distribution of carbon and nitrogen 5.5.3 Correlations between soil characteristics and geochemical variables 5.6 Discussion 5.6.1 Variability in soil and geochemical properties in Arctic valleys 5.6.2 Hillslope Processes 5.7 Conclusion 6 Eidessttatliche Erklärung A Appendix A.1 Chapter 3 A.2 Chapter 4 A.3 Chapter 5 Bibliography

Note: Jacobin legacy: the origins of social justice -- National welfare and the universal declaration -- FDR's second bill -- Globalizing welfare after empire -- Basic needs and human rights -- Global ethics from equality to subsistence -- Human rights in the neoliberal maelstrom -- Conclusion: Croesus's world.

Note: Contents: Introduction ; The Art of Seeing Networks ; Part I - Elementary Networks and Tools ; Surveying the Tools of the Craft ; Introducing NetworkX ; Introducing Gephi ; Case Study: Constructing a Network of Wikipedia Pages ; Part II - Networks Based on Explicit Relationships ; Understanding Social Networks ; Mastering Advanced Network Construction ; Measuring Networks Case Study: Panama Papers ; Part III - Networks Based on Co-Occurrences ; Constructing Semantic and Product Networks ; Unearthing the Network Structure ; Case Study: Performing Cultural Domain Analysis ; Case Study: Going from Products to Projects ; Part IV - Unleashing Similarity ; Similarity-Based Networks ; Harnessing Bipartite Networks ; Case Study: Building a Network of Trauma Types ; Part V - When Order Makes a Difference ; Directed Networks

Note: Inhaltsverzeichnis: - The First Geometric POD of LEO Satellites - a Piece of History - Reference Frame From the Combination of a LEO Satellite with GPS Constellation and Ground Network of GPS Stations - Geometrical Model of the Earth’s Geo center Based on Temporal Gravity Field Maps - First Phase Clocks and Frequency Transfer - First Geometric POD of GPS and Galileo Satellites - Kinematics of IGS Stations - Reduced-Kinematic POD - First GPS Baseline in Space - the GRACE Mission - Geometrical Modeling of the Ionosphere and the Troposphere with LEO Orbit - Aerodynamics in Low LEO: A Novel Approach to Modeling Air Density Based on IGS TEC Maps - GPS Single-Frequency: From First cm-POD to Single Frequency GNSS-RO/R - Absolute Code Biases Based on the Ambiguity-Free Linear Combination - DCBs without TEC - LEO Near-Field Multipath and Antenna Effects - Probing the Flyby Anomaly Using Kinematic POD - Exotic Applications of Kinematic POD - Galileo-2: A Highly Accurate Dynamical GEO Reference Frame to Complement the TRF - Geometrical Representation of Gravity Field Determination

Note: TABLE OF CONTENTS SUMMARY 1. BACKGROUND AND OVERARCHING GOALS OF MOSAiC 2. MEASUREMENTS AND REQUIREMENTS 2.1 Atmosphere (team ATMOS) 2.2 Sea Ice and Snow Cover (team ICE) 2.3 Ocean (team OCEAN) 2.4 Bio-geochemical System (team BGC) 2.5 Ecosystem (team ECO) 2.6 Cross-team coordination 3. OBSERVATIONAL SCALES AND SCIENTIFIC-TECHNICAL IMPLEMENTATION 3.1 Installations, Labs, and Containers on Polarstern 3.2 Major Installations on/in/under the Central lee Camp 3.3 Deployment and Operation ofthe Distributed Network 3.4 Airborne Observations 3.5 Hovercraft Observations 3.6. Other Main Platforms 3.7 Intensive Observation Periods 3.8 Events 4. PRACTICAL/ LOGISTICAL ASPECTS 4.1 Detailed Time Line (2016-2022) 4.2 Drift Trajectory and Re-supply 4.3 Personnel and Personnel Exchange 4.4 Routine Operations during the Drift 4.5 Governance Structure 4.6 Rescue and Alternative Plans 4.7 Safety Aspects during the Drift 4.8 Impacts of Polarstern on Measurements and Environment 4.9 Outreach and Media Concept 4.10 Preparation and summary workshops, conferences 5. IMPLEMENTATION OF REMOTE SENSING 5.1 Pre-drift Coordination of the Remote Sensing Program 5.2 Acquisition of Satellite Data during the Drift 5.3 Coordination with In-situ Measurements 6. IMPLEMENTATION OF NUMERICAL MODELS 6.1 Operational Forecast and Reanalysis Products of the MOSAiC Drift 6.2 Data Assimilation Studies 6.3 Process and Regional Modeling of the Sub-systems 6.4 Coupled Climate Modeling 7. DATA POLICY AND MANAGEMENT PLAN 7.1 Outcome ofthe St. Petersburg Implementation Workshop 7.2 The MOSAiC Data Group: Development ofthe Data Management Plan 7.3 The Technical Concept for Supporting the Data Life Cycle in MOSAiC 7.4 The Role of PANGAEA as MOSAiC Data Repository 7.5 Project Data Management and Publication 8. LINKS TO EXTERNAL PROGRAMS AND PROJECTS 8.1 Cooperation with External Projects and Programs 8.2 Cooperation with Parallel Experiments 9. APPENDIX 9.1 Preliminary Tables of Parameters for Sections 2.1 to 2.5 9.2 Preliminary Table of Partners 9.3 List of Abbreviations

Note: Contents: Part I: An Introduction to Fortran 90 and Numerical Methods ; 1: Fortran 90: A Simple Programming Language ; 2: Numerical Solution Methods ; Part II: Computational Economics for Beginners ; 3: The Static General Equilibrium Model ; 4: Topics in Finance and Risk Management ; 5: The Life Cycle Model and Intertemporal Choics ; 6: The Overlapping Generations Model ; 7: Extending the OLG Model ; Part III: Advanced Computational Economics ; 8: Introduction to Dynamic Programming ; 9: Dynamic Macro I: Infinite Horizon Models ; 10: Life-Cycle Choices and Risk ; 11: Dynamic Macro II: The Stochastic OLG Model

Note: Inhaltsverzeichnis 1. History and evolution of the postdoctoral scholar in the United States / Keith Micoli and Steve Wendell 2. A review of postdoc reforms in the United States and the case of the Fair Labor Standards Act updates of 2016 / Adriana Bankston and Gary S. McDowell 3. Institutional support, programs, and policies for postdoctoral training / Nisha A. Cavanaugh 4. Postdoc scholars in S&E departments : plights, departmental expectations, and policies / Xuhong Su and Mary Alexander 5. Proactive postdoc mentoring / Sarah C. Hokanson and Bennett B. Goldberg 6. Career coherence, agency, and the postdoctoral scholar / Karen J. Haley, Tara D. Hudson and Audrey J. Jaeger 7. European cross-national mixed-method study on early career researcher experience / Montserrat Castelló, Kirsi Pyhältö and Lynn McAlpine 8. Postdoc trajectories : making visible the invisible / Lynn McAlpine 9. Global perspectives on the postdoctoral scholar experience / Karri Holley ... [et al.]

Note: Contents: 1. What is degrowth? ; 2. The economics of degrowth ; 3. Economic growth from a degrowth perspective ; 4. The case for degrowth ; 5. The utopia of degrowth ; 6. Controversies, debates and future research

Note: Contents Acknowledgments 1 Introduction to environmental DNA (eDNA) 1.1 Definitions 1.2 A brief history of eDNA analysis 1.3 Constraints when working with eDNA 1.4 Workflow in eDNA studies and main methods used 1.5 Environmental DNA as a monitoring tool 2 DNA metabarcode choice and design 2.1 Which DNA metabarcode? 2.2 Properties of the ideal DNA metabarcode 2.3 In silica primer design and testing 2.3.1 Prerequisites 2.3.2 Reference sequences: description, filtering, and formatting for ecoPrimers 2.3.3 In silica primer design with ecoPrimers 2.3.3.1 'Ihe ecoPrimers output 2.3.4 In silica primer testing with ecoPCR 2.3.4.1 The ecoPCR output 2.3.4.2 Filtering of the ecoPCR output 2.3.4.3 Evaluation of primer conservation 2.3.4.4 Taxonomic resolution and Bs index 2.4 Examples of primer pairs available for DNA metabarcoding 3 Reference databases 3.1 Extracting reference databases from EMBL/GenBank/DDBJ 3.1.1 Downloading a local copy of EMBL 3.1.2 Identifying sequences corresponding to the relevant metabarcode 3.2 Marker-specific reference databases 3.2.1 Nuclear rRNA gene reference databases 3.2.2 Eukaryote-specific databases 3.3 Building a local reference database 3.3.1 PCR-based local reference database 3.3.2 Shotgun-based local reference database 3.4 Current challenges and future directions 4 Sampling 4.1 The cycle of eDNA in the environment 4.1.1 State and origin 4.1.2 Fate 4.1.3 Transport 4.2 Sampling design 4.2.1 Focusing on the appropriate DNA population 4.2.2 Defining the sampling strategy 4.3 Sample preservation 5 DNA extraction 5.1 From soil samples 5.2 From sediment 5.3 From litter 5.4 From fecal samples 5.5 From water samples 6 DNA amplification and multiplexing 6.1 Principle of the PCR 6.2 Which polymerase to choose? 6.3 The standard PCR reaction 6.4 The importance of including appropriate controls 6.4.1 Extraction negative controls 6.4.2 PCR negative controls 6.4.3 PCR positive controls 6.4.4 Tagging system controls 6.4.5 Internal controls 6.5 PCR optimization 6.6 How to limit the risk of contamination? 6.7 Blocking oligonucleotides for reducing the amplification of undesirable sequences 6.8 How many PCR replicates? 6.9 Multiplexing several metabarcodes within the same PCR 6.10 Multiplexing many samples on the same sequencing lane 6.10.1 Overview of the problem 6.10.2 Strategy 1: single-step PCR with Illumina adapters 6.10.3 Strategy 2: two-step PCR with Illumina adapters 6.10.4 Strategy 3: single-step PCR with tagged primers 7 DNA sequencing 7.1 Overview of the first, second, and third generations of sequencing technologies 7.2 The Illumina technology 7.2.1 Library preparation 7.2.2 Flow cell, bridge PCR, and clusters 7.2.3 Sequencing by synthesis 7.2.4 Quality scores of the sequence reads 8 DNA metabarcoding data analysis 8.1 Basic sequence handling and curation 8.1.1 Sequencing quality 8.1.1.1 The pros and cons of read quality-based filtering 8.1.1.2 Quality trimming software 8.1.2 Paired-end read pairing 8.1.3 Sequence demultiplexing 8.1.4 Sequence dereplication 8.1.5 Rough sequence curation 8.2 Sequence classification 8.2.1 Taxonomic classification 8.2.2 Unsupervised classification 8.2.3 Chimera identification 8.3 Taking advantages of experimental controls 8.3.1 Filtering out potential contaminants 8.3.2 Removing dysfunctional PCRs 8.4 General considerations on ecological analyses 8.4.1 Sampling effort and representativeness 8.4.1.1 Evaluating representativeness of the sequencing per PCR 8.4.1.2 Evaluating representativeness at the sampling unit or site level 8.4.2 Handling samples with varying sequencing depth 8.4.3 Going further and adapting the ecological models to metabarcoding 9 Single-species detection 9.1 Principle of the quantitative PCR (qPCR) 9.1.1 Recording amplicon accumulation in real time via fluorescence measurement 9.1.2 The typical amplification curve 9.1.3 Quantification of target sequences with the Ct method 9.2 Design and testing of qPCR barcodes targeting a single species 9.2.1 1he problem of specificity 9.2.2 qPCR primers and probe 9.2.3 Candidate qPCR barcodes 9.3 Additional experimental considerations 9.3.1 General issues associated with sampling, extraction, and PCR amplification 9.3.2 The particular concerns of contamination and inhibition 10 Environmental DNA for functional diversity 10.1 Functional diversity from DNA metabarcoding 10.1.1 Functional inferences 10.1.2 Targeting active populations 10.2 Metagenomics and metatranscriptomics: sequencing more than a barcode 10.2.1 General sampling constraints 10.2.1.1 Optimization of the number of samples 10.2.1.2 Enrichment in target organisms 10.2.1.3 Enrichment in functional information 10.2.2 General molecular constraints 10.2.3 From sequences to functions 10.2.3.1 Assembling (or not) a metagenome 10.2.3.2 Sorting contigs or reads in broad categories 10.2.3.3 Extracting functional information via taxonomic inferences 10.2.3.4 Functional annotation of metagenomes 11 Some early landmark studies 11.1 Emergence of the concept of eDNA and first results on microorganisms 11.2 Examining metagenomes to explore the functional information carried by eDNA 11.3 Extension to macroorganisms 12 Freshwater ecosystems 12.1 Production, persistence, transport, and delectability of eDNA in freshwater ecosystems 12.1.1 Production 12.1.2 Persistence 12.1.3 Transport/ diffusion distance 12.1.4 Detectability 12.2 Macroinvertebrates 12.3 Diatoms and microeukaryotes 12.4 Aquatic plants 12.5 Fish, amphibians, and other vertebrates 12.5.1 Species detection 12.5.2 Biomass estimates 12.6 Are rivers conveyer belts of biodiversity information? 13 Marine environments 13.1 Environmental DNA cycle and transport in marine ecosystems 13.2 Marine microbial diversity 13.3 Environmental DNA for marine macroorganisms 14 Terrestrial ecosystems 14.1 Delectability, persistence, and mobility of eDNA in soil 14.2 Plant community characterization 14.3 Earthworm community characterization 14.4 Bacterial community or metagenome characterization 14.5 Multitaxa diversity surveys 1 5 Paleoenvironments 15.1 Lake sediments 15.1.1 Pollen, macrofossils, and DNA metabarcoding 15.1.2 Plants and mammals from Lake Anteme 15.1.3 Viability in the ice-free corridor in North America 15.2 Permafrost 15.2.1 Overview of the emergence of permafrost as a source of eDNA 15.2.2 Large-scale analysis of permafrost samples for reconstructing past plant communities 15.3 Archaeological midden material 15.3.1 Bulk archaeological fish bones from Madagascar 15.3.2 Midden from Greenland to assess past human diet 16 Host-associated microbiota 16.1 DNA dynamics 16.2 Early molecular-based works 16.3 Post-holobiont works 17 Diet analysis 17.1 Some seminal diet studies 17.1.1 Proof of concept-analyzing herbivore diet using next-generation sequencing 17.1.2 Assessing the efficiency of conservation actions in Bialowieza forest 17.1.3 Characterizing carnivore diet, or how to disentangle predator and prey eDNA 17.1.4 Analyzing an omnivorous diet, or integrating several diets in a single one 17.2 Methodological and experimental specificities of eDNA diet analyses 17.2.1 eDNAsources 17.2.1.1 Feces 17.2.1.2 Gut content 17.2.1.3 Whole body 17.2.2 Quantitative aspects 17.2.2.1 Relationship between the amount of ingested food and DNA quantity in the sample 17.2.2.2 Quantifying DNA with PCR and next-generation sequencing 17.2.2.3 Empirical correction of abundances 17.2.3 Diet as a sample of the existing biodiversity 17.2.4 Problematic diets 18 Analysis of bulk samples 18.1 What is a bulk sample? 18.2 Case studies 18.2.1 Bulk insect samples for biodiversity monitoring 18.2.2 Nematode diversity in tropical rainforest 18.2.3 Marine metawan diversity in benthic ecosystems 18.3 Metabarcoding markers for bulk samples 18.4 Alternative strategies 19 The future of eDNA metabarcoding 19.1 PCR-based approaches 19.1.1 Singl

Note: N.F. entfällt ab 57.2000. - Volltext auch als Teil einer Datenbank verfügbar , Ersch. ab 2000 in engl. Sprache mit dt. Hauptsacht.

Note: Contents Part I Introduction 1 Machine Learning in Wildlife Biology: Algorithms, Data Issues and Availability, Workflows, Citizen Science, Code Sharing, Metadata and a Brief Historical Perspective / Grant R. W. Humphries and Falk Huettmann 2 Use of Machine Learning (ML) for Predicting and Analyzing Ecological and ‘Presence Only’ Data: An Overview of Applications and a Good Outlook / Falk Huettmann, Erica H. Craig, Keiko A. Herrick, Andrew P. Baltensperger, Grant R. W. Humphries, David J. Lieske, Katharine Miller, Timothy C. Mullet, Steffen Oppel, Cynthia Resendiz, Imme Rutzen, Moritz S. Schmid, Madan K. Suwal, and Brian D. Young 3 Boosting, Bagging and Ensembles in the Real World: An Overview, some Explanations and a Practical Synthesis for Holistic Global Wildlife Conservation Applications Based on Machine Learning with Decision Trees / Falk Huettmann Part II Predicting Patterns 4 From Data Mining with Machine Learning to Inference in Diverse and Highly Complex Data: Some Shared Experiences, Intellectual Reasoning and Analysis Steps for the Real World of Science Applications / Falk Huettmann 5 Ensembles of Ensembles: Combining the Predictions from Multiple Machine Learning Methods / David J. Lieske, Moritz S. Schmid, and Matthew Mahoney 6 Machine Learning for Macroscale Ecological Niche Modeling - a Multi-Model, Multi-Response Ensemble Technique for Tree Species Management Under Climate Change / Anantha M. Prasad 7 Mapping Aboveground Biomass of Trees Using Forest Inventory Data and Public Environmental Variables within the Alaskan Boreal Forest / Brian D. Young, John Yarie, David Verbyla, Falk Huettmann, and F. Stuart Chapin III Part III Data Exploration and Hypothesis Generation with Machine Learning 8 ‘Batteries’ in Machine Learning: A First Experimental Assessment of Inference for Siberian Crane Breeding Grounds in the Russian High Arctic Based on ‘Shaving’ 74 Predictors / Falk Huettmann, Chunrong Mi, and Yumin Guo 9 Landscape Applications of Machine Learning: Comparing Random Forests and Logistic Regression in Multi-Scale Optimized Predictive Modeling of American Marten Occurrence in Northern Idaho, USA / Samuel A. Cushman and Tzeidle N. Wasserman 10 Using Interactions among Species, Landscapes, and Climate to Inform Ecological Niche Models: A Case Study of American Marten (Martes americana) Distribution in Alaska / Andrew P. Baltensperger 11 Advanced Data Mining (Cloning) of Predicted Climate-Scapes and Their Variances Assessed with Machine Learning: An Example from Southern Alaska Shows Topographical Biases and Strong Differences / Falk Huettmann 12 Using TreeNet, a Machine Learning Approach to Better Understand Factors that Influence Elevated Blood Lead Levels in Wintering Golden Eagles in the Western United States / Erica H. Craig, Tim H. Craig, and Mark R. Fuller Part IV Novel Applications of Machine Learning Beyond Species Distribution Models 13 Breaking Away from ‘Traditional’ Uses of Machine Learning: A Case Study Linking Sooty Shearwaters (Ardenna griseus) and Upcoming Changes in the Southern Oscillation Index / Grant R. W. Humphries 14 Image Recognition in Wildlife Applications / Dawn R. Magness 15 Machine Learning Techniques for Quantifying Geographic Variation in Leach’s Storm-Petrel (Hydrobates leucorhous) Vocalizations / Grant R. W. Humphries, Rachel T. Buxton, and Ian L. Jones Part V Implementing Machine Learning for Resource Management 16 Machine Learning for ‘Strategic Conservation and Planning’: Patterns, Applications, Thoughts and Urgently Needed Global Progress for Sustainability / Falk Huettmann 17 How the Internet Can Know What You Want Before You Do: Web-Based Machine Learning Applications for Wildlife Management / Grant R. W. Humphries 18 Machine Learning and ‘The Cloud’ for Natural Resource Applications: Autonomous Online Robots Driving Sustainable Conservation Management Worldwide? / Grant R. W. Humphries and Falk Huettmann 19 Assessment of Potential Risks from Renewable Energy Development and Other Anthropogenic Factors to Wintering Golden Eagles in the Western United States / Erica H. Craig, Mark R. Fuller, Tim H. Craig, and Falk Huettmann Part VI Conclusions 20 A Perspective on the Future of Machine Learning: Moving Away from ‘Business as Usual’ and Towards a Holistic Approach of Global Conservation / Grant R. W. Humphries and Falk Huettmann Index

Note: Contents Automated Blood Cultures / Xiang Y. Han Laboratory Automation in Clinical Bacteriology / Antony Croxatto Biochemical Profile-Based Microbial Identification Systems / Safina Hafeez and Jaber Aslanzadeh Advanced Phenotypic Antimicrobial Susceptibility Testing Methods / Charles W. Stratton Rapid Microbial Antigen Tests / Sheldon Campbell and Marie L. Landry Antibody Detection: Principles and Applications / Yun F. (Wayne) Wang Procalcitonin and Other Host-Response-Based Biomarkers for Evaluation of Infection and Guidance of Antimicrobial Treatment / Philipp Schuetz, Ramon Sager, Yannick Wirz, and Beat Mueller Functional Assessment of Microbial, Viral, and Parasitic Infections Using Real-Time Cellular Analysis / Dazhi Jin, Xiao Xu, Min Zheng, Alex Mira, Brandon J. Lamarche, and Alex B. Ryder Cellular Fatty Acid-Based Microbial Identification and Antimicrobial Susceptibility Testing / Nicole Parrish and Stefan Riedel MALDI-TOF Mass Spectrometry-Based Microbial Identification and Beyond / Alexander Mellmann and Johannes Müthing Transcriptomic Techniques in Diagnostic Microbiology / Zachary E. Holcomb and Ephraim L. Tsalik The Use of Microbial Metabolites for the Diagnosis of Infectious Diseases / Mahesh J. Thalavitiya Acharige, Seena S. Koshy, and Sophia Koo Nucleic Acid Extraction and Enrichment / Jeong Hwan Shin Nonamplified Probe-Based Microbial Detection and Identification / Fann Wu, Tao Hong, and Phyllis Della-Latta Molecular Typing Techniques: State of the Art / Richard V. Goering PCR and Its Variations / Eleanor A. Powell and Michael Loeffelholz Non-PCR Amplification Techniques / Rosemary C. She, Ted E. Schutzbank, and Elizabeth M. Marlowe Real-Time and Digital PCR for Nucleic Acid Quantification / Alexander J. McAdam Direct Nucleotide Sequencing for Amplification Product Identification / Tao Hong Solid and Suspension Microarrays for Detection and Identification of Infectious Diseases / Sherry Dunbar, Janet Farhang, Shubhagata Das, Sabrina Ali, and Heng Qian Real-Time Detection of Amplification Products Through Fluorescence Quenching or Energy Transfer / Caitlin Otto and Shihai Huang PCR/Electrospray Ionization-Mass Spectrometry as an Infectious Disease Diagnostic Tool / Volkan Özenci and Kristoffer Strålin Nucleic Acid Amplicons Detected and Identified by T2 Magnetic Resonance / Jessica L. Snyder, Heather S. Lapp, Zhi-Xiang Luo, Brendan Manning, and Thomas J. Lowery Molecular Contamination and Amplification Product Inactivation / Susan Sefers and Jonathan E. Schmitz Index

Note: Contents Part I Setting the Scene The Anthropocene—What Does It Entail for Science? / Gesche Krause The Role of Knowledge Exchange in Earth System Science—The Earth System Knowledge Platform (ESKP) / Gesche Krause, Ute Münch, Jana Kandarr, Oliver Jorzik and Pia Klinghammer The AWI Approach at the Science-Stakeholder Interface / Gesche Krause, Klaus Grosfeld and Wolfgang Hiller Part II Dialogue Approaches of ESKP Contributions to AWI Knowledge Transfer Regional Awareness on Sea Level Rise Effects—What Do We Know About the South-Eastern North Sea Coast? / Nina Eschweiler, Tobias Dolch and Christian Buschbaum Climate Change and Biodiversity—Implications for the Local Fisheries Sector / Christina Hörterer, Maximilian Schupp, Andreas Benkens and Bela H. Buck Linking Biodiversity Research Communities / Sonja Knapp, Alexandra Kraberg, Stephan Frickenhaus, Stefan Klotz, Oliver Schweiger and Gesche Krause Engaging Forecast Users During the Year of Polar Prediction / Winfried Hoke, Kirstin Werner, Helge Goessling and Thomas Jung Governance of Resources for Arctic Sustainable Policy and Practice (GRASP)—Stakeholder Mapping / Sebastian Knecht, Andreas Herber and Kathrin Stephen Building Bridges at the Arctic Science-Policy Interface / Volker Rachold Part III Data-Products of ESKP Contributions to AWI Knowledge Transfer The Web Portal ‘meereisportal.de’ in Context of ESKP / Klaus Grosfeld, Renate Treffeisen, Jölund Asseng and Georg Heygster Knowledge Transfer by the Global Terrestrial Network for Permafrost (GTN-P) / Boris K. Biskaborn and Hugues Lantuit A Web-Based Information System for Macrobenthic Biodiversity in the German North Sea / Jan M. Holstein Tackling Marine Litter—LITTERBASE / Melanie Bergmann, Mine B. Tekman, Andreas Walter and Lars Gutow Part IV Modelling Approaches of ESKP Contributions to AWI Knowledge Transfer Arctic Sea Ice Change, Large-Scale Atmospheric Circulation Patterns and Extreme Climate and Weather in Europe / Ralf Jaiser and Dörthe Handorf Extending and Visualizing the TsunAWI Simulation Database of the Indonesia Tsunami Early Warning System (InaTEWS) / Antonia Immerz, Sven Harig and Natalja Rakowsky Streamflow Forecasting and Biodiversity / Monica Ionita, Madlene Pfeiffer and Stephan Frickenhaus Part V Pathways to Formalizing Knowledge Transfer Accompanying ESKP Projects—Development of a Process Assessment Strategy Within ESKP@AWI / Gesche Krause and Maximilian Felix Schupp Science and Society—The Time to Interact / Gesche Krause, Klaus Grosfeld and Annette Breckwoldt Erratum to: A Web-Based Information System for Macrobenthic Biodiversity in the German North Sea / Jan M. Holstein

Note: Contents Introduction / Aaron Micallef, Sebastian Krastel and Alessandra Savini Part I Data and Methods in Submarine Geomorphology Sidescan Sonar / Ingo Klaucke Multibeam Echosounders / John E. Hughes Clarke Reflection and Refraction Seismic Methods / Gareth J. Crutchley and Heidrun Kopp Quantitative Analyses of Morphological Data / Philippe Blondel Seafloor Sediment and Rock Sampling / Aggeliki Georgiopoulou ROVs and AUVs / Veerle A.I. Huvenne, Katleen Robert, Leigh Marsh, Claudio Lo Iacono, Tim Le Bas and Russell B. Wynn Part II Submarine Landforms and Processes Origin and Geomorphic Characteristics of Ocean Basins / Peter T. Harris and Miles Macmillan-Lawler Drivers of Seafloor Geomorphic Change / Angelo Camerlenghi Shallow Coastal Landforms / Fantina Madricardo and Federica Rizzetto Continental Shelf Landforms / Ruth Durán and Jorge Guillén Submarine Glacial Landforms / Christine L. Batchelor, Julian A. Dowdeswell and Dag Ottesen Submarine Landslides / Joshu Mountjoy and Aaron Micallef Submarine Canyons and Gullies / David Amblas, Silvia Ceramicola, Thomas P. Gerber, Miquel Canals, Francesco L. Chiocci, Julian A. Dowdeswell, Peter T. Harris, Veerle A.I. Huvenne, Steven Y.J. Lai, Galderic Lastras, Claudio Lo Iacono, Aaron Micallef, Joshu J. Mountjoy, Charles K. Paull, Pere Puig and Anna Sanchez-Vidal Submarine Fans and Their Channels, Levees, and Lobes / Mark E. Deptuck and Zoltán Sylvester Contourite Drifts and Associated Bedforms / Ibimina Esentia, Dorrik Stow and Zeinab Smillie Volcanic Islands and Seamounts / Daniele Casalbore Mid-ocean Ridges / Neil C. Mitchell Cold Seep Systems / Silvia Ceramicola, Stéphanie Dupré, Luis Somoza and John Woodside Abyssal Hills and Abyssal Plains / Marie-Helene Cormier and Heather Sloan Oceanic Trenches / Jacob Geersen, David Voelker and Jan H. Behrmann Cold-Water Carbonate Bioconstructions / Claudio Lo Iacono, Alessandra Savini and Daniela Basso Part III Applied Submarine Geomorphology Applied Geomorphology and Geohazard Assessment for Deepwater Development / Roger Moore, Geoff Davis and Oliver Dabson Seabed Mining / Anne Peukert, Sven Petersen, Jens Greinert and François Charlot Fishing Activities / Ferdinand K.J. Oberle, Pere Puig and Jacobo Martín National Programmes: Geomorphological Mapping at Multiple Scales for Multiple Purposes / Terje Thorsnes, Lilja R. Bjarnadóttir, Alexandra Jarna, Nicole Baeten, Gill Scott, Janine Guinan, Xavier Monteys, Dayton Dove, Sophie Green, Joana Gafeira and Alan Stevenson Part IV Conclusion Conclusion / Aaron Micallef, Sebastian Krastel and Alessandra Savini Erratum to: Submarine Geomorphology / Aaron Micallef, Sebastian Krastel and Alessandra Savini

Note: Contents 1 Introduction: Limits to Adaptation / Johanna Nalau and Walter Leal Filho Part I Limits to Climate Change Adaptation in Asia 2 Strategies and Barriers to Adaptation of Hazard-Prone Rural Households in Bangladesh / G. M. Monirul Alam, Khorshed Alam, Shahbaz Mushtaq, Most Nilufa Khatun and Walter Leal Filho 3 Governance Limits to Adaptation in Cambodia’s Health Sector / Daniel Gilfillan 4 Land-Based Strategic Model by Integrating Diverse Policies for Climate Change Adaptation in Nepal / Adish Khezri, Arbind Man Tuladhar and Jaap Zevenbergen 5 Climate Change and Migration in Bangladesh: Empirically Derived Lessons and Opportunities for Policy Makers and Practitioners / Johannes Luetz Part II Limits to Climate Change Adaptation in Africa 6 Limits to Climate Change Adaptation in Zimbabwe: Insights, Experiences and Lessons / Nelson Chanza 7 Pastoralists Shifting Strategies and Perceptions of Risk: Post-crisis Recovery in Damergou, Niger / Karen Marie Greenough 8 Political Limits to Climate Change Adaptation Practices: Insights from the Johannesburg Case / Karen Hetz 9 Constraints and Limits to Climate Change Adaptation Efforts in Nigeria / Idowu O. Ologeh, Joshua B. Akarakiri and Francis A. Adesina 10 Adapting Agriculture to Climate Change: Suitability of Banana Crop Production to Future Climate Change Over Uganda / Geoffrey Sabiiti, Joseph Mwalichi Ininda, Laban Ayieko Ogallo, Jully Ouma, Guleid Artan, Charles Basalirwa, Franklin Opijah, Alex Nimusiima, Saul Daniel Ddumba, Jasper Batureine Mwesigwa, George Otieno and Jamiat Nanteza 11 Local Adaptation to Climate Extremes in Domboshawa: Opportunities and Limitations / Vincent Itai Tanyanyiwa and Rejoice Madobi Part III Limits to Climate Change Adaptation in Australia, North-America and Europe 12 The Limits of Imagination / Liese Coulter 13 Climate Change Adaptation in Coastal East Arctic Ecosystems: Complexity and Challenges of Monitoring and Evaluation / Moktar Lamari, Line Poulin-Larivière and Johann L. Jacob 14 Limits to Adaptation on Climate Change in Bosnia and Herzegovina: Insights and Experiences / Goran Trbic, Davorin Bajic, Vladimir Djurdjevic, Vladan Ducic, Raduska Cupac, Đorđe Markez, Goran Vukmir, Radoslav Dekić and Tatjana Popov Part IV Limits to Climate Change Adaptation in the Pacific Region 15 Climate Change Adaptation Limits in Small Island Developing States / Stacy-ann Robinson 16 Limits to Coastal Adaptation in Samoa: Insights and Experiences / Richard Crichton and Miguel Esteban 17 Limits to Capital Works Adaptation in the Coastal Zones and Islands: Lessons for the Pacific / Brendan Mackey and Daniel Ware 18 A ‘Cost Barrier’ Perspective to Adaptation on a Coral Triangle Initiative (CTI) and Mangrove Rehabilitation Projects (MRP) in Solomon Islands / Michael Otoara Ha’apio, Walter Leal Filho and Morgan Wairiu 19 Customary Land and Climate Change Induced Relocation: A Case Study of Vunidogoloa Village, Vanua Levu, Fiji / Dhrishna Charan, Manpreet Kaur and Priyatma Singh 20 Limits to Adapting to Climate Change Through Relocations in Papua-New Guinea and Fiji / Dalila Gharbaoui and Julia Blocher 21 Atoll Habitability Thresholds / Mark H. N. Stege 22 Conclusions: Overcoming the Limits to Adaptation / Walter Leal Filho and Johanna Nalau

Note: Contents 1 Introduction to Spatial Ecology and Its Relevance for Conservation 1.1 What Is Spatial Ecology? 1.2 The Importance of Space in Ecology 1.3 The Importance of Space in Conservation 1.4 The Growth of Frameworks for Spatial Modeling 1.5 The Path Ahead References Part I Quantifying Spatial Pattern in Ecological Data 2 Scale 2.1 Introduction 2.2 Key Concepts and Approaches 2.2.1 Scale Defined and Clarified 2.2.2 Why Is Spatial Scale Important? 2.2.3 Multiscale and Multilevel Quantitative Problems 2.2.4 Spatial Scale and Study Design 2.3 Examples in R 2.3.1 Packages in R 2.3.2 The Data 2.3.3 A Simple Simulated Example 2.3.4 Multiscale Species Response to Land Cover 2.4 Next Steps and Advanced Issues 2.4.1 Identifying Characteristic Scales Beyond Species–Environment Relationships 2.4.2 Sampling and Scale 2.5 Conclusions References 3 Land-Cover Pattern and Change 3.1 Introduction 3.2 Key Concepts 3.2.1 Land Use Versus Land Cover 3.2.2 Conceptual Models for Land Cover and Habitat Change 3.2.3 Habitat Loss and Fragmentation 3.2.4 Quantifying Land-Cover Pattern 3.3 Examples in R 3.3.1 Packages in R 3.3.2 The Data 3.3.3 Quantifying Land-Cover Variation at Different Scales 3.3.4 Simulating Land Cover: Neutral Landscapes 3.4 Next Steps and Advanced Issues 3.4.1 Testing for Pattern Differences Between Landscapes 3.4.2 Land-Cover Quantification via Image Processing 3.4.3 Categorical Versus Continuous Metrics 3.5 Conclusions References 4 Spatial Dispersion and Point Data 4.1 Introduction 4.2 Key Concepts and Approaches 4.2.1 Characteristics of Point Patterns 4.2.2 Summary Statistics for Point Patterns 4.2.3 Common Statistical Models for Point Patterns 4.3 Examples in R 4.3.1 Packages in R 4.3.2 The Data 4.3.3 Creating Point Pattern Data and Visualizing It 4.3.4 Univariate Point Patterns 4.3.5 Marked Point Patterns 4.3.6 Inhomogeneous Point Processes and Point Process Models 4.3.7 Alternative Null Models 4.3.8 Simulating Point Processes 4.4 Next Steps and Advanced Issues 4.4.1 Space-Time Analysis 4.4.2 Replicated Point Patterns 4.5 Conclusions References 5 Spatial Dependence and Autocorrelation 5.1 Introduction 5.2 Key Concepts and Approaches 5.2.1 The Causes of Spatial Dependence 5.2.2 Why Spatial Dependence Matters 5.2.3 Quantifying Spatial Dependence 5.3 Examples in R 5.3.1 Packages in R 5.3.2 The Data 5.3.3 Correlograms 5.3.4 Variograms 5.3.5 Kriging 5.3.6 Simulating Spatially Autocorrelated Data 5.3.7 Multiscale Analysis 5.4 Next Steps and Advanced Issues 5.4.1 Local Spatial Dependence 5.4.2 Multivariate Spatial Dependence 5.5 Conclusions References 6 Accounting for Spatial Dependence in Ecological Data 6.1 Introduction 6.2 Key Concepts and Approaches 6.2.1 The Problem of Spatial Dependence in Ecology and Conservation 6.2.2 The Generalized Linear Model and Its Extensions 6.2.3 General Types of Spatial Models 6.2.4 Common Models that Account for Spatial Dependence 6.2.5 Inference Versus Prediction 6.3 Examples in R 6.3.1 Packages in R 6.3.2 The Data 6.3.3 Models that Ignore Spatial Dependence 6.3.4 Models that Account for Spatial Dependence 6.4 Next Steps and Advanced Issues 6.4.1 General Bayesian Models for Spatial Dependence 6.4.2 Detection Errors and Spatial Dependence 6.5 Conclusions References Part II Ecological Responses to Spatial Pattern and Conservation 7 Species Distributions 7.1 Introduction 7.2 Key Concepts and Approaches 7.2.1 The Niche Concept 7.2.2 Predicting Distributions or Niches? 7.2.3 Mechanistic Versus Correlative Distribution Models 7.2.4 Data for Correlative Distribution Models 7.2.5 Common Types of Distribution Modeling Techniques 7.2.6 Combining Models: Ensembles 7.2.7 Model Evaluation 7.3 Examples in R 7.3.1 Packages in R 7.3.2 The Data 7.3.3 Prepping the Data for Modeling 7.3.4 Contrasting Models 7.3.5 Interpreting Environmental Relationships 7.3.6 Model Evaluation 7.3.7 Combining Models: Ensembles 7.4 Next Steps and Advanced Issues 7.4.1 Incorporating Dispersal 7.4.2 Integrating Multiple Data Sources 7.4.3 Dynamic Models 7.4.4 Multi-species Models 7.4.5 Sampling Error and Distribution Models 7.5 Conclusions References 8 Space Use and Resource Selection 8.1 Introduction 8.2 Key Concepts and Approaches 8.2.1 Distinguishing Among the Diversity of Habitat-Related Concepts and Terms 8.2.2 Habitat Selection Theory 8.2.3 General Types of Habitat Use and Selection Data 8.2.4 Home Range and Space Use Approaches 8.2.5 Resource Selection Functions at Different Scales 8.3 Examples in R 8.3.1 Packages in R 8.3.2 The Data 8.3.3 Prepping the Data for Modeling 8.3.4 Home Range Analysis 8.3.5 Resource Selection Functions 8.4 Next Steps and Advanced Issues 8.4.1 Mechanistic Models and the Identification of Hidden States 8.4.2 Biotic Interactions 8.4.3 Sampling Error and Resource Selection Models 8.5 Conclusions References 9 Connectivity 9.1 Introduction 9.2 Key Concepts and Approaches 9.2.1 The Multiple Meanings of Connectivity 9.2.2 The Connectivity Concept 9.2.3 Factors Limiting Connectivity 9.2.4 Three Common Perspectives on Quantifying Connectivity 9.3 Examples in R 9.3.1 Packages in R 9.3.2 The Data 9.3.3 Functional Connectivity Among Protected Areas for Florida Panthers 9.3.4 Patch-Based Networks and Graph Theory 9.3.5 Combining Connectivity Mapping with Graph Theory 9.4 Next Steps and Advanced Issues 9.4.1 Connectivity in Space and Time 9.4.2 Individual-Based Models 9.4.3 Diffusion Models 9.4.4 Spatial Capture–Recapture 9.5 Conclusions References 10 Population Dynamics in Space 10.1 Introduction 10.2 Key Concepts and Approaches 10.2.1 Foundational Population Concepts 10.2.2 Spatial Population Concepts 10.2.3 Population Viability Analysis 10.2.4 Common Types of Spatial Population Models 10.3 Examples in R 10.3.1 Packages in R 10.3.2 The Data 10.3.3 Spatial Correlation and Synchrony 10.3.4 Metapopulation Metrics 10.3.5 Estimating Colonization–Extinction Dynamics 10.3.6 Projecting Dynamics 10.3.7 Metapopulation Viability and Environmental Change 10.4 Next Steps and Advanced Issues 10.4.1 Spatial Population Matrix Models 10.4.2 Diffusion and Spatial Dynamics 10.4.3 Agent-Based Models 10.4.4 Integrated Population Models 10.5 Conclusions References 11 Spatially Structured Communities 11.1 Introduction 11.2 Key Concepts and Approaches 11.2.1 Spatial Community Concepts 11.2.2 Common Approaches to Understanding Community–Environment Relationships 11.2.3 Spatial Models for Communities 11.3 Examples in R 11.3.1 Packages in R 11.3.2 The Data 11.3.3 Modeling Communities and Extrapolating in Space 11.3.4 Spatial Dependence in Communities 11.3.5 Community Models with Explicit Accounting for Space 11.4 Next Steps and Advanced Issues 11.4.1 Decomposition of Space–Environment Effects 11.4.2 Accounting for Dependence Among Species 11.4.3 Spatial Networks 11.5 Conclusions References 12 What Have We Learned? Looking Back and Pressing Forward 12.1 The Impact of Spatial Ecology and Conservation 12.2 Looking Forward: Frontiers for Spatial Ecology and Conservation 12.3 Where to Go from Here for Advanced Spatial Modeling? 12.4 Beyond R 12.5 Conclusions References Appendix A: An Introduction to R Index

Note: Contents Part I Adaptation Mechanisms for Cold 1 Gene Regulatory Networks Mediating Cold Acclimation: The CBF Pathway / Javier Barrero-Gil and Julio Salinas 2 RNA Regulation in Plant Cold Stress Response / Kentaro Nakaminami and Motoaki Seki 3 The Mechanism Enabling Hibernation in Mammals / Yuuki Horii, Takahiko Shiina, and Yasutake Shimizu 4 Freezing Tolerance of Plant Cells: From the Aspect of Plasma Membrane and Microdomain / Daisuke Takahashi, Matsuo Uemura, and Yukio Kawamura 5 Natural Variation in Freezing Tolerance and Cold Acclimation Response in Arabidopsis thaliana and Related Species / Ellen Zuther, Yang Ping Lee, Alexander Erban, Joachim Kopka, and Dirk K. Hincha 6 Ice Nucleation Activity in Plants: The Distribution, Characterization, and Their Roles in Cold Hardiness Mechanisms / Masaya Ishikawa, Hideyuki Yamazaki, Tadashi Kishimoto, Hiroki Murakawa, Timothy Stait-Gardner, Kazuyuki Kuchitsu, and William S. Price 7 Investigating Freezing Patterns in Plants Using Infrared Thermography / David P. Livingston III 8 Mechanism of Overwintering in Trees / Keita Arakawa, Jun Kasuga, and Naoki Takata 9 The Mechanism of Low-Temperature Tolerance in Fish / Kiyoshi Soyano and Yuji Mushirobira Part II Adaptation Mechanisms for Desiccation 10 Mechanisms Underlying Freezing and Desiccation Tolerance in Bryophytes / Daisuke Takezawa 11 Regulatory Gene Networks in Drought Stress Responses and Resistance in Plants / Fuminori Takahashi, Takashi Kuromori, Hikaru Sato, and Kazuo Shinozaki 12 Mechanism of Stomatal Closure in Plants Exposed to Drought and Cold Stress / Srinivas Agurla, Shashibhushan Gahir, Shintaro Munemasa, Yoshiyuki Murata, and Agepati S. Raghavendra 13 Mechanisms of Maturation and Germination in Crop Seeds Exposed to Environmental Stresses with a Focus on Nutrients, Water Status, and Reactive Oxygen Species / Yushi Ishibashi, Takashi Yuasa, and Mari Iwaya-Inoue 14 The Antioxidant System in the Anhydrobiotic Midge as an Essential, Adaptive Mechanism for Desiccation Survival / Alexander Nesmelov, Richard Cornette, Oleg Gusev, and Takahiro Kikawada 15 Physicochemical Aspects of the Biological Functions of Trehalose and Group 3 LEA Proteins as Desiccation Protectants / Takao Furuki and Minoru Sakurai Part III Application Technologies from Laboratory to Society 16 Supercooling-Promoting (Anti-ice Nucleation) Substances / Seizo Fujikawa, Chikako Kuwabara, Jun Kasuga, and Keita Arakawa 17 Applications of Antifreeze Proteins: Practical Use of the Quality Products from Japanese Fishes / Sheikh Mahatabuddin and Sakae Tsuda 18 Development and Application of Cryoprotectants / Robin Rajan and Kazuaki Matsumura 19 Cryopreservation of Plant Genetic Resources / Daisuke Tanaka, Takao Niino, and Matsuo Uemura 20 Applications of Freezing and Freeze-Drying in Pharmaceutical Formulations / Ken-ichi Izutsu 21 Control of Physical Changes in Food Products / Kiyoshi Kawai and Tomoaki Hagiwara Index

Note: Contents Part I Introduction to the Central Nervous System 1 Introduction to the Central Nervous System 1.1 The Neuron 1.2 The Nervous System 1.2.1 Peripheral Nervous System (Fig. 1.3) 1.2.2 Central Nervous System Bibliography 2 Neurocytology: Cells of the CNS 2.1 The Neuron 2.1.1 Dendrites 2.1.2 Soma 2.1.3 Golgi Type I and II Neurons 2.1.4 Dendritic Spines (Fig. 2.2) 2.1.5 Nucleus 2.1.6 Neuronal Cytoskeleton 2.1.7 Microtubules and Axoplasmic Flow 2.1.8 Neurofibrillary Tangles 2.2 Synapse 2.2.1 Synaptic Structure 2.2.2 Synaptic Types 2.2.3 Synaptic Transmission 2.2.4 Neurotransmitters (Table 2.3) 2.2.5 Modulators of Neurotransmission 2.2.6 Synaptic Vesicles (Fig. 2.16) (Table 2.4) 2.2.7 Effectors and Receptors 2.3 Supporting Cells of the Central Nervous System 2.3.1 Astrocytes (Figs. 2.6 and 2.14; Table 2.7) 2.3.2 Oligodendrocytes (Fig. 2.9) 2.3.3 Endothelial Cells 2.3.4 Mononuclear Cells: Monocytes and Microglia 2.3.5 Ependymal Cells (Fig. 2.20) 2.3.6 Supporting Cells in the Peripheral Nervous System 2.4 Response of the Nervous System to Injury 2.4.1 Degeneration 2.5 Regeneration 2.5.1 Peripheral Nerve Regeneration 2.5.2 Regeneration in the Central Nervous System 2.5.3 Neurogenesis in the Adult Brain Stem 2.5.4 Nerve Growth Factors (NGF) 2.5.5 Glial Response to Injury 2.6 Blood–Brain Barrier 2.6.1 Blood–Brain Barrier (Fig. 2.24) 2.6.2 Extracellular Space Specific References 3 Neuroembryology and Congenital Malformations 3.1 Formation of the Central Nervous System 3.2 Histogenesis 3.2.1 Repair of Damaged Nervous System 3.2.2 Growth Cone Guidance 3.2.3 Programmed Cell Death (PCD): Apoptosis 3.2.4 Neuronal Death 3.2.5 Development of Blood Vessels in the Brain 3.2.6 Ventricular System 3.2.7 Formation of Peripheral Nervous System 3.2.8 Spinal Cord Differentiation 3.3 Brain Differentiation 3.3.1 Rhombencephalon (Hindbrain) 〉 Pons, Medulla, and Cerebellum 3.3.2 Mesencephalon 〉 Adult Midbrain 3.3.3 Prosencephalon 〉 Cerebral Hemispheres and Diencephalon 3.3.4 Diencephalon 3.3.5 Cranial Nerves 3.3.6 Telencephalon 3.3.7 Primary Sulci 3.3.8 Development of the Cerebral Cortex 3.4 Prenatal Development of the Cerebral Cortex 3.5 Changes in the Cortical Architecture as a Function of Postnatal Age 3.6 Abnormal Development 3.6.1 Malformations Resulting from Abnormalities in Growth and Migration with Incomplete Development of the Brain 3.6.2 Genetically Linked Migration Disorders 3.6.3 Environmentally Induced Migration Disorder: Fetal Alcohol Syndrome 3.6.4 Malformations Resulting from Chromosomal Trisomy and Translocation 3.6.5 Malformations Resulting from Defective Fusion of Dorsal Structures 3.6.6 Malformations Characterized by Excessive Growth of Ectodermal and Mesodermal Tissue Affecting the Skin, Nervous System, and Other Tissues 3.6.7 Cutaneous Angiomatosis with Associated Malformations of the Central Nervous System 3.6.8 Malformations Resulting from Abnormalities in the Ventricular System Bibliography 4 Spinal Cord 4.1 Gross Anatomy 4.1.1 Spinal Cord: Structure and Function 4.1.2 Nerve Roots 4.1.3 Gray Matter 4.2 Interneurons 4.3 Central Pattern Generators 4.4 Segmental Function 4.4.1 Motor/Ventral Horn Cells 4.4.2 Sensory Receptors 4.4.3 Stretch Receptors 4.5 Nociception and Pain 4.5.1 Modulation of Pain Transmission 4.6 White Matter Tracts 4.6.1 Descending Tracts in the Spinal Cord 4.6.2 Ascending Tracts in the Spinal Cord 4.6.3 The Anterolateral Pathway 4.7 Upper and Lower Motor Neurons Lesions 4.7.1 Upper Motor Neuron Lesion (UMN) 4.7.2 Lower Motor Neuron Lesion 4.8 Illustrative Spinal Cord Case Histories 4.9 Illustrative Non-spinal Cord Cases with Involvement of Specific Peripheral Nerves: Case Histories 4.8–4.10 4.10 Carpal Tunnel Syndrome Bibliography 5 Brain Stem: Gross Anatomy 5.1 Gross Anatomical Divisions 5.1.1 Sites of Transition 5.2 Relationship of Regions in the Brain to the Ventricular System: Fig. 5.2 5.3 Gross Anatomy of Brain Stem and Diencephalon 5.3.1 Anterior Surface of Gross Brain Stem: Fig. 5.3 5.3.2 Posterior Surface of Brain Stem and Diencephalon: Fig. 5.4 5.4 Arterial Blood Supply to the Brain Stem and Diencephalon (Fig. 5.5) 5.4.1 Medulla 5.4.2 Pons 5.4.3 Midbrain 5.4.4 Diencephalon Bibliography 6 Brain Stem Functional Localization 6.1 Introduction to the Brain Stem 6.2 Differences Between the Spinal Cord and Brain Stem 6.3 Functional Localization in Brain Stem Coronal Sections and an Atlas of the Brain Stem 6.3.1 Medulla 6.3.2 Pons-Blood Supply: Basilar Artery and Its Branches 6.3.3 Midbrain Blood Supply: Basila Arrteraynd Posterio Crerebral Arteries 6.4 Midbrain Tectum 6.5 Midbrain Tegmentum 6.6 Superior Colliculus 6.6.1 Midbrain Tegmentum 6.6.2 Blood Supply: Posterior Cerebral Arteries 6.7 Superior Colliculus Tectum 6.8 Superior Colliculus Tegmentum 6.8.1 Superior ColliculusVentricular Zone 6.9 Functional Centers in the Brain Stem 6.9.1 Reticular Formation 6.9.2 Respiration Centers 6.9.3 Cardiovascular Centers 6.9.4 Deglutition 6.9.5 Vomiting 6.9.6 Emetic Center 6.9.7 Coughing 6.9.8 Taste 6.10 Localiozation of Dysfunction in the Cranial Nerves Associated with the Eye (Table 6.8) 6.11 Localization of Disease Processes in the Brain Stem 6.11.1 Exercise to Identify the Tracts and Nuclei in the Brain Stem (Figs. 6.10–6.14) Bibliography 7 The Cranial Nerves 7.1 How the Cranial Nerves Got Their Numbers 7.2 Functional Organization of Cranial Nerves 7.3 The Individual Cranial Nerves 7.3.1 Cranial Nerve I, Olfactory (Fig. 7.4), Special Sensory/Special Visceral Afferent 7.3.2 Cranial Nerve II, Optic (Fig. 7.5), Special Somatic Sensory 7.3.3 Cranial Nerve III, Oculomotor (Fig. 7.6), Pure Motor (Somatic and Parasympathetic, Only III) 7.3.4 Cranial Nerve IV, Trochlear (Fig. 7.6), Pure Motor 7.3.5 Cranial Nerve VI, Abducens (Fig. 7.6), Pure Motor 7.3.6 Cranial Nerve V, Trigeminal (Fig. 7.7), Mixed Nerve (Sensory and Motor but No Parasympathetic) 7.3.7 Cranial Nerve VII, Facial (Fig. 7.8), Mixed Nerve (Sensory, Motor, Parasympathetic) 7.3.8 Cranial Nerve VIII, Vestibulocochlear (Fig. 7.9), Pure Special Somatic Sensory 7.4 Auditory Pathway 7.4.1 Cranial Nerve IX, Glossopharyngeal (Fig. 7.13), Mixed (Sensory, Motor, Parasympathetic): Nerve to Third Pharyngeal Arch 7.4.2 Cranial Nerve X, Vagus (Fig. 7.14), Mixed (Sensory, Motor, Parasympathetic), and Longest Cranial Nerve 7.4.3 Cranial Nerve XI, Spinal Accessory (Fig. 7.15), Pure Motor: Somatic and Visceral 7.4.4 Cranial Nerve XII, Hypoglossal (Fig. 7.16): Pure Motor Nerve 7.5 Cranial Nerve Dysfunction 7.6 Cranial Nerve Case Histories Bibliography 8 Diencephalon 8.1 Overview 8.2 Functional Organization of Thalamic Nuclei (Table 8.1) 8.2.1 Sensory and Motor Relay Nuclei: The Ventrobasal Complex and Lateral Nucleus 8.2.2 Limbic Nuclei: The Anterior, Medial, Lateral Dorsal, Midline, and Intralaminar Nuclei (Fig. 8.4) 8.2.3 Specific Associational: Polymodal/Somatic Nuclei, the Pulvinar Nuclei (Fig. 8.5) 8.2.4 Special Somatic Sensory Nuclei: Vision and Audition, the Lateral Geniculate and Medial Geniculate Nuclei of the Metathalamus (Fig. 8.5): The Special Somatic Sensory Cranial Nerves Are Cranial Nerves II and VIII 8.2.5 Nonspecific Associational 8.3 White Matter of the Diencephalon 8.4 Relationship Between the Thalamus and the Cerebral Cortex (Figs. 8.7 and 8.8) 8.5 Subthalamus (Fig. 8.3) 8.6 Thalamic Atlas Figs. 8.10, 8.11, and 8.12 8.7 Level: Midbrain, Diencephalic Junction (Fig. 8.10) 8.8 Level: Midthalamus (Fig. 8.11) 8.9 Level: Anterior Tubercle of Thalamus (Fig. 8.12) Bibliography 9 Hypothalamus, Neuroendocrine System, and Autonomic Nervous System 9.1 Hypothalamus 9.1.1 Hypothalamic Nuclei 9.1.2 Afferent Pathways 9.1.3 Efferent Pathways (Fig. 9.6) 9.1.4 Functional Stability 9.2 Neuroendocrine System, the Hypothalamus, and Its Relation to the Hypophysis 9.2.1 Hypophysis Cerebri 9.2.2 Hypothalamic–Hypophyseal Portal System 9.2.3 Hypophysiotrophic Area 9.2.4 Hormones Produced by Hypothalamus 9.2.5 Hormones Produced in Adenohypophysis (Fig. 9.12) 9.2.6 Case 9.1 9.2.7 Hypothalamus and the Autono

Note: Contents Part I Challenges 1 Factor X – 25 Years – “Factor X Concept” Is Essential for Achieving Sustainable Development / Harry Lehmann, Friedrich Schmidt-Bleek, and Christopher Manstein 2 Necessities for a Resource Efficient Europe / Leida Rijnhout, Magda Stoczkiewicz, and Meadhbh Bolger 3 Global Megatrends and Resource Use – A Systemic Reflection / Ullrich Lorenz, Harald Ulrik Sverdrup, and Kristin Vala Ragnarsdottir 4 Data, Indicators and Targets for Comprehensive Resource Policies / Stephan Lutter, Stefan Giljum, and Martin Bruckner 5 The Critical Raw Materials Concept: Subjective, Multifactorial and Ever-Developing / Jan Kosmol, Felix Müller, and Hermann Keßler 6 Equitable, Just Access to Natural Resources: Environmental Narratives during Worsening Climate Crises / Patrick Bond Part II Implementation Strategies 7 Circular Economy: Origins and Future Orientations / Riina Antikainen, David Lazarevic, and Jyri Seppälä 8 Financial System, and Energy and Resource Husbandry / R. Andreas Kraemer 9 Developing Resource Competence – Anchoring Resource Conservation and Efficiency in the German Education System / Carolin Baedeker, Holger Rohn, Michael Scharp, and Jaya Bowry 10 The Way from Problem Scope Towards the Vision of a Low Resource Society – The First Working Period of the Resources Commission at the German Environment Agency (KRU) / Sascha Hermann and Christa Liedtke 11 Implementing Resource Efficiency in Europe – Overview of Policies, Instruments and Targets in 32 European Countries / Paweł Kaźmierczyk 12 The Resource Nexus and Resource Efficiency: What a Nexus Perspective Adds to the Story / Raimund Bleischwitz and Michal Miedzinski 13 Germany’s Resource Efficiency Agenda: Driving Momentum on the National Level and Beyond / Reinhard Kaiser 14 Results of Three Cost-Effective, Innovative and Transferable Resource-Efficiency Instruments for Industries in the Basque Country / Ander Elgorriaga Kunze and Ignacio Quintana San Miguel 15 The Circular Economy Package of the European Union / Joachim Wuttke 16 Saving Natural Resources Through Conversion and Constructional Densification in Urban Areas: Ecological Potentials and Limits / Daniel Reißmann and Matthias Buchert 17 The Path to Degrowth for a Sustainable Society / Serge Latouche Part III Examples of Good Practice 18 Social Innovation Repair – The R.U.S.Z Case: A Systemic Approach Contributing to the Unplanned Obsolescence of Capitalism / Sepp Eisenriegler and Greta Sparer 19 Resource Efficiency in the Building Sector / Klaus Dosch 20 Eco Efficiency and Circular Production: Cases from the Netherlands’ Eastern Region / Frank A.G. den Butter and Harry A.A.M. Webers 21 An Approach to Identify Resource Patterns on a Neighborhood Level / Magnus Österbring, Leonardo Rosado, Holger Wallbaum, and Paul Gontia 22 Strategic Business Examples from Finland: The Growth of the Smartup Industry / Tuuli Kaskinen, Satu Lähteenoja, Mikael Sokero, and Iiris Suomela 23 Circular Flanders: Adaptive Policy for a Circular Economy / Sam Deckmyn 24 The 100 Companies Project Resource Efficient Practice Cases from Producing Industry / Mario Schmidt 25 Lifestyle Material Footprint of Finnish Households – Insights, Targets, Transitions / Michael Lettenmeier 26 Construction 4.0: The LifeCycle Tower and Digitalised Timber Construction / Hubert Rhomberg 27 Protect Resources, Strengthen the Economy: Good Examples for Resource Efficiency in Industry and Handicraft Businesses / Peter Jahns 28 Chemical Leasing: A Business Model to Drive Resource Efficiency in the Supply Chain / Reinhard Joas, Veronika Abraham, and Anke Joas 29 Resource Efficiency for the Manufacturing Industries – A Holistic Approach / Werner Maass, Christof Oberender, and Martin Vogt 30 Towards a Resource Efficient and Greenhouse Gas Neutral Germany 2050 / Jens Günther, Harry Lehmann, Ullrich Lorenz, David Pfeiffer, and Katja Purr 31 Pope Francis’ Encyclical Laudato Si’ as a Catalyst for Societal Transformation? Critical Remarks and Presentation of an Inspired Exemplary Project as a Driver for Sustainability / Ulrich Bartosch, Christian Meier, and Till Weyers Index

Note: Contents Part I Organ and Tissue Mechanics Wood Cell Wall Structure and Organisation in Relation to Mechanics / Lennart Salmén Modelling, Evaluation and Biomechanical Consequences of Growth Stress Profiles Inside Tree Stems / Tancrède Alméras, Delphine Jullien and Joseph Gril Bending Stress in Plant Stems: Models and Assumptions / Christopher J. Stubbs, Navajit S. Baban, Daniel J. Robertson, Loay Alzube and Douglas D. Cook Tree Mechanics and Wind Loading / John Moore, Barry Gardiner and Damien Sellier Part II Growth, Morphogenesis and Motion The Mechanics of Leaf Growth on Large Scales / Eran Sharon and Michal Sahaf Twisting Growth in Plant Roots / Hirofumi Wada and Daichi Matsumoto Plants at Bodybuilding: Development of Plant “Muscles” / Tatyana Gorshkova, Polina Mikshina, Anna Petrova, Tatyana Chernova, Natalia Mokshina and Oleg Gorshkov Modeling Plant Morphogenesis: An Introduction / Anne-Lise Routier-Kierzkowska and Adam Runions Mechanical Conflicts in Growth Heterogeneity / Nathan Hervieux and Olivier Hamant Folding, Wrinkling, and Buckling in Plant Cell Walls / Dorota Borowska-Wykręt and Dorota Kwiatkowska Structural Principles in the Design of Hygroscopically Moving Plant Cells / Rivka Elbaum Using Modeling to Understand the Hygromechanical and Hysteretic Behavior of the S2 Cell Wall Layer of Wood / Dominique Derome, Karol Kulasinski, Chi Zhang, Mingyang Chen and Jan Carmeliet Part III Molecular Underpinnings of Cell Wall Mechanics Calcium–Pectin Chemistry and Biomechanics: Biological Background and Mathematical Modelling / Mariya Ptashnyk and Henry R. Allen Cell Wall Expansion as Viewed by the Creep Method / Dmitry Suslov and Kris Vissenberg Tensile Testing of Primary Plant Cells and Tissues / Amir J. Bidhendi and Anja Geitmann Part IV Water Transport, Mechanosensing and Biomimetics Water Motion and Sugar Translocation in Leaves / Tomas Bohr, Hanna Rademaker and Alexander Schulz Molecular Mechanisms of Mechanosensing and Mechanotransduction / Masatsugu Toyota, Takuya Furuichi and Hidetoshi Iida Biomechanics and Functional Morphology of Plants—Inspiration for Biomimetic Materials and Structures / Thomas Speck, Georg Bold, Tom Masselter, Simon Poppinga, Stefanie Schmier, Marc Thielen and Olga Speck Index

Note: Contents 1 Introduction 2 In the beginning….and somewhat later 3 How to make a habitable planet 4 Prebiotic chemical synthesis 5 The Origin of Life 6 Interlude 7 Photosynthesis: The Game Changer 8 The Rise of Oxygen and the origin of the Eukaryotic Cell 9 Earliest plants and animals 10 The Cambrian Explosion and emergence of “modern” body plans 11 The end of the Ordovician and the colonization of the land 12 The Permian extinction and rise of the dinosaurs 13 End of Cretaceous extinction: The end of the dinosaurs 14 The rise of mammals, the Genus Homo, and the ongoing extinction event 15 Conclusion Appendix 1. Analysis of tRNA sequences, searching for matches to modern protein amino acid sequences Appendix 2. Calculating the probability of the formation of the first protocell Index

Note: Contents Deciding for Remediation of the Seepage Barrier System in Foundation of an Earthfill Dam Based on the Monitoring Data and Numerical Analysis / Hamed Farshbaf Aghajani Nonlinear Seismic Response of Concrete Gravity Dams / Djamel Ouzandja, Boualem Tiliouine, and Toufiq Ouzandja Applied GIS to the Monitoring of Building Work Case Study: Construction of 2000 Houses in Ghadames-Lybia / Samir Medhioub, Mohamed Baklouti, and Slah Bouraoui Stability Analysis of Souk-Tleta Earth Dam, North Algeria / Ryma Afiri, Saida Hadj Abderrahmane, Lynda Djerbal, and Smail Gabi Static Liquefaction Analysis of the Limonar Tailings Dam in Peru / Herbert M. Maturano Rafael and Celso Romanel Probabilistic Seismic Hazard and Dynamic Stability Assessment of a Tailings Dam Located in Jamaica / Frank Perez and Celso Romanel Analysis and Recovery Proposal for Erosion Process Located in the City of Planaltina-GO / Rideci Farias, Rhael Maycon Noronha Ribeiro, Haroldo Paranhos, Itamar de Souza Bezerra, and Roberto Pimentel Soil Structure Interaction Studies with Use of Geosynthetics in Soils Beneath Footings / R. Shivashankar, Nalini E. Rebello, V.R. Sastry, and B.R. Jayalekshmi A Posteriori Error Estimation for the Non-associated Plasticity Drucker-Prager Model with Hardening / Dao Duy Lam Analysis of Structural Behaviour of Thick Composite Laminates on an Elastic Foundation Using Efficient Higher-Order Theory / Mokhtar Bouazza, Tawfiq Becheri, and Abderrahmane Boucheta 3D Numerical Simulation of the Goaf Due to Large-Scale Longwall Mining / Samar S. Ahmed, Marwan AlHeib, Yann Gunzburger, and Vincent Renaud A Suggested Model Using Quantitive and Qualitative Parameters for Cost Engineering of Mechanically Stabilised Earth Walls in Egypt / Joseph Meadows and John Erian Influence of Asphalt Mixture Ageing and Lowered Laboratory Compaction Rate on Stiffness and Cracking Behavior / Pavla Vacková, Jan Valentin, and Adriana Kotoušová Numerical Study of the Failure Surface in Granular Soil Under Two Closely Spaced Strip Footings / Assma Benbouza, Liela Arabet, and Khelifa Abbeche Evaporation Rate Dependence with Saturation Degree / Houcem Trabelsi Comparative Analysis of a Deep Excavation in a Clays Sequence in Bogota City, with an Emphasis on FEM and Auscultation from the View Point of the Soil-Structure Interaction / Lucero Amparo Estevez Rey Assessment of Granular Soil Failure at the Water Borehole Depth in South Eastern Nigeria by Discrete and Finite Element Methods / Kennedy C. Onyelowe, O.A. Ubachukwu, O.C. Ikpemo, and F.O. Okafor Effect of NBR-Waste on Rheological Properties of Modified Bitumen and Mechanical Characteristics of the Asphalt Mix / Khedoudja Soudani, Véronique Cerezo, and Smail Haddadi Numerical Check of the Meyerhof Bearing Capacity Equation for Shallow Foundations / Stefan Van Baars Utilization of Weathered Rock Mass as the China Three Gorges Dam Foundation / Shirong Xiao, Guodong Zhang, and Qingjun Zuo Displacement Assessment of Rock Socketed Shafts: A Numerical Approach / Asmaa M.H. Mahmoud and Ahmed M. Samieh Analysis and Modelling of Stiffened Slab Foundation on Expansive Soils / Mohamed A. Shams, Mohamed A. Shahin, and Mostafa A. Ismail Derivation of the Incremental Stress-Strain Relations for Expansive Soils and Implementation into the Boundary Element Method / Jamila El Brahmi and Mimoun Zoukaghe The Behaviour of Shallow Foundation Near Slope Under Inclined Loading / Messaoud Baazouzi, Mekki Mellas, Djamel Benmeddour, and Abdelhak Mabrouki Case Study About Erosion in Elmo SerejoAvenue, Taguatinga/Federal District – Brazil / Mariane Rodrigues da Vitória, Rideci Farias, Haroldo Paranhos, Itamar de Souza Bezerra, and Roberto Pimentel de Sousa Júnior Performance of Shallow Foundation Overlaying Cavernous Limestone / Ahmed M. El-Tohamy Numerical Investigations on Lateral Load Response of Fin Piles / K.V. Babu and B.V.S. Viswanadham Experiences with Tip Post Grouted Drilled Shafts in China / Zhihui Wan and Guoliang Dai Analysis on Post-peak and Creep Mechanical Behavior of Highly-Weathered Rock / Yinghua Tan and Qian Zhang Author Index

Note: Contents 1 Omics: A Holistic Approach in Cancer Treatment / Madhumati Bora and Pratibha Parihar 2 Plant miRNAs and Phytomolecules As Anticancer Therapeutics / Nikita Shukla, Virendra Shukla, and Sangeeta Saxena 3 Potential of Herbal Medicines in Colorectal Carcinoma and Their Mechanism of Action / Navina Panneerselvan, Rajeswari Ravindran, Palanisamy Arulselvan, and Ravindran Jaganathan 4 Elucidation of Mechanisms of Anticancer Plant Compounds Against the Tumor Cells / Radhakrishnan Narayanaswamy and Mallappa Kumara Swamy 5 Computational Approach Towards Exploring Interaction of Target Protein-Phytocompounds in Drug Development for Breast Cancer / Asita Elengoe and Salehhuddin Hamdan 6 Anticancer Potential of Andrographolide, a Diterpenoid Lactone from Andrographis paniculata: A Nature’s Treasure for Chemoprevention and Therapeutics / Imran Khan, Mohd Aslam Yusuf, Irfan Ahmad Ansari, and Mohd Sayeed Akhtar 7 Anticancer Activity of Herbal Medicine: Mechanism of Action / Nand Kumar Singh, Alok Kumar Yadav, Preeti Sirohi, Manjoo Rani, Saurabh Saraswat, Manish Pratap Singh, Ashutosh Mani, and Sameer Srivastava 8 Metabolomic Study of Chemo-preventive Phytochemicals and Their Therapeutic Prospects / Nibir Ranjan Parasar, Channakeshavaiah Chikkaputtaiah, Mohan Lal, and Mohd Sayeed Akhtar 9 CADD Studies Applied to Secondary Metabolites in the Anticancer Drug Research / Luciana Scotti, Nagendra Sastry Yarla, Francisco J. B. Mendonça Filho, José M. Barbosa Filho, Marcelo S. da Silva, Josean F. Tavares, and Marcus Tullius Scotti 10 Anticancerous Plant Compounds Affecting the Power House of Cancerous Cells: A Possible Herbal Mitocan / Shalini Mani, Nancy Taneja, Sweekriti Jain, and Manisha Singh 11 Phytoestrogens as a Natural Source for the Possible Colon Cancer Treatment / Suresh Challa, Rajanna Ajumeera, and Naresh Venna 12 Bioinformatics Approaches for Genomics and Post Genomics Applications of Anticancer Plants / Avni Mehta and Yasha Hasija 13 Fruits of Rosaceae Family as a Source of Anticancer Compounds and Molecular Innovations / Muhammad Sameeullah, Muttalip Gündoğdu, İhsan Canan, Turan Karadeniz, Muhammad Aasim, and Khalid Mahmood Khawar 14 Mechanism of Action of Anticancer Herbal Medicines / Mohd Gulfishan, Muhammad Afzal, Imran Kazmi, Anwarulabedin Mohsin Quazi, Tariq Ahmad Bhat, and Ajmat Jahan

Note: Contents Part I Principles, Approaches and Projects on Change Adaptation in Coastal Areas “We’re not Refugees, We’ll Stay Here Until We Die!”—Climate Change Adaptation and Migration Experiences Gathered from the Tulun and Nissan Atolls of Bougainville, Papua New Guinea / Johannes Luetz and Peni Hausia Havea Sustainable Small-scale Mariculture Ventures as a Comparative Climate Friendly Livelihood Alternative in Pohnpei, Federated States of Micronesia / Simon Ellis, Maria Haws, Jasmine Mendiola and Mikelson Hemil Planning and Urban Informality—Addressing Inclusiveness for Climate Resilience in the Pacific / Colleen Butcher-Gollach At the Frontline of Climate Change: Adaptation, Limitations and Way Forward for the South Pacific Island States / Dhrishna Charan, Kushaal Raj, Ravneel Chand, Lionel Joseph and Priyatma Singh Enhancing Adaptive Capacity and Climate Change Resilience of Coastal Communities in Yap / Murukesan Krishnapillai Capacity Development and TVET: Accredited Qualifications for Improving Resilience of Coastal Communities—A Vanuatu Case Study / Tess Martin, Sarah Hemstock, Helene Jacot Des Combes and Charles Pierce An Evaluation of Climate Change Effects on Fishermen and Adaption Strategies in Central Region, Ghana / Selorm Akaba and Samuel Akuamoah-Boateng Retreat or Rebuild: Exploring Geographic Retreat in Humanitarian Practices in Coastal Communities / Rosetta S. Elkin and Jesse M. Keenan “God and Tonga Are My Inheritance!”—Climate Change Impact on Perceived Spritiuality, Adaptation and Lessons Learnt from Kanokupolu, ‘Ahau, Tukutonga, Popua and Manuka in Tongatapu, Tonga / Peni Hausia Havea, Sarah L. Hemstock, Helene Jacot Des Combes and Johannes Luetz Ecosystem-Based Adaptation (EbA) for Coastal Resilience Against Water Related Disasters in Bangladesh / M. Mustafa Saroar Part II Case Studies on Climate Change Adaptation in Coastal Areas Black Pearl Farming as an Adaptation to Coastal Climate Change / Mattlan Zackhras, Payton Deeks and Simon Ellis Reviving Traditional Croplands to Improve Community Climate Resilience / Bernie Besebes Coping with Future Coastal Floods in Denmark—Advancing the Use of Global Frameworks / Martin Jebens and Carlo Sorensen Local Knowledge Co-production, Emergent Climate Adaptation Publics and Regional Experimentalist Governance: An Institutional Design Case Study / Nicole Lisa Klenk, James Ian MacLellan, Kim Reeder and Dragos Flueraru Economic Resiliency and Food Security in the Marshall Islands Through Polydactylus sexfilis Aquaculture / Kathleen Hicks and Ryan Murashige Advantages and Challenges of Participatory Management of Customary Coastal Areas in the French Islands of the Pacific / Allenbach Michel, Le Duff Matthieu, Dumas Pascal and Bouteiller Yolaine Courts as Decision-Makers on Sea Level Rise Adaptation Measures: Lessons from New Zealand / Catherine Iorns Magallanes, Vanessa James and Thomas Stuart Mapping of Benthic Habitats in Komave, Coral Coast Using WorldView-2 Satellite Imagery / Roselyn Naidu, Frank Muller-Karger and Mathew McCarthy Exploring the Practicability and Applicability of Payment for Ecosystem Services in the Protection of Samoa’s Selected Watershed Areas / Susana Taua’a Predicting True Climate Change Risks and Opportunities in the Cook Islands: How Vulnerable Are Pacific Maritime Supply Chain Stakeholders? / Jack Dyer Climate Change and Integrated Coastal Management: Risk Perception and Vulnerability in the Luanda Municipality (Angola) / Bernardo Castro, Walter Leal Filho, Fernando J. P. Caetano and Ulisses Miranda Azeiteiro A Psychological Model of Climate Change Adaptation: Influence of Resource Loss, Posttraumatic Growth, Norms, and Risk Perception Following Cyclone Winston in Fiji / David N. Sattler, Albert Whippy, James M. Graham and James Johnson ‘Yakasisi’ in Planning for a More Sustainable Future of Coastal Communities Impacted by Climate Change, Milne Bay, Papua New Guinea / David K. Mitchell and George Aigoma Limits and Barriers to Transformation: A Case Study of April Ridge Relocation Initiative, East Honiara, Solomon Islands / Michael Otoara Ha’apio, Keith Morrison, Ricardo Gonzalez, Morgan Wairiu and Elisabeth Holland Impacts of Climate Change in Coastal Areas: Lessons Learned and Experiences / Walter Leal Filho

Note: Contents 1 Introduction and Historical Perspective / Robert L. Price and W. Gray (Jay) Jerome 2 The Theory of Fluorescence / W. Gray (Jay) Jerome 3 Fluorescence Microscopy / W. Gray (Jay) Jerome and Robert L. Price 4 Specimen Preparation / W. Gray (Jay) Jerome, John Fuseler, Caleb A. Padgett, and Robert L. Price 5 Labeling Considerations for Confocal Microscopy / R. M. Albrecht and J. A. Oliver 6 Digital Imaging / W. Gray (Jay) Jerome 7 Confocal Digital Image Capture / W. Gray (Jay) Jerome 8 Types of Confocal Instruments: Basic Principles and Advantages and Disadvantages / John Fuseler, W. Gray (Jay) Jerome, and Robert L. Price 9 Setting the Confocal Microscope Operating Parameters / Amy E. Rowley, Anna M. Harper, and Robert L. Price 10 3D Reconstruction of Confocal Image Data / Thomas C. Trusk 11 Analysis of Image Similarity and Relationship / Jesse Aaron and Teng-Leong Chew 12 Ethics and Resources / W. Gray (Jay) Jerome and Robert L. Price Glossary (Terms Are Defined with Respect to Confocal Imaging) Index

Note: Contents List of most commonly used abbreviations I. Helmholtz Association - Mission and Strategy II. Helmholtz Research Field Earth and Environment II.1 Overview II. 2 Programs Ill. Alfred Wegener Institute Helmholtz Centre III.1 Organization Ill. 2 Strategic partnerships and cooperation Ill. 3 Research infrastructure Ill. 4 Career development, talent management and equal opportunity Ill. 5 Knowledge and technology transfer Ill. 6 Scientific awards and appointments Ill. 7 Membership of international Boards and Committees 2013-2016 (selection) IV. Research Units IV. 1a Research Unit 1a The polar atmosphere and cryosphere in a changing climate IV. 1a.1 Mission statement IV. 1a.2 Introduction IV. 1a.3 Scientific questions IV. 1a.4 Approach of the Research Unit IV. 1a.5 Structure of the Research Unit IV. 1a.6 Scientific outcomes IV. 1a.7 Leadership of and contributions to large national and international projects and programs IV. 1a.8 Career development and personnel turnover IV. 1a.9 Overview of Contribution to Grand Challenges IV. 1a.10 Outlook IV. 1a.11 Budget, personnel and publications IV. 1a.12 References IV. 1b Research Unit 1b Climate interactions with polar seas, marine ecosystems and biogeochemical processes IV. 1b.1 Mission statement IV. 1b.2 Introduction IV. 1b.3 Scientific questions IV. 1b.4 Approach of the Research Unit IV. 1b.5 Structure of the Research Unit IV. 1b.6 Scientific outcomes IV. 1b.7 Leadership of and contributions to large national and international projects and programs IV. 1b.8 Career development and personnel turnover IV. 1b.9 Overview of contribution to Grand Challenges IV. 1b.10 Outlook IV. 1b.11 Budget, personnel and publications IV. 1b.12 References IV.2 Research Unit 2 Fragile coasts and shelf seas IV. 2.1 Mission statement IV. 2.2 Introduction IV. 2.3 Scientific questions IV. 2.4 Approach of the Research Unit IV. 2.5 Structure of the Research Unit IV. 2.6 Scientific outcomes IV. 2.7 Leadership of and contributions to large national and international projects and programs IV. 2.8 Career development and personnel turnover IV. 2.9 Overview of contribution to Grand Challenges IV. 2.10 Outlook IV. 2.11 Budget, personnel and publications IV. 2.12 References IV. 3 Research Unit 3 The Earth system from a polar perspective: data, modeling and synthesis IV. 3.1 Mission statement IV. 3.2 Introduction IV. 3.3 Scientific questions IV. 3.4 Approach of the Research Unit IV. 3.5 Structure of the Research Unit IV. 3.6 Scientific outcomes IV. 3.7 Leadership and contributions to large national and international projects and programs IV. 3.8 Career development and personnel turnover IV. 3.9 Overview of contribution to Grand Challenges IV. 3.10 Outlook IV. 3.11 Budget, personnel and publications IV. 3.12 References IV. 4 Research Unit 4 Bridging research and society: products, tools and climate services IV. 4.1 Mission statement IV. 4.2 Introduction IV. 4.3 Scientific tasks and services IV. 4.4 Approach of the Research Unit IV. 4.5 Structure of the Research Unit IV. 4.6 Scientific outcomes IV. 4.7 Leadership of and contributions to large national and international projects and programs IV. 4.8 Career development and personnel turnover IV. 4.9 Outlook IV. 4.10 Budget, personnel and publications IV. 4.11 References IV.5 Research Unit 5 Research infrastructure - performance categories LK I and LK II IV. 5.1 Mission statement IV. 5.2 Overview IV. 5.3 Research Unit SA IV. 5.4 Research Unit 58 (LK II Infrastructure) V. Recommendations of the Helmholtz Senate V.1 Recommendations of the Helmholtz Senate V.2 Detailed recommendations of the Helmholtz Senate for each Research Unit (not covered above) Imprint

Note: Contents I. Selected scientific and coordinating staff Research Unit 1a: The polar atmosphere and cryosphere in a changing climate Boike, Julia Diekmann, Bernhard Eisen, Olaf Grosse, Guido Hellmer, Hartmut H. Herzschuh, Ulrike Humbert, Angelika Lantuit, Hugues Mollenhauer, Gesine Rex, Markus Wilhelms, Frank Research Unit lb: Climate interactions with polar seas, marine ecosystems Bridging research and society: products, tools and climate services and biogeochernical processes Boetius, Antje Bracher, Astrid Brey, Thomas Haas, Christian Kanzow, Torsten Klaas, Christine Meyer, Bettina Pörtner, Hans-Otto Richter, Claudio Rost, Björn Soltwedel, Thomas Strass, Volker H. Waite, Anya M. Research Unit 2: Fragile coasts and she!f seas Abele, Doris Boersma, Maarten Buschbaum, Christian Gerdts, Gunnar John, Uwe Kasten, Sabine Koch, Boris Wegner, K. Mathias Wiltshire, Karen Helen Research Unit 3: The Earth system from a polar perspective: data, modeling and synthesis Bijma, Jelle Jokat, Wilfried Jung, Thomas Knorr, Gregor Köhler, Peter Laepple, Thomas Lamy, Frank Lohmann, Gerrit Schlindwein, Vera Stein, Rüdiger Tiedemann, Ralf Wolf-Gladrow, Dieter Research Unit 4: Bridging research and society: products, tools and climate services Bergmann, Melanie Buck, Bela H. Frickenhaus, Stephan Grosfeld, Klaus Gutow, Lars Krause, Gesche Research Unit 5: Research infrastructure - performance categories LK I and LK II Nixdorf, Uwe II. Indicators and resources 1. Indicators and resources by Research Units 2. Indicators and resources by user facilities 3. Indicators and resources by program Program PACES II "Marine, Coastal and Polar Systems" 4. Indicators for the center Ill. Definition of indicators IV. List of abbreviations Imprint

Note: Contents: List of figures and tables. - List of boxes. - Acknowledgements. - List of abbreviations. - PART I INTRODUCTION . - 1. The Geopolitics of an Arctic Meltdown and the Question of EUropean Arctic Space. - PART II GEOPOLITICS. - 2. The Thought Experiment Referred to as Geopolitics. - PART III THE ARCTIC. - 3. Arctic Geopolitics and the Regional Zeitgeist of the Twenty-First Century. - PART IV THE EUROPEAN UNION. - 4. EUropean Dimensions of Arctic Presence. - 5. An Action in the Making: The EU’s Arctic Policy-Making Process. - 6. The EU’s Arctic Space-Making Practices. - PART V CONCLUSION. - 7. A European Geopolitical Subject in the Arctic?. - REFERENCES. - APPENDIX I. - APPENDIX II. - INDEX.

Note: Contents: Part I: Supply Chain Risk Management -- Chapter 1: Supply Chain Risk Management: A Comprehensive Review -- Chapter 1: Supply Chain Risk Management: A Comprehensive Review -- Chapter 3: Modeling Risk Emergence and Propagation in Buyer-Supplier-Customer Relationships -- Chapter 4: Managing Reputational Risks in Supply Chains -- Chapter 5: Managing IT and Cyber Risks in Supply Chains -- Chapter 6: Developing Supply Chain Risk Mitigation Strategies -- Part II: Supply Chain Vulnerability and Disruptions Management -- Chapter7: Analyzing Supply Chain Vulnerability through Simulation -- Chapter 8: Supply Chain Disruptions Preparedness Measures Using a Dynamic Model -- Chapter 9: A Quantitative Model for Analyzing Market Response during Supply Chain Disruptions -- Chapter 10: Supply Chain Risk Management in the Transmission and Amplification of Disruptions -- Chapter 11: Strategic Sourcing Under Supply Disruption Risk -- Chapter 12: Design and Evaluation of Global Supply Chain Considering Disruption Risk -- Part III: Toward a Resilient Supply Chain -- Chapter 13: Supply Chain Resiliency: A Review -- Chapter 14: The Role of Resiliency in Managing Supply Chains Disruptions -- Chapter 15: Designing Resilience into Service Supply Chains: A Conceptual Methodology -- Chapter 16: Resiliency in Supply Chain Systems: A Triadic Framework using Family Resilience Model -- Chapter 17: Cultivating Supply Chain Agility: Managerial Actions Derived From Established Antecedents -- Chapter 18: Assessing Supply Chain Resilience upon Critical Infrastructure Disruptions: A Multilevel Simulation Modelling Approach

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Note: Presents main results over 20 years of research in an underground rock laboratory in claystone, Well-illustrated examples of the different stages of repository evolution, The reader gets an excellent overview and never loses the common thread of the rather complex thematic, Contains invaluable data and information relevant to fundamental problems

Note: Contents: 1. Global politics and the environment ; Part I. Why Do Environmental Problems Occur?: 2. The tragedy of the commons ; 3. Population and poverty ; 4. Capitalism ; Part II. Responding to Global Environmental Problems: 5. Conflict and securitisation - water ; 6. Multilateral diplomacy - sustainable development ; 7. Transnational governance experiments - climate change ; 8. Aid and finance - deforestation ; 9. Individualising responsibility - unsustainable consumption ; 10. Problem displacement - hazardous substances ; 11. Resistance and localisation - unsustainable agriculture ; 12. Appraising global environmental governance

Note: New perspectives on pterosaur palaeobiology , Pterosaurs in Mesozoic food webs: a review of fossil evidence , Using three-dimensional, digital models of pterosaur skulls for the investigation of their relative bite forces and feeding styles , Pelvic musculature of Vectidraco daisymorrisae and consequences for pterosaur locomotion , Inferring the properties of the pterosaur wing membrane , Waves of bone deposition on the rostrum of the pterosaur Pteranodon , Neonate morphology and development in pterosaurs: evidence from a Ctenochasmatid embryo from the Early Cretaceous of Argentina , Short note on a new anurognathid pterosaur with evidence of perching behaviour from Jianchang of Liaoning Province, China , Pterosaur material from the uppermost Jurassic of the uppermost Morrison Formation, Breakfast Bench Facies, Como Bluff, Wyoming, including a pterosaur with pneumatized femora , The taxonomy and phylogeny of Diopecephalus kochi (Wagner, 1837) and ‘Germanodactylus rhamphastinus’ (Wagner, 1851) , A taxonomic revision of Noripterus complicidens and Asian members of the Dsungaripteridae , Topotype specimens probably attributable to the giant azhdarchid pterosaur Arambourgiania philadelphiae (Arambourg 1959) , The pterosaur assemblage of the Oxford Clay Formation (Jurassic, Callovian–Oxfordian) from the UK , Systematic reassessment of the first Jurassic pterosaur from Thailand , A large pterodactyloid pterosaur from the Late Cretaceous Ferron Sandstone of Utah , Cervical vertebrae of an enigmatic pterosaur from the Crato Formation (Lower Cretaceous, Araripe Basin, NE Brazil) , A wing metacarpal from Italy and its implications for latest Cretaceous pterosaur diversity , A new pterosaur specimen from the Upper Tunbridge Wells Sand Formation (Cretaceous, Valanginian) of southern England and a review of Lonchodectes sagittirostris (Owen 1874) , Online version

Note: Contents: 1 Our Approach ; 2 The Evolution and Governance Architecture of the United Nations Climate Change Regime ; 3 International Relations Theories and Climate Change Politics ; 4 Cooperation on Climate Change: Insights from Game Theory ; 5 Computational Models, Global Climate Change, and Policy ; 6 Environmental Protection, Differentiated Responsibility, and World Trade: Making Room for Climate Action ; 7 Major Countries ; 8 Nonstate Actors in International Policy Making: The Kyoto Protocol and Beyond ; 9 Business ; 10 Equity and Development: Developing Countries in the International Climate Negotiations ; 11 Implementation, Compliance, and Effectiveness of Policies and Institutions ; 12 Our Conclusions

Note: Environment and conflict -- Context matters : Ogoni and place making -- Locale : political and cultural context of mobilisation -- Landscape, capital and violence -- Why the Ogoni mobilised -- From grievances to micro-mobilisation : how the Ogoni mobilised -- Cultural basis of mobilisation -- Mobilisation : a place for moral motivation? -- Place and limit of mobilisation -- Conclusion.

Note: Contents: Introduction; Part I. Foundations: 1. Emergence and development of international environmental law; 2. Main features of international environmental law; 3. The principles of international environmental law; Part II. Substantive Regulation: 4. Oceans, seas and freshwater; 5. Atmosphere; 6. Biological diversity; 7. Dangerous substances and activities; Part III. Implementation: 8. Traditional approaches: responsibility/liability/adjudication; 9. Alternative approaches - facilitation and management of 'noncompliance'; Part IV. Interactions with Other Branches: 10. Interactions with human rights law; 11. Interactions with the law of armed conflict; 12. Interactions with international economic law

Note: Contents: 1 General introduction. - 1.1 Challenges of isotope-based temperature reconstructions. - 1.2 Thesis overview. - 1.3 Author contributions. - 2 Theoretical background. - 2.1 The isotopic composition of firn and ice. - 2.1.1 Fractionation of water isotopologues. - 2.1.2 Relationship with temperature. - 2.1.3 Measuring of the isotopic composition. - 2.2 Processes within the firn column. - 2.2.1 The firn column of polar ice sheets. - 2.2.2 The density of firn. - 2.2.3 The temperature profile of firn. - 2.2.4 Vapour diffusion in firn. - 2.3 Internal climate variability. - 3 Regional climate signal vs.local noise: a two-dimensional view of water isotopes. - 3.1 Introduction. - 3.2 Data and methods. - 3.3 Results. - 3.3.1 Trench isotope records. - 3.3.2 Single-profile representativity. - 3.3.3 Mean trench profiles. - 3.3.4 Spatial correlation structure. - 3.3.5 Statistical noise model. - 3.4 Discussion. - 3.4.1 Local noise vs. regional climate signal. - 3.4.2 Representativity of isotope signals. - 3.4.3 Implications. - 3.5 Conclusions. - 3.6 Appendix A: Derivation of noise model. - 3.6.1 Definitions. - 3.6.2 Derivation of model correlations. - 3.6.3 Estimation of parameters. - 3.7 Appendix B: Noise level after diffusion. - 4 Constraints on post-depositional isotope modifications in east antarctic firn. - 4.1 Introduction. - 4.2 Data and methods. - 4.2.1 Sampling and measurements. - 4.2.2 Trench depth scale. - 4.2.3 Spatial variability of trench profiles. - 4.2.4 Quantification of downward advection, densification and diffusion. - 4.2.5 Statistical tests. - 4.3 Results. - 4.3.1 Comparison of T15 and T13 isotope data. - 4.3.2 Expected isotope profile changes. - 4.3.3 Temporal vs. spatial variability. - 4.4 Discussion. - 4.4.1 Densification, diffusion and stratigraphic noise. - 4.4.2 Additional post-depositional modifications. - 4.5 Conclusions. - 5 On the similarity and apparent cycles of isotope variations. - 5.1 Introduction. - 5.2 Data and Methods. - 5.2.1 Data. - 5.2.2 Spectral analysis. - 5.2.3 Rice’s formula. - 5.2.4 Cycle length and amplitude estimation. - 5.2.5 Model for vertical isotope profiles. - 5.3 Results. - 5.3.1 Spectral analysis of isotope profiles. - 5.3.2 Theoretical and observed cycle length. - 5.3.3 Illustrative examples. - 5.3.4 Depth dependency of cycle length. - 5.3.5 Simulated vs. observed isotope variations. - 5.4 Discussion and summary. - 5.5 Conclusions. - 5.6 Appendix A: Input sensitivity. - 5.7 Appendix B: Additional results. - 5.8 Appendix C: Spectral significance testing. - 6 Timescale-dependency of antarctic isotope variations. - 6.1 Introduction. - 6.2 Data and methods. - 6.2.1 DML and WAIS isotope records. - 6.2.2 Spectral model. - 6.2.3 Timescale-dependent signal-to-noise ratio. - 6.2.4 Effects of diffusion and time uncertainty. - 6.2.5 Present-day temperature decorrelation. - 6.3 Results. - 6.3.1 Illustration of model approach. - 6.3.2 DML and WAIS isotope variability. - 6.4 Discussion. - 6.4.1 Interpretation of noise spectra. - 6.4.2 Interpretation of signal spectra. - 6.4.3 Signal-to-noise ratios. - 6.4.4 Differences between DML and WAIS. - 6.5 Conclusions. - 7 Declining temperature variability from LGM to holocene. - 8 General discussion and conclusions. - 8.1 Short-scale spatial and temporal isotope variability. - 8.1.1 Local spatial variability. - 8.1.2 Seasonal to interannual variability. - 8.1.3 Spatial vs. temporal variability. - 8.2 Extension to longer scales. - 8.2.1 Spatial vs. temporal variability on interannual timescales. - 8.2.2 Holocene and longer timescales. - 8.3 Concluding remarks and outlook. - Bibliography. - A Methods to: declining temperature variability from lgm to holocene. - A.1 Temperature proxy data. - A.2 Model-based temperature and variability change. - A.3 Temperature recalibration of proxy records. - A.3.1 Recalibration of ice-core records. - A.3.2 Recalibration of marine records. - A.4 Variance and variance ratio estimation. - A.5 Noise correction. - A.5.1 Testing effect of noise correction. - A.6 Effect of ecological adaption and bioturbation. - A.7 Effect of proxy sampling locations. - B Layering of surface snow and firn: noise or seasonal signal?. - B.1 Introduction. - B.2 Materials and methods. - B.2.1 Firn-core density profiles. - B.2.2 Trench density profiles. - B.2.3 Dielectric profiling and density estimates. - B.2.4 Comparison of DEP and CT density. - B.2.5 Ion measurements. - B.3 Results. - B.3.1 2-D trench density data. - B.3.2 Spatial correlation structure. - B.3.3 Comparison of mean density, isotope and impurity profiles. - B.3.4 Spectral analysis of vertical density data. - B.4 Discussion. - B.4.1 Spatial variability. - B.4.2 Representativeness of single profiles. - B.4.3 Seasonal cycle in snow density. - B.4.4 Density layering in firn and impurities. - B.5 Conclusions. - Acknowledgements - Danksagung.