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  • 1
    Electronic Resource
    Electronic Resource
    Eearly Bone Repair and Regeneration of Nano-Sized ß-Tricalcium Phosphates/Collagen Composite in Rabbits (2007)
    s.l. ; Stafa-Zurich, Switzerland
    Key engineering materials Vol. 330-332 (Feb. 2007), p. 397-400 
    Details
    ISSN: 1013-9826
    Source: Scientific.Net: Materials Science & Technology / Trans Tech Publications Archiv 1984-2008
    Topics: Mechanical Engineering, Materials Science, Production Engineering, Mining and Metallurgy, Traffic Engineering, Precision Mechanics
    Notes: A novel biomimetic composite consisted of nano β-tricalcium phosphate and collagen(n-TCP/Col.), having similar structure with the natural bone, was produced by a wet-chemicalmethod. The biological effect with and without n-TCP/Col on bone repair and regeneration wasevaluated by histological and radiological examination in a rabbit femoral condyle model. Theresults showed that radiopacity of implant decreased gradually and began to increase at 12 weeks,while no obvious changes for the control. Histological results revealed that trabecular bone formedaround the implant at 4 weeks and increased at 8 weeks; By 12 weeks, bone filling with Harvard’ssystem was observed around the implant. By contrast, only loose connective tissue was seen incontrol group. This was further illuminated by fluorescence microscopy. The results of this studysuggested that the novel nano β-tricalcium phosphate and collagen composite possessed goodproperties of osteoconductivity and degradation in the biological environment, which could havepotential application as a promising bone substitute
    Type of Medium: Electronic Resource
    URL: http://www.tib-hannover.de/fulltexts/2011/0528/01/52/transtech_doi~10.4028%252Fwww.scientific.net%252FKEM.330-332.397.pdf
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  • 2
    Electronic Resource
    Electronic Resource
    Improvement of the Adhesion and Proliferation of Human Osteoblastic-Like Cells with Biomimetic Nanoapatite Coatings (2007)
    s.l. ; Stafa-Zurich, Switzerland
    Key engineering materials Vol. 330-332 (Feb. 2007), p. 385-388 
    Details
    ISSN: 1013-9826
    Source: Scientific.Net: Materials Science & Technology / Trans Tech Publications Archiv 1984-2008
    Topics: Mechanical Engineering, Materials Science, Production Engineering, Mining and Metallurgy, Traffic Engineering, Precision Mechanics
    Notes: Biomimetic nanoapatite coatings was developed by functionally modified methods with acombination of topographic, chemical and biomimetic treatments on the surface of titanium (Ti)substrate. The biological behavior and bioactivity of functionally modified SLA implants withchemical and biomimetic treatments (SCB-treated Ti) using body like solution were investigated tocompare with untreated Ti and SLA Ti plates as controls. The cell attachment, proliferation,alkaline phosphotatse (AKP) activity, cell morphology and differentiation were evaluated by usingMTT, RT-PCR, scanning electron microscopy (SEM) and confocal laser-scanning microscope(CLSM) analysis system. The results showed that the cell adhesion and proliferation was enhancedon functionalized titanium surface with nano-scale apatite compared to the controls. SEMmicrographs also revealed that the osteoblast-like cells spreadly grew along the surface. Cellmorphology and differentiation could be further observed distinctly by CLSM graphs. Moreover,mRNA expression of alkaline phosphotatse in nucleus on the SCB-treated Ti increased obviouslyon the third day compared with the controls. The in vitro results demonstrated the remarkableimprovement on cell adhesion and proliferation of the biomimetic nanoapatite on SCB-treated Ti,which could be used for orthopaedic/dental implants
    Type of Medium: Electronic Resource
    URL: http://www.tib-hannover.de/fulltexts/2011/0528/01/52/transtech_doi~10.4028%252Fwww.scientific.net%252FKEM.330-332.385.pdf
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  • 3
    Electronic Resource
    Electronic Resource
    Biological Efficacy of Modified Structure of Polymer Surfaces for Bone Substitute (2007)
    s.l. ; Stafa-Zurich, Switzerland
    Key engineering materials Vol. 330-332 (Feb. 2007), p. 707-710 
    Details
    ISSN: 1013-9826
    Source: Scientific.Net: Materials Science & Technology / Trans Tech Publications Archiv 1984-2008
    Topics: Mechanical Engineering, Materials Science, Production Engineering, Mining and Metallurgy, Traffic Engineering, Precision Mechanics
    Notes: Hydroxyapatite (HA) coatings were introduced onto Poly L-lactic Acid (PLLA) polymerin a controlled manner by immobilized urease method with a shortened precipitation time.Osteoblastic-like cellular responses to the composite were examined in terms of cell proliferation,differentiation and cell morphology, as well as the expression of bone-associated genes. The cellsexhibited higher cellular proliferation at 2 and 4 days on the HA/PLLA composite compared toPLLA scaffold, while no significant difference was observed later at 6 days. The alkalinephosphatase (ALP) activity by cells at 7 days was statistically higher on HA/PLLA scaffold than onPLLA. Moreover, the gene expression of ALP and osteocalcin (OC) was up regulated on HA/PLLAcomposite by RT-PCR analysis. The preliminary study suggested that the use of the controlledmodification of hydroxyapatite coating on PLLA scaffold to produce HA/PLLA composite mightenhance cellular activity, indicating the potential use for bone substitute in tissue engineering
    Type of Medium: Electronic Resource
    URL: http://www.tib-hannover.de/fulltexts/2011/0528/01/53/transtech_doi~10.4028%252Fwww.scientific.net%252FKEM.330-332.707.pdf
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  • 4
    Electronic Resource
    Electronic Resource
    Early Peri-Implant Osteogenesis with Functionally Graded Nanophase Hydroxyapatite/Bioglass Coating on Ti Alloys (2007)
    s.l. ; Stafa-Zurich, Switzerland
    Key engineering materials Vol. 330-332 (Feb. 2007), p. 553-556 
    Details
    ISSN: 1013-9826
    Source: Scientific.Net: Materials Science & Technology / Trans Tech Publications Archiv 1984-2008
    Topics: Mechanical Engineering, Materials Science, Production Engineering, Mining and Metallurgy, Traffic Engineering, Precision Mechanics
    Notes: Although compositional gradients could be manufactured for the functionally gradedcoating that was showed to improve bonding strength between the coating and the substrate, thebiological efficacy of the graded coatings remained unclear. In this study, a functionally gradednanophase hydroxyapatite/bioglass (n-HA/bioglass) coating was prepared on a titanium (Ti)substrate for evaluating peri-implant osteogenesis in a canine model. The bone apposition andosteointegration of n-HA/bioglass coating were investigated at the interface compared with plasmaspraying HA (PS-HA) coating. The results showed that the coating degraded gradually over time butnot as fast as PS-HA coating did, and that more active bone apposition appeared on the n-HA/bioglasscoating. The in vivo study indicated that an early osteogenesis and osteointegration at the interfacecould be stimulated by the use of n-HA/bioglass coating in biological environment
    Type of Medium: Electronic Resource
    URL: http://www.tib-hannover.de/fulltexts/2011/0528/01/52/transtech_doi~10.4028%252Fwww.scientific.net%252FKEM.330-332.553.pdf
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  • 5
    Electronic Resource
    Electronic Resource
    In vitro Investigation of Mesenchymal Stem Cells with Nanophase PLGA/HA Composite (2007)
    s.l. ; Stafa-Zurich, Switzerland
    Key engineering materials Vol. 330-332 (Feb. 2007), p. 1153-1156 
    Details
    ISSN: 1013-9826
    Source: Scientific.Net: Materials Science & Technology / Trans Tech Publications Archiv 1984-2008
    Topics: Mechanical Engineering, Materials Science, Production Engineering, Mining and Metallurgy, Traffic Engineering, Precision Mechanics
    Notes: Bone grafts have been used to fill bone defects caused by disease or trauma. The amount ofautografts is limited and allogenic bone grafts may transmit diseases and cause immune responses.Numerous materials have been proposed and used as scaffolds for bone tissue reconstruction. In thisstudy, we tested nanophase PLGA/HA composite with mesenchymal stem cells in vitro to examineits biological response and cellular activity. The nanophase composite was compared toconventional polystyrene on cytocompatibility by cell attachment, proliferation, alkalinephosphotase activity test and scanning electron microscopy (SEM) analysis. The resultsdemonstrated that human mesenchymal cells showed more cell attachment and higher cellproliferation rate when growing on nanophase PLGA/HA composite than those growing onpolystyrene alone. And the composite also promoted MSC cells differentiate to osteoblast cells ascompared with control. It was suggested that the combination of bone marrow mesenchymal cellswith artificial materials or differentiation factors may enhance bone formation and regeneration,nanophase PLGA/HA composite might therefore be a promising scaffold material for bone tissuesubstitute in clinical application
    Type of Medium: Electronic Resource
    URL: http://www.tib-hannover.de/fulltexts/2011/0528/01/53/transtech_doi~10.4028%252Fwww.scientific.net%252FKEM.330-332.1153.pdf
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  • 6
    Electronic Resource
    Electronic Resource
    Effect of Woven Fabric Biodegradable Polyglycolic Acid on Joint Resurfacing with Fresh Chondrocytes in a Rabbit Model (2007)
    s.l. ; Stafa-Zurich, Switzerland
    Key engineering materials Vol. 330-332 (Feb. 2007), p. 1197-1200 
    Details
    ISSN: 1013-9826
    Source: Scientific.Net: Materials Science & Technology / Trans Tech Publications Archiv 1984-2008
    Topics: Mechanical Engineering, Materials Science, Production Engineering, Mining and Metallurgy, Traffic Engineering, Precision Mechanics
    Notes: To evaluate the effectiveness of the cell-material in situ on joint resurfacing, a wovenfabric polyglycolic acid (PGA) treated with fresh chondrocytes was used for repairing cartilagedefects. Full-thickness defects were created in the weight-bearing surfaces of the femoralintercondylar fossa in a rabbit model. The defect was filled with and without PGA under surgicalcondition. Before implantation, chondrocytes were co-cultured with PGA for one day. The animalswere sacrificed at eight weeks after implantation and evaluated grossly and histological score.Morphological examination showed that for PGA/chondrocytes group, the repaired tissue appearedsimilar in color and texture to the surrounding articular surface. While for the untreated control, nocartilage-like tissue was observed at all defects, but connective fibrous tissue. Histological analysisrevealed neochondrogenesis and clusters of cartilage matrix with specific safranin-O staining for thePGA/cell group. The Gross and histological evaluation indicated a significantly higher score forPGA/cell group than for PGA and control group. These results suggest that the woven fabric PGAmay facilitate the formation of cartilage tissues by providing a biodegradable and good-handlevehicle for the delivery to and retention of organized cell matrix constructs in vivo site. It mighttherefore enhance neochondrogenesis because of the superior biodegradable and biocompatible ofPGA scaffold sheet, while the more suitable biological environment might sustain cell growth andin situ cell function, suggesting a promising candidate for functional tissue engineering of clinicalenvironment
    Type of Medium: Electronic Resource
    URL: http://www.tib-hannover.de/fulltexts/2011/0528/01/53/transtech_doi~10.4028%252Fwww.scientific.net%252FKEM.330-332.1197.pdf
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  • 7
    Electronic Resource
    Electronic Resource
    Molecular beam epitaxial GaAs optical detectors on silica fibers (1988)
    Woodbury, NY : American Institute of Physics (AIP)
    Applied Physics Letters 52 (1988), S. 1768-1770 
    Details
    ISSN: 1077-3118
    Source: AIP Digital Archive
    Topics: Physics
    Notes: By using molecular beam epitaxy and post-growth annealing techniques, we have successfully made GaAs interdigitated photoconductive detectors on D-shaped silica fibers. The detectors exhibit low leakage current and internal photoconductive gains of up to 15 are measured. To our knowledge this is the first realization of active III-V optoelectronic devices on fibers and opens up the possibility of realizing optoelectronic integration and circuits directly on fibers.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1063/1.99620
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  • 8
    Electronic Resource
    Electronic Resource
    Estimation of Skin Target Site Acyclovir Concentrations Following Controlled (Trans)dermal Drug Delivery in Topical and Systemic Treatment of Cutaneous HSV-1 Infections in Hairless Mice (1994)
    Springer
    Pharmaceutical research 11 (1994), S. 1035-1041 
    Details
    ISSN: 1573-904X
    Keywords: transdermal delivery ; pharmacokinetics ; skin target site ; Herpes Simplex Virus-1 ; antiviral efficacy ; animal model
    Source: Springer Online Journal Archives 1860-2000
    Topics: Chemistry and Pharmacology
    Notes: Abstract The use of controlled transdermal delivery of acyclovir (AC V) in the treatment of cutaneous herpes simplex virus type 1 infections in hairless mice was investigated. Using an in vivoanimal model (A. Gonsho, et al. Int. J. Pharm. 65:183–194 (1990)) made it possible to quantify both, the topical and the systemic antiviral efficacy of ACV transdermal patches as a function of the drug delivery rate of the patches. Drug delivery rates required to attain systemic efficacy were found to be higher than the rates required to attain the same magnitude of topical efficacy. The ACV concentrations in the basal cell layer of the epidermis for 50% topical efficacy and 50% systemic efficacy were estimated. The basal epidermis layer was considered to be the site of antiviral drug activity (skin target site). Systemic plasma levels were obtained from pharmacokinetic studies and were used to estimate the ACV concentration achieved systemically in the basal epidermis layer. A computational model for drug permeation across skin was employed to estimate the ACV concentration achieved topically in the basal epidermis layer. Equal topical and systemic efficacies were found to correspond to equal drug concentrations at the site of antiviral activity. The length of the effective diffusion pathway of drug molecules in the dermis prior to entering the blood circulation was assumed to be approximately equal to 1/20 of the anatomical dermis thickness because of dermis vascularization.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1023/A:1018995606568
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  • 9
    Electronic Resource
    Electronic Resource
    Development of Nanophase β-Tricalcium Phosphate/Collagen Fiber Composites for Improving Cell Adhesion and Proliferation (2006)
    s.l. ; Stafa-Zurich, Switzerland
    Key engineering materials Vol. 309-311 (May 2006), p. 581-584 
    Details
    ISSN: 1013-9826
    Source: Scientific.Net: Materials Science & Technology / Trans Tech Publications Archiv 1984-2008
    Topics: Mechanical Engineering, Materials Science, Production Engineering, Mining and Metallurgy, Traffic Engineering, Precision Mechanics
    Notes: A novel porous beta-tricalcium phosphate /collagen fibers (β-TCP/CF) composite, having a well-dispersed nano-sized β-TCP in collagen matrix, was developed by a wet-chemical method. The nano-composite was compared to conventional β-TCP on cytocompatibility by cell attachment, proliferation, alkaline phosphotatse (AKP) activity and scanning electron microscopy (SEM) analysis. These in vitro assays showed that the β-TCP/CF composite elicited cell adhesion andproliferation better then controls. Moreover experiments on osteoblast-like cells showed improved cell growth with the highly characterized nanophase structure. SEM micrographs also showed that the nano-sized composite exhibited much more viable cells in attachment on the surface compared with the controls. At 1, 3 and 5 days, AKP activity was not significant different for the tested andcontrol samples, while at 7 day after culture, significantly increased AKP activity was observed for β-TCP/CF than for the control. The in vitro results obtained confirmed the remarkable improvement of cell adhesion and proliferation of the nano-sized β-TCP/CF composite, which may be a new promising candidate for tissue engineered bone substitute
    Type of Medium: Electronic Resource
    URL: http://www.tib-hannover.de/fulltexts/2011/0528/01/51/transtech_doi~10.4028%252Fwww.scientific.net%252FKEM.309-311.581.pdf
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  • 10
    Electronic Resource
    Electronic Resource
    Biological Behavior of Nano-Sized Zinc Containing Tricalcium Phosphate Coating on Titanium Alloys (2006)
    s.l. ; Stafa-Zurich, Switzerland
    Key engineering materials Vol. 309-311 (May 2006), p. 735-738 
    Details
    ISSN: 1013-9826
    Source: Scientific.Net: Materials Science & Technology / Trans Tech Publications Archiv 1984-2008
    Topics: Mechanical Engineering, Materials Science, Production Engineering, Mining and Metallurgy, Traffic Engineering, Precision Mechanics
    Type of Medium: Electronic Resource
    URL: http://www.tib-hannover.de/fulltexts/2011/0528/01/51/transtech_doi~10.4028%252Fwww.scientific.net%252FKEM.309-311.735.pdf
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