ISSN:
1013-9826
Source:
Scientific.Net: Materials Science & Technology / Trans Tech Publications Archiv 1984-2008
Topics:
Mechanical Engineering, Materials Science, Production Engineering, Mining and Metallurgy, Traffic Engineering, Precision Mechanics
Notes:
Two starting collagens, sponge and floc collagen, were used to preparecollagen/tricalcium phosphate (TCP) composites. The resulting composites were porous and had200μm pore size. However, there was a difference in the microstructure of the pore walls for thecomposites derived from the two collagens, the pore walls in sponge collagen/TCP compositewere still porous and had 200 nm micropores size, TCP particles were trapped in collagenmatrices. While floc collagen/TCP composite had smooth and dense walls in which TCP particleswere embedded. The difference could be attributed to the starting collagen with different status.Sponge collagen has a soft structure, which easily becomes disassembled fibrils during alkalitreatment, the disassembled fibrils are integrated again to form a dense morphology for pore wallsafter freeze-drying. While floc collagen has already a low disassembly degree, the alkali treatmentcould not be able to separate the fibrils, this remains as micropores in pore walls afterfreeze-drying. Both porous composites are significant in bone tissue engineering or regeneration.MTT test results showed the two composites had good cytocompatibility, and spongecollagen/TCP composite was somewhat better than floc collagen/TCP composite, which couldresult from that micropores derived roughness in pore walls of sponge collagen/TCP composite issuitable for cell growth
Type of Medium:
Electronic Resource
URL:
http://www.tib-hannover.de/fulltexts/2011/0528/01/52/transtech_doi~10.4028%252Fwww.scientific.net%252FKEM.330-332.495.pdf
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