ALBERT

All Library Books, journals and Electronic Records Telegrafenberg

X
Your search history is empty.
feed icon rss

Your email was sent successfully. Check your inbox.

An error occurred while sending the email. Please try again.

Proceed reservation?

Export
Filter
Collection
Keywords
Publisher
Language
Years
  • 1
    Online Resource
    Online Resource
    Evolutionary Dynamics of Malignancy : The Genetic and Environmental Causes of Cancer (2023)
    Cham :Springer International Publishing :
    Details
    Keywords: Cancer. ; Cancer Animal models. ; Cancer Treatment. ; Cancer Genetic aspects. ; Cancer Biology. ; Cancer Models. ; Cancer Therapy. ; Cancer Genetics and Genomics. ; Cancer Microenvironment.
    Description / Table of Contents: Chapter 1: Cancer as a Disease of Cell Proliferation -- Chapter 2: Genetic and Chromosomal Instability -- Chapter 3: Cancer as a Disease of Defective Cell Cycle Checkpoint Function -- Chapter 4: The DNA Damage Checkpoint -- Chapter 5: Dynamics of the Spindle Assembly Checkpoint -- Chapter 6: Cancer as a Disease of Complexity: The Dynamics of Drug Resistance -- Chapter 7: Chronic Myeloid Leukaemia: a One-Hit Malignancy -- Chapter 8: Chronic Myelomonocytic Leukaemia: a Three-Hit Malignancy -- Chapter 9: The Cancer Stem Cell and Tumour Progression -- Chapter 10: Evading the antitumour immune response -- Chapter 11: Implications of Evolutionary Dynamics for Cancer Treatment and Prevention -- Chapter 12: In science, all conclusions are provisional.
    Abstract: Advances in cancer genomics are transforming our understanding of cancer, and have profound implications for its prevention, diagnosis, and treatment. Evolutionary dynamics suggests that as few as two mutations can cause transformation of normal cells into cancer stem cells. A process of Darwinian selection, involving a further three or more mutations, taking place over a period of years, can then result in progression to a life-threatening tumour. In many cases the immune response can recognise and eliminate the mutant cells, but most advanced tumours have mutations that activate immune checkpoints and enable the tumour to hide from the immune system. For the most hard-to-treat tumours, future progress will require molecular diagnostics to detect cancer-causing mutations in healthy subjects, and new drugs or vaccines that prevent the progression process. Chapters of this book deal with the signalling pathways that control cell division, and changes in these pathways in cancer cells. Three cell cycle checkpoints that are often mutated in cancer are analysed in detail. A discussion of chronic myeloid leukaemia illustrates the role of reactive oxygen species in driving progression from a chronic to an acute condition. A single drug that suppresses reactive oxygen can prevent disease progression and turn an otherwise deadly disease into a condition that can be managed to enable many years of normal life. Another chapter discusses chronic myelomonocytic leukaemia, a disease that involves both genetic and epigenetic change. Tumour progression is discussed as a multi-stage process in which cancer stem cells evolve into genetically unstable, invasive, metastatic, drug-resistant growths. Each of these stages can act as targets for drugs or immunomodulators, but the future of cancer treatment lies in understanding tumour dynamics, and arresting malignancy at the earliest possible stage. Evolutionary dynamics is a primarily mathematical technique, but the target readership will be tumour biologists, clinicians, and drug developers. Computational detail is provided in an online supplement, but the main text emphasises the implications of the dynamics for an understanding of tumour biology and does not require mathematical expertise.
    Type of Medium: Online Resource
    Pages: XIV, 269 p. 96 illus., 58 illus. in color. , online resource.
    Edition: 1st ed. 2023.
    ISBN: 9783031325731
    URL: https://doi.org/10.1007/978-3-031-32573-1
    DOI: 10.1007/978-3-031-32573-1
    DDC: 571.978
    Language: English
    Location Call Number Expected Availability
    BibTip Others were also interested in ...
    E-BOOKS (AWI ONLY)
  • 2
    Online Resource
    Online Resource
    Ecosystem Collapse and Climate Change (2021)
    Cham :Springer International Publishing :
    Details
    Keywords: Biotic communities. ; Ecology . ; Conservation biology. ; Environmental management. ; Physical geography. ; Sustainability. ; Ecosystems. ; Ecology. ; Conservation Biology. ; Environmental Management. ; Earth System Sciences. ; Sustainability.
    Description / Table of Contents: Ecosystem Collapse and Climate Change: An Introduction -- PART I. Polar and Boreal Ecosystems -- Ecosystem Collapse on a Sub-Antarctic Island -- Permafrost Thaw in Northern Peatlands: Rapid Changes in Ecosystem and Landscape Functions -- Post-fire Recruitment Failure as a Driver of Forest to Non-forest Ecosystem Shifts in Boreal Regions -- A Paleo-perspective on Ecosystem Collapse in Boreal North America -- PART II. Temperate and Semi-arid Ecosystems -- The 2016 Tasmanian Wilderness Fires: Fire Regime Shifts and Climate Change in a Gondwanan Biogeographic Refugium -- Climate-Induced Global Forest Shifts due to Heatwave-Drought -- Extreme Events Trigger Terrestrial and Marine Ecosystem Collapses in the Southwestern USA and Southwestern Australia -- PART III. Tropical and Temperate Coastal Ecosystems -- Processes and Factors Driving Change in Mangrove Forests: An Evaluation Based on the Mass Dieback Event in Australia’s Gulf of Carpentaria -- Recurrent Mass-Bleaching and the Potential for Ecosystem Collapse on Australia’s Great Barrier Reef -- Sliding Toward the Collapse of Mediterranean Coastal Marine Rocky Ecosystems -- Marine Heatwave Drives Collapse of Kelp Forests in Western Australia -- Impact of Marine Heatwaves on Seagrass Ecosystems.
    Abstract: Human-driven greenhouse emissions are increasing the velocity of climate change and the frequency and intensity of climate extremes far above historical levels. These changes, along with other human-perturbations, are setting the conditions for more rapid and abrupt ecosystem dynamics and collapse. This book presents new evidence on the rapid emergence of ecosystem collapse in response to the progression of anthropogenic climate change dynamics that are expected to intensify as the climate continues to warm. Discussing implications for biodiversity conservation, the chapters provide examples of such dynamics globally covering polar and boreal ecosystems, temperate and semi-arid ecosystems, as well as tropical and temperate coastal ecosystems. Given its scope, the volume appeals to scientists in the fields of general ecology, terrestrial and coastal ecology, climate change impacts, and biodiversity conservation.
    Type of Medium: Online Resource
    Pages: VIII, 366 p. 93 illus., 86 illus. in color. , online resource.
    Edition: 1st ed. 2021.
    ISBN: 9783030713300
    Series Statement: Ecological Studies, Analysis and Synthesis, 241
    URL: https://doi.org/10.1007/978-3-030-71330-0
    DOI: 10.1007/978-3-030-71330-0
    DDC: 577
    Language: English
    Location Call Number Expected Availability
    BibTip Others were also interested in ...
    E-BOOKS (AWI ONLY)
  • 3
    facet.materialart.12
    Ecosystem collapse and climate change (2021)
    Cham : Springer
    Associated volumes
    Details
    Call number: 9783030713300 (e-book)
    In: Ecological studies, Volume 241
    Description / Table of Contents: Human-driven greenhouse emissions are increasing the velocity of climate change and the frequency and intensity of climate extremes far above historical levels. These changes, along with other human-perturbations, are setting the conditions for more rapid and abrupt ecosystem dynamics and collapse. This book presents new evidence on the rapid emergence of ecosystem collapse in response to the progression of anthropogenic climate change dynamics that are expected to intensify as the climate continues to warm. Discussing implications for biodiversity conservation, the chapters provide examples of such dynamics globally covering polar and boreal ecosystems, temperate and semi-arid ecosystems, as well as tropical and temperate coastal ecosystems. Given its scope, the volume appeals to scientists in the fields of general ecology, terrestrial and coastal ecology, climate change impacts, and biodiversity conservation.
    Type of Medium: 12
    Pages: 1 Online-Ressource (viii, 366 Seiten) , Illustrationen, Diagramme
    Edition: corrected publication 2021
    ISBN: 9783030713300 , 978-3-030-71330-0
    ISSN: 0070-8356 , 2196-971X
    Series Statement: Ecological studies 241
    URL: Ebook (access only within the AWI network)
    DOI: 10.1007/978-3-030-71330-0
    Language: English
    Note: Contents 1 Ecosystem Collapse and Climate Change: An Introduction / Josep G. Canadell and Robert B. Jackson Part I Polar and Boreal Ecosystems 2 Ecosystem Collapse on a Sub-Antarctic Island / Dana M. Bergstrom, Catherine R. Dickson, David J. Baker, Jennie Whinam, Patricia M. Selkirk, and Melodie A. McGeoch 3 Permafrost Thaw in Northern Peatlands: Rapid Changes in Ecosystem and Landscape Functions / David Olefeldt, Liam Heffernan, Miriam C. Jones, A. Britta K. Sannel, Claire C. Treat, and Merritt R. Turetsky 4 Post-fire Recruitment Failure as a Driver of Forest to Non-forest Ecosystem Shifts in Boreal Regions / Arden Burrell, Elena Kukavskaya, Robert Baxter, Qiaoqi Sun, and Kirsten Barrett 5 A Paleo-perspective on Ecosystem Collapse in Boreal North America / Serge Payette Part II Temperate and Semi-arid Ecosystems 6 The 2016 Tasmanian Wilderness Fires: Fire Regime Shifts and Climate Change in a Gondwanan Biogeographic Refugium / David M. J. S. Bowman, Dario Rodriguez-Cubillo, and Lynda D. Prior 7 Climate-Induced Global Forest Shifts due to Heatwave-Drought / Francisco Lloret and Enric Batllori 8 Extreme Events Trigger Terrestrial and Marine Ecosystem Collapses in the Southwestern USA and Southwestern Australia / Katinka X. Ruthrof, Joseph B. Fontaine, David D. Breshears, Jason P. Field, and Craig D. Allen Part III Tropical and Temperate Coastal Ecosystems 9 Processes and Factors Driving Change in Mangrove Forests: An Evaluation Based on the Mass Dieback Event in Australia’s Gulf of Carpentaria / Norman C. Duke, Lindsay B. Hutley, Jock R. Mackenzie, and Damien Burrows 10 Recurrent Mass-Bleaching and the Potential for Ecosystem Collapse on Australia’s Great Barrier Reef / Morgan S. Pratchett, Scott F. Heron, Camille Mellin, and Graeme S. Cumming 11 Sliding Toward the Collapse of Mediterranean Coastal Marine Rocky Ecosystems / Joaquim Garrabou, Jean-Baptiste Ledoux, Nathaniel Bensoussan, Daniel Gómez-Gras, and Cristina Linares 12 Marine Heatwave Drives Collapse of Kelp Forests in Western Australia / Thomas Wernberg 13 Impact of Marine Heatwaves on Seagrass Ecosystems / Oscar Serrano, Ariane Arias-Ortiz, Carlos M. Duarte, Gary A. Kendrick, and Paul S. Lavery Correction to: Ecosystem Collapse on a Sub-Antarctic Island / Dana M. Bergstrom, Catherine R. Dickson, David J. Baker, Jennie Whinam, Patricia M. Selkirk, and Melodie A. McGeoch Index
    Location Call Number Expected Availability
    BibTip Others were also interested in ...
    E-BOOK
  • 4
    facet.materialart.
    Unknown
    Close Encounters (2021)
    Academic Studies Press
    Details
    Publication Date: 2022-05-02
    Description: Close Encounters: Essays on Russian Literature combines discussions of ethical, esthetic, and philosophical interest raised by Pushkin, Gogol, Turgenev, Dostoevsky, Tolstoy, and Gorky, with close analyses of their texts. This book focuses on four thematic configurations: first (“Chance and Fate”), issues of freedom and responsibility, the necessity of free individual expression and yet the limits of will, or self-will; second (“Two Kinds of Beauty”), the unity of moral, esthetic, and spiritual categories, and the quest for the ideal; third (“Critical Perspectives”), examples of the type of commentary that approaches art with a unified ethical and spiritual perspective (Dostoevsky, Gorky, V.I. Ivanov, and the partially dissenting Bakhtin); and fourth (“Poems of Parting”), three poems (works by Tyutchev, Severyanin, and Pushkin) involving parting, loss, and recovery.
    Keywords: Arts ; Literary Collections ; Alexander Pushkin ; Fyodor Dostoevsky ; Ivan Turgenev ; Leo Tolstoy ; Mikhail Bakhtin
    Language: English
    Format: image/jpeg
    Format: image/jpeg
    Location Call Number Expected Availability
    BibTip Others were also interested in ...
    E-BOOK
  • 5
    facet.materialart.
    Unknown
    Jesuits in Spanish America before the Suppression (2023)
    Brill
    Details
    Publication Date: 2024-04-02
    Description: From the late sixteenth century until their expulsion in 1767, members of the Society of Jesus played an important role in the urban life of Spanish America and as administrators of frontier missions. This study examines the organization of the Society of Jesus in Spanish America in large provinces, as well as the different urban institutions such as colegios and frontier missions. It outlines the spiritual and educational activities in cities. The Jesuits supported the royal initiative to evangelize indigenous populations on the frontiers, but the outcomes that did not always conform to expectations. One reason for this was the effect of diseases such as smallpox on the indigenous populations. Finally, it examines the 1767 expulsion of the Jesuits from Spanish territories. Some died before leaving the Americas or at sea. The majority reached Spain and were later shipped to exile in the Papal States.
    Keywords: History ; American Studies ; thema EDItEUR::N History and Archaeology::NH History::NHK History of the Americas
    Language: English
    Format: image/jpeg
    Location Call Number Expected Availability
    BibTip Others were also interested in ...
    E-BOOK
  • 6
    facet.materialart.
    Unknown
    Jesuits in Spanish America before the Suppression  (2021)
    Brill | BRILL
    Details
    Publication Date: 2024-04-02
    Description: From the late sixteenth century until their expulsion in 1767, members of the Society of Jesus played an important role in the urban life of Spanish America and as administrators of frontier missions. This study examines the organization of the Society of Jesus in Spanish America in large provinces, as well as the different urban institutions such as colegios and frontier missions. It outlines the spiritual and educational activities in cities. The Jesuits supported the royal initiative to evangelize indigenous populations on the frontiers, but the outcomes that did not always conform to expectations. One reason for this was the effect of diseases such as smallpox on the indigenous populations. Finally, it examines the 1767 expulsion of the Jesuits from Spanish territories. Some died before leaving the Americas or at sea. The majority reached Spain and were later shipped to exile in the Papal States. Readership: All interested in the history of colonial Spanish America, the role of the Catholic church in colonial Spanish America, and frontier missions. Anyone interested in historical demography. Keywords: Society of Jesus, education, Misión Popular, colegios, frontier missions, Guaraní, Sonora-Sinaloa, Chaco, Baja California, expulsion.
    Keywords: History of the Americas ; thema EDItEUR::N History and Archaeology::NH History::NHK History of the Americas
    Language: English
    Format: image/png
    Format: image/jpeg
    Location Call Number Expected Availability
    BibTip Others were also interested in ...
    E-BOOK
  • 7
    facet.materialart.
    Unknown
    Soil inorganic carbon content from great plains of the United States of America and Pampas of Argentina (2020)
    PANGAEA
    Details
    Publication Date: 2023-01-30
    Description: This dataset compiles soil carbonate (i.e., soil inorganic carbon or SIC) content (% C) up to 7.8 m depth under natural vegetation (grassland or woodland) and cropland (rain-fed or irrigated). The dataset was collected to examine whether SIC content changes with decades-old agricultural conversion of natural vegetation. SIC represent more than a quarter of the terrestrial carbon pool and are often considered to be relatively stable, with fluxes significant only on geologic timescales. However, given the importance of climatic water balance on SIC accumulation, we tested the hypothesis that increased soil water storage and transport resulting from cultivation may enhance dissolution of SIC, altering their local stock at decadal timescales. We compared SIC storage to 7.3 m depth in eight sites across the Great Plains of the United States of America and the Pampas grasslands of Argentina, each site having paired plots of native vegetation and rain-fed croplands, and half of the sites having additional irrigated cropland plots. We took soil samples down to 8.5 m depth using a direct-push coring rig in the US sites and hand augers at the Argentinean sites. Sampling increments were every 0.3 m in the top 0.61 m of the soil and every 0.61 m thereafter in the US sites, and every 0.2 m to 1 m depth, then every 0.3 m to 4 m depth, and every 0.5 m thereafter in the Argentina sites. Sieved and homogenized soil samples were oven-dried at 60°C for for SIC measurement with a Carlo Erba Elemental Analyzer using the two-temperature combustion method. SIC contents are expressed as %C by weight; we note that this differs from carbonate contents reported by local soil surveys, which are %CaCO3 by weight. Inorganic carbon contents (%C) of the soil and carbonate nodules by depth were multiplied by soil and nodule weights and summed to estimate SIC storage.
    Keywords: Calcium Carbonate; Carbon, inorganic, total; DEPTH, soil; Elemental analyzer, CARLO ERBA; Event label; General-Levalle_soil; Goodwell_soil; Great Plains, United States of America; Hole; LATITUDE; LONGITUDE; Pampas, Argentina; Parera_soil; Quanah_soil; Riesel_soil; Rio-Bamba_soil; San-Angelo_soil; Site; SOIL; soil carbonates; soil inorganic carbon; Soil profile; Tribune_soil; Vegetation type
    Type: Dataset
    Format: text/tab-separated-values, 5256 data points
    Location Call Number Expected Availability
    BibTip Others were also interested in ...
    DATA PANGAEA
  • 8
    facet.materialart.
    Unknown
    Recalculation of air tempertures across the Eocene-Ologocene boundary of ODP Hole 151-913B (2012)
    PANGAEA
    Details
    Publication Date: 2024-01-09
    Keywords: 151-913B; AGE; Calculated; DEPTH, sediment/rock; DRILL; Drilling/drill rig; DSDP/ODP/IODP sample designation; Joides Resolution; Leg151; Methylation index of dominant branched tetraethers; North Greenland Sea; Ocean Drilling Program; ODP; Sample code/label; Temperature, air, annual mean
    Type: Dataset
    Format: text/tab-separated-values, 96 data points
    Location Call Number Expected Availability
    BibTip Others were also interested in ...
    DATA PANGAEA
  • 9
    facet.materialart.
    Unknown
    Revised calibration of the MBT-CBT paleotemperature proxy (2012)
    PANGAEA
    In:  Supplement to: Peterse, Francien; van der Meer, Jaap; Schouten, Stefan; Weijers, Johan W H; Fierer, Noah; Jackson, Robert B; Kim, Jung-Hyun; Sinninghe Damsté, Jaap S (2012): Revised calibration of the MBT–CBT paleotemperature proxy based on branched tetraether membrane lipids in surface soils. Geochimica et Cosmochimica Acta, 96, 215-229, https://doi.org/10.1016/j.gca.2012.08.011
    Details
    Publication Date: 2024-01-09
    Description: The MBT-CBT proxy for the reconstruction of paleotemperatures and past soil pH is based on the distribution of branched glycerol dialkyl glycerol tetraether (brGDGT) membrane lipids. The Methylation of Branched Tetraether (MBT) and the Cyclisation of Branched Tetraether (CBT) indices were developed to quantify these distributions, and significant empirical relations between these indices and annual mean air temperature (MAT) and/or soil pH were found in a large data set of soils. In this study, we extended this soil dataset to 278 globally distributed surface soils. Of these soils, 26% contains all nine brGDGTs, while in 63% of the soils the seven most common brGDGTs were detected, and the latter were selected for calibration purposes. This resulted in new transfer functions for the reconstruction of pH based on the CBT index: pH = 7.90-1.97 × CBT (r**2 = 0.70; RMSE = 0.8; n = 176), as well as for MAT based on the CBT index and methylation index based on the seven most abundant GDGTs (defined as MBT'): MAT = 0.81-5.67 × CBT + 31.0 × MBT' (r**2 = 0.59; RMSE = 5.0 °C; n = 176). The new transfer function for MAT has a substantially lower correlation coefficient than the original equation (r**2 = 0.77). To investigate possible improvement of the correlation, we used our extended global surface soil dataset to statistically derive the indices that best describe the relations of brGDGT composition with MAT and soil pH. These new indices, however, resulted in only a relatively minor increase in correlation coefficients, while they cannot be explained straightforwardly by physiological mechanisms. The large scatter in the calibration cannot be fully explained by local factors or by seasonality, but MAT for soils from arid regions are generally substantially (up to 20 °C) underestimated, suggesting that absolute brGDGT-based temperature records for these areas should be interpreted with caution. The applicability of the new MBT'-CBT calibration function was tested using previously published MBT-CBT-derived paleotemperature records covering the last deglaciation in Central Africa and East Asia, the Eocene-Oligocene boundary and the Paleocene-Eocene thermal maximum. The results show that trends remain similar in all records, but that absolute temperature estimates and the amplitude of temperature changes are lower for most records, and generally in better agreement with independent proxy data.
    Keywords: Ocean Drilling Program; ODP
    Type: Dataset
    Format: application/zip, 3 datasets
    Location Call Number Expected Availability
    BibTip Others were also interested in ...
    DATA PANGAEA
  • 10
    facet.materialart.
    Unknown
    Compilation of worldwide branched GDGTs distribution, and MBT' and CBT determination in surface soils (2012)
    PANGAEA
    Details
    Publication Date: 2024-04-25
    Keywords: Branched glycerol dialkyl glycerol tetraether; Comment; Cyclization ratio of branched tetraethers; DEPTH, sediment/rock; LATITUDE; LONGITUDE; Methylation index of dominant branched tetraethers; Ocean Drilling Program; ODP; pH, soil; Precipitation, annual mean; Reference/source; Sample code/label; Temperature, air, annual mean
    Type: Dataset
    Format: text/tab-separated-values, 3943 data points
    Location Call Number Expected Availability
    BibTip Others were also interested in ...
    DATA PANGAEA
Close ⊗
This website uses cookies and the analysis tool Matomo. More information can be found here...