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  • 2020-2024  (18)
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  • 1
    Online Resource
    Online Resource
    Evolutionary Dynamics of Malignancy : The Genetic and Environmental Causes of Cancer (2023)
    Cham :Springer International Publishing :
    Details
    Keywords: Cancer. ; Cancer Animal models. ; Cancer Treatment. ; Cancer Genetic aspects. ; Cancer Biology. ; Cancer Models. ; Cancer Therapy. ; Cancer Genetics and Genomics. ; Cancer Microenvironment.
    Description / Table of Contents: Chapter 1: Cancer as a Disease of Cell Proliferation -- Chapter 2: Genetic and Chromosomal Instability -- Chapter 3: Cancer as a Disease of Defective Cell Cycle Checkpoint Function -- Chapter 4: The DNA Damage Checkpoint -- Chapter 5: Dynamics of the Spindle Assembly Checkpoint -- Chapter 6: Cancer as a Disease of Complexity: The Dynamics of Drug Resistance -- Chapter 7: Chronic Myeloid Leukaemia: a One-Hit Malignancy -- Chapter 8: Chronic Myelomonocytic Leukaemia: a Three-Hit Malignancy -- Chapter 9: The Cancer Stem Cell and Tumour Progression -- Chapter 10: Evading the antitumour immune response -- Chapter 11: Implications of Evolutionary Dynamics for Cancer Treatment and Prevention -- Chapter 12: In science, all conclusions are provisional.
    Abstract: Advances in cancer genomics are transforming our understanding of cancer, and have profound implications for its prevention, diagnosis, and treatment. Evolutionary dynamics suggests that as few as two mutations can cause transformation of normal cells into cancer stem cells. A process of Darwinian selection, involving a further three or more mutations, taking place over a period of years, can then result in progression to a life-threatening tumour. In many cases the immune response can recognise and eliminate the mutant cells, but most advanced tumours have mutations that activate immune checkpoints and enable the tumour to hide from the immune system. For the most hard-to-treat tumours, future progress will require molecular diagnostics to detect cancer-causing mutations in healthy subjects, and new drugs or vaccines that prevent the progression process. Chapters of this book deal with the signalling pathways that control cell division, and changes in these pathways in cancer cells. Three cell cycle checkpoints that are often mutated in cancer are analysed in detail. A discussion of chronic myeloid leukaemia illustrates the role of reactive oxygen species in driving progression from a chronic to an acute condition. A single drug that suppresses reactive oxygen can prevent disease progression and turn an otherwise deadly disease into a condition that can be managed to enable many years of normal life. Another chapter discusses chronic myelomonocytic leukaemia, a disease that involves both genetic and epigenetic change. Tumour progression is discussed as a multi-stage process in which cancer stem cells evolve into genetically unstable, invasive, metastatic, drug-resistant growths. Each of these stages can act as targets for drugs or immunomodulators, but the future of cancer treatment lies in understanding tumour dynamics, and arresting malignancy at the earliest possible stage. Evolutionary dynamics is a primarily mathematical technique, but the target readership will be tumour biologists, clinicians, and drug developers. Computational detail is provided in an online supplement, but the main text emphasises the implications of the dynamics for an understanding of tumour biology and does not require mathematical expertise.
    Type of Medium: Online Resource
    Pages: XIV, 269 p. 96 illus., 58 illus. in color. , online resource.
    Edition: 1st ed. 2023.
    ISBN: 9783031325731
    URL: https://doi.org/10.1007/978-3-031-32573-1
    DOI: 10.1007/978-3-031-32573-1
    DDC: 571.978
    Language: English
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  • 2
    Online Resource
    Online Resource
    Ecosystem Collapse and Climate Change (2021)
    Cham :Springer International Publishing :
    Details
    Keywords: Biotic communities. ; Ecology . ; Conservation biology. ; Environmental management. ; Physical geography. ; Sustainability. ; Ecosystems. ; Ecology. ; Conservation Biology. ; Environmental Management. ; Earth System Sciences. ; Sustainability.
    Description / Table of Contents: Ecosystem Collapse and Climate Change: An Introduction -- PART I. Polar and Boreal Ecosystems -- Ecosystem Collapse on a Sub-Antarctic Island -- Permafrost Thaw in Northern Peatlands: Rapid Changes in Ecosystem and Landscape Functions -- Post-fire Recruitment Failure as a Driver of Forest to Non-forest Ecosystem Shifts in Boreal Regions -- A Paleo-perspective on Ecosystem Collapse in Boreal North America -- PART II. Temperate and Semi-arid Ecosystems -- The 2016 Tasmanian Wilderness Fires: Fire Regime Shifts and Climate Change in a Gondwanan Biogeographic Refugium -- Climate-Induced Global Forest Shifts due to Heatwave-Drought -- Extreme Events Trigger Terrestrial and Marine Ecosystem Collapses in the Southwestern USA and Southwestern Australia -- PART III. Tropical and Temperate Coastal Ecosystems -- Processes and Factors Driving Change in Mangrove Forests: An Evaluation Based on the Mass Dieback Event in Australia’s Gulf of Carpentaria -- Recurrent Mass-Bleaching and the Potential for Ecosystem Collapse on Australia’s Great Barrier Reef -- Sliding Toward the Collapse of Mediterranean Coastal Marine Rocky Ecosystems -- Marine Heatwave Drives Collapse of Kelp Forests in Western Australia -- Impact of Marine Heatwaves on Seagrass Ecosystems.
    Abstract: Human-driven greenhouse emissions are increasing the velocity of climate change and the frequency and intensity of climate extremes far above historical levels. These changes, along with other human-perturbations, are setting the conditions for more rapid and abrupt ecosystem dynamics and collapse. This book presents new evidence on the rapid emergence of ecosystem collapse in response to the progression of anthropogenic climate change dynamics that are expected to intensify as the climate continues to warm. Discussing implications for biodiversity conservation, the chapters provide examples of such dynamics globally covering polar and boreal ecosystems, temperate and semi-arid ecosystems, as well as tropical and temperate coastal ecosystems. Given its scope, the volume appeals to scientists in the fields of general ecology, terrestrial and coastal ecology, climate change impacts, and biodiversity conservation.
    Type of Medium: Online Resource
    Pages: VIII, 366 p. 93 illus., 86 illus. in color. , online resource.
    Edition: 1st ed. 2021.
    ISBN: 9783030713300
    Series Statement: Ecological Studies, Analysis and Synthesis, 241
    URL: https://doi.org/10.1007/978-3-030-71330-0
    DOI: 10.1007/978-3-030-71330-0
    DDC: 577
    Language: English
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  • 3
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    Ecosystem collapse and climate change (2021)
    Cham : Springer
    Associated volumes
    Details
    Call number: 9783030713300 (e-book)
    In: Ecological studies, Volume 241
    Description / Table of Contents: Human-driven greenhouse emissions are increasing the velocity of climate change and the frequency and intensity of climate extremes far above historical levels. These changes, along with other human-perturbations, are setting the conditions for more rapid and abrupt ecosystem dynamics and collapse. This book presents new evidence on the rapid emergence of ecosystem collapse in response to the progression of anthropogenic climate change dynamics that are expected to intensify as the climate continues to warm. Discussing implications for biodiversity conservation, the chapters provide examples of such dynamics globally covering polar and boreal ecosystems, temperate and semi-arid ecosystems, as well as tropical and temperate coastal ecosystems. Given its scope, the volume appeals to scientists in the fields of general ecology, terrestrial and coastal ecology, climate change impacts, and biodiversity conservation.
    Type of Medium: 12
    Pages: 1 Online-Ressource (viii, 366 Seiten) , Illustrationen, Diagramme
    Edition: corrected publication 2021
    ISBN: 9783030713300 , 978-3-030-71330-0
    ISSN: 0070-8356 , 2196-971X
    Series Statement: Ecological studies 241
    URL: Ebook (access only within the AWI network)
    DOI: 10.1007/978-3-030-71330-0
    Language: English
    Note: Contents 1 Ecosystem Collapse and Climate Change: An Introduction / Josep G. Canadell and Robert B. Jackson Part I Polar and Boreal Ecosystems 2 Ecosystem Collapse on a Sub-Antarctic Island / Dana M. Bergstrom, Catherine R. Dickson, David J. Baker, Jennie Whinam, Patricia M. Selkirk, and Melodie A. McGeoch 3 Permafrost Thaw in Northern Peatlands: Rapid Changes in Ecosystem and Landscape Functions / David Olefeldt, Liam Heffernan, Miriam C. Jones, A. Britta K. Sannel, Claire C. Treat, and Merritt R. Turetsky 4 Post-fire Recruitment Failure as a Driver of Forest to Non-forest Ecosystem Shifts in Boreal Regions / Arden Burrell, Elena Kukavskaya, Robert Baxter, Qiaoqi Sun, and Kirsten Barrett 5 A Paleo-perspective on Ecosystem Collapse in Boreal North America / Serge Payette Part II Temperate and Semi-arid Ecosystems 6 The 2016 Tasmanian Wilderness Fires: Fire Regime Shifts and Climate Change in a Gondwanan Biogeographic Refugium / David M. J. S. Bowman, Dario Rodriguez-Cubillo, and Lynda D. Prior 7 Climate-Induced Global Forest Shifts due to Heatwave-Drought / Francisco Lloret and Enric Batllori 8 Extreme Events Trigger Terrestrial and Marine Ecosystem Collapses in the Southwestern USA and Southwestern Australia / Katinka X. Ruthrof, Joseph B. Fontaine, David D. Breshears, Jason P. Field, and Craig D. Allen Part III Tropical and Temperate Coastal Ecosystems 9 Processes and Factors Driving Change in Mangrove Forests: An Evaluation Based on the Mass Dieback Event in Australia’s Gulf of Carpentaria / Norman C. Duke, Lindsay B. Hutley, Jock R. Mackenzie, and Damien Burrows 10 Recurrent Mass-Bleaching and the Potential for Ecosystem Collapse on Australia’s Great Barrier Reef / Morgan S. Pratchett, Scott F. Heron, Camille Mellin, and Graeme S. Cumming 11 Sliding Toward the Collapse of Mediterranean Coastal Marine Rocky Ecosystems / Joaquim Garrabou, Jean-Baptiste Ledoux, Nathaniel Bensoussan, Daniel Gómez-Gras, and Cristina Linares 12 Marine Heatwave Drives Collapse of Kelp Forests in Western Australia / Thomas Wernberg 13 Impact of Marine Heatwaves on Seagrass Ecosystems / Oscar Serrano, Ariane Arias-Ortiz, Carlos M. Duarte, Gary A. Kendrick, and Paul S. Lavery Correction to: Ecosystem Collapse on a Sub-Antarctic Island / Dana M. Bergstrom, Catherine R. Dickson, David J. Baker, Jennie Whinam, Patricia M. Selkirk, and Melodie A. McGeoch Index
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  • 4
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    Close Encounters (2021)
    Academic Studies Press
    Details
    Publication Date: 2022-05-02
    Description: Close Encounters: Essays on Russian Literature combines discussions of ethical, esthetic, and philosophical interest raised by Pushkin, Gogol, Turgenev, Dostoevsky, Tolstoy, and Gorky, with close analyses of their texts. This book focuses on four thematic configurations: first (“Chance and Fate”), issues of freedom and responsibility, the necessity of free individual expression and yet the limits of will, or self-will; second (“Two Kinds of Beauty”), the unity of moral, esthetic, and spiritual categories, and the quest for the ideal; third (“Critical Perspectives”), examples of the type of commentary that approaches art with a unified ethical and spiritual perspective (Dostoevsky, Gorky, V.I. Ivanov, and the partially dissenting Bakhtin); and fourth (“Poems of Parting”), three poems (works by Tyutchev, Severyanin, and Pushkin) involving parting, loss, and recovery.
    Keywords: Arts ; Literary Collections ; Alexander Pushkin ; Fyodor Dostoevsky ; Ivan Turgenev ; Leo Tolstoy ; Mikhail Bakhtin
    Language: English
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  • 5
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    Jesuits in Spanish America before the Suppression (2023)
    Brill
    Details
    Publication Date: 2024-04-02
    Description: From the late sixteenth century until their expulsion in 1767, members of the Society of Jesus played an important role in the urban life of Spanish America and as administrators of frontier missions. This study examines the organization of the Society of Jesus in Spanish America in large provinces, as well as the different urban institutions such as colegios and frontier missions. It outlines the spiritual and educational activities in cities. The Jesuits supported the royal initiative to evangelize indigenous populations on the frontiers, but the outcomes that did not always conform to expectations. One reason for this was the effect of diseases such as smallpox on the indigenous populations. Finally, it examines the 1767 expulsion of the Jesuits from Spanish territories. Some died before leaving the Americas or at sea. The majority reached Spain and were later shipped to exile in the Papal States.
    Keywords: History ; American Studies ; thema EDItEUR::N History and Archaeology::NH History::NHK History of the Americas
    Language: English
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  • 6
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    Jesuits in Spanish America before the Suppression  (2021)
    Brill | BRILL
    Details
    Publication Date: 2024-04-02
    Description: From the late sixteenth century until their expulsion in 1767, members of the Society of Jesus played an important role in the urban life of Spanish America and as administrators of frontier missions. This study examines the organization of the Society of Jesus in Spanish America in large provinces, as well as the different urban institutions such as colegios and frontier missions. It outlines the spiritual and educational activities in cities. The Jesuits supported the royal initiative to evangelize indigenous populations on the frontiers, but the outcomes that did not always conform to expectations. One reason for this was the effect of diseases such as smallpox on the indigenous populations. Finally, it examines the 1767 expulsion of the Jesuits from Spanish territories. Some died before leaving the Americas or at sea. The majority reached Spain and were later shipped to exile in the Papal States. Readership: All interested in the history of colonial Spanish America, the role of the Catholic church in colonial Spanish America, and frontier missions. Anyone interested in historical demography. Keywords: Society of Jesus, education, Misión Popular, colegios, frontier missions, Guaraní, Sonora-Sinaloa, Chaco, Baja California, expulsion.
    Keywords: History of the Americas ; thema EDItEUR::N History and Archaeology::NH History::NHK History of the Americas
    Language: English
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  • 7
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    Soil inorganic carbon content from great plains of the United States of America and Pampas of Argentina (2020)
    PANGAEA
    Details
    Publication Date: 2023-01-30
    Description: This dataset compiles soil carbonate (i.e., soil inorganic carbon or SIC) content (% C) up to 7.8 m depth under natural vegetation (grassland or woodland) and cropland (rain-fed or irrigated). The dataset was collected to examine whether SIC content changes with decades-old agricultural conversion of natural vegetation. SIC represent more than a quarter of the terrestrial carbon pool and are often considered to be relatively stable, with fluxes significant only on geologic timescales. However, given the importance of climatic water balance on SIC accumulation, we tested the hypothesis that increased soil water storage and transport resulting from cultivation may enhance dissolution of SIC, altering their local stock at decadal timescales. We compared SIC storage to 7.3 m depth in eight sites across the Great Plains of the United States of America and the Pampas grasslands of Argentina, each site having paired plots of native vegetation and rain-fed croplands, and half of the sites having additional irrigated cropland plots. We took soil samples down to 8.5 m depth using a direct-push coring rig in the US sites and hand augers at the Argentinean sites. Sampling increments were every 0.3 m in the top 0.61 m of the soil and every 0.61 m thereafter in the US sites, and every 0.2 m to 1 m depth, then every 0.3 m to 4 m depth, and every 0.5 m thereafter in the Argentina sites. Sieved and homogenized soil samples were oven-dried at 60°C for for SIC measurement with a Carlo Erba Elemental Analyzer using the two-temperature combustion method. SIC contents are expressed as %C by weight; we note that this differs from carbonate contents reported by local soil surveys, which are %CaCO3 by weight. Inorganic carbon contents (%C) of the soil and carbonate nodules by depth were multiplied by soil and nodule weights and summed to estimate SIC storage.
    Keywords: Calcium Carbonate; Carbon, inorganic, total; DEPTH, soil; Elemental analyzer, CARLO ERBA; Event label; General-Levalle_soil; Goodwell_soil; Great Plains, United States of America; Hole; LATITUDE; LONGITUDE; Pampas, Argentina; Parera_soil; Quanah_soil; Riesel_soil; Rio-Bamba_soil; San-Angelo_soil; Site; SOIL; soil carbonates; soil inorganic carbon; Soil profile; Tribune_soil; Vegetation type
    Type: Dataset
    Format: text/tab-separated-values, 5256 data points
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  • 8
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    Global Carbon Budget 2023 (2023)
    Copernicus Publications
    In:  EPIC3Earth System Science Data, Copernicus Publications, 15(12), pp. 5301-5369, ISSN: 1866-3508
    Details
    Publication Date: 2023-12-19
    Description: 〈jats:p〉Abstract. Accurate assessment of anthropogenic carbon dioxide (CO2) emissions and their redistribution among the atmosphere, ocean, and terrestrial biosphere in a changing climate is critical to better understand the global carbon cycle, support the development of climate policies, and project future climate change. Here we describe and synthesize data sets and methodology to quantify the five major components of the global carbon budget and their uncertainties. Fossil CO2 emissions (EFOS) are based on energy statistics and cement production data, while emissions from land-use change (ELUC), mainly deforestation, are based on land-use and land-use change data and bookkeeping models. Atmospheric CO2 concentration is measured directly, and its growth rate (GATM) is computed from the annual changes in concentration. The ocean CO2 sink (SOCEAN) is estimated with global ocean biogeochemistry models and observation-based fCO2 products. The terrestrial CO2 sink (SLAND) is estimated with dynamic global vegetation models. Additional lines of evidence on land and ocean sinks are provided by atmospheric inversions, atmospheric oxygen measurements, and Earth system models. The resulting carbon budget imbalance (BIM), the difference between the estimated total emissions and the estimated changes in the atmosphere, ocean, and terrestrial biosphere, is a measure of imperfect data and incomplete understanding of the contemporary carbon cycle. All uncertainties are reported as ±1σ. For the year 2022, EFOS increased by 0.9 % relative to 2021, with fossil emissions at 9.9±0.5 Gt C yr−1 (10.2±0.5 Gt C yr−1 when the cement carbonation sink is not included), and ELUC was 1.2±0.7 Gt C yr−1, for a total anthropogenic CO2 emission (including the cement carbonation sink) of 11.1±0.8 Gt C yr−1 (40.7±3.2 Gt CO2 yr−1). Also, for 2022, GATM was 4.6±0.2 Gt C yr−1 (2.18±0.1 ppm yr−1; ppm denotes parts per million), SOCEAN was 2.8±0.4 Gt C yr−1, and SLAND was 3.8±0.8 Gt C yr−1, with a BIM of −0.1 Gt C yr−1 (i.e. total estimated sources marginally too low or sinks marginally too high). The global atmospheric CO2 concentration averaged over 2022 reached 417.1±0.1 ppm. Preliminary data for 2023 suggest an increase in EFOS relative to 2022 of +1.1 % (0.0 % to 2.1 %) globally and atmospheric CO2 concentration reaching 419.3 ppm, 51 % above the pre-industrial level (around 278 ppm in 1750). Overall, the mean of and trend in the components of the global carbon budget are consistently estimated over the period 1959–2022, with a near-zero overall budget imbalance, although discrepancies of up to around 1 Gt C yr−1 persist for the representation of annual to semi-decadal variability in CO2 fluxes. Comparison of estimates from multiple approaches and observations shows the following: (1) a persistent large uncertainty in the estimate of land-use changes emissions, (2) a low agreement between the different methods on the magnitude of the land CO2 flux in the northern extra-tropics, and (3) a discrepancy between the different methods on the strength of the ocean sink over the last decade. This living-data update documents changes in methods and data sets applied to this most recent global carbon budget as well as evolving community understanding of the global carbon cycle. The data presented in this work are available at https://doi.org/10.18160/GCP-2023 (Friedlingstein et al., 2023). 〈/jats:p〉
    Repository Name: EPIC Alfred Wegener Institut
    Type: Article , isiRev
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  • 9
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    Global Carbon Budget 2022 (2022)
    Copernicus GmbH
    In:  EPIC3Earth System Science Data, Copernicus GmbH, 14(11), pp. 4811-4900, ISSN: 1866-3508
    Details
    Publication Date: 2023-07-17
    Description: Accurate assessment of anthropogenic carbon dioxide (CO2) emissions and their redistribution among the atmosphere, ocean, and terrestrial biosphere in a changing climate is critical to better understand the global carbon cycle, support the development of climate policies, and project future climate change. Here we describe and synthesize data sets and methodologies to quantify the five major components of the global carbon budget and their uncertainties. Fossil CO2 emissions (EFOS) are based on energy statistics and cement production data, while emissions from land-use change (ELUC), mainly deforestation, are based on land use and land-use change data and bookkeeping models. Atmospheric CO2 concentration is measured directly, and its growth rate (GATM) is computed from the annual changes in concentration. The ocean CO2 sink (SOCEAN) is estimated with global ocean biogeochemistry models and observation-based data products. The terrestrial CO2 sink (SLAND) is estimated with dynamic global vegetation models. The resulting carbon budget imbalance (BIM), the difference between the estimated total emissions and the estimated changes in the atmosphere, ocean, and terrestrial biosphere, is a measure of imperfect data and understanding of the contemporary carbon cycle. All uncertainties are reported as ±1σ. For the year 2021, EFOS increased by 5.1% relative to 2020, with fossil emissions at 10.1±0.5GtCyr-1 (9.9±0.5GtCyr-1 when the cement carbonation sink is included), and ELUC was 1.1±0.7GtCyr-1, for a total anthropogenic CO2 emission (including the cement carbonation sink) of 10.9±0.8GtCyr-1 (40.0±2.9GtCO2). Also, for 2021, GATM was 5.2±0.2GtCyr-1 (2.5±0.1ppmyr-1), SOCEAN was 2.9 ±0.4GtCyr-1, and SLAND was 3.5±0.9GtCyr-1, with a BIM of -0.6GtCyr-1 (i.e. the total estimated sources were too low or sinks were too high). The global atmospheric CO2 concentration averaged over 2021 reached 414.71±0.1ppm. Preliminary data for 2022 suggest an increase in EFOS relative to 2021 of +1.0% (0.1% to 1.9%) globally and atmospheric CO2 concentration reaching 417.2ppm, more than 50% above pre-industrial levels (around 278ppm). Overall, the mean and trend in the components of the global carbon budget are consistently estimated over the period 1959-2021, but discrepancies of up to 1GtCyr-1 persist for the representation of annual to semi-decadal variability in CO2 fluxes. Comparison of estimates from multiple approaches and observations shows (1) a persistent large uncertainty in the estimate of land-use change emissions, (2) a low agreement between the different methods on the magnitude of the land CO2 flux in the northern extratropics, and (3) a discrepancy between the different methods on the strength of the ocean sink over the last decade. This living data update documents changes in the methods and data sets used in this new global carbon budget and the progress in understanding of the global carbon cycle compared with previous publications of this data set. The data presented in this work are available at 10.18160/GCP-2022 (Friedlingstein et al., 2022b).
    Repository Name: EPIC Alfred Wegener Institut
    Type: Article , peerRev
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  • 10
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    Methane Emissions from Abandoned Oil and Gas Wells in California (2020)
    ACS (American Chemical Society)
    Details
    Publication Date: 2023-02-08
    Description: California hosts ∼124,000 abandoned and plugged (AP) oil and gas wells, ∼38,000 idle wells, and ∼63,000 active wells, whose methane (CH4) emissions remain largely unquantified at levels below ∼2 kg CH4 h–1. We sampled 121 wells using two methods: a rapid mobile plume integration method (detection ∼0.5 g CH4 h–1) and a more sensitive static flux chamber (detection ∼1 × 10–6 g CH4 h–1). We measured small but detectable methane emissions from 34 of 97 AP wells (mean emission: 0.286 g CH4 h–1). In contrast, we found emissions from 11 of 17 idle wells—which are not currently producing (mean: 35.4 g CH4 h–1)—4 of 6 active wells (mean: 189.7 g CH4 h–1), and one unplugged well—an open casing with no infrastructure present (10.9 g CH4 h–1). Our results support previous findings that emissions from plugged wells are low but are more substantial from idle wells. In addition, our smaller sample of active wells suggests that their reported emissions are consistent with previous studies and deserve further attention. Due to limited access, we could not measure wells in most major active oil and gas fields in California; therefore, we recommend additional data collection from all types of wells but especially active and idle wells.
    Type: Article , PeerReviewed
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