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  • 1
    Online Resource
    Online Resource
    Evolutionary Dynamics of Malignancy : The Genetic and Environmental Causes of Cancer (2023)
    Cham :Springer International Publishing :
    Details
    Keywords: Cancer. ; Cancer Animal models. ; Cancer Treatment. ; Cancer Genetic aspects. ; Cancer Biology. ; Cancer Models. ; Cancer Therapy. ; Cancer Genetics and Genomics. ; Cancer Microenvironment.
    Description / Table of Contents: Chapter 1: Cancer as a Disease of Cell Proliferation -- Chapter 2: Genetic and Chromosomal Instability -- Chapter 3: Cancer as a Disease of Defective Cell Cycle Checkpoint Function -- Chapter 4: The DNA Damage Checkpoint -- Chapter 5: Dynamics of the Spindle Assembly Checkpoint -- Chapter 6: Cancer as a Disease of Complexity: The Dynamics of Drug Resistance -- Chapter 7: Chronic Myeloid Leukaemia: a One-Hit Malignancy -- Chapter 8: Chronic Myelomonocytic Leukaemia: a Three-Hit Malignancy -- Chapter 9: The Cancer Stem Cell and Tumour Progression -- Chapter 10: Evading the antitumour immune response -- Chapter 11: Implications of Evolutionary Dynamics for Cancer Treatment and Prevention -- Chapter 12: In science, all conclusions are provisional.
    Abstract: Advances in cancer genomics are transforming our understanding of cancer, and have profound implications for its prevention, diagnosis, and treatment. Evolutionary dynamics suggests that as few as two mutations can cause transformation of normal cells into cancer stem cells. A process of Darwinian selection, involving a further three or more mutations, taking place over a period of years, can then result in progression to a life-threatening tumour. In many cases the immune response can recognise and eliminate the mutant cells, but most advanced tumours have mutations that activate immune checkpoints and enable the tumour to hide from the immune system. For the most hard-to-treat tumours, future progress will require molecular diagnostics to detect cancer-causing mutations in healthy subjects, and new drugs or vaccines that prevent the progression process. Chapters of this book deal with the signalling pathways that control cell division, and changes in these pathways in cancer cells. Three cell cycle checkpoints that are often mutated in cancer are analysed in detail. A discussion of chronic myeloid leukaemia illustrates the role of reactive oxygen species in driving progression from a chronic to an acute condition. A single drug that suppresses reactive oxygen can prevent disease progression and turn an otherwise deadly disease into a condition that can be managed to enable many years of normal life. Another chapter discusses chronic myelomonocytic leukaemia, a disease that involves both genetic and epigenetic change. Tumour progression is discussed as a multi-stage process in which cancer stem cells evolve into genetically unstable, invasive, metastatic, drug-resistant growths. Each of these stages can act as targets for drugs or immunomodulators, but the future of cancer treatment lies in understanding tumour dynamics, and arresting malignancy at the earliest possible stage. Evolutionary dynamics is a primarily mathematical technique, but the target readership will be tumour biologists, clinicians, and drug developers. Computational detail is provided in an online supplement, but the main text emphasises the implications of the dynamics for an understanding of tumour biology and does not require mathematical expertise.
    Type of Medium: Online Resource
    Pages: XIV, 269 p. 96 illus., 58 illus. in color. , online resource.
    Edition: 1st ed. 2023.
    ISBN: 9783031325731
    URL: https://doi.org/10.1007/978-3-031-32573-1
    DOI: 10.1007/978-3-031-32573-1
    DDC: 571.978
    Language: English
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  • 2
    Online Resource
    Online Resource
    Ecosystem Collapse and Climate Change (2021)
    Cham :Springer International Publishing :
    Details
    Keywords: Biotic communities. ; Ecology . ; Conservation biology. ; Environmental management. ; Physical geography. ; Sustainability. ; Ecosystems. ; Ecology. ; Conservation Biology. ; Environmental Management. ; Earth System Sciences. ; Sustainability.
    Description / Table of Contents: Ecosystem Collapse and Climate Change: An Introduction -- PART I. Polar and Boreal Ecosystems -- Ecosystem Collapse on a Sub-Antarctic Island -- Permafrost Thaw in Northern Peatlands: Rapid Changes in Ecosystem and Landscape Functions -- Post-fire Recruitment Failure as a Driver of Forest to Non-forest Ecosystem Shifts in Boreal Regions -- A Paleo-perspective on Ecosystem Collapse in Boreal North America -- PART II. Temperate and Semi-arid Ecosystems -- The 2016 Tasmanian Wilderness Fires: Fire Regime Shifts and Climate Change in a Gondwanan Biogeographic Refugium -- Climate-Induced Global Forest Shifts due to Heatwave-Drought -- Extreme Events Trigger Terrestrial and Marine Ecosystem Collapses in the Southwestern USA and Southwestern Australia -- PART III. Tropical and Temperate Coastal Ecosystems -- Processes and Factors Driving Change in Mangrove Forests: An Evaluation Based on the Mass Dieback Event in Australia’s Gulf of Carpentaria -- Recurrent Mass-Bleaching and the Potential for Ecosystem Collapse on Australia’s Great Barrier Reef -- Sliding Toward the Collapse of Mediterranean Coastal Marine Rocky Ecosystems -- Marine Heatwave Drives Collapse of Kelp Forests in Western Australia -- Impact of Marine Heatwaves on Seagrass Ecosystems.
    Abstract: Human-driven greenhouse emissions are increasing the velocity of climate change and the frequency and intensity of climate extremes far above historical levels. These changes, along with other human-perturbations, are setting the conditions for more rapid and abrupt ecosystem dynamics and collapse. This book presents new evidence on the rapid emergence of ecosystem collapse in response to the progression of anthropogenic climate change dynamics that are expected to intensify as the climate continues to warm. Discussing implications for biodiversity conservation, the chapters provide examples of such dynamics globally covering polar and boreal ecosystems, temperate and semi-arid ecosystems, as well as tropical and temperate coastal ecosystems. Given its scope, the volume appeals to scientists in the fields of general ecology, terrestrial and coastal ecology, climate change impacts, and biodiversity conservation.
    Type of Medium: Online Resource
    Pages: VIII, 366 p. 93 illus., 86 illus. in color. , online resource.
    Edition: 1st ed. 2021.
    ISBN: 9783030713300
    Series Statement: Ecological Studies, Analysis and Synthesis, 241
    URL: https://doi.org/10.1007/978-3-030-71330-0
    DOI: 10.1007/978-3-030-71330-0
    DDC: 577
    Language: English
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  • 3
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    Ecosystem collapse and climate change (2021)
    Cham : Springer
    Associated volumes
    Details
    Call number: 9783030713300 (e-book)
    In: Ecological studies, Volume 241
    Description / Table of Contents: Human-driven greenhouse emissions are increasing the velocity of climate change and the frequency and intensity of climate extremes far above historical levels. These changes, along with other human-perturbations, are setting the conditions for more rapid and abrupt ecosystem dynamics and collapse. This book presents new evidence on the rapid emergence of ecosystem collapse in response to the progression of anthropogenic climate change dynamics that are expected to intensify as the climate continues to warm. Discussing implications for biodiversity conservation, the chapters provide examples of such dynamics globally covering polar and boreal ecosystems, temperate and semi-arid ecosystems, as well as tropical and temperate coastal ecosystems. Given its scope, the volume appeals to scientists in the fields of general ecology, terrestrial and coastal ecology, climate change impacts, and biodiversity conservation.
    Type of Medium: 12
    Pages: 1 Online-Ressource (viii, 366 Seiten) , Illustrationen, Diagramme
    Edition: corrected publication 2021
    ISBN: 9783030713300 , 978-3-030-71330-0
    ISSN: 0070-8356 , 2196-971X
    Series Statement: Ecological studies 241
    URL: Ebook (access only within the AWI network)
    DOI: 10.1007/978-3-030-71330-0
    Language: English
    Note: Contents 1 Ecosystem Collapse and Climate Change: An Introduction / Josep G. Canadell and Robert B. Jackson Part I Polar and Boreal Ecosystems 2 Ecosystem Collapse on a Sub-Antarctic Island / Dana M. Bergstrom, Catherine R. Dickson, David J. Baker, Jennie Whinam, Patricia M. Selkirk, and Melodie A. McGeoch 3 Permafrost Thaw in Northern Peatlands: Rapid Changes in Ecosystem and Landscape Functions / David Olefeldt, Liam Heffernan, Miriam C. Jones, A. Britta K. Sannel, Claire C. Treat, and Merritt R. Turetsky 4 Post-fire Recruitment Failure as a Driver of Forest to Non-forest Ecosystem Shifts in Boreal Regions / Arden Burrell, Elena Kukavskaya, Robert Baxter, Qiaoqi Sun, and Kirsten Barrett 5 A Paleo-perspective on Ecosystem Collapse in Boreal North America / Serge Payette Part II Temperate and Semi-arid Ecosystems 6 The 2016 Tasmanian Wilderness Fires: Fire Regime Shifts and Climate Change in a Gondwanan Biogeographic Refugium / David M. J. S. Bowman, Dario Rodriguez-Cubillo, and Lynda D. Prior 7 Climate-Induced Global Forest Shifts due to Heatwave-Drought / Francisco Lloret and Enric Batllori 8 Extreme Events Trigger Terrestrial and Marine Ecosystem Collapses in the Southwestern USA and Southwestern Australia / Katinka X. Ruthrof, Joseph B. Fontaine, David D. Breshears, Jason P. Field, and Craig D. Allen Part III Tropical and Temperate Coastal Ecosystems 9 Processes and Factors Driving Change in Mangrove Forests: An Evaluation Based on the Mass Dieback Event in Australia’s Gulf of Carpentaria / Norman C. Duke, Lindsay B. Hutley, Jock R. Mackenzie, and Damien Burrows 10 Recurrent Mass-Bleaching and the Potential for Ecosystem Collapse on Australia’s Great Barrier Reef / Morgan S. Pratchett, Scott F. Heron, Camille Mellin, and Graeme S. Cumming 11 Sliding Toward the Collapse of Mediterranean Coastal Marine Rocky Ecosystems / Joaquim Garrabou, Jean-Baptiste Ledoux, Nathaniel Bensoussan, Daniel Gómez-Gras, and Cristina Linares 12 Marine Heatwave Drives Collapse of Kelp Forests in Western Australia / Thomas Wernberg 13 Impact of Marine Heatwaves on Seagrass Ecosystems / Oscar Serrano, Ariane Arias-Ortiz, Carlos M. Duarte, Gary A. Kendrick, and Paul S. Lavery Correction to: Ecosystem Collapse on a Sub-Antarctic Island / Dana M. Bergstrom, Catherine R. Dickson, David J. Baker, Jennie Whinam, Patricia M. Selkirk, and Melodie A. McGeoch Index
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  • 4
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    Close Encounters (2021)
    Academic Studies Press
    Details
    Publication Date: 2022-05-02
    Description: Close Encounters: Essays on Russian Literature combines discussions of ethical, esthetic, and philosophical interest raised by Pushkin, Gogol, Turgenev, Dostoevsky, Tolstoy, and Gorky, with close analyses of their texts. This book focuses on four thematic configurations: first (“Chance and Fate”), issues of freedom and responsibility, the necessity of free individual expression and yet the limits of will, or self-will; second (“Two Kinds of Beauty”), the unity of moral, esthetic, and spiritual categories, and the quest for the ideal; third (“Critical Perspectives”), examples of the type of commentary that approaches art with a unified ethical and spiritual perspective (Dostoevsky, Gorky, V.I. Ivanov, and the partially dissenting Bakhtin); and fourth (“Poems of Parting”), three poems (works by Tyutchev, Severyanin, and Pushkin) involving parting, loss, and recovery.
    Keywords: Arts ; Literary Collections ; Alexander Pushkin ; Fyodor Dostoevsky ; Ivan Turgenev ; Leo Tolstoy ; Mikhail Bakhtin
    Language: English
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  • 5
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    Jesuits in Spanish America before the Suppression (2023)
    Brill
    Details
    Publication Date: 2024-04-02
    Description: From the late sixteenth century until their expulsion in 1767, members of the Society of Jesus played an important role in the urban life of Spanish America and as administrators of frontier missions. This study examines the organization of the Society of Jesus in Spanish America in large provinces, as well as the different urban institutions such as colegios and frontier missions. It outlines the spiritual and educational activities in cities. The Jesuits supported the royal initiative to evangelize indigenous populations on the frontiers, but the outcomes that did not always conform to expectations. One reason for this was the effect of diseases such as smallpox on the indigenous populations. Finally, it examines the 1767 expulsion of the Jesuits from Spanish territories. Some died before leaving the Americas or at sea. The majority reached Spain and were later shipped to exile in the Papal States.
    Keywords: History ; American Studies ; thema EDItEUR::N History and Archaeology::NH History::NHK History of the Americas
    Language: English
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  • 6
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    Jesuits in Spanish America before the Suppression  (2021)
    Brill | BRILL
    Details
    Publication Date: 2024-04-02
    Description: From the late sixteenth century until their expulsion in 1767, members of the Society of Jesus played an important role in the urban life of Spanish America and as administrators of frontier missions. This study examines the organization of the Society of Jesus in Spanish America in large provinces, as well as the different urban institutions such as colegios and frontier missions. It outlines the spiritual and educational activities in cities. The Jesuits supported the royal initiative to evangelize indigenous populations on the frontiers, but the outcomes that did not always conform to expectations. One reason for this was the effect of diseases such as smallpox on the indigenous populations. Finally, it examines the 1767 expulsion of the Jesuits from Spanish territories. Some died before leaving the Americas or at sea. The majority reached Spain and were later shipped to exile in the Papal States. Readership: All interested in the history of colonial Spanish America, the role of the Catholic church in colonial Spanish America, and frontier missions. Anyone interested in historical demography. Keywords: Society of Jesus, education, Misión Popular, colegios, frontier missions, Guaraní, Sonora-Sinaloa, Chaco, Baja California, expulsion.
    Keywords: History of the Americas ; thema EDItEUR::N History and Archaeology::NH History::NHK History of the Americas
    Language: English
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    Format: image/jpeg
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