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  • 2000-2004  (165)
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  • 1
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    Seismic evidence for a tilted mantle plume and north-south mantle flow beneath Iceland (2002)
    In:  Earth planet. Sci. Lett., Luxembourg, Inst. Electrical & Electronics Engineers, vol. 197, no. 3-4, pp. 261-272, pp. B06303, (ISSN: 1340-4202)
    Details
    Publication Date: 2002
    Keywords: GeodesyY ; ConvolutionE ; hot ; spot ; Seismology ; EPSL
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    BIBLIOGRAPHY SEISMOLOGY
  • 2
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    Adaptive immune response of Vgamma2Vdelta2+ T cells during mycobacterial infections (2002)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 2002-03-23
    Description: To examine the role of T cell receptor (TCR) in gammadelta T cells in adaptive immunity, a macaque model was used to follow Vgamma2Vdelta2+ T cell responses to mycobacterial infections. These phosphoantigen-specific gammadelta T cells displayed major expansion during Mycobacterium bovis Bacille Calmette-Guerin (BCG) infection and a clear memory-type response after BCG reinfection. Primary and recall expansions of Vgamma2Vdelta2+ T cells were also seen during Mycobacterium tuberculosis infection of naive and BCG-vaccinated macaques, respectively. This capacity to rapidly expand coincided with a clearance of BCG bacteremia and immunity to fatal tuberculosis in BCG-vaccinated macaques. Thus, Vgamma2Vdelta2+ T cells may contribute to adaptive immunity to mycobacterial infections.〈br /〉〈br /〉〈a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2872146/" target="_blank"〉〈img src="https://static.pubmed.gov/portal/portal3rc.fcgi/4089621/img/3977009" border="0"〉〈/a〉   〈a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2872146/" target="_blank"〉This paper as free author manuscript - peer-reviewed and accepted for publication〈/a〉〈br /〉〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Shen, Yun -- Zhou, Dejiang -- Qiu, Liyou -- Lai, Xioamin -- Simon, Meredith -- Shen, Ling -- Kou, Zhongchen -- Wang, Qifan -- Jiang, Liming -- Estep, Jim -- Hunt, Robert -- Clagett, Michelle -- Sehgal, Prabhat K -- Li, Yunyaun -- Zeng, Xuejun -- Morita, Craig T -- Brenner, Michael B -- Letvin, Norman L -- Chen, Zheng W -- HL64560/HL/NHLBI NIH HHS/ -- R01 HL064560/HL/NHLBI NIH HHS/ -- R01 HL064560-04/HL/NHLBI NIH HHS/ -- R01 RR013601/RR/NCRR NIH HHS/ -- R01 RR013601-04/RR/NCRR NIH HHS/ -- RR13601/RR/NCRR NIH HHS/ -- New York, N.Y. -- Science. 2002 Mar 22;295(5563):2255-8.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Tuberculosis Research Unit, Division of Viral Pathogenesis, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA 02115, USA.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/11910108" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; Immunity, Innate/immunology ; Immunologic Memory/immunology ; Lymphocyte Activation ; Lymphocyte Count ; Macaca/*immunology/*microbiology ; Mycobacterium bovis/*immunology ; Mycobacterium tuberculosis/*immunology ; Receptors, Antigen, T-Cell, gamma-delta/*immunology ; T-Lymphocytes/cytology/*immunology ; Tuberculosis/*immunology/microbiology
    Print ISSN: 0036-8075
    Electronic ISSN: 1095-9203
    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
    Published by American Association for the Advancement of Science (AAAS)
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    PAPER CURRENT
  • 3
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    Crystal structure of the carboxyltransferase domain of acetyl-coenzyme A carboxylase (2003)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 2003-03-29
    Description: Acetyl-coenzyme A carboxylases (ACCs) are required for the biosynthesis and oxidation of long-chain fatty acids. They are targets for therapeutics against obesity and diabetes, and several herbicides function by inhibiting their carboxyltransferase (CT) domain. We determined the crystal structure of the free enzyme and the coenzyme A complex of yeast CT at 2.7 angstrom resolution and found that it comprises two domains, both belonging to the crotonase/ClpP superfamily. The active site is at the interface of a dimer. Mutagenesis and kinetic studies reveal the functional roles of conserved residues here. The herbicides target the active site of CT, providing a lead for inhibitor development against human ACCs.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Zhang, Hailong -- Yang, Zhiru -- Shen, Yang -- Tong, Liang -- New York, N.Y. -- Science. 2003 Mar 28;299(5615):2064-7.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Department of Biological Sciences, Columbia University, New York, NY 10027, USA.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/12663926" target="_blank"〉PubMed〈/a〉
    Keywords: Acetyl-CoA Carboxylase/antagonists & inhibitors/*chemistry/genetics/metabolism ; Amino Acid Sequence ; Binding Sites ; Biotin/chemistry/metabolism ; Catalysis ; Coenzyme A/chemistry/metabolism ; Crystallography, X-Ray ; Dimerization ; Enzyme Inhibitors/metabolism/pharmacology ; Hydrogen Bonding ; Kinetics ; Molecular Sequence Data ; Mutagenesis ; Protein Conformation ; Protein Folding ; Protein Structure, Secondary ; Protein Structure, Tertiary ; Pyridines/metabolism/pharmacology ; Saccharomyces cerevisiae/*enzymology
    Print ISSN: 0036-8075
    Electronic ISSN: 1095-9203
    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
    Published by American Association for the Advancement of Science (AAAS)
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  • 4
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    Ultrahigh strength and high electrical conductivity in copper (2004)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 2004-03-20
    Description: Methods used to strengthen metals generally also cause a pronounced decrease in electrical conductivity, so that a tradeoff must be made between conductivity and mechanical strength. We synthesized pure copper samples with a high density of nanoscale growth twins. They showed a tensile strength about 10 times higher than that of conventional coarse-grained copper, while retaining an electrical conductivity comparable to that of pure copper. The ultrahigh strength originates from the effective blockage of dislocation motion by numerous coherent twin boundaries that possess an extremely low electrical resistivity, which is not the case for other types of grain boundaries.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Lu, Lei -- Shen, Yongfeng -- Chen, Xianhua -- Qian, Lihua -- Lu, K -- New York, N.Y. -- Science. 2004 Apr 16;304(5669):422-6. Epub 2004 Mar 18.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Shenyang National Laboratory for Materials Science (SYNL), Institute of Metal Research, Chinese Academy of Sciences, Shenyang 110016, P.R. China.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/15031435" target="_blank"〉PubMed〈/a〉
    Print ISSN: 0036-8075
    Electronic ISSN: 1095-9203
    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
    Published by American Association for the Advancement of Science (AAAS)
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  • 5
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    A draft sequence for the genome of the domesticated silkworm (Bombyx mori) (2004)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 2004-12-14
    Description: We report a draft sequence for the genome of the domesticated silkworm (Bombyx mori), covering 90.9% of all known silkworm genes. Our estimated gene count is 18,510, which exceeds the 13,379 genes reported for Drosophila melanogaster. Comparative analyses to fruitfly, mosquito, spider, and butterfly reveal both similarities and differences in gene content.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Xia, Qingyou -- Zhou, Zeyang -- Lu, Cheng -- Cheng, Daojun -- Dai, Fangyin -- Li, Bin -- Zhao, Ping -- Zha, Xingfu -- Cheng, Tingcai -- Chai, Chunli -- Pan, Guoqing -- Xu, Jinshan -- Liu, Chun -- Lin, Ying -- Qian, Jifeng -- Hou, Yong -- Wu, Zhengli -- Li, Guanrong -- Pan, Minhui -- Li, Chunfeng -- Shen, Yihong -- Lan, Xiqian -- Yuan, Lianwei -- Li, Tian -- Xu, Hanfu -- Yang, Guangwei -- Wan, Yongji -- Zhu, Yong -- Yu, Maode -- Shen, Weide -- Wu, Dayang -- Xiang, Zhonghuai -- Yu, Jun -- Wang, Jun -- Li, Ruiqiang -- Shi, Jianping -- Li, Heng -- Li, Guangyuan -- Su, Jianning -- Wang, Xiaoling -- Li, Guoqing -- Zhang, Zengjin -- Wu, Qingfa -- Li, Jun -- Zhang, Qingpeng -- Wei, Ning -- Xu, Jianzhe -- Sun, Haibo -- Dong, Le -- Liu, Dongyuan -- Zhao, Shengli -- Zhao, Xiaolan -- Meng, Qingshun -- Lan, Fengdi -- Huang, Xiangang -- Li, Yuanzhe -- Fang, Lin -- Li, Changfeng -- Li, Dawei -- Sun, Yongqiao -- Zhang, Zhenpeng -- Yang, Zheng -- Huang, Yanqing -- Xi, Yan -- Qi, Qiuhui -- He, Dandan -- Huang, Haiyan -- Zhang, Xiaowei -- Wang, Zhiqiang -- Li, Wenjie -- Cao, Yuzhu -- Yu, Yingpu -- Yu, Hong -- Li, Jinhong -- Ye, Jiehua -- Chen, Huan -- Zhou, Yan -- Liu, Bin -- Wang, Jing -- Ye, Jia -- Ji, Hai -- Li, Shengting -- Ni, Peixiang -- Zhang, Jianguo -- Zhang, Yong -- Zheng, Hongkun -- Mao, Bingyu -- Wang, Wen -- Ye, Chen -- Li, Songgang -- Wang, Jian -- Wong, Gane Ka-Shu -- Yang, Huanming -- Biology Analysis Group -- 1 P50 HG02351/HG/NHGRI NIH HHS/ -- New York, N.Y. -- Science. 2004 Dec 10;306(5703):1937-40.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Southwest Agricultural University, Chongqing Beibei, 400716, China. xiaqy@swau.cq.cn〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/15591204" target="_blank"〉PubMed〈/a〉
    Keywords: Algorithms ; Animals ; Anopheles/genetics ; Body Patterning/genetics ; Bombyx/*genetics/growth & development/metabolism ; Butterflies/genetics ; Computational Biology ; DNA Transposable Elements ; Drosophila melanogaster/genetics ; Exocrine Glands/metabolism ; Expressed Sequence Tags ; Female ; Genes, Homeobox ; *Genes, Insect ; *Genome ; Immunity, Innate/genetics ; Insect Hormones/genetics ; Insect Proteins/genetics ; Male ; Molecular Sequence Data ; *Sequence Analysis, DNA ; Sequence Homology, Nucleic Acid ; Sex Determination Processes ; Spiders/genetics ; Wings, Animal/growth & development
    Print ISSN: 0036-8075
    Electronic ISSN: 1095-9203
    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
    Published by American Association for the Advancement of Science (AAAS)
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  • 6
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    Groundwater flow and geochemistry in the lower reaches of the Yellow River: a case study in Shandang Province, China (2002)
    Springer
    Details
    Publication Date: 2002-10-01
    Print ISSN: 1431-2174
    Electronic ISSN: 1435-0157
    Topics: Geosciences
    Published by Springer
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  • 7
    Electronic Resource
    Electronic Resource
    Structural and magnetic properties of R(Fe1−yCoy)12−xNbx compounds (2002)
    [S.l.] : American Institute of Physics (AIP)
    Journal of Applied Physics 91 (2002), S. 2165-2171 
    Details
    ISSN: 1089-7550
    Source: AIP Digital Archive
    Topics: Physics
    Notes: The magnetic properties of RFe12−xNbx and R(Fe1−yCoy)11.3Nb0.7 compounds with R=Y, Tb, and Dy have been investigated in the concentration region defined by 0.6〈x〈0.8 and y≤0.3, where the compounds are single phase with the ThMn12-type of structure. The Curie temperature TC of the RFe12−xNbx compounds is almost independent of the Nb content whereas the saturation magnetization Ms decreases with increasing Nb content. The spin-reorientation temperature Tsr of the TbFe12−xNbx and DyFe12−xNbx compounds decreases monotonically with increasing x. Substitution of Co for Fe in RFe11.3Nb0.7 leads to a remarkable increase of TC and the appearance of a maximum in the Co-concentration dependence of Ms. In contrast, Tsr decreases monotonically with increasing Co content for both R=Tb and Dy. The modification of T- and R-sublattice anisotropy originating from a change of the Nb content and from substitution of Co for Fe was analyzed by combining crystalline electric field theory and the individual-site model. © 2002 American Institute of Physics.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1063/1.1425441
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  • 8
    Electronic Resource
    Electronic Resource
    Composition, residual stress, and structural properties of thin tungsten nitride films deposited by reactive magnetron sputtering (2000)
    [S.l.] : American Institute of Physics (AIP)
    Journal of Applied Physics 88 (2000), S. 1380-1388 
    Details
    ISSN: 1089-7550
    Source: AIP Digital Archive
    Topics: Physics
    Notes: Thin tungsten nitride (WNx) films were produced by reactive dc magnetron sputtering of tungsten in an Ar–N2 gas mixture. The effects of the variation of nitrogen partial pressure on the composition, residual stress, and structural properties of these films as well as the influence of postdeposition annealing have been studied. The films were analyzed in situ by a cantilever beam technique, and ex situ by x-ray photoelectron spectroscopy, electron energy-loss spectroscopy, x-ray diffraction, and transmission electron microscopy (TEM). It was found that at N concentrations below 8 at. %, the films (typical 150 nm in thickness) were essentially bcc α-W. An amorphous phase was observed in the range of about 12–28 at. % N. When N concentrations reached ∼32 at. % or above, a single-phase structure of W2N was formed. Annealing of the as-deposited films resulted in crystallization of the amorphous or an improved crystallinity of the W2N structure, which was related to the N concentration. Stresses of all W and WNx films were compressive. As the N concentration was increased, the stress decreased and reached its lowest value for amorphous samples near 20 at. % N. Past this point, the compression of films rose again. These results can be ascribed to structural changes induced by the pressure-dependent variation in the average energy of particles bombarding the film during deposition. Cross-sectional TEM studies showed that all crystalline WNx films had columnar microstructures. The average column width near stoichiometry of W2N was ∼20±5 nm near the film surface. © 2000 American Institute of Physics.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1063/1.373827
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  • 9
    Electronic Resource
    Electronic Resource
    On the prediction of electromigration voiding using stress-based modeling (2000)
    [S.l.] : American Institute of Physics (AIP)
    Journal of Applied Physics 87 (2000), S. 4039-4041 
    Details
    ISSN: 1089-7550
    Source: AIP Digital Archive
    Topics: Physics
    Notes: In modeling electromigration failure, it is common to employ the concept of a critical stress at which interconnect failure occurs. In this report, we illustrate that the atomic flux divergence, obtained directly from the one-dimensional stress-based modeling, is more appropriate in characterizing the formation of void in electromigration. A numerical analysis was carried out, to model the evolution of stress, atomic flux, and flux divergence in an aluminum line containing a fast-diffusion segment. The maximum flux divergence, not the maximum tensile stress, predicts the voiding location which is consistent with microscopic observations in the experiments of Joo et al. [Acta. Mater. 46, 1969 (1998); J. Appl. Phys. 85, 2108 (1999)] utilizing nanoindented single-crystal aluminum lines. This is because the flux divergence directly reflects the extent of matter depletion, and thus the propensity of voiding. © 2000 American Institute of Physics.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1063/1.372452
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  • 10
    Electronic Resource
    Electronic Resource
    Residual stress, microstructure, and structure of tungsten thin films deposited by magnetron sputtering (2000)
    [S.l.] : American Institute of Physics (AIP)
    Journal of Applied Physics 87 (2000), S. 177-187 
    Details
    ISSN: 1089-7550
    Source: AIP Digital Archive
    Topics: Physics
    Notes: The residual stress and structural properties of tungsten thin films prepared by magnetron sputtering as a function of sputtering-gas pressure are reported. The films were analyzed in situ by a cantilever beam technique, and ex situ by x-ray diffraction, cross-sectional transmission electron microscopy (TEM), x-ray photoelectron spectroscopy, electron energy-loss spectrometry, and energy-filtered electron diffraction. It is found that the residual stress, microstructure, and surface morphology are clearly correlated. The film stresses, determined in real time during the film formation, depend strongly on the argon pressure and change from highly compressive to highly tensile in a relatively narrow pressure range of 12–26 mTorr. For pressures exceeding ∼60 mTorr, the stress in the film is nearly zero. It is also found that the nonequilibrium A15 W structure is responsible for the observed tensile stress, whereas the stable bcc W or a mixture of bcc W and A15 W are in compression. Cross-sectional TEM evidence indicates that the compressively stressed films contain a dense microstructure without any columns, while the films having tensile stress have a very columnar microstructure. High sputtering-gas pressure conditions yield dendritic-like film growth, resulting in complete relaxation of the residual tensile stresses. Structural details of the A15 W and amorphous W phases were also investigated at the atomic level using energy-filtered electron diffraction with reduced radial distribution function G(r) analysis. By comparing the experimental and simulated G(r) distributions, the A15 W structure is determined to be composed of ordered and stacking faulted W3W structures and the amorphous W has a disordered structure of W3O. The effect of oxygen in stabilizing the A15 phase found is explained on the basis of structural and thermodynamic stability. © 2000 American Institute of Physics.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1063/1.371841
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