ALBERT

All Library Books, journals and Electronic Records Telegrafenberg

feed icon rss

Ihre E-Mail wurde erfolgreich gesendet. Bitte prüfen Sie Ihren Maileingang.

Leider ist ein Fehler beim E-Mail-Versand aufgetreten. Bitte versuchen Sie es erneut.

Vorgang fortführen?

Exportieren
  • 1
    Publikationsdatum: 2010-07-20
    Beschreibung: Chronic myelogenous leukaemia (CML) can progress from a slow growing chronic phase to an aggressive blast crisis phase, but the molecular basis of this transition remains poorly understood. Here we have used mouse models of CML to show that disease progression is regulated by the Musashi-Numb signalling axis. Specifically, we find that the chronic phase is marked by high levels of Numb expression whereas the blast crisis phase has low levels of Numb expression, and that ectopic expression of Numb promotes differentiation and impairs advanced-phase disease in vivo. As a possible explanation for the decreased levels of Numb in the blast crisis phase, we show that NUP98-HOXA9, an oncogene associated with blast crisis CML, can trigger expression of the RNA-binding protein Musashi2 (Msi2), which in turn represses Numb. Notably, loss of Msi2 restores Numb expression and significantly impairs the development and propagation of blast crisis CML in vitro and in vivo. Finally we show that Msi2 expression is not only highly upregulated during human CML progression but is also an early indicator of poorer prognosis. These data show that the Musashi-Numb pathway can control the differentiation of CML cells, and raise the possibility that targeting this pathway may provide a new strategy for the therapy of aggressive leukaemias.〈br /〉〈br /〉〈a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2918284/" target="_blank"〉〈img src="https://static.pubmed.gov/portal/portal3rc.fcgi/4089621/img/3977009" border="0"〉〈/a〉   〈a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2918284/" target="_blank"〉This paper as free author manuscript - peer-reviewed and accepted for publication〈/a〉〈br /〉〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Ito, Takahiro -- Kwon, Hyog Young -- Zimdahl, Bryan -- Congdon, Kendra L -- Blum, Jordan -- Lento, William E -- Zhao, Chen -- Lagoo, Anand -- Gerrard, Gareth -- Foroni, Letizia -- Goldman, John -- Goh, Harriet -- Kim, Soo-Hyun -- Kim, Dong-Wook -- Chuah, Charles -- Oehler, Vivian G -- Radich, Jerald P -- Jordan, Craig T -- Reya, Tannishtha -- AI067798/AI/NIAID NIH HHS/ -- CA122206/CA/NCI NIH HHS/ -- CA140371/CA/NCI NIH HHS/ -- CA18029/CA/NCI NIH HHS/ -- DK072234/DK/NIDDK NIH HHS/ -- DK63031/DK/NIDDK NIH HHS/ -- DP1 CA174422/CA/NCI NIH HHS/ -- DP1 OD006430/OD/NIH HHS/ -- DP1 OD006430-01/OD/NIH HHS/ -- DP1 OD006430-02/OD/NIH HHS/ -- DP1OD006430/OD/NIH HHS/ -- HL097767/HL/NHLBI NIH HHS/ -- P01 CA018029/CA/NCI NIH HHS/ -- R01 CA140371/CA/NCI NIH HHS/ -- R01 DK063031/DK/NIDDK NIH HHS/ -- R01 DK063031-01/DK/NIDDK NIH HHS/ -- R01 DK063031-01S1/DK/NIDDK NIH HHS/ -- R01 DK063031-02/DK/NIDDK NIH HHS/ -- R01 DK063031-03/DK/NIDDK NIH HHS/ -- R01 DK063031-04/DK/NIDDK NIH HHS/ -- R01 DK063031-05/DK/NIDDK NIH HHS/ -- R01 DK063031-06/DK/NIDDK NIH HHS/ -- R01 DK063031-07/DK/NIDDK NIH HHS/ -- R01 DK063031-07S1/DK/NIDDK NIH HHS/ -- R01 DK063031-08/DK/NIDDK NIH HHS/ -- R01 DK072234/DK/NIDDK NIH HHS/ -- R01 DK072234-01A1/DK/NIDDK NIH HHS/ -- R01 DK072234-02/DK/NIDDK NIH HHS/ -- R01 DK072234-03/DK/NIDDK NIH HHS/ -- R01 DK072234-04/DK/NIDDK NIH HHS/ -- R01 HL097767/HL/NHLBI NIH HHS/ -- R01 HL097767-01/HL/NHLBI NIH HHS/ -- R01 HL097767-02/HL/NHLBI NIH HHS/ -- T32 GM007184-33/GM/NIGMS NIH HHS/ -- U19 AI067798/AI/NIAID NIH HHS/ -- U19 AI067798-010006/AI/NIAID NIH HHS/ -- U19 AI067798-020006/AI/NIAID NIH HHS/ -- U19 AI067798-030006/AI/NIAID NIH HHS/ -- U19 AI067798-040006/AI/NIAID NIH HHS/ -- U19 AI067798-050006/AI/NIAID NIH HHS/ -- England -- Nature. 2010 Aug 5;466(7307):765-8. doi: 10.1038/nature09171. Epub 2010 Jul 18.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Department of Pharmacology and Cancer Biology, Duke University Medical Center, Durham, North Carolina 27710, USA.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/20639863" target="_blank"〉PubMed〈/a〉
    Schlagwort(e): Animals ; Blast Crisis/genetics/metabolism/pathology ; *Cell Differentiation/genetics ; Disease Progression ; Fusion Proteins, bcr-abl/genetics/metabolism ; Gene Expression Regulation, Neoplastic ; Homeodomain Proteins/genetics/metabolism ; Humans ; Leukemia, Myelogenous, Chronic, BCR-ABL Positive/genetics/*metabolism/*pathology ; Membrane Proteins/biosynthesis/genetics/metabolism ; Mice ; Mice, Inbred C57BL ; Nerve Tissue Proteins/biosynthesis/genetics/metabolism ; Nuclear Pore Complex Proteins/genetics/metabolism ; Oncogene Proteins, Fusion/genetics/metabolism ; Prognosis ; RNA-Binding Proteins/biosynthesis/genetics/*metabolism ; Receptor, Notch1/metabolism ; Signal Transduction ; Tumor Suppressor Protein p53/metabolism ; Up-Regulation
    Print ISSN: 0028-0836
    Digitale ISSN: 1476-4687
    Thema: Biologie , Chemie und Pharmazie , Medizin , Allgemeine Naturwissenschaft , Physik
    Standort Signatur Erwartet Verfügbarkeit
    BibTip Andere fanden auch interessant ...
  • 2
    Publikationsdatum: 2013-12-11
    Beschreibung: The Curiosity rover discovered fine-grained sedimentary rocks, which are inferred to represent an ancient lake and preserve evidence of an environment that would have been suited to support a martian biosphere founded on chemolithoautotrophy. This aqueous environment was characterized by neutral pH, low salinity, and variable redox states of both iron and sulfur species. Carbon, hydrogen, oxygen, sulfur, nitrogen, and phosphorus were measured directly as key biogenic elements; by inference, phosphorus is assumed to have been available. The environment probably had a minimum duration of hundreds to tens of thousands of years. These results highlight the biological viability of fluvial-lacustrine environments in the post-Noachian history of Mars.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Grotzinger, J P -- Sumner, D Y -- Kah, L C -- Stack, K -- Gupta, S -- Edgar, L -- Rubin, D -- Lewis, K -- Schieber, J -- Mangold, N -- Milliken, R -- Conrad, P G -- DesMarais, D -- Farmer, J -- Siebach, K -- Calef, F 3rd -- Hurowitz, J -- McLennan, S M -- Ming, D -- Vaniman, D -- Crisp, J -- Vasavada, A -- Edgett, K S -- Malin, M -- Blake, D -- Gellert, R -- Mahaffy, P -- Wiens, R C -- Maurice, S -- Grant, J A -- Wilson, S -- Anderson, R C -- Beegle, L -- Arvidson, R -- Hallet, B -- Sletten, R S -- Rice, M -- Bell, J 3rd -- Griffes, J -- Ehlmann, B -- Anderson, R B -- Bristow, T F -- Dietrich, W E -- Dromart, G -- Eigenbrode, J -- Fraeman, A -- Hardgrove, C -- Herkenhoff, K -- Jandura, L -- Kocurek, G -- Lee, S -- Leshin, L A -- Leveille, R -- Limonadi, D -- Maki, J -- McCloskey, S -- Meyer, M -- Minitti, M -- Newsom, H -- Oehler, D -- Okon, A -- Palucis, M -- Parker, T -- Rowland, S -- Schmidt, M -- Squyres, S -- Steele, A -- Stolper, E -- Summons, R -- Treiman, A -- Williams, R -- Yingst, A -- MSL Science Team -- New York, N.Y. -- Science. 2014 Jan 24;343(6169):1242777. doi: 10.1126/science.1242777. Epub 2013 Dec 9.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Division of Geologic and Planetary Sciences, California Institute of Technology, Pasadena, CA 91125, USA.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/24324272" target="_blank"〉PubMed〈/a〉
    Schlagwort(e): Bays ; Carbon/analysis ; *Exobiology ; *Extraterrestrial Environment ; Geologic Sediments/analysis/classification ; Hydrogen/analysis ; Hydrogen-Ion Concentration ; Iron/analysis/chemistry ; *Mars ; Nitrogen/analysis ; Oxidation-Reduction ; Oxygen/analysis ; Phosphorus/analysis ; Salinity ; Sulfur/analysis/chemistry ; *Water
    Print ISSN: 0036-8075
    Digitale ISSN: 1095-9203
    Thema: Biologie , Chemie und Pharmazie , Informatik , Medizin , Allgemeine Naturwissenschaft , Physik
    Standort Signatur Erwartet Verfügbarkeit
    BibTip Andere fanden auch interessant ...
  • 3
    Publikationsdatum: 2005-07-16
    Beschreibung: Gross inequities in disease burden between developed and developing countries are now the subject of intense global attention. Public and private donors have marshaled resources and created organizational structures to accelerate the development of new health products and to procure and distribute drugs and vaccines for the poor. Despite these encouraging efforts directed primarily from and funded by industrialized countries, sufficiency and sustainability remain enormous challenges because of the sheer magnitude of the problem. Here we highlight a complementary and increasingly important means to improve health equity: the growing ability of some developing countries to undertake health innovation.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Morel, Carlos M -- Acharya, Tara -- Broun, Denis -- Dangi, Ajit -- Elias, Christopher -- Ganguly, N K -- Gardner, Charles A -- Gupta, R K -- Haycock, Jane -- Heher, Anthony D -- Hotez, Peter J -- Kettler, Hannah E -- Keusch, Gerald T -- Krattiger, Anatole F -- Kreutz, Fernando T -- Lall, Sanjaya -- Lee, Keun -- Mahoney, Richard -- Martinez-Palomo, Adolfo -- Mashelkar, R A -- Matlin, Stephen A -- Mzimba, Mandi -- Oehler, Joachim -- Ridley, Robert G -- Senanayake, Pramilla -- Singer, Peter -- Yun, Mikyung -- New York, N.Y. -- Science. 2005 Jul 15;309(5733):401-4.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Center for Technological Development in Health, Oswaldo Cruz Foundation (FIOCRUZ), Avenida Brasil 4365, Rio de Janeiro, RJ 21040-900, Brazil. morel@fiocruz.br〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/16020723" target="_blank"〉PubMed〈/a〉
    Schlagwort(e): *Biomedical Research/economics ; Biotechnology ; *Delivery of Health Care/organization & administration ; Developed Countries ; *Developing Countries ; *Diffusion of Innovation ; Drug Industry ; Health Policy ; Humans ; International Cooperation ; Patents as Topic ; Private Sector ; Public Sector ; Publishing ; Technology Transfer
    Print ISSN: 0036-8075
    Digitale ISSN: 1095-9203
    Thema: Biologie , Chemie und Pharmazie , Informatik , Medizin , Allgemeine Naturwissenschaft , Physik
    Standort Signatur Erwartet Verfügbarkeit
    BibTip Andere fanden auch interessant ...
  • 4
    Publikationsdatum: 2015-10-10
    Beschreibung: The landforms of northern Gale crater on Mars expose thick sequences of sedimentary rocks. Based on images obtained by the Curiosity rover, we interpret these outcrops as evidence for past fluvial, deltaic, and lacustrine environments. Degradation of the crater wall and rim probably supplied these sediments, which advanced inward from the wall, infilling both the crater and an internal lake basin to a thickness of at least 75 meters. This intracrater lake system probably existed intermittently for thousands to millions of years, implying a relatively wet climate that supplied moisture to the crater rim and transported sediment via streams into the lake basin. The deposits in Gale crater were then exhumed, probably by wind-driven erosion, creating Aeolis Mons (Mount Sharp).〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Grotzinger, J P -- Gupta, S -- Malin, M C -- Rubin, D M -- Schieber, J -- Siebach, K -- Sumner, D Y -- Stack, K M -- Vasavada, A R -- Arvidson, R E -- Calef, F 3rd -- Edgar, L -- Fischer, W F -- Grant, J A -- Griffes, J -- Kah, L C -- Lamb, M P -- Lewis, K W -- Mangold, N -- Minitti, M E -- Palucis, M -- Rice, M -- Williams, R M E -- Yingst, R A -- Blake, D -- Blaney, D -- Conrad, P -- Crisp, J -- Dietrich, W E -- Dromart, G -- Edgett, K S -- Ewing, R C -- Gellert, R -- Hurowitz, J A -- Kocurek, G -- Mahaffy, P -- McBride, M J -- McLennan, S M -- Mischna, M -- Ming, D -- Milliken, R -- Newsom, H -- Oehler, D -- Parker, T J -- Vaniman, D -- Wiens, R C -- Wilson, S A -- New York, N.Y. -- Science. 2015 Oct 9;350(6257):aac7575. doi: 10.1126/science.aac7575.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Division of Geologic and Planetary Sciences, California Institute of Technology, Pasadena, CA 91125, USA. ; Department of Earth Science and Engineering, Imperial College London, London SW7 2AZ, UK. ; Malin Space Science Systems, Post Office Box 910148, San Diego, CA 92121, USA. ; Department of Earth and Planetary Sciences, University of California-Santa Cruz, Santa Cruz, CA 95064, USA. ; Department of Geological Sciences, Indiana University, Bloomington, IN 47405, USA. ; Department of Earth and Planetary Sciences, University of California-Davis, Davis, CA 95616, USA. ; Jet Propulsion Laboratory, California Institute of Technology, Pasadena, CA 91109, USA. ; Department of Earth and Planetary Sciences, Washington University in St. Louis, St. Louis, MO 63130, USA. ; Astrogeology Science Center, U.S. Geological Survey, Flagstaff, AZ 86001, USA. ; Center for Earth and Planetary Studies, National Air and Space Museum, Smithsonian Institution, Washington, DC 20560, USA. ; Department of Earth and Planetary Sciences, University of Tennessee, Knoxville, TN 37996, USA. ; Department of Earth and Planetary Sciences, Johns Hopkins University, Baltimore, MD 21218, USA. ; Laboratoire Planetologie et Geodynamique de Nantes-Le Centre National de la Recherche, Unite Mixte de Recherche 6112 and Universite de Nantes, 44322 Nantes, France. ; Planetary Science Institute, Tucson, AZ 85719, USA. ; Department of Geology, Western Washington University, Bellingham, WA 98225, USA. ; Department of Space Sciences, NASA Ames Research Center, Moffett Field, CA 94035, USA. ; NASA Goddard Space Flight Center, Greenbelt, MD 20771, USA. ; Department of Earth and Planetary Science, University of California-Berkeley, Berkeley, CA 94720, USA. ; Laboratoire de Geologie de Lyon, Universite de Lyon, 69364 Lyon, France. ; Department of Geology and Geophysics, Texas A&M University, College Station, TX 77843, USA. ; Department of Physics, University of Guelph, Guelph, Ontario N1G 2W1, Canada. ; Department of Geosciences, Stony Brook University, Stony Brook, NY 11794-2100, USA. ; Department of Geological Sciences, University of Texas at Austin, Austin, TX 78712, USA. ; Astromaterials Research and Exploration Science Division, NASA Johnson Space Center, Houston, TX 77058, USA. ; Department of Geological Sciences, Brown University, Providence, RI 02912, USA. ; Institute of Meteoritics, University of New Mexico, Albuquerque, NM 87131 USA. ; LZ Technology, NASA Johnson Space Center, Houston, TX 77058, USA. ; Space Remote Sensing, Los Alamos National Laboratory, Los Alamos, NM 87544, USA.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/26450214" target="_blank"〉PubMed〈/a〉
    Schlagwort(e): Climate ; Exhumation ; *Lakes ; *Mars ; Paleontology
    Print ISSN: 0036-8075
    Digitale ISSN: 1095-9203
    Thema: Biologie , Chemie und Pharmazie , Informatik , Medizin , Allgemeine Naturwissenschaft , Physik
    Standort Signatur Erwartet Verfügbarkeit
    BibTip Andere fanden auch interessant ...
Schließen ⊗
Diese Webseite nutzt Cookies und das Analyse-Tool Matomo. Weitere Informationen finden Sie hier...