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  • 1
    Electronic Resource
    Electronic Resource
    Single calcium-dependent cation channels in mouse pancreatic acinar cells (1984)
    Springer
    The journal of membrane biology 81 (1984), S. 83-87 
    Details
    ISSN: 1432-1424
    Keywords: pancreatic acinar cells ; nonselective cation channel ; Ca2+-sensitivity ; patch clamp ; single-channel recording
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology , Chemistry and Pharmacology
    Notes: Summary The Ca2+-activated nonselective cation channel in mouse pancreatic acini has been studied with the help of patch-clamp single-channel current recording in both the cell-attached conformation and in excised inside-out membrane patches. In intact resting mouse pancreatic acinar cells no unitary activity was observed. Adding saponin to the bath solution to disrupt the plasma membrane (apart from the isolated patch membrane from which current recording was made) evoked unitary inward current steps when the free ionized Ca2+ concentration in the bath ([Ca2+] i ) was 5×10−8 m or above. When an electrically isolated patch membrane was excised and the internal aspects of the plasma membrane were exposed to the bath solution, channel activation could be obtained when [Ca2+] i was 10−7 m or above. However, with the passage of time the total inward current declined and about 1 min after excision no unitary current steps could be observed. At this stage Ca2+ in micromolar concentration was needed to open the channels and several hundred micromoles of Ca2+ per liter were required for maximal channel activation. Our results indicate that the Ca2+-activated nonselective cation channel is more sensitive to internal Ca2+ than hitherto understood and that it may therefore play a role under physiological conditions in intact cells.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01868812
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  • 2
    Electronic Resource
    Electronic Resource
    Lithium isotope separation by laser (1982)
    Springer
    Applied physics 28 (1982), S. 73-76 
    Details
    ISSN: 1432-0649
    Keywords: 35
    Source: Springer Online Journal Archives 1860-2000
    Topics: Physics
    Notes: Abstract A lithium isotope separation was performed using a laser isotope separation method. It was found that the lithium atoms with a natural isotopic abundance enhanced its6Li concentration up to over 90% by tuning the laser wavelength to the2 P 1/2 of6Li. Too high power, however, leads to a loss of enrichment due to the power broadening effect which was analysed by the equation of motion of density matrices.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00693895
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  • 3
    Electronic Resource
    Electronic Resource
    Bioavailability and diuretic effect of furosemide during long-term treatment of chronic respiratory failure (1985)
    Springer
    European journal of clinical pharmacology 28 (1985), S. 53-59 
    Details
    ISSN: 1432-1041
    Keywords: furosemide ; respiratory failure ; furosemide glucuronide ; first-pass metabolism ; diuretic effect ; bioavailability ; food effect ; chronic treatment
    Source: Springer Online Journal Archives 1860-2000
    Topics: Chemistry and Pharmacology , Medicine
    Notes: Summary The bioavailability and diuretic effect of furosemide 40 mg administered orally for at least 6 months have been compared in patients with chronic respiratory failure and in healthy controls. The mean urinary recovery of unchanged drug was 11.5 mg and 9.41 mg in 24 h after pre- and postprandial administration to 10 patients, whereas the recovery was 14.4 mg in 10 healthy subjects. The diuretic effect, in terms of urine flow and sodium ion excretion in the 6 h after administration, was also less in patients than in healthy subjects. This was ascribed to the lower bioavailability of furosemide in patients, based on the urinary recovery of unchanged drug, and not to a lower level of response to furosemide than in healthy subjects. The mean absolute bioavailability of furosemide in 6 patients was 41.3% and 63.4%, respectively, calculated from unchanged drug and total drug (unchanged plus glucuronide conjugate). Approximately 53.9% of the dose of furosemide was excreted as the glucuronide conjugate after oral administration, and 34.2% after i.v. injection in the 6 patients. In 3 of the 6 patients studied, a distinct first-pass effect for glucuronidation of furosemide was observed after oral administration. In another study, the mean glucuronide fraction recovered in 24-h urine was 20.7% and 7.3% (p〈0.01) in 38 patients and 12 healthy subjects, respectively. The fraction in urine was not affected by changing the dose of furosemide from 20 to 120 mg. The lower bioavailability in patients as compared to healthy subjects is ascribed to enhanced glucuronidation and incomplete drug absorption.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00635708
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  • 4
    Electronic Resource
    Electronic Resource
    Energy-dependent deposition processes of size-selected Ag nanoclusters on highly-oriented pyrolytic graphite (2000)
    College Park, Md. : American Institute of Physics (AIP)
    The Journal of Chemical Physics 112 (2000), S. 9961-9966 
    Details
    ISSN: 1089-7690
    Source: AIP Digital Archive
    Topics: Physics , Chemistry and Pharmacology
    Notes: Singly charged cations of silver atoms and clusters (Agn+, n=1,3,5,7,9) were deposited on highly oriented pyrolytic graphite substrates at well-controlled, various collision energies. The total amount of Ag atoms remaining on the substrates after collision was quantified by measuring the Ag 3d5/2 photoelectron intensities. The collision energy dependence of the amount of deposited Ag atoms revealed that, for all the species, there are three distinct energy regions, for which soft landing, rebounding, or implantation is a dominant process, and that the energy ranges for the processes strongly depend on the cluster size. The deposition efficiency vs collision energy curve for each cluster is well fitted to that for Ag1, by considering the difference between the contact area of Ag1 with the surface and that of the cluster, reflecting the compactness of the clusters. Boundaries between the different deposition regimes for the clusters were less distinct than those for Ag1. Considering anisotropy in shape of a cluster, deposition efficiency around the implantation threshold was calculated, which well explains the indistinctness of the threshold observed in the experimental data. This supports the picture that the energy given to a unit surface area determines the collision process. © 2000 American Institute of Physics.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1063/1.481632
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  • 5
    Electronic Resource
    Electronic Resource
    Optical switching in polymer gels (1996)
    [S.l.] : American Institute of Physics (AIP)
    Journal of Applied Physics 80 (1996), S. 131-136 
    Details
    ISSN: 1089-7550
    Source: AIP Digital Archive
    Topics: Physics
    Notes: Soft materials have long been sought after for use in devices such as actuators, artificial muscles, separators, switches, sensors, memories, and so forth. We developed a soft, optically transparent material using polymer gels that can not only be activated by visible light (switched on) but also deactivated (switched off) by altering the local environment using three different means: pH, temperature, and light. This copolymer gel is a covalently cross-linked network of N-isopropylacrylamide, sodium acrylate, and a chromophore, which is found to undergo phase transitions exhibiting large hysteresis in the degree of swelling in response to pH, temperature, and light. In each system, between the transitions for swelling and shrinking, the gel can show either a swollen or a collapsed state, which can be selected according to the history of the variables. It has been established that a thermoresponsive gel with chromophore exhibits a local volume phase transition upon illumination with visible light. By making use of this phenomenon, we have successfully controlled the phase in which a gel exists with visible light: Without light illumination the gel stays in the swollen state. Upon illumination beyond a threshold intensity, however, a volume transition is locally induced, thereby forming a material in which both phases coexist stably for at least several hours after the light source has been removed. The phenomenological stability of the material in the coexistence state is discussed on the basis of the Landau theory. © 1996 American Institute of Physics.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1063/1.362768
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  • 6
    Electronic Resource
    Electronic Resource
    Bloch line propagation with film thickness modulation bit patterns (abstract) : 35th annual conference on magnetism and magnetic materials (1991)
    [S.l.] : American Institute of Physics (AIP)
    Journal of Applied Physics 69 (1991), S. 5767-5767 
    Details
    ISSN: 1089-7550
    Source: AIP Digital Archive
    Topics: Physics
    Notes: Bloch line (BL) propagation with a field-access scheme is necessary for the memory with low power consumption and high storage density. Previously we reported the field-access propagation using Co-Pt bit patterns.1 In these propagation patterns, (a) the drive field margins depend on the BL propagating direction to the magnetized direction of Co-Pt patterns and (b) the operating bias field margins are different at each corner of the stripe domain. The purpose of this paper is to solve these two problems. A new propagation method has been investigated using film thickness modulation patterns.2 The materials used here were magnetic bubble garnet films with composition of (YSmLuCa)3(FeGe)5O12. Fundamental characteristics of the samples are as follows: saturation induction 4πMs 200 G, anisotropy field Hk 1700 Oe, stripe width w and thickness h 5 μm. The thickness modulation patterns with an amplitude of about 1000 A were fabricated with the ion milling method. The stripe domains were stabilized around the 100% etched grooves, and aligned with 18 μm period. BL pair was propagated in the all part of the stripe domain walls at 500 kHz frequency, applying the triangular bias pulsed field with 50 ns rise time and 1000 ns fall time. As the result of the experiments, it has been found that the drive field margins are independent of BL propagation direction and the difference in the operating bias field margins at the each corner of the stripe domain becomes smaller. The BL propagation around the stripe domain was achieved with 5% bias field margin at the drive field of 8.5 Oe.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1063/1.347869
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  • 7
    Electronic Resource
    Electronic Resource
    Preservation of fixed anionic sites in the GBM in the acute proteinuric phase of cationic antigen mediated in-situ immune complex glomerulonephritis in the rat (1984)
    Springer
    Histochemistry and cell biology 81 (1984), S. 243-246 
    Details
    ISSN: 1432-119X
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology , Medicine
    Notes: Summary Cationic antigens have been observed to bind with the negatively charged glomerular basement membrane (GBM). Using the cationic reagent polyethyleneimine (PEI), the distribution of glomerular anionic sites was evaluated ultrastructurally in the early stage (2 h-day 7) of cationic antigen mediated in-situ immune complex formation type glomerulonephritis (GN) in the rat. — Renal perfusion via the renal artery with 100 μg of cationized human IgG (pl〉9.5), followed by the i.v. injection of specific antibodies, led to an initial increase in urinary albumin excretion, subsequent massive globulinuria and the formation of numerous subepithelial deposits on day 7. — The most striking alteration in glomerular anionic sites was observed on the epithelial cell surface coat; the PEI deposition on the epithelial cell surface was almost identical to that in control glomeruli at 2 and 4 h after the induction of GN; thereafter, on day 7, a broad loss of anionic sites was obseryed on flattened epithelial foot processes. In contrast, fixed anionic sites of the laminae rarae of the GBM showed no apparent alterations in the distribution and number from 2 h to day 7 and did not disappear even in the lamina rara externa adjacent to subepithelial deposits. — These findings not only show that fixed anionic sites of the GBM, in contrast to the rapid decrease in those of the epithelial cell surface, are not completely neutralized or destroyed even in GN, in which cationic antigen participates in the in-situ formation of GBM-deposits. This also indicates that initial impairment of the charge-selective barrier of the GBM by the in-situ interaction between cationic antigen and antibody, is followed by the disfunction of the size-selective permselectivity of the GBM, ultimately causing massive proteinuria.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00495634
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  • 8
    Electronic Resource
    Electronic Resource
    Adsorption and colloidal behavior of traces of hexavalent tellurium in aqueous solutions (1993)
    Springer
    Journal of radioanalytical and nuclear chemistry 170 (1993), S. 347-351 
    Details
    ISSN: 1588-2780
    Source: Springer Online Journal Archives 1860-2000
    Topics: Chemistry and Pharmacology , Energy, Environment Protection, Nuclear Power Engineering
    Notes: Abstract The solutions of carrier-free125mTe(VI) have been prepared by oxidizing125mTe(IV) with bromine. Using carrier-free125mTe(VI) as a tracer, the effects of pH, NaCl concentration, and tellurium(VI) concentration on the adsorption and colloidal properties of tellurium(VI) in NaCl solution have been studied. It has been found that traces of tellurium(VI) are adsorbed on filter paper and show colloidal behavior in the basic region. A method has been devised for the separation of carrier-free125mTe from its parent nuclide125Sb, based on the adsorption properties of125mTe(VI) in basic solutions.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF02041469
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  • 9
    Electronic Resource
    Electronic Resource
    Interaction between human evoked electrospinograms elicited by segmental and descending volleys (1979)
    Springer
    Cellular and molecular life sciences 35 (1979), S. 1199-1200 
    Details
    ISSN: 1420-9071
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology , Medicine
    Notes: Summary Interaction between the slow negative-positive waves of human evoked electrospinograms produced by descending and segmental volleys was tested under general anaesthesia. A partial occlusion was demonstrated in these slow waves.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01963287
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  • 10
    Electronic Resource
    Electronic Resource
    Effects of intracellular or extracellular application of tetraethylammonium on the action potential in cultured chick embryonic heart muscle cell (1980)
    Springer
    Cellular and molecular life sciences 36 (1980), S. 557-558 
    Details
    ISSN: 1420-9071
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology , Medicine
    Notes: Summary The effects of tetraethylammonium (TEA) on the action potential in cultured chick embryonic heart muscle cells were investigated. The onset of prolongation of the action potential occurred within 10 min following intracellular iontophoretic application of TEA, but after more than 50 min following extracellular application. These facts suggest that the major site of action of TEA is on the inner surface of the membrane in these cells.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01965798
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