ISSN:
1420-9071
Keywords:
Carbon dioxide
;
serotonin
;
canine cerebral artery
;
basilar artery
;
middle cerebral artery
Source:
Springer Online Journal Archives 1860-2000
Topics:
Biology
,
Medicine
Notes:
Abstract The responses of basilar arteries (BAs) to serotonin were attenuated by high $$P_{CO_2 } $$ (86±1 mm Hg) and the pH matched acidotic solution ( $$P_{CO_2 } $$ 37±1 mm Hg), whereas the responses of middle cerebral arteries (MCAs) were not. High $$P_{CO_2 } $$ decreased the basal tone of both arteries, and the changes in basal tone due to high $$P_{CO_2 } $$ were not influenced by 3×10−7 M imipramine, 10−5 M pargyline or 10−4 M aspirin. The responses of BAs to serotonin were attenuated by high $$P_{CO_2 } $$ in the presence of imipramine, pargyline and aspirin. The responses of MCAs to serotonin were not influenced by high $$P_{CO_2 } $$ in the presence of pargyline and aspirin, but attenuated by high $$P_{CO_2 } $$ in the presence of imipramine.
Type of Medium:
Electronic Resource
URL:
http://dx.doi.org/10.1007/BF01948002
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