ALBERT

All Library Books, journals and Electronic Records Telegrafenberg

X
feed icon rss

Your email was sent successfully. Check your inbox.

An error occurred while sending the email. Please try again.

Proceed reservation?

Export
  • 1
    facet.materialart.
    Unknown
    Sparse optical microstimulation in barrel cortex drives learned behaviour in freely moving mice (2007)
    Nature Publishing Group (NPG)
    Details
    Publication Date: 2007
    Description: Electrical microstimulation can establish causal links between the activity of groups of neurons and perceptual and cognitive functions. However, the number and identities of neurons microstimulated, as well as the number of action potentials evoked, are difficult to ascertain. To address these issues we introduced the light-gated algal channel channelrhodopsin-2 (ChR2) specifically into a small fraction of layer 2/3 neurons of the mouse primary somatosensory cortex. ChR2 photostimulation in vivo reliably generated stimulus-locked action potentials at frequencies up to 50 Hz. Here we show that naive mice readily learned to detect brief trains of action potentials (five light pulses, 1 ms, 20 Hz). After training, mice could detect a photostimulus firing a single action potential in approximately 300 neurons. Even fewer neurons (approximately 60) were required for longer stimuli (five action potentials, 250 ms). Our results show that perceptual decisions and learning can be driven by extremely brief epochs of cortical activity in a sparse subset of supragranular cortical pyramidal neurons.〈br /〉〈br /〉〈a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3425380/" target="_blank"〉〈img src="https://static.pubmed.gov/portal/portal3rc.fcgi/4089621/img/3977009" border="0"〉〈/a〉   〈a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3425380/" target="_blank"〉This paper as free author manuscript - peer-reviewed and accepted for publication〈/a〉〈br /〉〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Huber, Daniel -- Petreanu, Leopoldo -- Ghitani, Nima -- Ranade, Sachin -- Hromadka, Tomas -- Mainen, Zach -- Svoboda, Karel -- Howard Hughes Medical Institute/ -- England -- Nature. 2008 Jan 3;451(7174):61-4.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Howard Hughes Medical Institute, Janelia Farm Research Campus, Ashburn, Virginia 20147, USA.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/18094685" target="_blank"〉PubMed〈/a〉
    Keywords: Action Potentials/physiology/radiation effects ; Algal Proteins/genetics/metabolism ; Animals ; Behavior, Animal/*physiology/*radiation effects ; Cerebral Cortex/cytology/*physiology/*radiation effects ; Electric Stimulation ; Learning/*physiology/radiation effects ; Mice ; Movement/*physiology ; Optics and Photonics ; Photic Stimulation ; Pyramidal Cells/metabolism/radiation effects ; Rhodopsins, Microbial/genetics/metabolism
    Print ISSN: 0028-0836
    Electronic ISSN: 1476-4687
    Topics: Biology , Chemistry and Pharmacology , Medicine , Natural Sciences in General , Physics
    Published by Nature Publishing Group (NPG)
    Location Call Number Expected Availability
    BibTip Others were also interested in ...
    PAPER CURRENT
  • 2
    facet.materialart.
    Unknown
    Reverse engineering the mouse brain (2009)
    Nature Publishing Group (NPG)
    Details
    Publication Date: 2009-10-16
    Description: Behaviour is governed by activity in highly structured neural circuits. Genetically targeted sensors and switches facilitate measurement and manipulation of activity in vivo, linking activity in defined nodes of neural circuits to behaviour. Because of access to specific cell types, these molecular tools will have the largest impact in genetic model systems such as the mouse. Emerging assays of mouse behaviour are beginning to rival those of behaving monkeys in terms of stimulus and behavioural control. We predict that the confluence of new behavioural and molecular tools in the mouse will reveal the logic of complex mammalian circuits.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉O'Connor, Daniel H -- Huber, Daniel -- Svoboda, Karel -- Howard Hughes Medical Institute/ -- England -- Nature. 2009 Oct 15;461(7266):923-9. doi: 10.1038/nature08539.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Janelia Farm Research Campus, Howard Hughes Medical Institute, 19700 Helix Drive, Ashburn, Virginia 20147, USA.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/19829372" target="_blank"〉PubMed〈/a〉
    Keywords: Action Potentials ; Animals ; Behavior, Animal/physiology ; Brain/*cytology/*metabolism/physiology ; Mice ; Neural Pathways/*physiology ; Somatosensory Cortex/cytology/metabolism/physiology
    Print ISSN: 0028-0836
    Electronic ISSN: 1476-4687
    Topics: Biology , Chemistry and Pharmacology , Medicine , Natural Sciences in General , Physics
    Published by Nature Publishing Group (NPG)
    Location Call Number Expected Availability
    BibTip Others were also interested in ...
    PAPER CURRENT
  • 3
    facet.materialart.
    Unknown
    Nonlinear dendritic integration of sensory and motor input during an active sensing task (2012)
    Nature Publishing Group (NPG)
    Details
    Publication Date: 2012-11-13
    Description: Active dendrites provide neurons with powerful processing capabilities. However, little is known about the role of neuronal dendrites in behaviourally related circuit computations. Here we report that a novel global dendritic nonlinearity is involved in the integration of sensory and motor information within layer 5 pyramidal neurons during an active sensing behaviour. Layer 5 pyramidal neurons possess elaborate dendritic arborizations that receive functionally distinct inputs, each targeted to spatially separate regions. At the cellular level, coincident input from these segregated pathways initiates regenerative dendritic electrical events that produce bursts of action potential output and circuits featuring this powerful dendritic nonlinearity can implement computations based on input correlation. To examine this in vivo we recorded dendritic activity in layer 5 pyramidal neurons in the barrel cortex using two-photon calcium imaging in mice performing an object-localization task. Large-amplitude, global calcium signals were observed throughout the apical tuft dendrites when active touch occurred at particular object locations or whisker angles. Such global calcium signals are produced by dendritic plateau potentials that require both vibrissal sensory input and primary motor cortex activity. These data provide direct evidence of nonlinear dendritic processing of correlated sensory and motor information in the mammalian neocortex during active sensation.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Xu, Ning-long -- Harnett, Mark T -- Williams, Stephen R -- Huber, Daniel -- O'Connor, Daniel H -- Svoboda, Karel -- Magee, Jeffrey C -- Howard Hughes Medical Institute/ -- England -- Nature. 2012 Dec 13;492(7428):247-51. doi: 10.1038/nature11601. Epub 2012 Nov 11.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Howard Hughes Medical Institute, Janelia Farm Research Campus, Ashburn, Virginia 20147, USA.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/23143335" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; Behavior, Animal/*physiology ; Calcium/metabolism ; Dendrites/*physiology ; Male ; Mice ; Mice, Inbred C57BL ; Motor Activity/*physiology ; Patch-Clamp Techniques ; Pyramidal Cells/physiology ; Sensation/*physiology ; Signal Transduction
    Print ISSN: 0028-0836
    Electronic ISSN: 1476-4687
    Topics: Biology , Chemistry and Pharmacology , Medicine , Natural Sciences in General , Physics
    Published by Nature Publishing Group (NPG)
    Location Call Number Expected Availability
    BibTip Others were also interested in ...
    PAPER CURRENT
  • 4
    facet.materialart.
    Unknown
    A sub-Mercury-sized exoplanet (2013)
    Nature Publishing Group (NPG)
    Details
    Publication Date: 2013-02-22
    Description: Since the discovery of the first exoplanets, it has been known that other planetary systems can look quite unlike our own. Until fairly recently, we have been able to probe only the upper range of the planet size distribution, and, since last year, to detect planets that are the size of Earth or somewhat smaller. Hitherto, no planets have been found that are smaller than those we see in the Solar System. Here we report a planet significantly smaller than Mercury. This tiny planet is the innermost of three that orbit the Sun-like host star, which we have designated Kepler-37. Owing to its extremely small size, similar to that of the Moon, and highly irradiated surface, the planet, Kepler-37b, is probably rocky with no atmosphere or water, similar to Mercury.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Barclay, Thomas -- Rowe, Jason F -- Lissauer, Jack J -- Huber, Daniel -- Fressin, Francois -- Howell, Steve B -- Bryson, Stephen T -- Chaplin, William J -- Desert, Jean-Michel -- Lopez, Eric D -- Marcy, Geoffrey W -- Mullally, Fergal -- Ragozzine, Darin -- Torres, Guillermo -- Adams, Elisabeth R -- Agol, Eric -- Barrado, David -- Basu, Sarbani -- Bedding, Timothy R -- Buchhave, Lars A -- Charbonneau, David -- Christiansen, Jessie L -- Christensen-Dalsgaard, Jorgen -- Ciardi, David -- Cochran, William D -- Dupree, Andrea K -- Elsworth, Yvonne -- Everett, Mark -- Fischer, Debra A -- Ford, Eric B -- Fortney, Jonathan J -- Geary, John C -- Haas, Michael R -- Handberg, Rasmus -- Hekker, Saskia -- Henze, Christopher E -- Horch, Elliott -- Howard, Andrew W -- Hunter, Roger C -- Isaacson, Howard -- Jenkins, Jon M -- Karoff, Christoffer -- Kawaler, Steven D -- Kjeldsen, Hans -- Klaus, Todd C -- Latham, David W -- Li, Jie -- Lillo-Box, Jorge -- Lund, Mikkel N -- Lundkvist, Mia -- Metcalfe, Travis S -- Miglio, Andrea -- Morris, Robert L -- Quintana, Elisa V -- Stello, Dennis -- Smith, Jeffrey C -- Still, Martin -- Thompson, Susan E -- England -- Nature. 2013 Feb 28;494(7438):452-4. doi: 10.1038/nature11914. Epub 2013 Feb 20.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉NASA Ames Research Center, Moffett Field, California 94035, USA. thomas.barclay@nasa.gov〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/23426260" target="_blank"〉PubMed〈/a〉
    Print ISSN: 0028-0836
    Electronic ISSN: 1476-4687
    Topics: Biology , Chemistry and Pharmacology , Medicine , Natural Sciences in General , Physics
    Published by Nature Publishing Group (NPG)
    Location Call Number Expected Availability
    BibTip Others were also interested in ...
    PAPER CURRENT
  • 5
    facet.materialart.
    Unknown
    Gravity modes as a way to distinguish between hydrogen- and helium-burning red giant stars (2011)
    Nature Publishing Group (NPG)
    Details
    Publication Date: 2011-04-02
    Description: Red giants are evolved stars that have exhausted the supply of hydrogen in their cores and instead burn hydrogen in a surrounding shell. Once a red giant is sufficiently evolved, the helium in the core also undergoes fusion. Outstanding issues in our understanding of red giants include uncertainties in the amount of mass lost at the surface before helium ignition and the amount of internal mixing from rotation and other processes. Progress is hampered by our inability to distinguish between red giants burning helium in the core and those still only burning hydrogen in a shell. Asteroseismology offers a way forward, being a powerful tool for probing the internal structures of stars using their natural oscillation frequencies. Here we report observations of gravity-mode period spacings in red giants that permit a distinction between evolutionary stages to be made. We use high-precision photometry obtained by the Kepler spacecraft over more than a year to measure oscillations in several hundred red giants. We find many stars whose dipole modes show sequences with approximately regular period spacings. These stars fall into two clear groups, allowing us to distinguish unambiguously between hydrogen-shell-burning stars (period spacing mostly approximately 50 seconds) and those that are also burning helium (period spacing approximately 100 to 300 seconds).〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Bedding, Timothy R -- Mosser, Benoit -- Huber, Daniel -- Montalban, Josefina -- Beck, Paul -- Christensen-Dalsgaard, Jorgen -- Elsworth, Yvonne P -- Garcia, Rafael A -- Miglio, Andrea -- Stello, Dennis -- White, Timothy R -- De Ridder, Joris -- Hekker, Saskia -- Aerts, Conny -- Barban, Caroline -- Belkacem, Kevin -- Broomhall, Anne-Marie -- Brown, Timothy M -- Buzasi, Derek L -- Carrier, Fabien -- Chaplin, William J -- Di Mauro, Maria Pia -- Dupret, Marc-Antoine -- Frandsen, Soren -- Gilliland, Ronald L -- Goupil, Marie-Jo -- Jenkins, Jon M -- Kallinger, Thomas -- Kawaler, Steven -- Kjeldsen, Hans -- Mathur, Savita -- Noels, Arlette -- Aguirre, Victor Silva -- Ventura, Paolo -- England -- Nature. 2011 Mar 31;471(7340):608-11. doi: 10.1038/nature09935.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Sydney Institute for Astronomy, School of Physics, University of Sydney, New South Wales 2006, Australia. t.bedding@physics.usyd.edu.au〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/21455175" target="_blank"〉PubMed〈/a〉
    Print ISSN: 0028-0836
    Electronic ISSN: 1476-4687
    Topics: Biology , Chemistry and Pharmacology , Medicine , Natural Sciences in General , Physics
    Published by Nature Publishing Group (NPG)
    Location Call Number Expected Availability
    BibTip Others were also interested in ...
    PAPER CURRENT
  • 6
    facet.materialart.
    Unknown
    Multiple dynamic representations in the motor cortex during sensorimotor learning (2012)
    Nature Publishing Group (NPG)
    Details
    Publication Date: 2012-04-28
    Description: The mechanisms linking sensation and action during learning are poorly understood. Layer 2/3 neurons in the motor cortex might participate in sensorimotor integration and learning; they receive input from sensory cortex and excite deep layer neurons, which control movement. Here we imaged activity in the same set of layer 2/3 neurons in the motor cortex over weeks, while mice learned to detect objects with their whiskers and report detection with licking. Spatially intermingled neurons represented sensory (touch) and motor behaviours (whisker movements and licking). With learning, the population-level representation of task-related licking strengthened. In trained mice, population-level representations were redundant and stable, despite dynamism of single-neuron representations. The activity of a subpopulation of neurons was consistent with touch driving licking behaviour. Our results suggest that ensembles of motor cortex neurons couple sensory input to multiple, related motor programs during learning.〈br /〉〈br /〉〈a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4601999/" target="_blank"〉〈img src="https://static.pubmed.gov/portal/portal3rc.fcgi/4089621/img/3977009" border="0"〉〈/a〉   〈a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4601999/" target="_blank"〉This paper as free author manuscript - peer-reviewed and accepted for publication〈/a〉〈br /〉〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Huber, D -- Gutnisky, D A -- Peron, S -- O'Connor, D H -- Wiegert, J S -- Tian, L -- Oertner, T G -- Looger, L L -- Svoboda, K -- Howard Hughes Medical Institute/ -- England -- Nature. 2012 Apr 25;484(7395):473-8. doi: 10.1038/nature11039.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Janelia Farm Research Campus, Howard Hughes Medical Institute, 19700 Helix Drive, Ashburn, Virginia 20147, USA.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/22538608" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; Behavior, Animal/physiology ; Feedback, Sensory/*physiology ; Hippocampus/physiology ; Learning/*physiology ; Long-Term Potentiation/physiology ; Mice ; Microscopy ; *Models, Neurological ; Motor Cortex/cytology/*physiology ; Neuronal Plasticity/physiology ; Psychomotor Performance/physiology ; Rats ; Tongue/physiology ; Touch/physiology ; Vibrissae/physiology
    Print ISSN: 0028-0836
    Electronic ISSN: 1476-4687
    Topics: Biology , Chemistry and Pharmacology , Medicine , Natural Sciences in General , Physics
    Published by Nature Publishing Group (NPG)
    Location Call Number Expected Availability
    BibTip Others were also interested in ...
    PAPER CURRENT
  • 7
    facet.materialart.
    Unknown
    Activity in motor-sensory projections reveals distributed coding in somatosensation (2012)
    Nature Publishing Group (NPG)
    Details
    Publication Date: 2012-08-28
    Description: Cortical-feedback projections to primary sensory areas terminate most heavily in layer 1 (L1) of the neocortex, where they make synapses with tuft dendrites of pyramidal neurons. L1 input is thought to provide 'contextual' information, but the signals transmitted by L1 feedback remain uncharacterized. In the rodent somatosensory system, the spatially diffuse feedback projection from vibrissal motor cortex (vM1) to vibrissal somatosensory cortex (vS1, also known as the barrel cortex) may allow whisker touch to be interpreted in the context of whisker position to compute object location. When mice palpate objects with their whiskers to localize object features, whisker touch excites vS1 and later vM1 in a somatotopic manner. Here we use axonal calcium imaging to track activity in vM1--〉vS1 afferents in L1 of the barrel cortex while mice performed whisker-dependent object localization. Spatially intermingled individual axons represent whisker movements, touch and other behavioural features. In a subpopulation of axons, activity depends on object location and persists for seconds after touch. Neurons in the barrel cortex thus have information to integrate movements and touches of multiple whiskers over time, key components of object identification and navigation by active touch.〈br /〉〈br /〉〈a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3443316/" target="_blank"〉〈img src="https://static.pubmed.gov/portal/portal3rc.fcgi/4089621/img/3977009" border="0"〉〈/a〉   〈a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3443316/" target="_blank"〉This paper as free author manuscript - peer-reviewed and accepted for publication〈/a〉〈br /〉〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Petreanu, Leopoldo -- Gutnisky, Diego A -- Huber, Daniel -- Xu, Ning-long -- O'Connor, Dan H -- Tian, Lin -- Looger, Loren -- Svoboda, Karel -- Howard Hughes Medical Institute/ -- England -- Nature. 2012 Sep 13;489(7415):299-303. doi: 10.1038/nature11321.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Janelia Farm Research Campus, Howard Hughes Medical Institute, Ashburn, Virginia 20147, USA.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/22922646" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; Axons/metabolism ; Calcium Signaling ; Feedback, Physiological ; Male ; Mice ; Mice, Inbred C57BL ; Motor Cortex/cytology/*physiology ; Motor Neurons/metabolism ; Movement/physiology ; *Neural Pathways ; Physical Stimulation ; Somatosensory Cortex/cytology/*physiology ; Touch/*physiology ; Vibrissae/*physiology
    Print ISSN: 0028-0836
    Electronic ISSN: 1476-4687
    Topics: Biology , Chemistry and Pharmacology , Medicine , Natural Sciences in General , Physics
    Published by Nature Publishing Group (NPG)
    Location Call Number Expected Availability
    BibTip Others were also interested in ...
    PAPER CURRENT
  • 8
    facet.materialart.
    Unknown
    Hierarchy of orofacial rhythms revealed through whisking and breathing (2013)
    Nature Publishing Group (NPG)
    Details
    Publication Date: 2013-04-30
    Description: Whisking and sniffing are predominant aspects of exploratory behaviour in rodents. Yet the neural mechanisms that generate and coordinate these and other orofacial motor patterns remain largely uncharacterized. Here we use anatomical, behavioural, electrophysiological and pharmacological tools to show that whisking and sniffing are coordinated by respiratory centres in the ventral medulla. We delineate a distinct region in the ventral medulla that provides rhythmic input to the facial motor neurons that drive protraction of the vibrissae. Neuronal output from this region is reset at each inspiration by direct input from the pre-Botzinger complex, such that high-frequency sniffing has a one-to-one relationship with whisking, whereas basal respiration is accompanied by intervening whisks that occur between breaths. We conjecture that the respiratory nuclei, which project to other premotor regions for oral and facial control, function as a master clock for behaviours that coordinate with breathing.〈br /〉〈br /〉〈a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4159559/" target="_blank"〉〈img src="https://static.pubmed.gov/portal/portal3rc.fcgi/4089621/img/3977009" border="0"〉〈/a〉   〈a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4159559/" target="_blank"〉This paper as free author manuscript - peer-reviewed and accepted for publication〈/a〉〈br /〉〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Moore, Jeffrey D -- Deschenes, Martin -- Furuta, Takahiro -- Huber, Daniel -- Smear, Matthew C -- Demers, Maxime -- Kleinfeld, David -- MT-5877/Canadian Institutes of Health Research/Canada -- NS047101/NS/NINDS NIH HHS/ -- NS058668/NS/NINDS NIH HHS/ -- NS066664/NS/NINDS NIH HHS/ -- R01 NS058668/NS/NINDS NIH HHS/ -- Howard Hughes Medical Institute/ -- England -- Nature. 2013 May 9;497(7448):205-10. doi: 10.1038/nature12076. Epub 2013 Apr 28.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Department of Physics, University of California at San Diego, 9500 Gilman Drive, La Jolla, California 92093, USA.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/23624373" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; Biological Clocks/physiology ; Face/anatomy & histology/physiology ; Female ; Head Movements/*physiology ; Kainic Acid/administration & dosage/pharmacology ; Male ; Medulla Oblongata/cytology/physiology ; Muscle, Skeletal/physiology ; Rats ; Rats, Long-Evans ; *Respiration ; Smell/*physiology ; Vibrissae/innervation/*physiology
    Print ISSN: 0028-0836
    Electronic ISSN: 1476-4687
    Topics: Biology , Chemistry and Pharmacology , Medicine , Natural Sciences in General , Physics
    Published by Nature Publishing Group (NPG)
    Location Call Number Expected Availability
    BibTip Others were also interested in ...
    PAPER CURRENT
  • 9
    facet.materialart.
    Unknown
    A prevalence of dynamo-generated magnetic fields in the cores of intermediate-mass stars (2016)
    Nature Publishing Group (NPG)
    Details
    Publication Date: 2016-01-05
    Description: Magnetic fields play a part in almost all stages of stellar evolution. Most low-mass stars, including the Sun, show surface fields that are generated by dynamo processes in their convective envelopes. Intermediate-mass stars do not have deep convective envelopes, although 10 per cent exhibit strong surface fields that are presumed to be residuals from the star formation process. These stars do have convective cores that might produce internal magnetic fields, and these fields might survive into later stages of stellar evolution, but information has been limited by our inability to measure the fields below the stellar surface. Here we report the strength of dipolar oscillation modes for a sample of 3,600 red giant stars. About 20 per cent of our sample show mode suppression, by strong magnetic fields in the cores, but this fraction is a strong function of mass. Strong core fields occur only in red giants heavier than 1.1 solar masses, and the occurrence rate is at least 50 per cent for intermediate-mass stars (1.6-2.0 solar masses), indicating that powerful dynamos were very common in the previously convective cores of these stars.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Stello, Dennis -- Cantiello, Matteo -- Fuller, Jim -- Huber, Daniel -- Garcia, Rafael A -- Bedding, Timothy R -- Bildsten, Lars -- Aguirre, Victor Silva -- England -- Nature. 2016 Jan 21;529(7586):364-7. doi: 10.1038/nature16171. Epub 2016 Jan 4.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Sydney Institute for Astronomy (SIfA), School of Physics, University of Sydney, Sydney, New South Wales 2006, Australia. ; Stellar Astrophysics Centre, Department of Physics and Astronomy, Aarhus University, Ny Munkegade 120, DK-8000 Aarhus C, Denmark. ; Kavli Institute for Theoretical Physics, University of California, Santa Barbara, California 93106, USA. ; TAPIR, Walter Burke Institute for Theoretical Physics, Mailcode 350-17, California Institute of Technology, Pasadena, California 91125, USA. ; SETI Institute, 189 Bernardo Avenue, Mountain View, California 94043, USA. ; Laboratoire AIM, CEA/DSM-CNRS-Universite Paris Diderot-IRFU/SAp Centre de Saclay, 91191 Gif-sur-Yvette Cedex, France. ; Department of Physics, University of California, Santa Barbara, California 93106, USA.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/26727160" target="_blank"〉PubMed〈/a〉
    Print ISSN: 0028-0836
    Electronic ISSN: 1476-4687
    Topics: Biology , Chemistry and Pharmacology , Medicine , Natural Sciences in General , Physics
    Published by Nature Publishing Group (NPG)
    Location Call Number Expected Availability
    BibTip Others were also interested in ...
    PAPER CURRENT
  • 10
    facet.materialart.
    Unknown
    Learning-related fine-scale specificity imaged in motor cortex circuits of behaving mice (2010)
    Nature Publishing Group (NPG)
    Details
    Publication Date: 2010-04-09
    Description: Cortical neurons form specific circuits, but the functional structure of this microarchitecture and its relation to behaviour are poorly understood. Two-photon calcium imaging can monitor activity of spatially defined neuronal ensembles in the mammalian cortex. Here we applied this technique to the motor cortex of mice performing a choice behaviour. Head-fixed mice were trained to lick in response to one of two odours, and to withhold licking for the other odour. Mice routinely showed significant learning within the first behavioural session and across sessions. Microstimulation and trans-synaptic tracing identified two non-overlapping candidate tongue motor cortical areas. Inactivating either area impaired voluntary licking. Imaging in layer 2/3 showed neurons with diverse response types in both areas. Activity in approximately half of the imaged neurons distinguished trial types associated with different actions. Many neurons showed modulation coinciding with or preceding the action, consistent with their involvement in motor control. Neurons with different response types were spatially intermingled. Nearby neurons (within approximately 150 mum) showed pronounced coincident activity. These temporal correlations increased with learning within and across behavioural sessions, specifically for neuron pairs with similar response types. We propose that correlated activity in specific ensembles of functionally related neurons is a signature of learning-related circuit plasticity. Our findings reveal a fine-scale and dynamic organization of the frontal cortex that probably underlies flexible behaviour.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Komiyama, Takaki -- Sato, Takashi R -- O'Connor, Daniel H -- Zhang, Ying-Xin -- Huber, Daniel -- Hooks, Bryan M -- Gabitto, Mariano -- Svoboda, Karel -- Howard Hughes Medical Institute/ -- England -- Nature. 2010 Apr 22;464(7292):1182-6. doi: 10.1038/nature08897. Epub 2010 Apr 7.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Janelia Farm Research Campus, HHMI, Ashburn, Virginia 20147, USA. komiyamat@janelia.hhmi.org〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/20376005" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; Axonal Transport ; Behavior, Animal/*physiology ; Choice Behavior/physiology ; Learning/*physiology ; Male ; Mice ; Mice, Inbred C57BL ; Motor Cortex/*cytology/*physiology ; Motor Neurons/physiology ; Neural Pathways/*physiology ; Odors/analysis ; Pyramidal Cells/physiology ; Reward ; Stimulation, Chemical ; Time Factors ; Tongue/cytology/innervation/physiology
    Print ISSN: 0028-0836
    Electronic ISSN: 1476-4687
    Topics: Biology , Chemistry and Pharmacology , Medicine , Natural Sciences in General , Physics
    Published by Nature Publishing Group (NPG)
    Location Call Number Expected Availability
    BibTip Others were also interested in ...
    PAPER CURRENT
Close ⊗
This website uses cookies and the analysis tool Matomo. More information can be found here...