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  • American Association for the Advancement of Science (AAAS)  (57)
  • Oxford University Press
  • 1990-1994  (67)
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  • 1
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    Mutagenesis and mapping of a mouse gene, Clock, essential for circadian behavior (1994)
    American Association for the Advancement of Science (AAAS)
    Details
    Publikationsdatum: 1994-04-29
    Beschreibung: In a search for genes that regulate circadian rhythms in mammals, the progeny of mice treated with N-ethyl-N-nitrosourea (ENU) were screened for circadian clock mutations. A semidominant mutation, Clock, that lengthens circadian period and abolishes persistence of rhythmicity was identified. Clock segregated as a single gene that mapped to the midportion of mouse chromosome 5, a region syntenic to human chromosome 4. The power of ENU mutagenesis combined with the ability to clone murine genes by map position provides a generally applicable approach to study complex behavior in mammals.〈br /〉〈br /〉〈a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3839659/" target="_blank"〉〈img src="https://static.pubmed.gov/portal/portal3rc.fcgi/4089621/img/3977009" border="0"〉〈/a〉   〈a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3839659/" target="_blank"〉This paper as free author manuscript - peer-reviewed and accepted for publication〈/a〉〈br /〉〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Vitaterna, M H -- King, D P -- Chang, A M -- Kornhauser, J M -- Lowrey, P L -- McDonald, J D -- Dove, W F -- Pinto, L H -- Turek, F W -- Takahashi, J S -- P30-CA07175/CA/NCI NIH HHS/ -- R01-DK40493/DK/NIDDK NIH HHS/ -- T32 NS071040/NS/NINDS NIH HHS/ -- Howard Hughes Medical Institute/ -- etc. -- New York, N.Y. -- Science. 1994 Apr 29;264(5159):719-25.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Department of Neurobiology and Physiology, Northwestern University, Evanston, IL 60208.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/8171325" target="_blank"〉PubMed〈/a〉
    Schlagwort(e): Animals ; *Chromosome Mapping ; Chromosomes, Human, Pair 4 ; Circadian Rhythm/*genetics ; Ethylnitrosourea ; Female ; *Genes ; Genotype ; Humans ; Male ; Mice ; Mice, Inbred C57BL ; *Mutagenesis ; Phenotype
    Print ISSN: 0036-8075
    Digitale ISSN: 1095-9203
    Thema: Biologie , Chemie und Pharmazie , Informatik , Medizin , Allgemeine Naturwissenschaft , Physik
    Publiziert von American Association for the Advancement of Science (AAAS)
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  • 2
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    Quasicrystal publications (1990)
    American Association for the Advancement of Science (AAAS)
    Details
    Publikationsdatum: 1990-05-25
    Beschreibung: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Gayle, F W -- New York, N.Y. -- Science. 1990 May 25;248(4958):944.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/17745389" target="_blank"〉PubMed〈/a〉
    Print ISSN: 0036-8075
    Digitale ISSN: 1095-9203
    Thema: Biologie , Chemie und Pharmazie , Informatik , Medizin , Allgemeine Naturwissenschaft , Physik
    Publiziert von American Association for the Advancement of Science (AAAS)
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  • 3
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    Science, citation, and funding (1991)
    American Association for the Advancement of Science (AAAS)
    Details
    Publikationsdatum: 1991-03-22
    Beschreibung: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Lancaster, F W -- New York, N.Y. -- Science. 1991 Mar 22;251(5000):1409.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/17779409" target="_blank"〉PubMed〈/a〉
    Print ISSN: 0036-8075
    Digitale ISSN: 1095-9203
    Thema: Biologie , Chemie und Pharmazie , Informatik , Medizin , Allgemeine Naturwissenschaft , Physik
    Publiziert von American Association for the Advancement of Science (AAAS)
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  • 4
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    Cell-adhesive motif in region II of malarial circumsporozoite protein (1990)
    American Association for the Advancement of Science (AAAS)
    Details
    Publikationsdatum: 1990-09-28
    Beschreibung: The segment of the malarial circumsporozoite (CS) protein designated Region II is highly conserved among different malarial species. A similar sequence is also present in several other proteins, including thrombospondin, properdin, and a blood-stage antigen of Plasmodium falciparum. By means of peptides synthesized from sequences of the Plasmodium vivax CS protein in the vicinity of Region II, it was found that two overlapping 18- to 20-amino acid peptides promoted the adhesion of a variety of human hematopoietic cell lines. The amino acid sequence valine-threonine-cysteineglycine (VTCG), contained within this common motif, was shown to be the critical sequence for the observed cell-adhesive properties.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Rich, K A -- George, F W 4th -- Law, J L -- Martin, W J -- New York, N.Y. -- Science. 1990 Sep 28;249(4976):1574-7.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Department of Pathology, University of Southern California School of Medicine, Los Angeles 90033.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/2120774" target="_blank"〉PubMed〈/a〉
    Schlagwort(e): Amino Acid Sequence ; Animals ; Antigens, Protozoan/*genetics ; *Cell Adhesion ; Cell Line ; Fluorescein-5-isothiocyanate ; Fluoresceins ; Fluorescent Dyes ; Humans ; Molecular Sequence Data ; Peptides/chemical synthesis ; Plasmodium falciparum/*genetics ; Plasmodium vivax/*genetics ; Protozoan Proteins/*genetics ; Thiocyanates
    Print ISSN: 0036-8075
    Digitale ISSN: 1095-9203
    Thema: Biologie , Chemie und Pharmazie , Informatik , Medizin , Allgemeine Naturwissenschaft , Physik
    Publiziert von American Association for the Advancement of Science (AAAS)
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  • 5
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    Valuing the health benefits of clean air (1992)
    American Association for the Advancement of Science (AAAS)
    Details
    Publikationsdatum: 1992-02-14
    Beschreibung: An assessment of health effects due to ozone and particulate matter (PM10) suggests that each of the 12 million residents of the South Coast Air Basin of California experiences ozone-related symptoms on an average of up to 17 days each year and faces an increased risk of death in any year of 1/10,000 as a result of elevated PM10 exposure. The estimated annual economic value of avoiding these effects is nearly $10 billion. Attaining air pollution standards may save 1600 lives a year in the region.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Hall, J V -- Winer, A M -- Kleinman, M T -- Lurmann, F W -- Brajer, V -- Colome, S D -- New York, N.Y. -- Science. 1992 Feb 14;255(5046):812-7.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Department of Economics, California State University, Fullerton 92634.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/1536006" target="_blank"〉PubMed〈/a〉
    Schlagwort(e): Air Pollutants/adverse effects ; Air Pollution/adverse effects/*economics ; California ; Cost-Benefit Analysis ; Dose-Response Relationship, Drug ; Humans ; Ozone/adverse effects ; Respiratory Tract Diseases/economics/etiology
    Print ISSN: 0036-8075
    Digitale ISSN: 1095-9203
    Thema: Biologie , Chemie und Pharmazie , Informatik , Medizin , Allgemeine Naturwissenschaft , Physik
    Publiziert von American Association for the Advancement of Science (AAAS)
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  • 6
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    DNA sequencing by primer walking with strings of contiguous hexamers (1992)
    American Association for the Advancement of Science (AAAS)
    Details
    Publikationsdatum: 1992-12-11
    Beschreibung: When template DNA is saturated with a single-stranded DNA binding protein (SSB), strings of three or four contiguous hexanucleotides (hexamers) can cooperate through base-stacking interactions to prime DNA synthesis specifically from the 3' end of the string. Under the same conditions, priming by individual hexamers is suppressed. Strings of three of four hexamers representing more than 200 of the 4096 possible hexamers primed easily readable sequence ladders at more than 75 different sites in single-stranded or denatured double-stranded templates 6.4 kilobases to 40 kilobase pairs long, with a success rate of 60 to 90 percent. A synthesis of 1 micromole of hexamer supplies enough material for thousands of primings, so multiple libraries of all 4096 hexamers could be distributed at a reasonable cost. Such libraries would allow rapid and economical sequencing. Automating this strategy could increase the speed and efficiency of large-scale DNA sequencing by at least an order of magnitude.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Kieleczawa, J -- Dunn, J J -- Studier, F W -- New York, N.Y. -- Science. 1992 Dec 11;258(5089):1787-91.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Biology Department, Brookhaven National Laboratory, Upton, NY 11973.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/1465615" target="_blank"〉PubMed〈/a〉
    Schlagwort(e): *Base Sequence ; Binding Sites ; DNA/*genetics/metabolism ; DNA, Viral/genetics ; DNA-Binding Proteins/metabolism ; Escherichia coli/metabolism ; *Genetic Techniques ; Molecular Sequence Data ; Nucleic Acid Denaturation ; Oligodeoxyribonucleotides ; Sulfur Radioisotopes ; Templates, Genetic
    Print ISSN: 0036-8075
    Digitale ISSN: 1095-9203
    Thema: Biologie , Chemie und Pharmazie , Informatik , Medizin , Allgemeine Naturwissenschaft , Physik
    Publiziert von American Association for the Advancement of Science (AAAS)
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  • 7
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    Orientational dielectric relaxation of collisionless molecules (1990)
    American Association for the Advancement of Science (AAAS)
    Details
    Publikationsdatum: 1990-03-30
    Beschreibung: The generation of the orientation component of the polarization of matter in an electric field has previously been thought to require interaction of molecules with their neighbors. It is demonstrated that, even in the absence of collisions between neighboring molecules, hot isolated polyatomic molecules can reorient in response to an external field, thereby giving rise to the orientation component of polarization. This reorientation occurs through the interaction of rotation with molecular vibrations, which provides a heat bath to establish thermal rotational equilibrium. This effect is demonstrated for o-difluorobenzene, o-dichlorobenzene, and p-chlorotoluene, with an inhomogeneous electric field used to deflect molecular beams of these molecules.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Farley, F W -- McClelland, G M -- New York, N.Y. -- Science. 1990 Mar 30;247(4950):1572-5.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/17782813" target="_blank"〉PubMed〈/a〉
    Print ISSN: 0036-8075
    Digitale ISSN: 1095-9203
    Thema: Biologie , Chemie und Pharmazie , Informatik , Medizin , Allgemeine Naturwissenschaft , Physik
    Publiziert von American Association for the Advancement of Science (AAAS)
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  • 8
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    International congress of entomology (1990)
    American Association for the Advancement of Science (AAAS)
    Details
    Publikationsdatum: 1990-10-19
    Beschreibung: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Anderson, J R -- Doyen, J T -- Hoy, M A -- Koehler, C -- Pipa, R L -- Andres, L A -- Haverty, M I -- Hoy, J B -- Knop, N F -- Ehrlich, P R -- Greenstone, M -- Plapp, F W Jr -- Shuping, Y -- New York, N.Y. -- Science. 1990 Oct 19;250(4979):360.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/17793005" target="_blank"〉PubMed〈/a〉
    Print ISSN: 0036-8075
    Digitale ISSN: 1095-9203
    Thema: Biologie , Chemie und Pharmazie , Informatik , Medizin , Allgemeine Naturwissenschaft , Physik
    Publiziert von American Association for the Advancement of Science (AAAS)
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  • 9
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    Sea-surface temperature from coral skeletal strontium/calcium ratios (1992)
    American Association for the Advancement of Science (AAAS)
    Details
    Publikationsdatum: 1992-07-31
    Beschreibung: Seasonal records of tropical sea-surface temperature (SST) over the past 10(5) years can be recovered from high-precision measurements of coral strontium/calcium ratios with the use of thermal ionization mass spectrometry. The temperature dependence of these ratios was calibrated with corals collected at SST recording stations and by (18)O/(16)O thermometry. The results suggest that mean monthly SST may be determined with an apparent accuracy of better than 0.5 degrees C. Measurements on a fossil coral indicate that 10,200 years ago mean annual SSTs near Vanuatu in the southwestern Pacific Ocean were about 5 degrees C colder than today and that seasonal variations in SST were larger. These data suggest that tropical climate zones were compressed toward the equator during deglaciation.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Beck, J W -- Edwards, R L -- Ito, E -- Taylor, F W -- Recy, J -- Rougerie, F -- Joannot, P -- Henin, C -- New York, N.Y. -- Science. 1992 Jul 31;257(5070):644-7.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/17740731" target="_blank"〉PubMed〈/a〉
    Print ISSN: 0036-8075
    Digitale ISSN: 1095-9203
    Thema: Biologie , Chemie und Pharmazie , Informatik , Medizin , Allgemeine Naturwissenschaft , Physik
    Publiziert von American Association for the Advancement of Science (AAAS)
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  • 10
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    Studies of unusual simple molecules by neutralization-reionization mass spectrometry (1990)
    American Association for the Advancement of Science (AAAS)
    Details
    Publikationsdatum: 1990-02-23
    Beschreibung: Reactive or unstable molecules are key intermediates in many important reactions, but can be difficult to prepare for experimental studies. Species with missing (:CH-OH) or extra (H3) substituents can often be formed conveniently in the gas phase by neutralizing a beam of a more stable ionic counterpart (CH = O+H, H3+). Reionization of the neutral after approximately 10(-6) seconds tests its stability, whereas its unimolecular chemistry can be probed by preparing it with different amounts of internal energy. The resulting neutral products are reionized and mass analyzed. Isomers are then characterized by ion dissociation and a third mass-analysis step. Many unusual molecules have been characterized with this technique, which can also be used to probe complex unimolecular chemistry, such as that of cyclobutadiene and ethylene oxide.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉McLafferty, F W -- GM-16609/GM/NIGMS NIH HHS/ -- New York, N.Y. -- Science. 1990 Feb 23;247(4945):925-9.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Cornell University, Baker Laboratory, Ithaca, NY 14853-1301.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/2305261" target="_blank"〉PubMed〈/a〉
    Schlagwort(e): Butadienes ; Chemical Phenomena ; Chemistry ; Ethylene Oxide ; Free Radicals ; Hydrocarbons ; *Ions ; *Mass Spectrometry ; Methane/analogs & derivatives ; Molecular Structure ; Thermodynamics
    Print ISSN: 0036-8075
    Digitale ISSN: 1095-9203
    Thema: Biologie , Chemie und Pharmazie , Informatik , Medizin , Allgemeine Naturwissenschaft , Physik
    Publiziert von American Association for the Advancement of Science (AAAS)
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