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  • Springer  (62)
  • 1975-1979  (55)
  • 1960-1964  (5)
  • 1940-1944  (2)
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  • 1
    Electronic Resource
    Electronic Resource
    Enrichment of auxotrophic mutants inHansenula polymorpha (1977)
    Springer
    Applied microbiology and biotechnology 4 (1977), S. 45-49 
    Details
    ISSN: 1432-0614
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology , Process Engineering, Biotechnology, Nutrition Technology
    Notes: Summary An enrichment scheme was designed for the isolation of auxotrophic mutants of the thermotolerant and methanol-utilizing yeast,Hansenula polymorpha, by the use of the polyene antibiotic nystatin. This treatment resulted in auxotrophic isolates at a frequency of 75%. With or without nystatin enrichment, the vast majority of obtained auxotrophs required nucleic acid bases.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01390669
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  • 2
    Electronic Resource
    Electronic Resource
    Pharmacokinetics of cefoxitin in patients with normal or impaired renal function (1979)
    Springer
    European journal of clinical pharmacology 16 (1979), S. 119-124 
    Details
    ISSN: 1432-1041
    Keywords: cefoxitin ; renal impairment ; pharmacokinetics
    Source: Springer Online Journal Archives 1860-2000
    Topics: Chemistry and Pharmacology , Medicine
    Notes: Summary The pharmacokinetics of cefoxitin have been determined after a single i.v. injection of 15 mg/kg body weight in 10 patients with normal renal function and 20 patients with varying degrees of renal impairment. The kinetics of the antibiotic followed an open two-compartment model. In patients with normal renal function the following pharmacokinetic parameters were found: $$\begin{gathered} \begin{array}{*{20}c} {\alpha = 8.66 h^{ - 1} } & {\beta = 1.21 h^{ - 1} } & {K_{12} = 3.47 h^{ - 1} } \\ \end{array} \hfill \\ \begin{array}{*{20}c} {K_{21} = 3.17 h^{ - 1} } & {K_{13} = 3.15 h^{ - 1} } & {V_c = 4.24 l.} \\ \end{array} \hfill \\ \begin{array}{*{20}c} {V_p = 4.87 l.} & { Vd_{ss} = 9.11 l.} \\ \end{array} \hfill \\ \end{gathered}$$ In the patients with renal impairment there was a significant decrease in $$\mathop \alpha \limits_, \mathop \beta \limits_, $$ K12, K21 and K13, and an increase in the apparent volume of distribution. The degree of plasma protein binding in patients with normal renal function was 73.6% and this was diminished in patients with renal impairment. A linear relationship between K13 of cefoxitin and creatinine clearance was demonstrated. The dosage regimen for patients with renal impairment should be adjusted by modifying the dosage interval whilst maintaining the amount administered.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00563118
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  • 3
    Electronic Resource
    Electronic Resource
    Dynamic properties of cat tenuissimus muscle (1979)
    Springer
    Biological cybernetics 33 (1979), S. 187-197 
    Details
    ISSN: 1432-0770
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology , Computer Science , Physics
    Notes: Abstract Some of the factors which influence the development of tension in cat tenuissimus muscle were studied quantitatively. Under isometric conditions, it was shown that the dynamic properties of the relationship between the tension of the muscle and its electrical stimulation depend on the mean rate of stimulation. This non-linear effect cannot be explained on the basis of the dependence of muscle tension on instantaneous rate of stimulation since the tension due to a stimulus following closely a previous stimulus is augmented, but the time course of the twitch response is unaltered. The interaction between the tension due to active contraction and that due to the viscoelastic properties of the muscle was investigated by independently varying muscle length and the rate of stimulation. Within the limits of resolution of the data, it was concluded that these two components of tension are additive and that muscle stiffness is related to the instantaneous tension of the muscle.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00337408
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  • 4
    Electronic Resource
    Electronic Resource
    The G-banded prophase chromosomes of man (1975)
    Springer
    Human genetics 〈Berlin〉 27 (1975), S. 167-172 
    Details
    ISSN: 1432-1203
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology , Medicine
    Notes: Summary Using a simple G-banding technique developed in our laboratory, analysis of late prophases enables the visualization of approximately 1000 bands in the haploid set of human chromosomes. These bands have been classified according to the recommendations of the Paris Conference. The increased resolution offered by this technique is likely to be useful in the study of the structure and molecular organization of chromosomes and in identifying minute chromosome defects in birth defects and neoplasia.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00278343
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  • 5
    Electronic Resource
    Electronic Resource
    Lactate dehydrogenases in cyanobacteria (1975)
    Springer
    Archives of microbiology 104 (1975), S. 57-65 
    Details
    ISSN: 1432-072X
    Keywords: Cyanobacteria ; Lactate Dehydrogenases ; Lactate Metabolism ; Synechococcus ; Aphanocapsa
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology
    Notes: Abstract NAD-linked lactate dehydrogenases specific for the d- and l-lactate have been demonstrated in a number of strains of unicellular cyanobacteria. The d-lactate dehydrogenase of one strain (Synechococcus 6716) was partially purified and its properties were studied. The enzyme has a molecular weight of ca. 115000–120000, is highly specific, autooxidizable, and susceptible to inhibition by iodoacetamide, oxamate and ATP. The possible physiological functions of the enzyme in the metabolism of the organism were investigated. d-lactate carbon was incorporated in cell material during photosynthetic growth with CO2, but lactate was not used as sole source of carbon for photosynthetic or chemosynthetic development. d-lactate and pyruvate were oxidized aerobically in the dark by resting cell suspensions with the assimilation mainly of the the C3 and C3 carbon atoms. In the oxidation of lactate, acetate was excreted into the medium. No fermentation of glucose was found, but a small amount of d-lactate was detected as a product of endogenous dark metabolism of the cell. All enzymes required for the production of lactate from glucose and from glycogen were found in exponentially growing cells, but the activity of some key enzymes was low or undetectable in old cultures.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00447300
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  • 6
    Electronic Resource
    Electronic Resource
    Stress relaxation due to steam curing (1977)
    Springer
    Materials and structures 10 (1977), S. 351-356 
    Details
    ISSN: 1359-5997
    Source: Springer Online Journal Archives 1860-2000
    Topics: Architecture, Civil Engineering, Surveying
    Description / Table of Contents: Résumé Une nouvelle expression pour la relaxation isotherme, qui a été précédemment déduite, a été judicieusement modifiée pour étudier l’influence d’un cycle d’étuvage sur la perte de contrainte des éléments en béton précontraint par fil adhérent. Une nouvelle méthode pour le calcul des pertes de contrainte est ainsi proposée. La méthode tient compte aussi de l’influence sur la relaxation du relâchement de l’acier pendant le chauffage «loosening» et du raccourcissement élastique du béton quand on libère la force de précontrainte. La théorie a donné lieu à deux séries d’essais afin de prédire la relaxation. Les deux paramètres empiriques de la théorie ont été déterminés au moyen d’un essai de relaxation isotherme pour la première série et d’un essai de traction pour la seconde. Les valeurs de la relaxation pendant et après étuvage, que prédit la théorie, concordent avec les résultats. D’après la théorie également, une stabilisation complète doit intervenir après l’étuvage dans des délais qui dépendent de sa température et de sa durée, en accord avec le résultat des essais. En outre, pour de plus longues périodes la théorie prévoit une augmentation des valeurs de relaxation. Malheureusement, ces valeurs ne peuvent être vérifiées en l’absence de résultats expérimentaux.
    Notes: Abstract A new equation for isothermal relaxation of stress-relieved steel previously derived, has been modified to study stress losses in prestressed elements due to steam curing of concrete. A calculation method is proposed, which takes into account the effect of loosening during heating and of releasing of the prestressing force. The theory predicts a complete stress stabilization after steam curing up to times depending on temperature and duration of the steam curing. Furthermore, for longer periods the theory predicts an increase of the relaxation values. Tests performed show an excellent agreement between theory and experimental results.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF02473732
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  • 7
    Electronic Resource
    Electronic Resource
    High-affinity binding ofβ-alanine to cerebral synaptosomes might involve glycine-receptors (1978)
    Springer
    Cellular and molecular life sciences 34 (1978), S. 1169-1170 
    Details
    ISSN: 1420-9071
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology , Medicine
    Notes: Summary High-affinity, Na+-independent binding of β-alanine to a synaptosomal fraction of rat brain was potently inhibited by glycine and by some other α-amino acids, but not by taurine or GABA. This binding mechanism, which was also sensitive to both bicuculline and strychnine, might involve synaptic receptors for both β-alanine and glycine.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01922937
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  • 8
    Electronic Resource
    Electronic Resource
    A new formula for relaxation of stress-relieved steels (1976)
    Springer
    Materials and structures 9 (1976), S. 411-417 
    Details
    ISSN: 1359-5997
    Source: Springer Online Journal Archives 1860-2000
    Topics: Architecture, Civil Engineering, Surveying
    Description / Table of Contents: Résumé A partir de l’analyse des mécanismes de la déformation plastique on arrive à déduire une expression qui nous donne la déformation plastique en fonction d’une variable qui dépend de la contrainte de la température et du temps: c’est la contrainte effective. En appliquant cette expression au phénomène de la relaxation des aciers de précontrainte, on déduit une nouvelle formule qui détermine la perte de contrainte en fonction de la contrainte effective de l’acier. Cette expression est valable dans un certain intervalle de températures (20 à 60°C), et de tensions (jusqu’à 80% de la charge unitaire maximale) et l’influence du matériel n’est représentée que par deux paramètres empiriques. Pour vérifier la validité de cette expression on expose les résultats des essais qui ont été réalisés sur deux aciers stabilisés. Pour l’un de ces aciers on a exploré l’intervalle de tension et de températures considéré auparavant. Les essais à hautes températures ont été réalisés suivant une nouvelle méthode: tandis que pour les essais à 20°C la vitesse de mise en charge a été de 3,3 MN/m2.s, pour les essais à 40°C la vitesse employée a été de 33 MN/m2.s et pour les essais à 60°C elle était de 250 MN/m2.s. Le temps de maintien de la charge initiale a été réduit à 13 secondes pour les essais à 40°C et à 1,8 secondes pour les essais à 60°C. Les résultats de ces essais s’accordent très bien avec l’expression théorique. Finalement on applique cette expression à d’autres essais qui ont été publiés par le C.U.R. et par Brachet, Jacques et Atallah et on vérifie sa validité avec les résultats de ces essais.
    Notes: Abstract From the basic mechanisms of plastic deformation, a new equation for the isothermal relaxation has been derived, depending on two empirical parameters. Relaxation tests show the validity of the formula to explain isothermal relaxation losses in stress-relieved steels and to take into account the influence of the temperature up to 60°C and the initial stress up to 0.80 u.t.s. A new testing method, as deduced from the formula, for high temperature relaxation tests is proposed. Finally, the equation has been applied to test results from other authors obtaining again an excellent agreement with them.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF02473776
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  • 9
    Electronic Resource
    Electronic Resource
    On the mineralocorticoid and hypertensogenic properties of 16β-Hydroxy-Dehydroepiandrosterone (1976)
    Springer
    Cellular and molecular life sciences 32 (1976), S. 1067-1069 
    Details
    ISSN: 1420-9071
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology , Medicine
    Notes: Summary Dosages of either 1 or 2 mg daily of 16β-hydroxy-dehydroepiandrosterone, given to mononephretomized, salt-loaded female rats, had no detectable effect upon saline consumption, blood pressure, kallikrein excretion or heart and kidney weight. Its alleged mineralocorticoid properties, as judged by these criteria, were not demonstrable.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01933976
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  • 10
    Electronic Resource
    Electronic Resource
    Dopamine beta-hydroxylase in human synovial fluid (1977)
    Springer
    Cellular and molecular life sciences 33 (1977), S. 650-652 
    Details
    ISSN: 1420-9071
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology , Medicine
    Notes: Summary Dopamine beta-hydroxylase (DBH) activity has been found in synovial fluid obtained from human knees. The enzyme activity was about 5% of the activity found in the serum of the same control patients. DBH activity in synovial fluid of patients suffering osteoarthritis was 3 times higher.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01946554
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