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On the mineralocorticoid and hypertensogenic properties of 16β-Hydroxy-Dehydroepiandrosterone

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  • Endocrinologica
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Summary

Dosages of either 1 or 2 mg daily of 16β-hydroxy-dehydroepiandrosterone, given to mononephretomized, salt-loaded female rats, had no detectable effect upon saline consumption, blood pressure, kallikrein excretion or heart and kidney weight. Its alleged mineralocorticoid properties, as judged by these criteria, were not demonstrable.

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Authors and Affiliations

  1. Department of Internal Medicine, University of Texas Health Science Center at Dallas, 75235, Dallas, Texas, USA

    C. Gomez-Sanchez, O. B. Holland, C. E. Hall & S. Ayachi

  2. Department of Physiology and Biophysics, University of Texas Medical Branch, 77550, Galveston, Texas, USA

    C. Gomez-Sanchez, O. B. Holland, C. E. Hall & S. Ayachi

Authors
  1. C. Gomez-Sanchez
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  2. O. B. Holland
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  3. C. E. Hall
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  4. S. Ayachi
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Additional information

This study was supported by a grant No. HL 15319 from the United States Public Health Service.

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Gomez-Sanchez, C., Holland, O.B., Hall, C.E. et al. On the mineralocorticoid and hypertensogenic properties of 16β-Hydroxy-Dehydroepiandrosterone. Experientia 32, 1067–1069 (1976). https://doi.org/10.1007/BF01933976

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  • DOI: https://doi.org/10.1007/BF01933976

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