Summary
Dopamine beta-hydroxylase (DBH) activity has been found in synovial fluid obtained from human knees. The enzyme activity was about 5% of the activity found in the serum of the same control patients. DBH activity in synovial fluid of patients suffering osteoarthritis was 3 times higher.
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References
A. D. Smith and H. Winkler in: Catecholamines, p. 538. Ed. H. Blaschko and E. Muscholl. Springer-Verlag, Berlin 1972.
M. Goldstein, L. S. Freedman and M. Bonnay, Experientia27, 632 (1971).
R. Weinshilboum and J. Axerold, Circulation Res.28, 307 (1971).
S. H. Ngai, W. Dairman, M. Marchelle and S. Spector, Life Sci.14, 2431 (1974).
S. B. Ross, H. E. Eriksson and W. Hellstrom, Acta physiol. scand.92, 578 (1974).
D. Hamerman, L. C. Rosenberg and M. Schubert, J. Bone Joint Surg.52-A, 725 (1970).
A. G. García and S. M. Kipekar, J. Pharmac. exp. Ther.192, 343 (1975).
L. S. Freedman, T. Ohuchi, M. Goldstein, F. Axerold, I. Fish and J. Dancis. Nature236, 310 (1972).
M. Schubert and D. Hamerman, Bull. rheum. Dis.14, 345 (1964).
D. Hamerman and B. Peter, Bull. rheum. Dis.16, 396 (1966).
S. Friedman and S. Kaufman, J. biol. Chem.240, 4763 (1965).
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We thank for the expert technical assistance of Mr Angel García. We are grateful to Drs S. J. Fidone and A. Sillero for assistance with the manuscript. Supported by a grant from the Galerias Preciados Foundation, Valladolid, Spain.
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Sanchez-Martín, M., García, A.G. Dopamine beta-hydroxylase in human synovial fluid. Experientia 33, 650–652 (1977). https://doi.org/10.1007/BF01946554
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DOI: https://doi.org/10.1007/BF01946554