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  • 1
    Electronic Resource
    Electronic Resource
    A filterable virus as a causative agent of epidemic hepatitis (1944)
    Springer
    Antonie van Leeuwenhoek 10 (1944), S. 29-40 
    Details
    ISSN: 1572-9699
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology
    Notes: Summary In four patients suffering from epidemic hepatitis we succeeded in isolating from the blood during the fever period and from the urine during the jaundice, a filterable virus, which is pathogenic to the guinea pig and which can be inoculated to this animal in different ways, but by preference intraperitoneally. Fever, which sometimes lasts only one day, is the only morbid symptom observed in guinea pigs. In these animals the virus can be shown in the organs and in the blood during the fever period; after that it is excreted with the urine during apparently a short period. The virus has been grown on the chorioallantois of the chick embryo so far during 20 passages. The virus is resistant to glycerol, drying and low temperatures, not to formaline and heating. In the livers of the guinea pigs focal changes (degeneration, dissociation, necrobiosis, yellow liver-atrophy) may be found. After dulling through the disease immunity occurs, whilst in the serum of recovered patients and guinea pigs neutralizing antibodies can be detected.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF02272783
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  • 2
    Electronic Resource
    Electronic Resource
    The monkey pathogenicity of the Columbia SK virus and the mouse-adapted Lansing strain of poliomyelitis virus, and the influence of monkey passage on the characteristics of the virus (1950)
    Springer
    Antonie van Leeuwenhoek 16 (1950), S. 9-19 
    Details
    ISSN: 1572-9699
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology
    Notes: Summary The intracerebral inoculation of cynomolgus monkeys with Columbia SK virus (mouse brain suspension) produced flaccid paralysis after an incubation period of 3 to 5 days. In the spinal cord leucocytic infiltrations, acute necrosis and neuronophagia of anterior horn cells were found. Similar lesions, but far less extensive were found in the medulla and the brain stem, whereas leucocytic perivascular infiltrations were present in the motor area of the cerebral cortex. Small accumulations of leucocytes were observed in the heart muscle and in the epicardium. The Lansing strain of poliomyelitis virus produced essentially similar lesions, though less extensive, and the incubation period was 14 days. In the heart muscle and the epicardium of a Lansing-infected monkey small mononuclear infiltrations were found. The mouse infectivity titer of the ColSK virus decreased rapidly after monkey passage, and there was a simultaneous decrease of the hemagglutination titer with sheep red cells. No close antigenic relationship between the Y-SK and the ColSK virus was demonstrated by the hemagglutination inhibition reaction with sera from monkeys immunized against Y-SK and ColSK virus. The question is discussed, whether or not the ColSK group of viruses, which should be considered to be of animal origin, has to be classed into the family of poliomyelitis viruses as a fourth immunological type.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF02274395
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  • 3
    Electronic Resource
    Electronic Resource
    Studies on haemagglutination by the EMC-MM-Columbia SK-group of viruses (1951)
    Springer
    Antonie van Leeuwenhoek 17 (1951), S. 137-145 
    Details
    ISSN: 1572-9699
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF02062258
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  • 4
    Electronic Resource
    Electronic Resource
    Netherlands society for microbiology meeting at Utrecht on 15 May 1970 (1970)
    Springer
    Antonie van Leeuwenhoek 36 (1970), S. 579-587 
    Details
    ISSN: 1572-9699
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF02069060
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  • 5
    Electronic Resource
    Electronic Resource
    A phenomenon resembling anaphylactic shock after treatment with sulphapyridine (1944)
    Springer
    Antonie van Leeuwenhoek 10 (1944), S. 17-22 
    Details
    ISSN: 1572-9699
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology
    Notes: Summary Two patients on which a successful operation of the stomach had been performed developed fever some days after the operation, notwithstanding a prophylactic treatment with sulphapyridine and both of them died rather suddenly respectively 9 and 10 days after the operation. On obduction in both cases hemorrhagic serous-cellular bronchopneumonia were found in the caudal parts of the lungs, all the organs were very hyperaemious and the heart did not show any alteration. To account for the fatal course the possibility of chemospecific anaphylaxis to sulphapyridine has been considered. We succeeded in inducing in guinea pigs by means of sulphapyridine a shock, which, however, did not result in death. Such a shock could be induced as early as five days after sensibilization. The adding of the filtrate of inflammated lung tissue resulted in a deadly shock. In this connection the surmisal was made that also in the patients a sensibilization by sulphapyridine had occurred and that the pneumonia, which as such could not sufficiently account for the death, has furthered the arising of shock. We have pointed to the various facts which disagree with the identification of the phenomenon observed with an anaphylactic shock. We mention, however, that there is a certain agreement with the phenomenon ofSanarelli-Shartzman and that ofGlaubach.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF02272780
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  • 6
    Electronic Resource
    Electronic Resource
    Activation of inapparent infection with ectromelia and pneumonia virus in mice (1949)
    Springer
    Antonie van Leeuwenhoek 15 (1949), S. 41-48 
    Details
    ISSN: 1572-9699
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology
    Notes: Summary In mice used for the adaptation of a strain of influenza A virus, peculiar lunglesions, differing from influenza lesions, were found. Afterwards cases of ectromelia were observed in the same mouse colony, and the ectromelia virus was demonstrated in the clinically manifest cases as well as in the lunglesions of apparently normal mice that died after intranasal instillation of influenza virus. A few years later mice from a different colony were used for influenza B virus adaptation and in attempts to demonstrate a virus in the blood and throat washings of persons suffering from an acute respiratory disease, which prevailed in a rural municipality. In a number of mice that had been infected intranasally with influenza B virus, and with defibrinated blood and throat washings of patients, a pneumonia developed after some blind passages, which appeared to be caused by the mouse pneumonia virus. 10.4 per cent of apparently normal mice in the colony proved to be carriers of the virus. The causative agent of the epidemic in the village could not be detected. In convalescent as well as in acute phase and in normal sera from persons in a different region, neutralizing antibodies against the mouse pneumonia virus could be demonstrated.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF02062630
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  • 7
    Electronic Resource
    Electronic Resource
    Experimental transmission of infectious mononucleosis to monkeys, and the hemagglutination of erythrocytes treated with newcastle disease virus (1950)
    Springer
    Antonie van Leeuwenhoek 16 (1950), S. 21-30 
    Details
    ISSN: 1572-9699
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology
    Notes: Summary The intramuscular and subcutaneous inoculation of Cynomolgus monkeys with bacteriologically sterile blood, suspensions of swollen lymph glands, and with throat-washings treated with penicillin and streptomycin, from patients suffering from infectious mononucleosis, and the inoculation with cerebrospinal fluid from a patient presenting symptoms of meningoencephalitis in the course of infectious mononucleosis, resulted in an experimental disease, which resembled abortive cases of infectious mononucleosis in man. The principal features of the experimental disease were a rise of thePaul-Bunnell titre, an increase of the percentage of mononuclear cells, a slight leucocytosis followed by a slight to moderate leucopenia, and sometimes a febrile reaction. These results are suggestive for the viral etiology of infectious mononucleosis, and they indicate that the agent is present in the pharyngeal secretions. This may give an explanation for the method of spread of the disease. Human O and chicken erythrocytes were brought in contact with the virus of Newcastle Disease, and cells treated in that way were agglutinated by 27 of 28 normal human sera to a titre of 1:64 or less. From 39 mononucleosis sera 70 per cent caused hemagglutination of N.C.D. treated human red cells and 46 per cent caused hemagglutination of N.C.D. treated chicken red cells to a titre of 1:128 or higher (maximum 1:1024). No correlation could be demonstrated between the titre of thePaul-Bunnell reaction and that of the N.C.D. treated red cells.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF02274396
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  • 8
    Electronic Resource
    Electronic Resource
    Manifestation of a laboratory epizootic of rabbit pox by non-specific stimuli (1951)
    Springer
    Antonie van Leeuwenhoek 17 (1951), S. 232-236 
    Details
    ISSN: 1572-9699
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology
    Notes: Summary An epizootic of rabbit pox among laboratory rabbits is described. The animals were probably infected by neurovaccinia used in laboratory experiments. The disease appeared after intracerebral inoculation of cerebrospinal fluid from patients suffering from various disorders of the central nervous system, which indicates, that non-specific stimuli may give rise to a clinical manifestation of a latent infection, evidence of which was obtained experimentally. The virus isolated possessed the pathogenic and immunologic properties of neurovaccinia virus.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF02062268
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  • 9
    Electronic Resource
    Electronic Resource
    Virusmeningitis (1946)
    Springer
    Antonie van Leeuwenhoek 11 (1946), S. 180-185 
    Details
    ISSN: 1572-9699
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology
    Notes: Summary From the cerebrospinal fluid of a patient, suffering from a so-called aseptical meningitis, a virus was isolated, whose characteristics completely corresponded with the virus of lymphocytic choriomeningitis ofArmstrong andLillie. The intracerebral inoculation into the mouse is always fatal, and causes a lymphocytic meningo-encephalitis. The intraperitoneal and subcutaneous inoculations are usually not fatal, and do not always contract the disease. The virus could be cultivated on the egg membrane. The convalescent serum contained neutralizing antibodies.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF02272703
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  • 10
    Electronic Resource
    Electronic Resource
    Virus infection of the bone-marrow (1947)
    Springer
    Antonie van Leeuwenhoek 13 (1947), S. 149-152 
    Details
    ISSN: 1572-9699
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology
    Notes: Summary From the bone-marrow and the blood of two children who were suffering from a chronic disease characterized by intermittent fever and swelling of the spleen and the liver, a virus pathogenic for mice after intraperitoneal inoculation has been isolated. It could be cultivated in the chick embryo after inoculation in the allantoic cavity. In infected mice a developmental cycle has been shown. According to its properties the virus might be one of the psittacosis-lymphogranuloma venereum group, though an antigenic relationship with the viruses of psittacosis and lymphogranuloma venereum could not be established.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF02272756
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