ISSN:
1572-9699
Source:
Springer Online Journal Archives 1860-2000
Topics:
Biology
Notes:
Summary In mice used for the adaptation of a strain of influenza A virus, peculiar lunglesions, differing from influenza lesions, were found. Afterwards cases of ectromelia were observed in the same mouse colony, and the ectromelia virus was demonstrated in the clinically manifest cases as well as in the lunglesions of apparently normal mice that died after intranasal instillation of influenza virus. A few years later mice from a different colony were used for influenza B virus adaptation and in attempts to demonstrate a virus in the blood and throat washings of persons suffering from an acute respiratory disease, which prevailed in a rural municipality. In a number of mice that had been infected intranasally with influenza B virus, and with defibrinated blood and throat washings of patients, a pneumonia developed after some blind passages, which appeared to be caused by the mouse pneumonia virus. 10.4 per cent of apparently normal mice in the colony proved to be carriers of the virus. The causative agent of the epidemic in the village could not be detected. In convalescent as well as in acute phase and in normal sera from persons in a different region, neutralizing antibodies against the mouse pneumonia virus could be demonstrated.
Type of Medium:
Electronic Resource
URL:
http://dx.doi.org/10.1007/BF02062630
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