ISSN:
1572-9699
Source:
Springer Online Journal Archives 1860-2000
Topics:
Biology
Notes:
Summary The intracerebral inoculation of cynomolgus monkeys with Columbia SK virus (mouse brain suspension) produced flaccid paralysis after an incubation period of 3 to 5 days. In the spinal cord leucocytic infiltrations, acute necrosis and neuronophagia of anterior horn cells were found. Similar lesions, but far less extensive were found in the medulla and the brain stem, whereas leucocytic perivascular infiltrations were present in the motor area of the cerebral cortex. Small accumulations of leucocytes were observed in the heart muscle and in the epicardium. The Lansing strain of poliomyelitis virus produced essentially similar lesions, though less extensive, and the incubation period was 14 days. In the heart muscle and the epicardium of a Lansing-infected monkey small mononuclear infiltrations were found. The mouse infectivity titer of the ColSK virus decreased rapidly after monkey passage, and there was a simultaneous decrease of the hemagglutination titer with sheep red cells. No close antigenic relationship between the Y-SK and the ColSK virus was demonstrated by the hemagglutination inhibition reaction with sera from monkeys immunized against Y-SK and ColSK virus. The question is discussed, whether or not the ColSK group of viruses, which should be considered to be of animal origin, has to be classed into the family of poliomyelitis viruses as a fourth immunological type.
Type of Medium:
Electronic Resource
URL:
http://dx.doi.org/10.1007/BF02274395
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