ISSN:
1572-9699
Source:
Springer Online Journal Archives 1860-2000
Topics:
Biology
Notes:
Summary Two patients on which a successful operation of the stomach had been performed developed fever some days after the operation, notwithstanding a prophylactic treatment with sulphapyridine and both of them died rather suddenly respectively 9 and 10 days after the operation. On obduction in both cases hemorrhagic serous-cellular bronchopneumonia were found in the caudal parts of the lungs, all the organs were very hyperaemious and the heart did not show any alteration. To account for the fatal course the possibility of chemospecific anaphylaxis to sulphapyridine has been considered. We succeeded in inducing in guinea pigs by means of sulphapyridine a shock, which, however, did not result in death. Such a shock could be induced as early as five days after sensibilization. The adding of the filtrate of inflammated lung tissue resulted in a deadly shock. In this connection the surmisal was made that also in the patients a sensibilization by sulphapyridine had occurred and that the pneumonia, which as such could not sufficiently account for the death, has furthered the arising of shock. We have pointed to the various facts which disagree with the identification of the phenomenon observed with an anaphylactic shock. We mention, however, that there is a certain agreement with the phenomenon ofSanarelli-Shartzman and that ofGlaubach.
Type of Medium:
Electronic Resource
URL:
http://dx.doi.org/10.1007/BF02272780
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