ALBERT

All Library Books, journals and Electronic Records Telegrafenberg

X
feed icon rss

Your email was sent successfully. Check your inbox.

An error occurred while sending the email. Please try again.

Proceed reservation?

Export
  • 1
    facet.materialart.
    Unknown
    Reversal of bone loss in mice by nongenotropic signaling of sex steroids (2002)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 2002-10-26
    Description: We show that sex steroids protect the adult murine skeleton through a mechanism that is distinct from that used to preserve the mass and function of reproductive organs. The classical genotropic actions of sex steroid receptors are dispensable for their bone protective effects, but essential for their effects on reproductive tissues. A synthetic ligand (4-estren-3alpha,17beta-diol) that reproduces the nongenotropic effects of sex steroids, without affecting classical transcription, increases bone mass and strength in ovariectomized females above the level of the estrogen-replete state and is at least as effective as dihydrotestosterone in orchidectomized males, without affecting reproductive organs. Such ligands merit investigation as potential therapeutic alternatives to hormone replacement for osteoporosis in both women and men [corrected].〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Kousteni, S -- Chen, J R -- Bellido, T -- Han, L -- Ali, A A -- O'Brien, C A -- Plotkin, L -- Fu, Q -- Mancino, A T -- Wen, Y -- Vertino, A M -- Powers, C C -- Stewart, S A -- Ebert, R -- Parfitt, A M -- Weinstein, R S -- Jilka, R L -- Manolagas, S C -- KO2-AR02127/AR/NIAMS NIH HHS/ -- P01-AG13918/AG/NIA NIH HHS/ -- New York, N.Y. -- Science. 2002 Oct 25;298(5594):843-6.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Division of Endocrinology and Metabolism, Department of Internal Medicine, and Center for Osteoporosis and Metabolic Bone Diseases, University of Arkansas for Medical Sciences, Little Rock, AR 72205, USA.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/12399595" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; Apoptosis/drug effects ; Body Weight/drug effects ; Bone Density/*drug effects ; Bone and Bones/*drug effects/physiology ; Breast Neoplasms/pathology ; Cell Division/drug effects ; Cells, Cultured ; Compressive Strength/drug effects ; Dihydrotestosterone/pharmacology ; Estradiol/pharmacology ; Estrenes/metabolism/*pharmacology ; Female ; Humans ; Male ; Mice ; Orchiectomy ; Organ Size/drug effects ; Osteoblasts/*drug effects/physiology ; Osteocalcin/blood ; Osteoclasts/*drug effects/physiology ; Osteogenesis/drug effects ; Osteoporosis/drug therapy ; Ovariectomy ; Pyrazoles/pharmacology ; Receptors, Estrogen/metabolism ; Seminal Vesicles/drug effects ; Transcription, Genetic/drug effects ; Tumor Cells, Cultured ; Uterus/drug effects/metabolism
    Print ISSN: 0036-8075
    Electronic ISSN: 1095-9203
    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
    Published by American Association for the Advancement of Science (AAAS)
    Location Call Number Expected Availability
    BibTip Others were also interested in ...
    PAPER CURRENT
  • 2
    facet.materialart.
    Unknown
    Cell cycle arrest by Vpr in HIV-1 virions and insensitivity to antiretroviral agents (1998)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1998-07-10
    Description: Expression of human immunodeficiency virus-type 1 (HIV-1) Vpr after productive infection of T cells induces cell cycle arrest in the G2 phase of the cell cycle. In the absence of de novo expression, HIV-1 Vpr packaged into virions still induced cell cycle arrest. Naturally noninfectious virus or virus rendered defective for infection by reverse transcriptase or protease inhibitors were capable of inducing Vpr-mediated cell cycle arrest. These results suggest a model whereby both infectious and noninfectious virions in vivo, such as those surrounding follicular dendritic cells, participate in immune suppression.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Poon, B -- Grovit-Ferbas, K -- Stewart, S A -- Chen, I S -- AI28697/AI/NIAID NIH HHS/ -- CA70018/CA/NCI NIH HHS/ -- T32/A107388/PHS HHS/ -- New York, N.Y. -- Science. 1998 Jul 10;281(5374):266-9.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Department of Microbiology and Immunology and Medicine, UCLA AIDS Institute, and Jonsson Comprehensive Cancer Center, UCLA School of Medicine, Los Angeles, CA 90095, USA.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/9657723" target="_blank"〉PubMed〈/a〉
    Keywords: Anti-HIV Agents/pharmacology ; Antigens, Thy-1/analysis/genetics ; *G2 Phase/drug effects ; Gene Products, vpr/*physiology ; Genes, Reporter ; Genes, vpr ; HIV Protease Inhibitors/pharmacology ; HIV-1/drug effects/*physiology ; HeLa Cells ; Humans ; Indinavir/pharmacology ; Leukocytes/virology ; Nevirapine/pharmacology ; Reverse Transcriptase Inhibitors/pharmacology ; Virion/physiology ; Zidovudine/pharmacology ; vpr Gene Products, Human Immunodeficiency Virus
    Print ISSN: 0036-8075
    Electronic ISSN: 1095-9203
    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
    Published by American Association for the Advancement of Science (AAAS)
    Location Call Number Expected Availability
    BibTip Others were also interested in ...
    PAPER CURRENT
  • 3
    facet.materialart.
    Unknown
    \Structural geology of the Rub' Al-Khali Basin, Saudi Arabia (2016)
    Wiley
    In: Tectonics
    Details
    Publication Date: 2016-09-27
    Description: The Rub' Al-Khali basin lies below a Quaternary sand sea and the structural evolution from the late Precambrian to Neogene is known only from reflection seismic, gravity and magnetic data, and wells. Gravity and magnetic data show north-south and northwest-southeast trends, matching mapped Precambrian faults. The deepest structures imaged on reflection seismic data are undrilled Precambrian rifts filled with layered strata at depths up to 13 km. The distribution of Ediacaran – Cambrian Ara/Hormuz mobile salt is restricted to an embayment in the eastern Rub' Al-Khali. The Precambrian rifts show local inversion and were peneplained at base Phanerozoic. A broad crustal-scale fold (Qatar Arch) developed in the Carboniferous and amplified in the late Triassic, separating sub-basins in the west and east Rub' Al-Khali. A phase of kilometer-scale folding occurred in the late Cretaceous, coeval with thrusting and ophiolite obduction in eastern Oman. These folds trend predominantly north-south, oblique to the northwesterly shortening direction, and occasionally have steep fault zones close to their axial surfaces. The trend and location of these folds closely matches the Precambrian lineaments identified in this study, demonstrating preferential reactivation of basement structures. Compression along the Zagros suture reactivated these folds in the Neogene, this time the result of highly oblique, north-northeast to south-southwest shortening. Cretaceous-Tertiary fold style is interpreted as transpression with minor strain partitioning. Permian, Jurassic and Eocene evaporite horizons played no role in the structural evolution of the basin but the Eocene evaporites caused widespread kilometer-scale dissolution collapse structures in the basin center.
    Print ISSN: 0278-7407
    Electronic ISSN: 1944-9194
    Topics: Geosciences
    Published by Wiley on behalf of American Geophysical Union (AGU).
    Location Call Number Expected Availability
    BibTip Others were also interested in ...
    PAPER CURRENT
  • 4
    Electronic Resource
    Electronic Resource
    Identification of nucleotide-excision-repair genes on human chromosomes 2 and 13 by functional complementation in hamster-human hybrids (1987)
    Springer
    Somatic cell and molecular genetics 13 (1987), S. 539-551 
    Details
    ISSN: 1572-9931
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology , Medicine
    Notes: Abstract The CHO UV-sensitive mutants UV24 and UV135 (complementation groups 3 and 5, respectively) are defective in nucleotide excision repair. After fusing each mutant with human lymphocytes, resistant hybrid clones showing genetic complementation were isolated by repeated exposure to UV radiation. Using a combination of isozyme markers, DNA probes,and cytogenetic methods to analyze the primary hybrids and their subclones, correction of the repair defect was shown to be correlated with the presence of a specific human chromosome in each case. Chromosome 2 corrected UV24, and the gene responsible was designated ERCC3.Line UV135 was corrected by human chromosome 13 and the gene designated ERCC5.The UV-sensitive mouse cell line, Q31, was shown not to complement UV135 and thus appears to be mutated in the same genetic locus (homologous to ERCC5)as UV135. Breakage of complementing chromosomes with retention of the genes correcting repair defects allowed the following provisional assignments: regional localization of ERCC5to 13q14-q34, exclusion of ERCC3from the region of chromosome 2 distal to p23, and relief of the ambiguity of ACPlassignment (2p23 or 2p25) to 2p23 proximal to MDH1.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01534495
    Location Call Number Expected Availability
    BibTip Others were also interested in ...
    Paper (German National Licenses)
    Fulltext
  • 5
    Electronic Resource
    Electronic Resource
    An eighth complementation group of rodent cells hypersensitive to ultraviolet radiation (1988)
    Springer
    Somatic cell and molecular genetics 14 (1988), S. 605-612 
    Details
    ISSN: 1572-9931
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology , Medicine
    Notes: Abstract Two mutant lines (US31, US46) of mouse lymphoma cells that are hypersensitive to ultraviolet (UV) radiation were previously found to belong to different complementation groups. The mutants were tested for their ability to complement the six known complementation groups of UV-sensitive Chinese hamster ovary (CHO) cells, which are defective in nucleotide excision repair, as well as a seventh group represented by a V79 mutant. Hybrid cells were produced by fusion with polyethylene glycol and tested in situfor UV resistance. The mouse mutant US46 complemented all CHO mutants except UV61. Therefore, US46 is assigned to the same complementation group as UV61, and it is probably defective in the same locus. The mouse mutant US31 produced UV-resistant hybrid cells in each of the seven crosses, indicating that it forms an eighth complementation group among the rodent mutants. Thus, at least eight genes are likely required to repair UV damage in rodent cells.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01535314
    Location Call Number Expected Availability
    BibTip Others were also interested in ...
    Paper (German National Licenses)
    Fulltext
  • 6
    facet.materialart.
    Unknown
    Salt tectonics in the North Sea Basin: a structural style template for seismic interpreters (2007)
    In:  Geological Society Special Publication 272: 361-396.
    Details
    Publication Date: 2007-10-08
    Description: The North Sea Basin contains a widespread Permian salt layer that reached a depositional thickness of c. 1 km in the basin centre. This layer profoundly affected structural style of the post-salt succession and the basin can be divided into structural domains on this basis. In combination with regional 3D seismic data and several thousand wells this makes the North Sea a natural laboratory for salt tectonics. Four principal structural domains are illustrated here. (1) Minibasin subsidence and salt wall growth on the West Central Shelf in the Late Permian to Triassic. This area was exhumed and differentially eroded prior to Jurassic rifting, creating palaeogeomorphology analogous to the present-day Paradox Basin, Utah. (2) Regional tilt during the Mesozoic and Cenozoic led to basin-scale gravity sliding with updip detached extensional faults and downdip compressional structures, similar to gravity sliding in the circum-Atlantic salt basins. (3) Jurassic rifting propagated across the salt basin, displaying spatial variation in extensional fault style, partly as a function of salt layer thickness. (4) North Sea salt thickness was not sufficient for salt canopy development but there are two suites of minor intrusions: cylindrical, passive diapirs with associated fault and fracture patterns in the central North Sea, and sills where Permian salt from reactive diapirs intruded along thin Triassic salt layers in the southern North Sea. Cretaceous to Palaeogene regional shortening affected all these domains, resulting in a variety of reactivation styles that do not fit within commonly used definitions of inversion tectonics. The North Sea salt tectonic domains form the basis of a matrix approach to salt structure initiating and driving mechanisms, and a mechanostratigraphic scheme for tectonic structure classification.
    Location Call Number Expected Availability
    BibTip Others were also interested in ...
    PAPER
  • 7
    facet.materialart.
    Unknown
    The role of spectral curvature mapping in characterizing subsurface strain distributions (2003)
    In:  Geological Society Special Publication 209: 127-143.
    Details
    Publication Date: 2003-01-01
    Description: The curvature of structured geological surfaces can be used to assess the degree of strain they have undergone. In many hydrocarbon reservoirs, this strain is expressed as brittle fracturing that may significantly impact reservoir performance. Here we describe the development of an algorithm for measuring the curvature of gridded surfaces derived from seismic data. For any grid node, the algorithm calculates the magnitude and orientations of the two principal curvatures, K1 and K2, from which other curvature measurements can be derived, such as Gaussian curvature and summed absolute curvature (K1 + K2). The algorithm has also been used to generate plots of summed absolute curvature as a function of grid node separation (k versus {lambda}). These spectral' or k{lambda} plots can be generated for each grid node and allow the definition of short-wavelength, high-amplitude noise cut-off lengths. They also deliver intermediate wavelength features such as fault drag or buckle folding and the identification of long-wavelength (basin-scale) curvatures. Portions of these data can be collapsed into single values by calculating the integral of the k{lambda} curve. Further filters designed to screen the effects of background tectonic, or non-tectonic, curvatures can be applied to the k{lambda} integral. This algorithm has been tested using data from several North Sea chalk fields. A range of alternative types of curvature and curvature spectra are compared with other approaches to curvature calculation and other factors relevant to the calibration of such techniques in terms of the distribution of brittle fractures in sedimentary rocks. The k{lambda} integral provides a relatively simple approach to calculating the degree of multi-wavelength strain present at a particular grid node. Freeing algorithms from the restriction of the arbitrarily' selected minimum grid node spacing is a key step towards calibrating measured curvature against strain mechanisms. However, care must be taken to separate intrinsic and tectonic curvatures when generating and interpreting k{lambda} plots and their integrals.
    Location Call Number Expected Availability
    BibTip Others were also interested in ...
    PAPER
  • 8
    facet.materialart.
    Unknown
    Telomerase contributes to tumorigenesis by a telomere length-independent mechanism (2002)
    National Academy of Sciences
    Details
    Publication Date: 2002-08-22
    Print ISSN: 0027-8424
    Electronic ISSN: 1091-6490
    Topics: Biology , Medicine , Natural Sciences in General
    Published by National Academy of Sciences
    Location Call Number Expected Availability
    BibTip Others were also interested in ...
    PAPER CURRENT
  • 9
    facet.materialart.
    Unknown
    Lentiviral delivery of HIV-1 Vpr protein induces apoptosis in transformed cells (1999)
    National Academy of Sciences
    Details
    Publication Date: 1999-10-12
    Print ISSN: 0027-8424
    Electronic ISSN: 1091-6490
    Topics: Biology , Medicine , Natural Sciences in General
    Published by National Academy of Sciences
    Location Call Number Expected Availability
    BibTip Others were also interested in ...
    PAPER CURRENT
  • 10
    facet.materialart.
    Unknown
    Structural controls on mud volcano vent distributions: examples from Azerbaijan and Lusi, east Java (2011)
    Geological Society of London
    Details
    Publication Date: 2011-06-16
    Description: : Structural mapping, nearest neighbour and two-point azimuth statistical analysis of mud volcano vent distributions from nine examples in Azerbaijan and the Lusi mud volcano in east Java are described. Distributions are non-random, forming alignments subparallel to faults within anticlines, ring faults, conjugate faults and detachment faults; this finding confirms a spatial relationship and supports a model for subsurface flow along these features as well as showing fractionation at depth. As fracture and fault orientations are related to structures such as anticlines and the in situ stress state they are therefore predictable. We use vent distributions in Azerbaijan, where the structural geology is well constrained, to propose what controls the distribution of 169 vents at the Lusi mud volcano. This mud volcano system shows evidence for initial eruptions along a NE–SW trend, parallel to the Watukosek fault, changing to eruptions that follow east–west trends, subparallel to regional fold axes. Our analysis indicates that regions east and west of the Lusi mud volcano are more likely to be affected by new vents than those to the north and south, owing to probable onset of elongate caldera collapse within a 10 km diameter of the central vent.
    Print ISSN: 0016-7649
    Topics: Geosciences
    Published by Geological Society of London
    Location Call Number Expected Availability
    BibTip Others were also interested in ...
    PAPER CURRENT
Close ⊗
This website uses cookies and the analysis tool Matomo. More information can be found here...