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  • 1
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    Helix reorganization observed by transient 2D IR [Chemistry] (2013)
    National Academy of Sciences
    Details
    Publication Date: 2013-10-23
    Description: The relaxation of helical structures very close to equilibrium is observed via transient 2D IR spectroscopy. An initial distribution of synthetically distorted helices having an unnatural bridge linking the 10th and 12th residues of an alanine-rich α-helix is released to evolve into the equilibrium distribution of α-helix conformations. The bridge...
    Print ISSN: 0027-8424
    Electronic ISSN: 1091-6490
    Topics: Biology , Medicine , Natural Sciences in General
    Published by National Academy of Sciences
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  • 2
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    Histone H2B Ubiquitination Promotes the Function of the Anaphase-Promoting Complex/Cyclosome in Schizosaccharomyces pombe (2014)
    Genetics Society of America (GSA)
    Details
    Publication Date: 2014-08-14
    Description: Ubiquitination and deubiquitination of proteins are reciprocal events involved in many cellular processes, including the cell cycle. During mitosis, the metaphase to anaphase transition is regulated by the ubiquitin ligase activity of the anaphase-promoting complex/cyclosome (APC/C). Although the E3 ubiquitin ligase function of the APC/C has been well characterized, it is not clear whether deubiquitinating enzymes (DUBs) play a role in reversing APC/C substrate ubiquitination. Here we performed a genetic screen to determine what DUB, if any, antagonizes the function of the APC/C in the fission yeast Schizosaccharomyces pombe . We found that deletion of ubp8 , encoding the Spt-Ada-Gcn5-Acetyl transferase (SAGA) complex associated DUB, suppressed temperature-sensitive phenotypes of APC/C mutants cut9-665 , lid1-6 , cut4-533 , and slp1-362 . Our analysis revealed that Ubp8 antagonizes APC/C function in a mechanism independent of the spindle assembly checkpoint and proteasome activity. Notably, suppression of APC/C mutants was linked to loss of Ubp8 catalytic activity and required histone H2B ubiquitination. On the basis of these data, we conclude that Ubp8 antagonizes APC/C function indirectly by modulating H2B ubiquitination status.
    Electronic ISSN: 2160-1836
    Topics: Biology
    Published by Genetics Society of America (GSA)
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  • 3
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    Halo masses of Mg II absorbers at z~ 0.5 from Sloan Digital Sky Survey Data Release 7 (2014)
    Oxford University Press
    Details
    Publication Date: 2014-03-01
    Description: We present the cross-correlation function of Mg ii absorbers with respect to a volume-limited sample of luminous red galaxies (LRGs) at z  = 0.45–0.60 using the largest Mg ii absorber sample and a new LRG sample from Sloan Digital Sky Survey Data Release 7. We present the clustering signal of absorbers on projected scales r p = 0.3-35 h –1 Mpc in four $W_{\rm r}^{\lambda 2796}$ bins spanning $W_{\rm r}^{\lambda 2796}=0.4{\rm -}5.6$ Å. We found that on average Mg ii absorbers reside in haloes 〈log M h 〉 12.1, similar to the halo mass of an L * galaxy. We report that the weakest absorbers in our sample with $W_{\rm r}^{\lambda 2796}=0.4{\rm -}1.1$ Å reside in relatively massive haloes with $\langle \log M_{\rm h} \rangle \approx 12.5^{+0.6}_{-1.3}$ , while stronger absorbers reside in haloes of similar or lower masses 〈log M h 〉 11.6 + 0.9 . We compared our bias data points, b , and the frequency distribution function of absorbers, $f_{W_{\rm r}}$ , with a simple model incorporating an isothermal density profile to mimic the distribution of absorbing gas in haloes. We also compared the bias data points with Tinker & Chen who developed halo occupation distribution models of Mg ii absorbers that are constrained by b and $f_{W_{\rm r}}$ . The simple isothermal model can be ruled at a 2.8 level mostly because of its inability to reproduce $f_{W_{\rm r}}$ . However, b values are consistent with both models, including Tinker & Chen. In addition, we show that the mean b of absorbers does not decrease beyond $W_{\rm r}^{\lambda 2796} \approx 1.6$ Å. The flat or potential upturn of b for $W_{\rm r}^{\lambda 2796}\gtrsim 1.6$ Å absorbers suggests the presence of additional cool gas in massive haloes.
    Print ISSN: 0035-8711
    Electronic ISSN: 1365-2966
    Topics: Physics
    Published by Oxford University Press
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  • 4
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    PDZ domain binding selectivity is optimized across the mouse proteome (2007)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 2007-07-21
    Description: PDZ domains have long been thought to cluster into discrete functional classes defined by their peptide-binding preferences. We used protein microarrays and quantitative fluorescence polarization to characterize the binding selectivity of 157 mouse PDZ domains with respect to 217 genome-encoded peptides. We then trained a multidomain selectivity model to predict PDZ domain-peptide interactions across the mouse proteome with an accuracy that exceeds many large-scale, experimental investigations of protein-protein interactions. Contrary to the current paradigm, PDZ domains do not fall into discrete classes; instead, they are evenly distributed throughout selectivity space, which suggests that they have been optimized across the proteome to minimize cross-reactivity. We predict that focusing on families of interaction domains, which facilitates the integration of experimentation and modeling, will play an increasingly important role in future investigations of protein function.〈br /〉〈br /〉〈a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2674608/" target="_blank"〉〈img src="https://static.pubmed.gov/portal/portal3rc.fcgi/4089621/img/3977009" border="0"〉〈/a〉   〈a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2674608/" target="_blank"〉This paper as free author manuscript - peer-reviewed and accepted for publication〈/a〉〈br /〉〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Stiffler, Michael A -- Chen, Jiunn R -- Grantcharova, Viara P -- Lei, Ying -- Fuchs, Daniel -- Allen, John E -- Zaslavskaia, Lioudmila A -- MacBeath, Gavin -- 1 RO1 GM072872-01/GM/NIGMS NIH HHS/ -- 5 T32 GM07598-25/GM/NIGMS NIH HHS/ -- R01 GM072872/GM/NIGMS NIH HHS/ -- R01 GM072872-04/GM/NIGMS NIH HHS/ -- New York, N.Y. -- Science. 2007 Jul 20;317(5836):364-9.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Department of Chemistry and Chemical Biology, Harvard University, 12 Oxford Street, Cambridge, MA 02138, USA.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/17641200" target="_blank"〉PubMed〈/a〉
    Keywords: Algorithms ; Amino Acid Sequence ; Animals ; Computational Biology ; Computer Simulation ; Fluorescence Polarization ; Mice ; Peptides/*metabolism ; Protein Array Analysis ; Protein Binding ; *Protein Structure, Tertiary ; Proteome/chemistry/*metabolism
    Print ISSN: 0036-8075
    Electronic ISSN: 1095-9203
    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
    Published by American Association for the Advancement of Science (AAAS)
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  • 5
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    Reversal of bone loss in mice by nongenotropic signaling of sex steroids (2002)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 2002-10-26
    Description: We show that sex steroids protect the adult murine skeleton through a mechanism that is distinct from that used to preserve the mass and function of reproductive organs. The classical genotropic actions of sex steroid receptors are dispensable for their bone protective effects, but essential for their effects on reproductive tissues. A synthetic ligand (4-estren-3alpha,17beta-diol) that reproduces the nongenotropic effects of sex steroids, without affecting classical transcription, increases bone mass and strength in ovariectomized females above the level of the estrogen-replete state and is at least as effective as dihydrotestosterone in orchidectomized males, without affecting reproductive organs. Such ligands merit investigation as potential therapeutic alternatives to hormone replacement for osteoporosis in both women and men [corrected].〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Kousteni, S -- Chen, J R -- Bellido, T -- Han, L -- Ali, A A -- O'Brien, C A -- Plotkin, L -- Fu, Q -- Mancino, A T -- Wen, Y -- Vertino, A M -- Powers, C C -- Stewart, S A -- Ebert, R -- Parfitt, A M -- Weinstein, R S -- Jilka, R L -- Manolagas, S C -- KO2-AR02127/AR/NIAMS NIH HHS/ -- P01-AG13918/AG/NIA NIH HHS/ -- New York, N.Y. -- Science. 2002 Oct 25;298(5594):843-6.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Division of Endocrinology and Metabolism, Department of Internal Medicine, and Center for Osteoporosis and Metabolic Bone Diseases, University of Arkansas for Medical Sciences, Little Rock, AR 72205, USA.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/12399595" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; Apoptosis/drug effects ; Body Weight/drug effects ; Bone Density/*drug effects ; Bone and Bones/*drug effects/physiology ; Breast Neoplasms/pathology ; Cell Division/drug effects ; Cells, Cultured ; Compressive Strength/drug effects ; Dihydrotestosterone/pharmacology ; Estradiol/pharmacology ; Estrenes/metabolism/*pharmacology ; Female ; Humans ; Male ; Mice ; Orchiectomy ; Organ Size/drug effects ; Osteoblasts/*drug effects/physiology ; Osteocalcin/blood ; Osteoclasts/*drug effects/physiology ; Osteogenesis/drug effects ; Osteoporosis/drug therapy ; Ovariectomy ; Pyrazoles/pharmacology ; Receptors, Estrogen/metabolism ; Seminal Vesicles/drug effects ; Transcription, Genetic/drug effects ; Tumor Cells, Cultured ; Uterus/drug effects/metabolism
    Print ISSN: 0036-8075
    Electronic ISSN: 1095-9203
    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
    Published by American Association for the Advancement of Science (AAAS)
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  • 6
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    Legionnaires' disease: concentrations of selenium and other elements (1979)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1979-12-21
    Description: Selenium concentrations in the serums of 17 acutely ill Legionnaires' disease patients were significantly lower than in their matching convalescent-phase serums. This trend was not observed in ten similarly paired samples of serum from control patients with pneumonia. There were no significant differences in the concentrations of nickel, copper, bromine, rubidium, lead, barium, or titanium in the serums of Legionnaires' disease and control patients.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Chen, J R -- Anderson, J M -- New York, N.Y. -- Science. 1979 Dec 21;206(4425):1426-7.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/505018" target="_blank"〉PubMed〈/a〉
    Keywords: Humans ; Legionnaires' Disease/*blood ; Metals/blood ; Nickel/blood ; Selenium/*blood
    Print ISSN: 0036-8075
    Electronic ISSN: 1095-9203
    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
    Published by American Association for the Advancement of Science (AAAS)
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  • 7
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    End-Cap Modified Unsaturated Polyesters With Low Styrene Emission (2018)
    Institute of Physics (IOP)
    Details
    Publication Date: 2018-05-17
    Description: A benzyl end-cap-unsaturated polyester resin (BP-UPR) with low styrene emission was synthesized. The structure of BP-UPR was characterized by Fourier transform infrared (FT-IR) spectroscopy. According to gel permeation chromatography (GPC) measurement, the BP-UPR has a relative low molecular weight (M n =1754) and narrow polydispersity of 1.68. The styrene content of BP-UPR is only 25.1%, 8.3% lower than that of a commercial unsaturated polyester resin (C-UPR) with similar viscosity. The styrene emission of BP-UPR and C-UPR was compared by Luong–Walewski method. At the gel point (17 minutes), the styrene emission of BP-UPR is only 38.9g/m 2 , 15.9% lower than that of C-UPR. After curing for 2 hours, the total styrene emission of BP-UPR is only 62.5 g/m 2 , which is 48.0% lower than that of C-UPR.
    Print ISSN: 1757-8981
    Electronic ISSN: 1757-899X
    Topics: Mechanical Engineering, Materials Science, Production Engineering, Mining and Metallurgy, Traffic Engineering, Precision Mechanics
    Published by Institute of Physics (IOP)
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  • 8
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    Novel Ni-based catalysts for hydrogen generation from hydrolysis of ammonia borane (2018)
    Institute of Physics (IOP)
    Details
    Publication Date: 2018-07-13
    Description: Hydrogen can be regarded as the most promising clean energy in the 21 st century. Up to now, hydrogen production is still a challenge for scientists. With further research, many theories of hydrogen generation have been delivered successfully. Ni-based catalysts hydrolyze ammonia borane can be simple and effective. Ammonia borane (H 3 NBH 3 , AB) has the advantages of high hydrogen storage density and mild hydrogen release conditions. And in the paper, recent research achievements were reviewed on the application of Ni-based catalysts for hydrolysis of AB. It presented some kinds of catalysts with high catalysis capacities.
    Print ISSN: 1757-8981
    Electronic ISSN: 1757-899X
    Topics: Mechanical Engineering, Materials Science, Production Engineering, Mining and Metallurgy, Traffic Engineering, Precision Mechanics
    Published by Institute of Physics (IOP)
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  • 9
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    Thymic apoptosis drives tTreg development [Immunology] (2014)
    National Academy of Sciences
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    Publication Date: 2014-01-29
    Description: Maintenance of immune tolerance critically depends upon regulatory T cells that express the transcription factor forkhead box P3 (Foxp3). These CD4+ T cells can be generated in the thymus, termed thymus-derived regulatory T cells (tTregs), but their developmental pathway remains incompletely understood. tTreg development has been shown to be delayed...
    Print ISSN: 0027-8424
    Electronic ISSN: 1091-6490
    Topics: Biology , Medicine , Natural Sciences in General
    Published by National Academy of Sciences
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  • 10
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    3D microtissue failure [Cell Biology] (2013)
    National Academy of Sciences
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    Publication Date: 2013-12-25
    Description: In this paper we report a fundamental morphological instability of constrained 3D microtissues induced by positive chemomechanical feedback between actomyosin-driven contraction and the mechanical stresses arising from the constraints. Using a 3D model for mechanotransduction we find that perturbations in the shape of contractile tissues grow in an unstable manner...
    Print ISSN: 0027-8424
    Electronic ISSN: 1091-6490
    Topics: Biology , Medicine , Natural Sciences in General
    Published by National Academy of Sciences
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