Publication Date:
1995-06-09
Description:
A molecule isolated from the cerebrospinal fluid of sleep-deprived cats has been chemically characterized and identified as cis-9,10-octadecenoamide. Other fatty acid primary amides in addition to cis-9,10-octadecenoamide were identified as natural constituents of the cerebrospinal fluid of cat, rat, and human, indicating that these compounds compose a distinct family of brain lipids. Synthetic cis-9,10-octadecenoamide induced physiological sleep when injected into rats. Together, these results suggest that fatty acid primary amides may represent a previously unrecognized class of biological signaling molecules.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Cravatt, B F -- Prospero-Garcia, O -- Siuzdak, G -- Gilula, N B -- Henriksen, S J -- Boger, D L -- Lerner, R A -- 1 S10 RR07273-01/RR/NCRR NIH HHS/ -- New York, N.Y. -- Science. 1995 Jun 9;268(5216):1506-9.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Department of Chemistry, Scripps Research Institute, La Jolla, CA 92307, USA.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/7770779" target="_blank"〉PubMed〈/a〉
Keywords:
Animals
;
*Brain Chemistry
;
Cats
;
Cerebrosides/*cerebrospinal fluid/chemistry/pharmacology
;
Humans
;
Lipids/*cerebrospinal fluid/chemistry/pharmacology
;
Magnetic Resonance Spectroscopy
;
Mass Spectrometry
;
Molecular Weight
;
Oleic Acids/*cerebrospinal fluid/chemistry/pharmacology
;
Rats
;
Signal Transduction
;
*Sleep/drug effects
;
Spectrometry, Mass, Fast Atom Bombardment
;
Spectrophotometry, Infrared
Print ISSN:
0036-8075
Electronic ISSN:
1095-9203
Topics:
Biology
,
Chemistry and Pharmacology
,
Computer Science
,
Medicine
,
Natural Sciences in General
,
Physics
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