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  • 1
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    Modulation of the shade regulatory network [Plant Biology] (2014)
    National Academy of Sciences
    Details
    Publication Date: 2014-04-30
    Description: Plants such as Arabidopsis thaliana respond to foliar shade and neighbors who may become competitors for light resources by elongation growth to secure access to unfiltered sunlight. Challenges faced during this shade avoidance response (SAR) are different under a light-absorbing canopy and during neighbor detection where light remains abundant. In...
    Print ISSN: 0027-8424
    Electronic ISSN: 1091-6490
    Topics: Biology , Medicine , Natural Sciences in General
    Published by National Academy of Sciences
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  • 2
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    The magnitude and duration of Late Ordovician-Early Silurian glaciation (2011)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 2011-01-29
    Description: Understanding ancient climate changes is hampered by the inability to disentangle trends in ocean temperature from trends in continental ice volume. We used carbonate "clumped" isotope paleothermometry to constrain ocean temperatures, and thereby estimate ice volumes, through the Late Ordovician-Early Silurian glaciation. We find tropical ocean temperatures of 32 degrees to 37 degrees C except for short-lived cooling by ~5 degrees C during the final Ordovician stage. Evidence for ice sheets spans much of the study interval, but the cooling pulse coincided with a glacial maximum during which ice volumes likely equaled or exceeded those of the last (Pleistocene) glacial maximum. This cooling also coincided with a large perturbation of the carbon cycle and the Late Ordovician mass extinction.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Finnegan, Seth -- Bergmann, Kristin -- Eiler, John M -- Jones, David S -- Fike, David A -- Eisenman, Ian -- Hughes, Nigel C -- Tripati, Aradhna K -- Fischer, Woodward W -- New York, N.Y. -- Science. 2011 Feb 18;331(6019):903-6. doi: 10.1126/science.1200803. Epub 2011 Jan 27.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Division of Geological and Planetary Sciences, California Institute of Technology, Pasadena, CA 91125, USA. sethf@caltech.edu〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/21273448" target="_blank"〉PubMed〈/a〉
    Print ISSN: 0036-8075
    Electronic ISSN: 1095-9203
    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
    Published by American Association for the Advancement of Science (AAAS)
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  • 3
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    Detrimental consequences of small rapid laser fluctuations on stimulated Raman adiabatic passage (2014)
    American Physical Society (APS)
    Details
    Publication Date: 2014-01-24
    Description: Author(s): L. P. Yatsenko, B. W. Shore, and K. Bergmann We discuss the detrimental effect of small rapid random fluctuations of laser-field amplitude and phase upon the efficiency of stimulated Raman adiabatic passage (STIRAP). Such fluctuations typically accompany the laser stabilization procedures that produce nearly monochromatic light on top of a muc... [Phys. Rev. A 89, 013831] Published Thu Jan 23, 2014
    Keywords: Quantum optics, physics of lasers, nonlinear optics, classical optics
    Print ISSN: 1050-2947
    Electronic ISSN: 1094-1622
    Topics: Physics
    Published by American Physical Society (APS)
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  • 4
    Electronic Resource
    Electronic Resource
    Fundamental frequencies increasing with reduced masses: an inverse quantum isotope effect in molecules with shallow double-well potentials, E.g. semibullvalenes (1993)
    s.l. : American Chemical Society
    Journal of the American Chemical Society 115 (1993), S. 1490-1495 
    Details
    ISSN: 1520-5126
    Source: ACS Legacy Archives
    Topics: Chemistry and Pharmacology
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1021/ja00057a038
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  • 5
    Electronic Resource
    Electronic Resource
    Laser diagnostic in molecular beams (1975)
    Springer
    Applied physics 8 (1975), S. 65-70 
    Details
    ISSN: 1432-0630
    Keywords: Nozzle beams ; Laser Diagnostic
    Source: Springer Online Journal Archives 1860-2000
    Topics: Mechanical Engineering, Materials Science, Production Engineering, Mining and Metallurgy, Traffic Engineering, Precision Mechanics , Physics
    Notes: Abstract The output from a stabilized, tunable single-mode laser is split into two beams which cross the molecular beam perpendicularly and at an angle of β to the beam axis. Tuning the laser frequency across the unshifted and Doppler-shifted absorption profile of the molecular transition yileds the velocity distribution of the molecules in the beam for individual quantum states. The internal state distribution among vibrational and rotational levels in the beam can be determined by comparing the fluorescence simultaneously induced in the beam and in a cell with molecules in thermal equilibrium.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00883672
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  • 6
    Electronic Resource
    Electronic Resource
    Disposition of β-methyldigoxin in man (1975)
    Springer
    European journal of clinical pharmacology 9 (1975), S. 105-114 
    Details
    ISSN: 1432-1041
    Keywords: Methyldigoxin ; excretion ; deep compartment ; O-demethylation ; glycosides ; metabolism
    Source: Springer Online Journal Archives 1860-2000
    Topics: Chemistry and Pharmacology , Medicine
    Notes: Summary The time course of radioactivity in plasma and the excretion in urine and faeces over 7 days were determined in 12 healthy subjects after single oral and intravenous doses of a solution of3H-β-methyldigoxin. 62.2±2.1 and 29.0±5.2 per cent of the dose were excreted in urine and faeces, respectively, within 7 days of intravenous administration, compared with 55.2±2.8 and 28.6±5.7 per cent after oral administration. This indicates almost complete absorption of the glycoside when given in solution. 12 hours after its administration a pseudo-distribution equilibrium was reached and the average half life of tritiated compounds was 1.3 days. By 48 – 96 hours after treatment the average half life was 2.8 days. O-demethylation was revealed as the main metabolic degradation step in man. The rate of Demethylation was higher after oral than i.v. administration. Thus, only 31% of the radioactivity excreted in the urine consisted of unchanged β-methyldigoxin after oral administration compared to 51% after i.v. dosing. Only traces of bis- and monoglycosides were excreted in urine, but there were considerable amounts in faeces, where they accounted for more than 35% of the total excretion. Up to 40% of the radioactivity in plasma and urine consisted of polar conjugates during the first 12 hours after administration of β-methyldigoxin. The mono- and bisglycosides were identified as the main products of conjugation. During the 7 days approximately 15% of the administered dose was metabolized by splitting off glycosidic bonds and conjugation to polar compounds.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00614005
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  • 7
    Electronic Resource
    Electronic Resource
    Preface (1991)
    Springer
    European journal of clinical pharmacology 40 (1991), S. S1 
    Details
    ISSN: 1432-1041
    Source: Springer Online Journal Archives 1860-2000
    Topics: Chemistry and Pharmacology , Medicine
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01409398
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  • 8
    Electronic Resource
    Electronic Resource
    Differences in the response of serum lipoproteins to fenofibrate between women and men with primary hypercholesterolaemia (1996)
    Springer
    European journal of clinical pharmacology 50 (1996), S. 365-369 
    Details
    ISSN: 1432-1041
    Keywords: Key words Hyperlipoproteinaemia ; Fenofibrate; fenofibric acid ; sex differences ; long-term treatment
    Source: Springer Online Journal Archives 1860-2000
    Topics: Chemistry and Pharmacology , Medicine
    Notes: Abstract Objective: We studied possible sex differences of the effect of fenofibrate on serum lipoproteins. Twenty-three patients with primary hypercholesterolaemia (10 postmenopausal women and 13 aged-matched men) were treated with slow-release fenofibrate for 96 weeks. Results: Steady state lipoprotein concentrations were reached after 12 and 24 weeks of treatment in women and men, respectively. During the subsequent follow-up the lipoprotein concentrations remained constant. In women total and low-density lipoprotein (LDL) cholesterol decreased from 299 to 234 mg⋅dl−1 and from 210 to 151 mg⋅dl−1, respectively, and in men from 265 to 233 mg⋅dl−1 and from 192 to 160 mg⋅dl−1. The decrease in triglycerides was also more pronounced in women (−42%) than in men (−18%). High-density lipoprotein (HDL) cholesterol increased significantly in women from 53 to 63 mg⋅dl−1 but not in men (45 to 50 mg⋅dl−1). Since the changes in LDL and HDL cholesterol occurred in opposite directions, the decrease in LDL/HDL cholesterol ratio was accentuated in both groups. However, this ratio was decreased almost twofold in women (−41%) compared to men (−23%). Although the serum concentrations of fenofibric acid were 1.3-fold higher in women than in men, which was probably due to the higher body weight in men (1.2-fold), this difference can hardly explain the favorable effect on lipoproteins in women. Conclusion: The present study indicates that fenofibrate might be very effective by reducing the concentrations of atherogenic lipoproteins in postmenopausal women.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/s002280050124
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  • 9
    Electronic Resource
    Electronic Resource
    Mechanisms of action of plant sterols on inhibition of cholesterol absorption (1991)
    Springer
    European journal of clinical pharmacology 40 (1991), S. S59 
    Details
    ISSN: 1432-1041
    Keywords: Sitosterol ; sitostanol ; cholesterol absorption
    Source: Springer Online Journal Archives 1860-2000
    Topics: Chemistry and Pharmacology , Medicine
    Notes: Summary The effects of two different plant sterols on intestinal cholesterol absorption were compared in normal volunteers by an intestinal perfusion study during a control period followed by high dose infusion of sitosterol or sitostanol (3.6 μmol/min), to which subjects were allocated in a randomized manner. Cholesterol absorption during the control period was similar in the two groups, averaging 0.88 ± 0.48 μmol/min (32 ± 11%) for group I (sitosterol) and 0.68 ± 0.33 μmol/min (29 ± 9%) for group II (sitostanol). The infusion of a high dose of sitosterol resulted in a significant reduction of cholesterol absorption to 0.47 μmol/min (16%). Following the same dose of sitostanol, cholesterol absorption diminished significantly to 0.15 ± 0.11 μmol/min (5.1 ± 2.9%). Overall cholesterol absorption declined during sitosterol infusion by almost 50%, whereas sitostanol infusion caused a reduction of cholesterol absorption by almost 85%. These findings of a more effective inhibition of cholesterol absorption by sitostanol might confirm the observation recorded by others that an increase in hydrophobicity of a plant sterol results in a higher affinity but lower capacity to mixed micells. This may cause an effective displacement of cholesterol from micellar binding and therefore diminished cholesterol absorption.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01409411
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  • 10
    Electronic Resource
    Electronic Resource
    Short note (1991)
    Springer
    European journal of clinical pharmacology 40 (1991), S. 638-638 
    Details
    ISSN: 1432-1041
    Source: Springer Online Journal Archives 1860-2000
    Topics: Chemistry and Pharmacology , Medicine
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00279988
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