ALBERT

Description: California's ongoing, unprecedented drought is having profound impacts on the state's resources. Here we assess its impact on 98 deep-seated, slow-moving landslides in Northern California. We used aerial photograph analysis, satellite interferometry, and satellite pixel tracking to measure earthflow velocities spanning 1944–2015 and compared these trends with the Palmer Drought Severity Index, a proxy for soil moisture and pore pressure that governs landslide motion. We find that earthflow velocities reached a historical low in the 2012–2015 drought, but that their deceleration began at the turn of the century in response to a longer-term moisture deficit. Our analysis implies depth-dependent sensitivity of earthflows to climate forcing, with thicker earthflows reflecting longer-term climate trends and thinner earthflows exhibiting less systematic velocity variations. These findings have implications for mechanical-hydrologic interactions that link landslide movement with climate change as well as sediment delivery in the region.

Description: Transforming growth factor alpha (TGF-alpha) is produced by and required for the growth of epithelial cells and is angiogenic in vivo. Since epidermal hyperplasia and angiogenesis are hallmarks of psoriasis, TGF-alpha gene expression was analyzed in epidermal biopsies of normal and psoriatic skin. TGF-alpha messenger RNA and protein are much more abundant in lesional psoriatic epidermis than in normal-appearing skin of psoriatic patients or in normal epidermis. In contrast, messenger RNA levels of transforming growth factor beta 1 (TGF-beta 1), which inhibits epithelial cell growth, are not significantly different in normal, uninvolved, and lesional psoriatic epidermis. Thus, psoriatic epidermal hyperplasia may involve increased expression of a keratinocyte mitogen (TGF-alpha) rather than deficient expression of a growth inhibitor (TGF-beta 1).〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Elder, J T -- Fisher, G J -- Lindquist, P B -- Bennett, G L -- Pittelkow, M R -- Coffey, R J Jr -- Ellingsworth, L -- Derynck, R -- Voorhees, J J -- 5-T32-AM07197-10/AM/NIADDK NIH HHS/ -- New York, N.Y. -- Science. 1989 Feb 10;243(4892):811-4.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Department of Dermatology, University of Michigan, Ann Arbor 48109.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/2916128" target="_blank"〉PubMed〈/a〉

Description: The natriuretic peptides are hormones that can stimulate natriuretic, diuretic, and vasorelaxant activity in vivo, presumably through the activation of two known cell surface receptor guanylyl cyclases (ANPR-A and ANPR-B). Although atrial natriuretic peptide (ANP) and, to a lesser extent, brain natriuretic peptide (BNP) are efficient activators of the ANPR-A guanylyl cyclase, neither hormone can significantly stimulate ANPR-B. A member of this hormone family, C-type natriuretic peptide (CNP), potently and selectively activated the human ANPR-B guanylyl cyclase. CNP does not increase guanosine 3',5'-monophosphate accumulation in cells expressing human ANPR-A. The affinity of CNP for ANPR-B is 50- or 500-fold higher than ANP or BNP, respectively. This ligand-receptor pair may be involved in the regulation of fluid homeostasis by the central nervous system.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Koller, K J -- Lowe, D G -- Bennett, G L -- Minamino, N -- Kangawa, K -- Matsuo, H -- Goeddel, D V -- New York, N.Y. -- Science. 1991 Apr 5;252(5002):120-3.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Department of Molecular Biology, Genentech, Inc., South San Francisco 94080.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/1672777" target="_blank"〉PubMed〈/a〉

Description: To understand the biology and evolution of ruminants, the cattle genome was sequenced to about sevenfold coverage. The cattle genome contains a minimum of 22,000 genes, with a core set of 14,345 orthologs shared among seven mammalian species of which 1217 are absent or undetected in noneutherian (marsupial or monotreme) genomes. Cattle-specific evolutionary breakpoint regions in chromosomes have a higher density of segmental duplications, enrichment of repetitive elements, and species-specific variations in genes associated with lactation and immune responsiveness. Genes involved in metabolism are generally highly conserved, although five metabolic genes are deleted or extensively diverged from their human orthologs. The cattle genome sequence thus provides a resource for understanding mammalian evolution and accelerating livestock genetic improvement for milk and meat production.〈br /〉〈br /〉〈a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2943200/" target="_blank"〉〈img src="https://static.pubmed.gov/portal/portal3rc.fcgi/4089621/img/3977009" border="0"〉〈/a〉   〈a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2943200/" target="_blank"〉This paper as free author manuscript - peer-reviewed and accepted for publication〈/a〉〈br /〉〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Bovine Genome Sequencing and Analysis Consortium -- Elsik, Christine G -- Tellam, Ross L -- Worley, Kim C -- Gibbs, Richard A -- Muzny, Donna M -- Weinstock, George M -- Adelson, David L -- Eichler, Evan E -- Elnitski, Laura -- Guigo, Roderic -- Hamernik, Debora L -- Kappes, Steve M -- Lewin, Harris A -- Lynn, David J -- Nicholas, Frank W -- Reymond, Alexandre -- Rijnkels, Monique -- Skow, Loren C -- Zdobnov, Evgeny M -- Schook, Lawrence -- Womack, James -- Alioto, Tyler -- Antonarakis, Stylianos E -- Astashyn, Alex -- Chapple, Charles E -- Chen, Hsiu-Chuan -- Chrast, Jacqueline -- Camara, Francisco -- Ermolaeva, Olga -- Henrichsen, Charlotte N -- Hlavina, Wratko -- Kapustin, Yuri -- Kiryutin, Boris -- Kitts, Paul -- Kokocinski, Felix -- Landrum, Melissa -- Maglott, Donna -- Pruitt, Kim -- Sapojnikov, Victor -- Searle, Stephen M -- Solovyev, Victor -- Souvorov, Alexandre -- Ucla, Catherine -- Wyss, Carine -- Anzola, Juan M -- Gerlach, Daniel -- Elhaik, Eran -- Graur, Dan -- Reese, Justin T -- Edgar, Robert C -- McEwan, John C -- Payne, Gemma M -- Raison, Joy M -- Junier, Thomas -- Kriventseva, Evgenia V -- Eyras, Eduardo -- Plass, Mireya -- Donthu, Ravikiran -- Larkin, Denis M -- Reecy, James -- Yang, Mary Q -- Chen, Lin -- Cheng, Ze -- Chitko-McKown, Carol G -- Liu, George E -- Matukumalli, Lakshmi K -- Song, Jiuzhou -- Zhu, Bin -- Bradley, Daniel G -- Brinkman, Fiona S L -- Lau, Lilian P L -- Whiteside, Matthew D -- Walker, Angela -- Wheeler, Thomas T -- Casey, Theresa -- German, J Bruce -- Lemay, Danielle G -- Maqbool, Nauman J -- Molenaar, Adrian J -- Seo, Seongwon -- Stothard, Paul -- Baldwin, Cynthia L -- Baxter, Rebecca -- Brinkmeyer-Langford, Candice L -- Brown, Wendy C -- Childers, Christopher P -- Connelley, Timothy -- Ellis, Shirley A -- Fritz, Krista -- Glass, Elizabeth J -- Herzig, Carolyn T A -- Iivanainen, Antti -- Lahmers, Kevin K -- Bennett, Anna K -- Dickens, C Michael -- Gilbert, James G R -- Hagen, Darren E -- Salih, Hanni -- Aerts, Jan -- Caetano, Alexandre R -- Dalrymple, Brian -- Garcia, Jose Fernando -- Gill, Clare A -- Hiendleder, Stefan G -- Memili, Erdogan -- Spurlock, Diane -- Williams, John L -- Alexander, Lee -- Brownstein, Michael J -- Guan, Leluo -- Holt, Robert A -- Jones, Steven J M -- Marra, Marco A -- Moore, Richard -- Moore, Stephen S -- Roberts, Andy -- Taniguchi, Masaaki -- Waterman, Richard C -- Chacko, Joseph -- Chandrabose, Mimi M -- Cree, Andy -- Dao, Marvin Diep -- Dinh, Huyen H -- Gabisi, Ramatu Ayiesha -- Hines, Sandra -- Hume, Jennifer -- Jhangiani, Shalini N -- Joshi, Vandita -- Kovar, Christie L -- Lewis, Lora R -- Liu, Yih-Shin -- Lopez, John -- Morgan, Margaret B -- Nguyen, Ngoc Bich -- Okwuonu, Geoffrey O -- Ruiz, San Juana -- Santibanez, Jireh -- Wright, Rita A -- Buhay, Christian -- Ding, Yan -- Dugan-Rocha, Shannon -- Herdandez, Judith -- Holder, Michael -- Sabo, Aniko -- Egan, Amy -- Goodell, Jason -- Wilczek-Boney, Katarzyna -- Fowler, Gerald R -- Hitchens, Matthew Edward -- Lozado, Ryan J -- Moen, Charles -- Steffen, David -- Warren, James T -- Zhang, Jingkun -- Chiu, Readman -- Schein, Jacqueline E -- Durbin, K James -- Havlak, Paul -- Jiang, Huaiyang -- Liu, Yue -- Qin, Xiang -- Ren, Yanru -- Shen, Yufeng -- Song, Henry -- Bell, Stephanie Nicole -- Davis, Clay -- Johnson, Angela Jolivet -- Lee, Sandra -- Nazareth, Lynne V -- Patel, Bella Mayurkumar -- Pu, Ling-Ling -- Vattathil, Selina -- Williams, Rex Lee Jr -- Curry, Stacey -- Hamilton, Cerissa -- Sodergren, Erica -- Wheeler, David A -- Barris, Wes -- Bennett, Gary L -- Eggen, Andre -- Green, Ronnie D -- Harhay, Gregory P -- Hobbs, Matthew -- Jann, Oliver -- Keele, John W -- Kent, Matthew P -- Lien, Sigbjorn -- McKay, Stephanie D -- McWilliam, Sean -- Ratnakumar, Abhirami -- Schnabel, Robert D -- Smith, Timothy -- Snelling, Warren M -- Sonstegard, Tad S -- Stone, Roger T -- Sugimoto, Yoshikazu -- Takasuga, Akiko -- Taylor, Jeremy F -- Van Tassell, Curtis P -- Macneil, Michael D -- Abatepaulo, Antonio R R -- Abbey, Colette A -- Ahola, Virpi -- Almeida, Iassudara G -- Amadio, Ariel F -- Anatriello, Elen -- Bahadue, Suria M -- Biase, Fernando H -- Boldt, Clayton R -- Carroll, Jeffery A -- Carvalho, Wanessa A -- Cervelatti, Eliane P -- Chacko, Elsa -- Chapin, Jennifer E -- Cheng, Ye -- Choi, Jungwoo -- Colley, Adam J -- de Campos, Tatiana A -- De Donato, Marcos -- Santos, Isabel K F de Miranda -- de Oliveira, Carlo J F -- Deobald, Heather -- Devinoy, Eve -- Donohue, Kaitlin E -- Dovc, Peter -- Eberlein, Annett -- Fitzsimmons, Carolyn J -- Franzin, Alessandra M -- Garcia, Gustavo R -- Genini, Sem -- Gladney, Cody J -- Grant, Jason R -- Greaser, Marion L -- Green, Jonathan A -- Hadsell, Darryl L -- Hakimov, Hatam A -- Halgren, Rob -- Harrow, Jennifer L -- Hart, Elizabeth A -- Hastings, Nicola -- Hernandez, Marta -- Hu, Zhi-Liang -- Ingham, Aaron -- Iso-Touru, Terhi -- Jamis, Catherine -- Jensen, Kirsty -- Kapetis, Dimos -- Kerr, Tovah -- Khalil, Sari S -- Khatib, Hasan -- Kolbehdari, Davood -- Kumar, Charu G -- Kumar, Dinesh -- Leach, Richard -- Lee, Justin C-M -- Li, Changxi -- Logan, Krystin M -- Malinverni, Roberto -- Marques, Elisa -- Martin, William F -- Martins, Natalia F -- Maruyama, Sandra R -- Mazza, Raffaele -- McLean, Kim L -- Medrano, Juan F -- Moreno, Barbara T -- More, Daniela D -- Muntean, Carl T -- Nandakumar, Hari P -- Nogueira, Marcelo F G -- Olsaker, Ingrid -- Pant, Sameer D -- Panzitta, Francesca -- Pastor, Rosemeire C P -- Poli, Mario A -- Poslusny, Nathan -- Rachagani, Satyanarayana -- Ranganathan, Shoba -- Razpet, Andrej -- Riggs, Penny K -- Rincon, Gonzalo -- Rodriguez-Osorio, Nelida -- Rodriguez-Zas, Sandra L -- Romero, Natasha E -- Rosenwald, Anne -- Sando, Lillian -- Schmutz, Sheila M -- Shen, Libing -- Sherman, Laura -- Southey, Bruce R -- Lutzow, Ylva Strandberg -- Sweedler, Jonathan V -- Tammen, Imke -- Telugu, Bhanu Prakash V L -- Urbanski, Jennifer M -- Utsunomiya, Yuri T -- Verschoor, Chris P -- Waardenberg, Ashley J -- Wang, Zhiquan -- Ward, Robert -- Weikard, Rosemarie -- Welsh, Thomas H Jr -- White, Stephen N -- Wilming, Laurens G -- Wunderlich, Kris R -- Yang, Jianqi -- Zhao, Feng-Qi -- 062023/Wellcome Trust/United Kingdom -- 077198/Wellcome Trust/United Kingdom -- BBS/B/13438/Biotechnology and Biological Sciences Research Council/United Kingdom -- BBS/B/13446/Biotechnology and Biological Sciences Research Council/United Kingdom -- P30 DA018310/DA/NIDA NIH HHS/ -- U54 HG003273/HG/NHGRI NIH HHS/ -- U54 HG003273-04/HG/NHGRI NIH HHS/ -- U54 HG003273-04S1/HG/NHGRI NIH HHS/ -- U54 HG003273-05/HG/NHGRI NIH HHS/ -- U54 HG003273-05S1/HG/NHGRI NIH HHS/ -- U54 HG003273-05S2/HG/NHGRI NIH HHS/ -- U54 HG003273-06/HG/NHGRI NIH HHS/ -- U54 HG003273-06S1/HG/NHGRI NIH HHS/ -- U54 HG003273-06S2/HG/NHGRI NIH HHS/ -- U54 HG003273-07/HG/NHGRI NIH HHS/ -- U54 HG003273-08/HG/NHGRI NIH HHS/ -- New York, N.Y. -- Science. 2009 Apr 24;324(5926):522-8. doi: 10.1126/science.1169588.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/19390049" target="_blank"〉PubMed〈/a〉

Description: ABSTRACT Landslides and rockfalls are key geomorphic processes in mountain basins. Their quantification and characterization are critical for understanding the processes of slope failure and their contributions to erosion and landscape evolution. We used digital photogrammetry to produce a multi-temporal record of erosion (1963 – 2005) of a rock slope at the head of the Illgraben, a very active catchment prone to debris flows in Switzerland. Slope failures affect 70% of the study slope and erode the slope at an average rate of 0.39 ± 0.03 m yr¯¹. The analysis of individual slope failures yielded an inventory of ~2500 failures ranging over 6 orders of magnitude in volume, despite the small slope area and short study period. The slope failures form a characteristic magnitude-frequency distribution with a rollover and a power-law tail between ~200 m³ and 1.6x10⁶ m³ with an exponent of 1.65. Slope failure volume scales with area as a power law with an exponent of 1.1. Both values are low for studies of bedrock landslides and rockfall and result from the highly fractured and weathered state of the quartzitic bedrock. Our data suggest that the magnitude-frequency distribution is the result of two separate slope failure processes. Type (1) failures are frequent, small slides and slumps within the weathered layer of highly fractured rock and loose sediment, and make up the rollover. Type (2) failures are less frequent and larger rockslides and rockfalls within the internal bedded and fractured slope along pre-determined potential failure surfaces, and make up the power-law tail. Rockslides and rockfalls of high magnitude and relatively low frequency make up 99% of the total failure volume and are thus responsible for the high erosion rate. They are also significant in the context of landscape evolution as they occur on slopes above 45° and limit the relief of the slope. Copyright © 2012 John Wiley & Sons, Ltd.

Description: Identifying and quantifying the dominant processes of erosion and tracking the fate of sediment, wood, and carbon eroded during floods is important for understanding channel response to floods, downstream sediment and carbon loading, and the influence of extreme events on landscapes and the terrestrial carbon cycle. We quantify sediment, wood, and organic carbon (OC) from source to local sink following an extreme flood in the tectonically quiescent, semiarid Colorado (USA) Front Range. Erosion of 〉500,000 m 3 or as much as ~115 yr of weathering products occurred through landsliding and channel erosion during September 2013 flooding. More than half of the eroded sediment was deposited at the inlet and delta of a water supply reservoir, resulting in the equivalent of 100 yr of reservoir sedimentation and 2% loss in water storage capacity. The flood discharged 28 Mg C/km 2 , producing an event OC flux equivalent to humid, tectonically active areas. Post-flood remobilization resulted in a further ~100 yr of reservoir sedimentation plus export of an additional 1.3 Mg C/km 2 of wood, demonstrating the ongoing impact of the flood on reservoir capacity and carbon cycling. Pronounced channel widening during the flood created accommodation space for 40% of flood sediment and storage of wood and eroded carbon. We conclude that confined channels, normally dismissed as transport reaches, can store and export substantial amounts of flood constituents.

Description: Variable geometry and distribution of stratigraphic sequences of fluvial fans in the eastern San Joaquin Basin, California, were controlled by tectonics, through basin subsidence and basin width, and response to Quaternary climate change, related to the degree of change in sediment supply to stream discharge ratios and local base-level elevation changes. Three fluvial fans -- the Kings River, Tuolumne River and Chowchilla River fans -- illustrate the influence of these factors on ultimate sequence geometry. In areas with high subsidence rates (e.g. the Kings River fluvial fan) sequences are relatively thick and apices of subsequent sequences are vertically stacked. Areas with relatively low subsidence rates (e.g. the Tuolumne River fan) produced laterally stacked sequences. Rivers that experienced a significant increase in sediment supply to stream discharge ratios due to direct connection to outwash from glaciated portions of the Sierra Nevada developed high accommodation space and relatively thick sequences with deep incised valleys. Conversely, rivers that were not connected to glaciated regions (e.g. the Chowchilla River fan) and, thus, experienced a relatively minor change in sediment supply to discharge ratios during climate change events, produced thinner sequences that lack deep incised valleys. Local base-level connection to sea level, via the axial San Joaquin River, produced deeper incised valleys than those of internally drained rivers. Finally, narrow basin width allowed glacially connected fans to completely fill available accommodation space, thus producing smaller fans that lack preservation of distal, interglacial deposits. Evaluation of these controls allows prediction of sequence geometries and facies distributions for other San Joaquin Basin fans for input into future hydrogeological models.

Description: Establishing landscape response to uplift is critical for interpreting sediment fluxes, hazard potential, and topographic evolution. We assess how landslides shape terrain in response to a wave of uplift traversing the northern California Coast Ranges (United States) in the wake of the Mendocino Triple Junction. We extracted knickpoints, landslide erosion rates, and topographic metrics across the region modified by Mendocino Triple Junction migration. Landslide erosion rates mapped from aerial imagery are consistent with modeled uplift and exhumation, while hillslope gradient is invariant across the region, suggesting that landslides accommodate uplift, as predicted by the threshold slope model. Landslides are concentrated along steepened channel reaches downstream of knickpoints generated by base-level fall at channel outlets, and limit slope angles and relief. We find evidence that landslide-derived coarse sediment delivery may suppress catchment-wide channel incision and landscape denudation over the time required for the uplift wave to traverse the region. We conclude that a landslide cover effect may provide a mechanism for the survival of relict terrain and orogenic relief in the northern Californian Coast Ranges and elsewhere over millennial time scales.