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  • 1
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    A promiscuous intermediate underlies the evolution of LEAFY DNA binding specificity (2014)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 2014-01-18
    Description: Transcription factors (TFs) are key players in evolution. Changes affecting their function can yield novel life forms but may also have deleterious effects. Consequently, gene duplication events that release one gene copy from selective pressure are thought to be the common mechanism by which TFs acquire new activities. Here, we show that LEAFY, a major regulator of flower development and cell division in land plants, underwent changes to its DNA binding specificity, even though plant genomes generally contain a single copy of the LEAFY gene. We examined how these changes occurred at the structural level and identify an intermediate LEAFY form in hornworts that appears to adopt all different specificities. This promiscuous intermediate could have smoothed the evolutionary transitions, thereby allowing LEAFY to evolve new binding specificities while remaining a single-copy gene.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Sayou, Camille -- Monniaux, Marie -- Nanao, Max H -- Moyroud, Edwige -- Brockington, Samuel F -- Thevenon, Emmanuel -- Chahtane, Hicham -- Warthmann, Norman -- Melkonian, Michael -- Zhang, Yong -- Wong, Gane Ka-Shu -- Weigel, Detlef -- Parcy, Francois -- Dumas, Renaud -- New York, N.Y. -- Science. 2014 Feb 7;343(6171):645-8. doi: 10.1126/science.1248229. Epub 2014 Jan 16.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉CNRS, Laboratoire de Physiologie Cellulaire et Vegetale (LPCV), UMR 5168, 38054 Grenoble, France.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/24436181" target="_blank"〉PubMed〈/a〉
    Keywords: Amino Acid Sequence ; Arabidopsis Proteins/chemistry/classification/genetics ; DNA, Plant/*chemistry ; DNA-Binding Proteins/*chemistry/classification/*genetics ; Electrophoretic Mobility Shift Assay ; *Evolution, Molecular ; Gene Dosage ; Molecular Sequence Data ; Mutation ; Phylogeny ; Plant Proteins/*chemistry/classification/*genetics ; Protein Binding/genetics ; Protein Structure, Tertiary ; Species Specificity ; Transcription Factors/chemistry/classification/genetics
    Print ISSN: 0036-8075
    Electronic ISSN: 1095-9203
    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
    Published by American Association for the Advancement of Science (AAAS)
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  • 2
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    Evolution. Response to Comment on "A promiscuous intermediate underlies the evolution of LEAFY DNA binding specificity" (2015)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 2015-02-07
    Description: Brunkard et al. propose that the identification of novel LEAFY sequences contradicts our model of evolution through promiscuous intermediates. Based on the debate surrounding land plant phylogeny and on our analysis of these interesting novel sequences, we explain why there is no solid evidence to disprove our model.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Brockington, Samuel F -- Moyroud, Edwige -- Sayou, Camille -- Monniaux, Marie -- Nanao, Max H -- Thevenon, Emmanuel -- Chahtane, Hicham -- Warthmann, Norman -- Melkonian, Michael -- Zhang, Yong -- Wong, Gane Ka-Shu -- Weigel, Detlef -- Dumas, Renaud -- Parcy, Francois -- New York, N.Y. -- Science. 2015 Feb 6;347(6222):621. doi: 10.1126/science.1256011.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Department of Plant Sciences, University of Cambridge, Downing Street, Cambridge CB2 3EA, UK. ; Wellcome Trust Center for Cell Biology, Michael Swann Building 5.1, King's Buildings. Edinburgh, EH9 3JR, UK. ; Department of Comparative Development and Genetics, Max Planck Institute for Plant Breeding Research, Carl-von-Linne Weg 10, 50829, Koln, Germany. ; European Molecular Biology Laboratory (EMBL), 6 Rue Jules Horowitz, BP 181, 38042 Grenoble, France. Unit of Virus Host-Cell Interactions, Universite Grenoble Alpes (UGA), Centre National de la Recherche Scientifique (CNRS), EMBL, UMI 3265, 6 Rue Jules Horowitz, 38042 Grenoble Cedex 9, France. francois.parcy@cea.fr mnanao@embl.fr. ; CNRS, Laboratoire de Physiologie Cellulaire et Vegetale (LPCV), UMR 5168, 38054 Grenoble, France. UGA, LPCV, F-38054 Grenoble, France. Commissariat a l'energie atomique et aux energies alternatives, Direction des Sciences du Vivant, Institut de Recherches en Technologies et Sciences pour le Vivant, LPCV, F-38054 Grenoble, France. Institut National de la Recherche Agronomique, LPCV, F-38054 Grenoble, France. ; Research School of Biology, The Australian National University, Acton, ACT 0200, Australia. ; Botanisches Institut, Lehrstuhl I, Universitat zu Koln, Biozentrum Koln, Zulpicher Strasse 47b, 50674 Koln, Germany. ; Beijing Genomics Institute, Shenzhen, Beishan Industrial Zone, Yantian District, Shenzhen 518083, China. ; Beijing Genomics Institute, Shenzhen, Beishan Industrial Zone, Yantian District, Shenzhen 518083, China Department of Biological Sciences, Department of Medicine, University of Alberta, Edmonton AB, T6G 2E9, Canada. ; Department of Molecular Biology, Max Planck Institute for Developmental Biology, 72076 Tubingen, Germany. ; CNRS, Laboratoire de Physiologie Cellulaire et Vegetale (LPCV), UMR 5168, 38054 Grenoble, France. UGA, LPCV, F-38054 Grenoble, France. Commissariat a l'energie atomique et aux energies alternatives, Direction des Sciences du Vivant, Institut de Recherches en Technologies et Sciences pour le Vivant, LPCV, F-38054 Grenoble, France. Institut National de la Recherche Agronomique, LPCV, F-38054 Grenoble, France. francois.parcy@cea.fr mnanao@embl.fr.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/25657241" target="_blank"〉PubMed〈/a〉
    Keywords: DNA, Plant/*chemistry ; DNA-Binding Proteins/*chemistry/*genetics ; *Evolution, Molecular ; Plant Proteins/*chemistry/*genetics
    Print ISSN: 0036-8075
    Electronic ISSN: 1095-9203
    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
    Published by American Association for the Advancement of Science (AAAS)
    Location Call Number Expected Availability
    BibTip Others were also interested in ...
    PAPER CURRENT
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