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  • 1
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    Organ regeneration does not require a functional stem cell niche in plants (2009)
    Nature Publishing Group (NPG)
    Details
    Publication Date: 2009-02-03
    Description: Plants rely on the maintenance of stem cell niches at their apices for the continuous growth of roots and shoots. However, although the developmental plasticity of plant cells has been demonstrated, it is not known whether the stem cell niche is required for organogenesis. Here we explore the capacity of a broad range of differentiating cells to regenerate an organ without the activity of a stem cell niche. Using a root-tip regeneration system in Arabidopsis thaliana to track the molecular and functional recovery of cell fates, we show that re-specification of lost cell identities begins within hours of excision and that the function of specialized cells is restored within one day. Critically, regeneration proceeds in plants with mutations that fail to maintain the stem cell niche. These results show that stem-cell-like properties that mediate complete organ regeneration are dispersed in plant meristems and are not restricted to niches, which nonetheless seem to be necessary for indeterminate growth. This regenerative reprogramming of an entire organ without transition to a stereotypical stem cell environment has intriguing parallels to recent reports of induced transdifferentiation of specific cell types in the adult organs of animals.〈br /〉〈br /〉〈a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2649681/" target="_blank"〉〈img src="https://static.pubmed.gov/portal/portal3rc.fcgi/4089621/img/3977009" border="0"〉〈/a〉   〈a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2649681/" target="_blank"〉This paper as free author manuscript - peer-reviewed and accepted for publication〈/a〉〈br /〉〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Sena, Giovanni -- Wang, Xiaoning -- Liu, Hsiao-Yun -- Hofhuis, Hugo -- Birnbaum, Kenneth D -- 5R01GM078279/GM/NIGMS NIH HHS/ -- R01 GM078279/GM/NIGMS NIH HHS/ -- R01 GM078279-03/GM/NIGMS NIH HHS/ -- England -- Nature. 2009 Feb 26;457(7233):1150-3. doi: 10.1038/nature07597. Epub 2009 Jan 28.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉New York University, Department of Biology, Center for Genomics and Systems Biology, Silver Building, 100 Washington Square East, New York, New York 10003, USA.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/19182776" target="_blank"〉PubMed〈/a〉
    Keywords: Arabidopsis/cytology/*growth & development ; Biomarkers/analysis ; Cell Lineage ; Cell Transdifferentiation ; Indoleacetic Acids/metabolism ; Oligonucleotide Array Sequence Analysis ; Organogenesis ; Plant Roots/cytology/growth & development ; Regeneration/*physiology ; Starch/analysis/metabolism ; *Stem Cell Niche/physiology ; Stem Cells/cytology/metabolism
    Print ISSN: 0028-0836
    Electronic ISSN: 1476-4687
    Topics: Biology , Chemistry and Pharmacology , Medicine , Natural Sciences in General , Physics
    Published by Nature Publishing Group (NPG)
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  • 2
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    A molecular framework for plant regeneration (2006)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 2006-01-21
    Description: Plants and some animals have a profound capacity to regenerate organs from adult tissues. Molecular mechanisms for regeneration have, however, been largely unexplored. Here we investigate a local regeneration response in Arabidopsis roots. Laser-induced wounding disrupts the flow of auxin-a cell-fate-instructive plant hormone-in root tips, and we demonstrate that resulting cell-fate changes require the PLETHORA, SHORTROOT, and SCARECROW transcription factors. These transcription factors regulate the expression and polar position of PIN auxin efflux-facilitating membrane proteins to reconstitute auxin transport in renewed root tips. Thus, a regeneration mechanism using embryonic root stem-cell patterning factors first responds to and subsequently stabilizes a new hormone distribution.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Xu, Jian -- Hofhuis, Hugo -- Heidstra, Renze -- Sauer, Michael -- Friml, Jiri -- Scheres, Ben -- New York, N.Y. -- Science. 2006 Jan 20;311(5759):385-8.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Department of Molecular Genetics, Utrecht University, Padualaan 8, 3584CH Utrecht, Netherlands.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/16424342" target="_blank"〉PubMed〈/a〉
    Keywords: Arabidopsis/cytology/genetics/metabolism/*physiology ; Arabidopsis Proteins/genetics/metabolism ; Biological Transport ; Cell Nucleus/metabolism ; Genes, Plant ; Indoleacetic Acids/*metabolism/pharmacology ; Membrane Transport Proteins/*metabolism ; Models, Biological ; Plant Growth Regulators/*metabolism ; Plant Roots/cytology/*physiology ; Recombinant Fusion Proteins/metabolism ; *Regeneration ; Stem Cells/metabolism ; Transcription Factors/genetics/*metabolism
    Print ISSN: 0036-8075
    Electronic ISSN: 1095-9203
    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
    Published by American Association for the Advancement of Science (AAAS)
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