Publication Date:
2011-07-30
Description:
Plants generate effective responses to infection by recognizing both conserved and variable pathogen-encoded molecules. Pathogens deploy virulence effector proteins into host cells, where they interact physically with host proteins to modulate defense. We generated an interaction network of plant-pathogen effectors from two pathogens spanning the eukaryote-eubacteria divergence, three classes of Arabidopsis immune system proteins, and ~8000 other Arabidopsis proteins. We noted convergence of effectors onto highly interconnected host proteins and indirect, rather than direct, connections between effectors and plant immune receptors. We demonstrated plant immune system functions for 15 of 17 tested host proteins that interact with effectors from both pathogens. Thus, pathogens from different kingdoms deploy independently evolved virulence proteins that interact with a limited set of highly connected cellular hubs to facilitate their diverse life-cycle strategies.〈br /〉〈br /〉〈a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3170753/" target="_blank"〉〈img src="https://static.pubmed.gov/portal/portal3rc.fcgi/4089621/img/3977009" border="0"〉〈/a〉 〈a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3170753/" target="_blank"〉This paper as free author manuscript - peer-reviewed and accepted for publication〈/a〉〈br /〉〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Mukhtar, M Shahid -- Carvunis, Anne-Ruxandra -- Dreze, Matija -- Epple, Petra -- Steinbrenner, Jens -- Moore, Jonathan -- Tasan, Murat -- Galli, Mary -- Hao, Tong -- Nishimura, Marc T -- Pevzner, Samuel J -- Donovan, Susan E -- Ghamsari, Lila -- Santhanam, Balaji -- Romero, Viviana -- Poulin, Matthew M -- Gebreab, Fana -- Gutierrez, Bryan J -- Tam, Stanley -- Monachello, Dario -- Boxem, Mike -- Harbort, Christopher J -- McDonald, Nathan -- Gai, Lantian -- Chen, Huaming -- He, Yijian -- European Union Effectoromics Consortium -- Vandenhaute, Jean -- Roth, Frederick P -- Hill, David E -- Ecker, Joseph R -- Vidal, Marc -- Beynon, Jim -- Braun, Pascal -- Dangl, Jeffery L -- BB/E024815/1/Biotechnology and Biological Sciences Research Council/United Kingdom -- BB/G015066/1/Biotechnology and Biological Sciences Research Council/United Kingdom -- E024815/Biotechnology and Biological Sciences Research Council/United Kingdom -- F005806/Biotechnology and Biological Sciences Research Council/United Kingdom -- G015066/Biotechnology and Biological Sciences Research Council/United Kingdom -- GM-066025/GM/NIGMS NIH HHS/ -- P50 HG004233/HG/NHGRI NIH HHS/ -- P50 HG004233-04/HG/NHGRI NIH HHS/ -- P50-HG004233/HG/NHGRI NIH HHS/ -- R01 GM066025/GM/NIGMS NIH HHS/ -- R01 GM066025-07/GM/NIGMS NIH HHS/ -- New York, N.Y. -- Science. 2011 Jul 29;333(6042):596-601. doi: 10.1126/science.1203659.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Department of Biology, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599, USA.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/21798943" target="_blank"〉PubMed〈/a〉
Keywords:
Arabidopsis/genetics/*immunology/*metabolism/microbiology
;
Bacterial Proteins/metabolism
;
Evolution, Molecular
;
Genes, Plant
;
*Host-Pathogen Interactions
;
Immunity, Innate
;
Oomycetes/pathogenicity
;
Plant Diseases/*immunology
;
*Plant Immunity
;
Protein Interaction Mapping
;
Pseudomonas syringae/pathogenicity
;
Receptors, Immunologic/*metabolism
;
Virulence Factors/*metabolism
Print ISSN:
0036-8075
Electronic ISSN:
1095-9203
Topics:
Biology
,
Chemistry and Pharmacology
,
Computer Science
,
Medicine
,
Natural Sciences in General
,
Physics
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