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  • American Association for the Advancement of Science (AAAS)
  • American Physical Society (APS)
  • Public Library of Science
  • 2000-2004  (22)
  • 2001  (22)
  • 1
    Publication Date: 2001-10-27
    Description: Listeria monocytogenes is a food-borne pathogen with a high mortality rate that has also emerged as a paradigm for intracellular parasitism. We present and compare the genome sequences of L. monocytogenes (2,944,528 base pairs) and a nonpathogenic species, L. innocua (3,011,209 base pairs). We found a large number of predicted genes encoding surface and secreted proteins, transporters, and transcriptional regulators, consistent with the ability of both species to adapt to diverse environments. The presence of 270 L. monocytogenes and 149 L. innocua strain-specific genes (clustered in 100 and 63 islets, respectively) suggests that virulence in Listeria results from multiple gene acquisition and deletion events.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Glaser, P -- Frangeul, L -- Buchrieser, C -- Rusniok, C -- Amend, A -- Baquero, F -- Berche, P -- Bloecker, H -- Brandt, P -- Chakraborty, T -- Charbit, A -- Chetouani, F -- Couve, E -- de Daruvar, A -- Dehoux, P -- Domann, E -- Dominguez-Bernal, G -- Duchaud, E -- Durant, L -- Dussurget, O -- Entian, K D -- Fsihi, H -- Garcia-del Portillo, F -- Garrido, P -- Gautier, L -- Goebel, W -- Gomez-Lopez, N -- Hain, T -- Hauf, J -- Jackson, D -- Jones, L M -- Kaerst, U -- Kreft, J -- Kuhn, M -- Kunst, F -- Kurapkat, G -- Madueno, E -- Maitournam, A -- Vicente, J M -- Ng, E -- Nedjari, H -- Nordsiek, G -- Novella, S -- de Pablos, B -- Perez-Diaz, J C -- Purcell, R -- Remmel, B -- Rose, M -- Schlueter, T -- Simoes, N -- Tierrez, A -- Vazquez-Boland, J A -- Voss, H -- Wehland, J -- Cossart, P -- New York, N.Y. -- Science. 2001 Oct 26;294(5543):849-52.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Genomique des Microorganismes Pathogenes, Unite des Interactions Bacteries-Cellules, Service d'Informatique Scientifique, Institut Pasteur, 25-28 rue du Dr. Roux, 75724 Paris, France.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/11679669" target="_blank"〉PubMed〈/a〉
    Keywords: Adaptation, Physiological ; Amino Acid Motifs ; Bacillus subtilis/genetics ; Bacterial Proteins/chemistry/*genetics/physiology ; Base Composition ; Carrier Proteins/chemistry/genetics ; Chromosomes, Bacterial/genetics ; DNA, Bacterial/chemistry/genetics ; Gene Transfer, Horizontal ; Genes, Bacterial ; *Genome, Bacterial ; Genomics ; Listeria/chemistry/*genetics/physiology ; Listeria monocytogenes/chemistry/*genetics/pathogenicity/physiology ; Membrane Proteins/chemistry/genetics ; Sequence Analysis, DNA ; Staphylococcus aureus/genetics ; Transcription Factors/chemistry/genetics ; Virulence/genetics
    Print ISSN: 0036-8075
    Electronic ISSN: 1095-9203
    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
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  • 2
    Publication Date: 2001-02-13
    Description: The Indian Ocean Experiment (INDOEX) was an international, multiplatform field campaign to measure long-range transport of air pollution from South and Southeast Asia toward the Indian Ocean during the dry monsoon season in January to March 1999. Surprisingly high pollution levels were observed over the entire northern Indian Ocean toward the Intertropical Convergence Zone at about 6 degrees S. We show that agricultural burning and especially biofuel use enhance carbon monoxide concentrations. Fossil fuel combustion and biomass burning cause a high aerosol loading. The growing pollution in this region gives rise to extensive air quality degradation with local, regional, and global implications, including a reduction of the oxidizing power of the atmosphere.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Lelieveld, J -- Crutzen, P J -- Ramanathan, V -- Andreae, M O -- Brenninkmeijer, C M -- Campos, T -- Cass, G R -- Dickerson, R R -- Fischer, H -- de Gouw, J A -- Hansel, A -- Jefferson, A -- Kley, D -- de Laat, A T -- Lal, S -- Lawrence, M G -- Lobert, J M -- Mayol-Bracero, O L -- Mitra, A P -- Novakov, T -- Oltmans, S J -- Prather, K A -- Reiner, T -- Rodhe, H -- Scheeren, H A -- Sikka, D -- Williams, J -- New York, N.Y. -- Science. 2001 Feb 9;291(5506):1031-6.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Max-Planck-Institute for Chemistry, Post Office Box 3060, D-55020 Mainz, Germany. lelieveld@mpch-mainz.mpg.de〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/11161214" target="_blank"〉PubMed〈/a〉
    Keywords: Aerosols ; Agriculture ; *Air Pollution ; Asia ; Asia, Southeastern ; Atmosphere ; Biomass ; Carbon ; Carbon Monoxide ; Coal Ash ; Fossil Fuels ; Industrial Waste ; Nitrogen Oxides ; Oceans and Seas ; Ozone ; Particulate Matter ; Seasons
    Print ISSN: 0036-8075
    Electronic ISSN: 1095-9203
    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
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  • 3
    Publication Date: 2001-09-29
    Description: Late Pleistocene changes in oceanic primary productivity along the equator in the Indian and Pacific oceans are revealed by quantitative changes in nanoplankton communities preserved in nine deep-sea cores. We show that variations in equatorial productivity are primarily caused by glacial-interglacial variability and by precession-controlled changes in the east-west thermocline slope of the Indo-Pacific. The precession-controlled variations in productivity are linked to processes similar to the Southern Oscillation phenomenon, and they precede changes in the oxygen isotopic ratio, which indicates that they are not the result of ice sheet fluctuations. The 30,000-year spectral peak in the tropical Indo-Pacific Ocean productivity records is also present in the Antarctica atmospheric CO2 record, suggesting an important role for equatorial biological productivity in modifying atmospheric CO2.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Beaufort, L -- de Garidel-Thoron, T -- Mix, A C -- Pisias, N G -- New York, N.Y. -- Science. 2001 Sep 28;293(5539):2440-4.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉CNRS-CEREGE, BP 80, 13545 Aix-en-Provence Cedex 04, France.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/11577233" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; Atmosphere ; Carbon Dioxide ; *Climate ; *Ecosystem ; *Eukaryota ; *Fossils ; Indian Ocean ; Light ; Marine Biology ; Oxygen Isotopes ; Pacific Ocean ; *Plankton ; Seawater ; Time
    Print ISSN: 0036-8075
    Electronic ISSN: 1095-9203
    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
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  • 4
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    American Association for the Advancement of Science (AAAS)
    Publication Date: 2001-07-28
    Description: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉De La Cruz, E M -- Pollard, T D -- New York, N.Y. -- Science. 2001 Jul 27;293(5530):616-8.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Department of Molecular Biophysics and Biochemistry, Yale University, New Haven, CT 06520, USA.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/11474090" target="_blank"〉PubMed〈/a〉
    Keywords: Actin Depolymerizing Factors ; Actins/*chemistry/*metabolism ; Adenosine Diphosphate/chemistry/*metabolism ; Adenosine Triphosphate/chemistry/metabolism ; Biopolymers/chemistry/metabolism ; *Contractile Proteins ; Crystallography, X-Ray ; Hydrolysis ; Microfilament Proteins/metabolism ; Phosphates/metabolism ; Profilins ; Protein Binding ; Protein Conformation ; Protein Structure, Secondary ; Protein Structure, Tertiary ; Protein Subunits ; Rhodamines/metabolism ; Thymosin/metabolism
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    Electronic ISSN: 1095-9203
    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
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  • 5
    Publication Date: 2001-08-11
    Description: The power of placebos has long been recognized for improving numerous medical conditions such as Parkinson's disease (PD). Little is known, however, about the mechanism underlying the placebo effect. Using the ability of endogenous dopamine to compete for [11C]raclopride binding as measured by positron emission tomography, we provide in vivo evidence for substantial release of endogenous dopamine in the striatum of PD patients in response to placebo. Our findings indicate that the placebo effect in PD is powerful and is mediated through activation of the damaged nigrostriatal dopamine system.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉de la Fuente-Fernandez, R -- Ruth, T J -- Sossi, V -- Schulzer, M -- Calne, D B -- Stoessl, A J -- New York, N.Y. -- Science. 2001 Aug 10;293(5532):1164-6.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Neurodegenerative Disorders Centre, TRIUMF, University of British Columbia, Vancouver, BC, Canada V6T 2B5.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/11498597" target="_blank"〉PubMed〈/a〉
    Keywords: Aged ; Antiparkinson Agents/administration & dosage/*therapeutic use ; Apomorphine/administration & dosage/*therapeutic use ; Corpus Striatum/*metabolism/radionuclide imaging ; Dopamine/*metabolism ; Female ; Humans ; Male ; Middle Aged ; Parkinson Disease/*drug therapy/metabolism ; *Placebo Effect ; Placebos/administration & dosage ; Raclopride/metabolism ; Synapses/metabolism ; Tomography, Emission-Computed
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    Electronic ISSN: 1095-9203
    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
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  • 6
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    American Association for the Advancement of Science (AAAS)
    Publication Date: 2001-04-05
    Description: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉de Lozanne, A -- New York, N.Y. -- Science. 2001 Mar 30;291(5513):2561-2.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Department of Physics, University of Texas, Austin, TX 78712, USA. lozanne@physics.utexas.edu〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/11286280" target="_blank"〉PubMed〈/a〉
    Print ISSN: 0036-8075
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  • 7
    Publication Date: 2001-11-03
    Description: Human immunodeficiency virus-1 (HIV-1) Vpr expression halts the proliferation of human cells at or near the G2 cell-cycle checkpoint. The transition from G2 to mitosis is normally controlled by changes in the state of phosphorylation and subcellular compartmentalization of key cell-cycle regulatory proteins. In studies of the intracellular trafficking of these regulators, we unexpectedly found that wild-type Vpr, but not Vpr mutants impaired for G2 arrest, induced transient, localized herniations in the nuclear envelope (NE). These herniations were associated with defects in the nuclear lamina. Intermittently, these herniations ruptured, resulting in the mixing of nuclear and cytoplasmic components. These Vpr-induced NE changes probably contribute to the observed cell-cycle arrest.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉de Noronha, C M -- Sherman, M P -- Lin, H W -- Cavrois, M V -- Moir, R D -- Goldman, R D -- Greene, W C -- KO8 AI01866/AI/NIAID NIH HHS/ -- P30 MH59037/MH/NIMH NIH HHS/ -- R01 AI145234/AI/NIAID NIH HHS/ -- New York, N.Y. -- Science. 2001 Nov 2;294(5544):1105-8.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Gladstone Institute of Virology and Immunology, Department of Medicine, University of California, San Francisco, CA 94103, USA.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/11691994" target="_blank"〉PubMed〈/a〉
    Keywords: Active Transport, Cell Nucleus ; Cell Cycle Proteins/metabolism ; Cell Nucleus/*metabolism/virology ; Cyclin B/metabolism ; Cyclin B1 ; Cytoplasm/metabolism ; *G2 Phase ; Gene Products, vpr/genetics/*physiology ; HIV-1/*physiology ; HeLa Cells ; Humans ; *Lamin Type B ; Lamins ; Macrophages/virology ; Microscopy, Fluorescence ; Microscopy, Video ; Mitosis ; Mutation ; Nuclear Envelope/*metabolism/ultrastructure ; Nuclear Pore Complex Proteins/metabolism ; Nuclear Proteins/metabolism ; Protein-Tyrosine Kinases/metabolism ; Recombinant Fusion Proteins/metabolism ; Transfection ; Virus Integration ; cdc25 Phosphatases/metabolism ; vpr Gene Products, Human Immunodeficiency Virus
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  • 8
    Publication Date: 2001-03-10
    Description: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Nadeau, J H -- Balling, R -- Barsh, G -- Beier, D -- Brown, S D -- Bucan, M -- Camper, S -- Carlson, G -- Copeland, N -- Eppig, J -- Fletcher, C -- Frankel, W N -- Ganten, D -- Goldowitz, D -- Goodnow, C -- Guenet, J L -- Hicks, G -- Hrabe de Angelis, M -- Jackson, I -- Jacob, H J -- Jenkins, N -- Johnson, D -- Justice, M -- Kay, S -- Kingsley, D -- Lehrach, H -- Magnuson, T -- Meisler, M -- Poustka, A -- Rinchik, E M -- Rossant, J -- Russell, L B -- Schimenti, J -- Shiroishi, T -- Skarnes, W C -- Soriano, P -- Stanford, W -- Takahashi, J S -- Wurst, W -- Zimmer, A -- International Mouse Mutagenesis Consortium -- New York, N.Y. -- Science. 2001 Feb 16;291(5507):1251-5.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Department of Genetics, BRB 624, Case Western Reserve University School of Medicine, 10900 Euclid Avenue, Cleveland, OH 44106, USA. jhn4@po.cwru.edu〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/11233449" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; Chromosome Mapping ; *Computational Biology ; Costs and Cost Analysis ; Genes/physiology ; Genetic Techniques ; *Genome ; *Genomics ; International Cooperation ; Mice/*genetics ; Mutagenesis ; Mutation ; Phenotype ; Private Sector ; Public Sector ; Research Support as Topic ; *Sequence Analysis, DNA
    Print ISSN: 0036-8075
    Electronic ISSN: 1095-9203
    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
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  • 9
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    American Association for the Advancement of Science (AAAS)
    Publication Date: 2001-03-17
    Description: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Springer, M S -- de Jong, W W -- New York, N.Y. -- Science. 2001 Mar 2;291(5509):1709-11.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Department of Biology, University of California, Riverside, CA 92521 USA. springer@citrus.ucr.edu〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/11253193" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; Biological Evolution ; DNA, Mitochondrial/genetics ; Genomics ; Humans ; Mammals/anatomy & histology/*classification/genetics ; Meta-Analysis as Topic ; Pedigree ; *Phylogeny ; Sequence Analysis, DNA
    Print ISSN: 0036-8075
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    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
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  • 10
    Publication Date: 2001-07-28
    Description: Polymerization of isocyanopeptides results in the formation of high molecular mass polymers that fold in a proteinlike fashion to give helical strands in which the peptide chains are arranged in beta-sheets. The beta-helical polymers retain their structure in water and unfold in a cooperative process at elevated temperatures. The peptide architecture in these polymers is a different form of the beta-helix motif found in proteins. Unlike their natural counterparts, which contain arrays of large beta-sheets stacked in a helical fashion, the isocyanopeptide polymers have a central helical core that acts as a director for the beta-sheet-like arrangement of the peptide side arms. The helical structure of these isocyanopeptide polymers has the potential to be controlled through tailoring of the side branches and the hydrogen-bonding network present in the beta-sheets.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Cornelissen, J J -- Donners, J J -- de Gelder, R -- Graswinckel, W S -- Metselaar, G A -- Rowan, A E -- Sommerdijk, N A -- Nolte, R J -- New York, N.Y. -- Science. 2001 Jul 27;293(5530):676-80.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Department of Organic Chemistry, University of Nijmegen, Toernooiveld 1, 6525 ED Nijmegen, Netherlands.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/11474106" target="_blank"〉PubMed〈/a〉
    Keywords: Alanine/*chemistry ; Circular Dichroism ; Cyanides/*chemistry ; Hydrogen Bonding ; Magnetic Resonance Spectroscopy ; Microscopy, Atomic Force ; Molecular Conformation ; Oligopeptides/chemistry ; Peptides/*chemistry ; Polymers/chemistry ; Protein Folding ; *Protein Structure, Secondary ; Spectrophotometry, Infrared ; Temperature ; Trifluoroacetic Acid ; Water/chemistry
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    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
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