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  • American Association for the Advancement of Science (AAAS)  (759)
  • 2000-2004
  • 1995-1999  (418)
  • 1980-1984  (341)
  • 1940-1944
  • 1995  (418)
  • 1980  (341)
Sammlung
Schlagwörter
Verlag/Herausgeber
Erscheinungszeitraum
  • 2000-2004
  • 1995-1999  (418)
  • 1980-1984  (341)
  • 1940-1944
Jahr
  • 1
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    The minimal gene complement of Mycoplasma genitalium (1995)
    American Association for the Advancement of Science (AAAS)
    Details
    Publikationsdatum: 1995-10-20
    Beschreibung: The complete nucleotide sequence (580,070 base pairs) of the Mycoplasma genitalium genome, the smallest known genome of any free-living organism, has been determined by whole-genome random sequencing and assembly. A total of only 470 predicted coding regions were identified that include genes required for DNA replication, transcription and translation, DNA repair, cellular transport, and energy metabolism. Comparison of this genome to that of Haemophilus influenzae suggests that differences in genome content are reflected as profound differences in physiology and metabolic capacity between these two organisms.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Fraser, C M -- Gocayne, J D -- White, O -- Adams, M D -- Clayton, R A -- Fleischmann, R D -- Bult, C J -- Kerlavage, A R -- Sutton, G -- Kelley, J M -- Fritchman, R D -- Weidman, J F -- Small, K V -- Sandusky, M -- Fuhrmann, J -- Nguyen, D -- Utterback, T R -- Saudek, D M -- Phillips, C A -- Merrick, J M -- Tomb, J F -- Dougherty, B A -- Bott, K F -- Hu, P C -- Lucier, T S -- Peterson, S N -- Smith, H O -- Hutchison, C A 3rd -- Venter, J C -- AI33161/AI/NIAID NIH HHS/ -- AIO8998/AI/NIAID NIH HHS/ -- HL19171/HL/NHLBI NIH HHS/ -- New York, N.Y. -- Science. 1995 Oct 20;270(5235):397-403.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Institute for Genomic Research, Rockville, MD 20850, USA.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/7569993" target="_blank"〉PubMed〈/a〉
    Schlagwort(e): Antigenic Variation/genetics ; Bacterial Proteins/genetics ; Biological Transport/genetics ; DNA Repair/genetics ; DNA Replication/genetics ; DNA, Bacterial/genetics ; Databases, Factual ; Energy Metabolism/genetics ; Genes, Bacterial ; *Genome, Bacterial ; Haemophilus influenzae/genetics ; Molecular Sequence Data ; Mycoplasma/*genetics/immunology/metabolism ; Open Reading Frames ; Protein Biosynthesis ; *Sequence Analysis, DNA ; Transcription, Genetic
    Print ISSN: 0036-8075
    Digitale ISSN: 1095-9203
    Thema: Biologie , Chemie und Pharmazie , Informatik , Medizin , Allgemeine Naturwissenschaft , Physik
    Publiziert von American Association for the Advancement of Science (AAAS)
    Standort Signatur Erwartet Verfügbarkeit
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  • 2
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    An STS-based map of the human genome (1995)
    American Association for the Advancement of Science (AAAS)
    Details
    Publikationsdatum: 1995-12-22
    Beschreibung: A physical map has been constructed of the human genome containing 15,086 sequence-tagged sites (STSs), with an average spacing of 199 kilobases. The project involved assembly of a radiation hybrid map of the human genome containing 6193 loci and incorporated a genetic linkage map of the human genome containing 5264 loci. This information was combined with the results of STS-content screening of 10,850 loci against a yeast artificial chromosome library to produce an integrated map, anchored by the radiation hybrid and genetic maps. The map provides radiation hybrid coverage of 99 percent and physical coverage of 94 percent of the human genome. The map also represents an early step in an international project to generate a transcript map of the human genome, with more than 3235 expressed sequences localized. The STSs in the map provide a scaffold for initiating large-scale sequencing of the human genome.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Hudson, T J -- Stein, L D -- Gerety, S S -- Ma, J -- Castle, A B -- Silva, J -- Slonim, D K -- Baptista, R -- Kruglyak, L -- Xu, S H -- Hu, X -- Colbert, A M -- Rosenberg, C -- Reeve-Daly, M P -- Rozen, S -- Hui, L -- Wu, X -- Vestergaard, C -- Wilson, K M -- Bae, J S -- Maitra, S -- Ganiatsas, S -- Evans, C A -- DeAngelis, M M -- Ingalls, K A -- Nahf, R W -- Horton, L T Jr -- Anderson, M O -- Collymore, A J -- Ye, W -- Kouyoumjian, V -- Zemsteva, I S -- Tam, J -- Devine, R -- Courtney, D F -- Renaud, M T -- Nguyen, H -- O'Connor, T J -- Fizames, C -- Faure, S -- Gyapay, G -- Dib, C -- Morissette, J -- Orlin, J B -- Birren, B W -- Goodman, N -- Weissenbach, J -- Hawkins, T L -- Foote, S -- Page, D C -- Lander, E S -- HG00017/HG/NHGRI NIH HHS/ -- HG00098/HG/NHGRI NIH HHS/ -- New York, N.Y. -- Science. 1995 Dec 22;270(5244):1945-54.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Whitehead-MIT Center for Genome Research, Whitehead Institute for Biomedical Research, Cambridge, MA 02142, USA.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/8533086" target="_blank"〉PubMed〈/a〉
    Schlagwort(e): Animals ; Cell Line ; *Chromosome Mapping ; Chromosomes, Artificial, Yeast ; Databases, Factual ; Gene Expression ; Genetic Markers ; *Genome, Human ; *Human Genome Project ; Humans ; Hybrid Cells ; Polymerase Chain Reaction ; *Sequence Analysis, DNA ; *Sequence Tagged Sites
    Print ISSN: 0036-8075
    Digitale ISSN: 1095-9203
    Thema: Biologie , Chemie und Pharmazie , Informatik , Medizin , Allgemeine Naturwissenschaft , Physik
    Publiziert von American Association for the Advancement of Science (AAAS)
    Standort Signatur Erwartet Verfügbarkeit
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  • 3
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    Genomic structure of an attenuated quasi species of HIV-1 from a blood transfusion donor and recipients (1995)
    American Association for the Advancement of Science (AAAS)
    Details
    Publikationsdatum: 1995-11-10
    Beschreibung: A blood donor infected with human immunodeficiency virus-type 1 (HIV-1) and a cohort of six blood or blood product recipients infected from this donor remain free of HIV-1-related disease with stable and normal CD4 lymphocyte counts 10 to 14 years after infection. HIV-1 sequences from either virus isolates or patient peripheral blood mononuclear cells had similar deletions in the nef gene and in the region of overlap of nef and the U3 region of the long terminal repeat (LTR). Full-length sequencing of one isolate genome and amplification of selected HIV-1 genome regions from other cohort members revealed no other abnormalities of obvious functional significance. These data show that survival after HIV infection can be determined by the HIV genome and support the importance of nef or the U3 region of the LTR in determining the pathogenicity of HIV-1.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Deacon, N J -- Tsykin, A -- Solomon, A -- Smith, K -- Ludford-Menting, M -- Hooker, D J -- McPhee, D A -- Greenway, A L -- Ellett, A -- Chatfield, C -- Lawson, V A -- Crowe, S -- Maerz, A -- Sonza, S -- Learmont, J -- Sullivan, J S -- Cunningham, A -- Dwyer, D -- Dowton, D -- Mills, J -- New York, N.Y. -- Science. 1995 Nov 10;270(5238):988-91.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉AIDS Molecular Biology Unit, Macfarlane Burnet Centre for Medical Research, Fairfield, Victoria, Australia.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/7481804" target="_blank"〉PubMed〈/a〉
    Schlagwort(e): Adult ; Aged ; Base Composition ; Base Sequence ; *Blood Donors ; Blood Transfusion ; CD4 Lymphocyte Count ; Cohort Studies ; Disease Progression ; Female ; Gene Rearrangement ; *Genes, nef ; Genome, Viral ; HIV Infections/immunology/transmission/*virology ; *HIV Long Terminal Repeat ; HIV-1/*genetics/*pathogenicity/physiology ; Humans ; Male ; Middle Aged ; Molecular Sequence Data ; Multigene Family ; Sequence Deletion ; Virulence ; Virus Replication
    Print ISSN: 0036-8075
    Digitale ISSN: 1095-9203
    Thema: Biologie , Chemie und Pharmazie , Informatik , Medizin , Allgemeine Naturwissenschaft , Physik
    Publiziert von American Association for the Advancement of Science (AAAS)
    Standort Signatur Erwartet Verfügbarkeit
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  • 4
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    Preliminary results on the plasma environment of saturn from the pioneer 11 plasma analyzer experiment (1980)
    American Association for the Advancement of Science (AAAS)
    Details
    Publikationsdatum: 1980-01-25
    Beschreibung: The Ames Research Center Pioneer 11 plasma analyzer experiment provided measurements of the solar wind interaction with Saturn and the character of the plasma environment within Saturn's magnetosphere. It is shown that Saturn has a detached bow shock wave and magnetopause quite similar to those at Earth and Jupiter. The scale size of the interaction region for Saturn is roughly one-third that at Jupiter, but Saturn's magnetosphere is equally responsive to changes in the solar wind dynamic pressure. Saturn's outer magnetosphere is inflated, as evidenced by the observation of large fluxes of corotating plasma. It is postulated that Saturn's magnetosphere may undergo a large expansion when the solar wind pressure is greatly diminished by the presence of Jupiter's extended magnetospheric tail when the two planets are approximately aligned along the same solar radial vector.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Wolfe, J H -- Mihalov, J D -- Collard, H R -- McKibbin, D D -- Frank, L A -- Intriligator, D S -- New York, N.Y. -- Science. 1980 Jan 25;207(4429):403-7.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/17833548" target="_blank"〉PubMed〈/a〉
    Print ISSN: 0036-8075
    Digitale ISSN: 1095-9203
    Thema: Biologie , Chemie und Pharmazie , Informatik , Medizin , Allgemeine Naturwissenschaft , Physik
    Publiziert von American Association for the Advancement of Science (AAAS)
    Standort Signatur Erwartet Verfügbarkeit
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  • 5
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    Dimethyl and monomethyl sulfate: presence in coal fly ash and airborne particulate matter (1980)
    American Association for the Advancement of Science (AAAS)
    Details
    Publikationsdatum: 1980-01-11
    Beschreibung: Dimethyl sulfate and its hydrolysis product monomethyl sulfate have been found at concentrations as high as 830 parts per million in fly ash and in airborne particulate matter from coal combustion processes. This discovery poses a new environmental problem because of the mutagenic and carcinogenic properties of these compounds.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Lee, M L -- Later, D W -- Rollins, D K -- Eatough, D J -- Hansen, L D -- New York, N.Y. -- Science. 1980 Jan 11;207(4427):186-8.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/7350652" target="_blank"〉PubMed〈/a〉
    Schlagwort(e): Air Pollutants/*analysis ; Carcinogens/analysis ; *Coal ; Power Plants ; Sulfuric Acids/*analysis
    Print ISSN: 0036-8075
    Digitale ISSN: 1095-9203
    Thema: Biologie , Chemie und Pharmazie , Informatik , Medizin , Allgemeine Naturwissenschaft , Physik
    Publiziert von American Association for the Advancement of Science (AAAS)
    Standort Signatur Erwartet Verfügbarkeit
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  • 6
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    Absorption of solar radiation by clouds: observations versus models (1995)
    American Association for the Advancement of Science (AAAS)
    Details
    Publikationsdatum: 1995-01-27
    Beschreibung: There has been a long history of unexplained anomalous absorption of solar radiation by clouds. Collocated satellite and surface measurements of solar radiation at five geographically diverse locations showed significant solar absorption by clouds, resulting in about 25 watts per square meter more global-mean absorption by the cloudy atmosphere than predicted by theoretical models. It has often been suggested that tropospheric aerosols could increase cloud absorption. But these aerosols are temporally and spatially heterogeneous, whereas the observed cloud absorption is remarkably invariant with respect to season and location. Although its physical cause is unknown, enhanced cloud absorption substantially alters our understanding of the atmosphere's energy budget.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Cess, R D -- Zhang, M H -- Minnis, P -- Corsetti, L -- Dutton, E G -- Forgan, B W -- Garber, D P -- Gates, W L -- Hack, J J -- Harrison, E F -- Jing, X -- Kiehi, J T -- Long, C N -- Morcrette, J J -- Potter, G L -- Ramanathan, V -- Subasilar, B -- Whitlock, C H -- Young, D F -- Zhou, Y -- New York, N.Y. -- Science. 1995 Jan 27;267(5197):496-9.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/17788783" target="_blank"〉PubMed〈/a〉
    Print ISSN: 0036-8075
    Digitale ISSN: 1095-9203
    Thema: Biologie , Chemie und Pharmazie , Informatik , Medizin , Allgemeine Naturwissenschaft , Physik
    Publiziert von American Association for the Advancement of Science (AAAS)
    Standort Signatur Erwartet Verfügbarkeit
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  • 7
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    Seasonal precipitation timing and ice core records (1995)
    American Association for the Advancement of Science (AAAS)
    Details
    Publikationsdatum: 1995-07-14
    Beschreibung: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Charles, C D -- Rind, D -- Jouzel, J -- Koster, R D -- Fairbanks, R G -- New York, N.Y. -- Science. 1995 Jul 14;269(5221):247-8.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/17789853" target="_blank"〉PubMed〈/a〉
    Print ISSN: 0036-8075
    Digitale ISSN: 1095-9203
    Thema: Biologie , Chemie und Pharmazie , Informatik , Medizin , Allgemeine Naturwissenschaft , Physik
    Publiziert von American Association for the Advancement of Science (AAAS)
    Standort Signatur Erwartet Verfügbarkeit
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  • 8
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    Aberrant subcellular localization of BRCA1 in breast cancer (1995)
    American Association for the Advancement of Science (AAAS)
    Details
    Publikationsdatum: 1995-11-03
    Beschreibung: The BRCA1 gene product was identified as a 220-kilodalton nuclear phosphoprotein in normal cells, including breast ductal epithelial cells, and in 18 of 20 tumor cell lines derived from tissues other than breast and ovary. In 16 of 17 breast and ovarian cancer lines and 17 of 17 samples of cells obtained from malignant effusions, however, BRCA1 localized mainly in cytoplasm. Absence of BRCA1 or aberrant subcellular location was also observed to a variable extent in histological sections of many breast cancer biopsies. These findings suggest that BRCA1 abnormalities may be involved in the pathogenesis of many breast cancers, sporadic as well as familial.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Chen, Y -- Chen, C F -- Riley, D J -- Allred, D C -- Chen, P L -- Von Hoff, D -- Osborne, C K -- Lee, W H -- CA58318/CA/NCI NIH HHS/ -- EY05758/EY/NEI NIH HHS/ -- P50CA58183/CA/NCI NIH HHS/ -- New York, N.Y. -- Science. 1995 Nov 3;270(5237):789-91.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Center for Molecular Medicine/Institute of Biotechnology, University of Texas Health Science Center at San Antonio 78245, USA.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/7481765" target="_blank"〉PubMed〈/a〉
    Schlagwort(e): Amino Acid Sequence ; BRCA1 Protein ; Base Sequence ; Breast/*chemistry ; Breast Neoplasms/*chemistry/ultrastructure ; Cell Fractionation ; Cell Line ; Cell Nucleus/chemistry ; Cytoplasm/*chemistry ; Female ; Humans ; Male ; Molecular Sequence Data ; Mutation ; Neoplasm Proteins/*analysis/genetics/metabolism ; Neoplasms/chemistry/ultrastructure ; Ovarian Neoplasms/chemistry/ultrastructure ; Pleural Effusion, Malignant/chemistry/pathology ; Transcription Factors/*analysis/genetics/metabolism ; Tumor Cells, Cultured
    Print ISSN: 0036-8075
    Digitale ISSN: 1095-9203
    Thema: Biologie , Chemie und Pharmazie , Informatik , Medizin , Allgemeine Naturwissenschaft , Physik
    Publiziert von American Association for the Advancement of Science (AAAS)
    Standort Signatur Erwartet Verfügbarkeit
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  • 9
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    The Hubble Space Telescope (HST) observing campaign on comet Shoemaker-Levy 9 (1995)
    American Association for the Advancement of Science (AAAS)
    Details
    Publikationsdatum: 1995-03-03
    Beschreibung: The Hubble Space Telescope made systematic observations of the split comet P/Shoemaker-Levy 9 (SL9) (P designates a periodic comet) starting in July 1993 and continuing through mid-July 1994 when the fragments plunged into Jupiter's atmosphere. Deconvolutions of Wide Field Planetary Camera images indicate that the diameters of some fragments may have been as large as approximately 2 to 4 kilometers, assuming a geometric albedo of 4 percent, but significantly smaller values (that is, 〈 1 kilometer) cannot be ruled out. Most of the fragments (or nuclei) were embedded in circularly symmetric inner comae from July 1993 until late June 1994, implying that there was continuous, but weak, cometary activity. At least a few nuclei fragmented into separate, condensed objects well after the breakup of the SL9 parent body, which argues against the hypothesis that the SL9 fragments were swarms of debris with no dominant, central bodies. Spectroscopic observations taken on 14 July 1994 showed an outburst in magnesium ion emission that was followed closely by a threefold increase in continuum emission, which may have been caused by the electrostatic charging and subsequent explosion of dust as the comet passed from interplanetary space into the jovian magnetosphere. No OH emission was detected, but the derived upper limit on the H2O production rate of approximately 10(27) molecules per second does not necessarily imply that the object was water-poor.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Weaver, H A -- A'Hearn, M F -- Arpigny, C -- Boice, D C -- Feldman, P D -- Larson, S M -- Lamy, P -- Levy, D H -- Marsden, B G -- Meech, K J -- New York, N.Y. -- Science. 1995 Mar 3;267(5202):1282-8.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Space Telescope Science Institute, Baltimore, MD 21218.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/7871424" target="_blank"〉PubMed〈/a〉
    Schlagwort(e): Atmosphere ; *Extraterrestrial Environment ; Hydroxyl Radical/analysis ; *Jupiter ; Magnesium/analysis ; *Solar System ; Spectrum Analysis ; Water/analysis
    Print ISSN: 0036-8075
    Digitale ISSN: 1095-9203
    Thema: Biologie , Chemie und Pharmazie , Informatik , Medizin , Allgemeine Naturwissenschaft , Physik
    Publiziert von American Association for the Advancement of Science (AAAS)
    Standort Signatur Erwartet Verfügbarkeit
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  • 10
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    Liposomes revisited (1995)
    American Association for the Advancement of Science (AAAS)
    Details
    Publikationsdatum: 1995-03-03
    Beschreibung: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Lasic, D D -- Papahadjopoulos, D -- New York, N.Y. -- Science. 1995 Mar 3;267(5202):1275-6.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉MegaBios Corporation, Burlingame, CA 94010.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/7871422" target="_blank"〉PubMed〈/a〉
    Schlagwort(e): Animals ; Doxorubicin/administration & dosage ; *Drug Carriers ; *Genetic Therapy ; Humans ; Lipid Bilayers/chemistry ; *Liposomes/chemistry/pharmacokinetics ; Neoplasms/drug therapy ; Transfection
    Print ISSN: 0036-8075
    Digitale ISSN: 1095-9203
    Thema: Biologie , Chemie und Pharmazie , Informatik , Medizin , Allgemeine Naturwissenschaft , Physik
    Publiziert von American Association for the Advancement of Science (AAAS)
    Standort Signatur Erwartet Verfügbarkeit
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