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Response: Attenuated HIV Vaccine: Caveats (1996)

N. J. Deacon ; D. A. McPhee ; S. Crowe ; [weitere]

American Association for the Advancement of Science (AAAS)

In: Science. 271(5257): 1791-2. doi: 10.1126/science.271.5257.1791.

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Publikationsdatum: 1996-03-29

Beschreibung: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Deacon, N J -- McPhee, D A -- Crowe, S -- Learmont, J -- Mills, J -- New York, N.Y. -- Science. 1996 Mar 29;271(5257):1791-2.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/17812357" target="_blank"〉PubMed〈/a〉

Print ISSN: 0036-8075

Digitale ISSN: 1095-9203

Thema: Biologie , Chemie und Pharmazie , Informatik , Medizin , Allgemeine Naturwissenschaft , Physik

Publiziert von American Association for the Advancement of Science (AAAS)

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Genomic structure of an attenuated quasi species of HIV-1 from a blood transfusion donor and recipients (1995)

N. J. Deacon ; A. Tsykin ; A. Solomon ; [weitere]

American Association for the Advancement of Science (AAAS)

In: Science. 270(5238): 988-91.

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Publikationsdatum: 1995-11-10

Beschreibung: A blood donor infected with human immunodeficiency virus-type 1 (HIV-1) and a cohort of six blood or blood product recipients infected from this donor remain free of HIV-1-related disease with stable and normal CD4 lymphocyte counts 10 to 14 years after infection. HIV-1 sequences from either virus isolates or patient peripheral blood mononuclear cells had similar deletions in the nef gene and in the region of overlap of nef and the U3 region of the long terminal repeat (LTR). Full-length sequencing of one isolate genome and amplification of selected HIV-1 genome regions from other cohort members revealed no other abnormalities of obvious functional significance. These data show that survival after HIV infection can be determined by the HIV genome and support the importance of nef or the U3 region of the LTR in determining the pathogenicity of HIV-1.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Deacon, N J -- Tsykin, A -- Solomon, A -- Smith, K -- Ludford-Menting, M -- Hooker, D J -- McPhee, D A -- Greenway, A L -- Ellett, A -- Chatfield, C -- Lawson, V A -- Crowe, S -- Maerz, A -- Sonza, S -- Learmont, J -- Sullivan, J S -- Cunningham, A -- Dwyer, D -- Dowton, D -- Mills, J -- New York, N.Y. -- Science. 1995 Nov 10;270(5238):988-91.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉AIDS Molecular Biology Unit, Macfarlane Burnet Centre for Medical Research, Fairfield, Victoria, Australia.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/7481804" target="_blank"〉PubMed〈/a〉

Schlagwort(e): Adult ; Aged ; Base Composition ; Base Sequence ; *Blood Donors ; Blood Transfusion ; CD4 Lymphocyte Count ; Cohort Studies ; Disease Progression ; Female ; Gene Rearrangement ; *Genes, nef ; Genome, Viral ; HIV Infections/immunology/transmission/*virology ; *HIV Long Terminal Repeat ; HIV-1/*genetics/*pathogenicity/physiology ; Humans ; Male ; Middle Aged ; Molecular Sequence Data ; Multigene Family ; Sequence Deletion ; Virulence ; Virus Replication

Print ISSN: 0036-8075

Digitale ISSN: 1095-9203

Thema: Biologie , Chemie und Pharmazie , Informatik , Medizin , Allgemeine Naturwissenschaft , Physik

Publiziert von American Association for the Advancement of Science (AAAS)

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Distinct pathways of viral spread in the host determined by reovirus S1 gene segment (1986)

K. L. Tyler ; D. A. McPhee ; B. N. Fields

American Association for the Advancement of Science (AAAS)

In: Science. 233(4765): 770-4.

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Publikationsdatum: 1986-08-15

Beschreibung: The genetic and molecular mechanisms that determine the capacity of a virus to utilize distinct pathways of spread in an infected host were examined by using reoviruses. Both reovirus type 1 and reovirus type 3 spread to the spinal cord following inoculation into the hindlimb or forelimb footpad of newborn mice. For type 3 this spread is through nerves and occurs via the microtubule-associated system of fast axonal transport. By contrast, type 1 spreads to the spinal cord through the bloodstream. With the use of reassortant viruses containing various combinations of double-stranded RNA segments (genes) derived from type 1 and type 3, the viral S1 double-stranded RNA segment was shown to be responsible for determining the capacity of reoviruses to spread to the central nervous system through these distinct pathways.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Tyler, K L -- McPhee, D A -- Fields, B N -- 2 P01 NS16998/NS/NINDS NIH HHS/ -- 5 R01 AI13178/AI/NIAID NIH HHS/ -- K11-AI00610/AI/NIAID NIH HHS/ -- New York, N.Y. -- Science. 1986 Aug 15;233(4765):770-4.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/3016895" target="_blank"〉PubMed〈/a〉

Schlagwort(e): Animals ; Forelimb ; *Genes, Viral ; Hindlimb ; Mammalian orthoreovirus 3/*genetics/pathogenicity ; Mice ; Reoviridae/*genetics/pathogenicity ; Reoviridae Infections/microbiology ; Sciatic Nerve/physiology ; Species Specificity ; Spinal Cord/*microbiology

Print ISSN: 0036-8075

Digitale ISSN: 1095-9203

Thema: Biologie , Chemie und Pharmazie , Informatik , Medizin , Allgemeine Naturwissenschaft , Physik

Publiziert von American Association for the Advancement of Science (AAAS)

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Autologous red cell agglutination assay for HIV-1 antibodies: simplified test with whole blood (1988)

B. E. Kemp ; D. B. Rylatt ; P. G. Bundesen ; [weitere]

American Association for the Advancement of Science (AAAS)

In: Science. 241(4871): 1352-4.

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Publikationsdatum: 1988-09-09

Beschreibung: An antibody detection procedure based on agglutination of autologous red cells has been developed for samples of whole blood. A nonagglutinating monoclonal antibody to human red blood cells conjugated to a synthetic peptide antigen (in this case residues 579 to 601 of the HIV-1 envelope precursor, Arg-Ile-Leu-Ala-Val-Glu-Arg-Tyr-Leu-Lys-Asp-Gln-Gln-Leu-Leu-Gly-Ile-Trp- Gly-Cys - Ser-Gly-Lys) permitted the detection of antibodies to the human immunodeficiency virus type 1 (HIV-1) in 10 microliters of whole blood within 2 minutes. Agglutination was specifically inhibited by addition of synthetic peptide antigen but not by unrelated peptides. The frequency of false positive results was 0.1% with HIV-1 seronegative blood donors (n = 874). The false negative results were approximately 1% (n = 81). The autologous red cell agglutination test is potentially suitable for simple, rapid, qualitative screening for antibodies to a variety of antigens of medical and veterinary diagnostic significance.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Kemp, B E -- Rylatt, D B -- Bundesen, P G -- Doherty, R R -- McPhee, D A -- Stapleton, D -- Cottis, L E -- Wilson, K -- John, M A -- Khan, J M -- New York, N.Y. -- Science. 1988 Sep 9;241(4871):1352-4.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Department of Medicine, University of Melbourne, Repatriation General Hospital, Victoria, Australia.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/3413497" target="_blank"〉PubMed〈/a〉

Schlagwort(e): *Agglutination Tests ; Antibodies, Viral/*analysis ; Antibody Specificity ; Glycoproteins/immunology ; HIV/*immunology ; HIV Seropositivity/*diagnosis ; Humans ; Oligopeptides/immunology ; Retroviridae Proteins/immunology ; Viral Envelope Proteins/immunology

Print ISSN: 0036-8075

Digitale ISSN: 1095-9203

Thema: Biologie , Chemie und Pharmazie , Informatik , Medizin , Allgemeine Naturwissenschaft , Physik

Publiziert von American Association for the Advancement of Science (AAAS)

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Imaging the magmatic system of Mono Basin, California, with magnetotellurics in three-dimensions (2015)

J. R. Peacock, M. T. Mangan, D. McPhee, D. A. Ponce

Wiley

In: Journal of Geophysical Research JGR - Solid Earth

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Publikationsdatum: 2015-10-21

Beschreibung: A three-dimensional (3D) electrical resistivity model of Mono Basin in eastern California unveils a complex subsurface filled with zones of partial melt, fluid-filled fracture networks, cold plutons, and regional faults. In 2013, 62 broadband magnetotelluric (MT) stations were collected in an array around southeastern Mono Basin from which a 3D electrical resistivity model was created with a resolvable depth of 35 km. Multiple robust electrical resistivity features were found that correlate with existing geophysical observations. The most robust features are two 300 ± 50 km 3 near vertical conductive bodies (3-10 Ω·m) that underlie the southeast and northeastern margin of Mono Craters below 10 km depth. These features are interpreted as magmatic crystal-melt mush zones of 15 ± 5% interstitial melt surrounded by hydrothermal fluids and are likely sources for Holocene eruptions. Two conductive east-dipping structures appear to connect each magma source region to the surface. A conductive arc-like structure (〈 0.9 Ω·m) links the northernmost mush column at 10 km depth to just below vents near Panum Crater, where the high conductivity suggests the presence of hydrothermal fluids. The connection from the southernmost mush column at 10 km depth to below South Coulée is less obvious with higher resistivity (200 Ω·m) suggestive of a cooled connection. A third, less constrained conductive feature (4-10 Ω·m) 15 km deep extending to 35 km is located west of Mono Craters near the eastern front of the Sierra Nevada escarpment, and is coincident with a zone of sporadic, long–period earthquakes that are characteristic of a fluid-filled (magmatic or metamorphic) fracture network. A resistive feature (10 3 -10 5 Ω·m) located under Aeolian Buttes contains a deep root down to 25 km. The eastern edge of this resistor appears to structurally control the arcuate shape of Mono Craters. These observations have been combined to form a new conceptual model of the magmatic system beneath Mono Craters to a depth of 30 km.

Print ISSN: 0148-0227

Thema: Geologie und Paläontologie , Physik

Publiziert von Wiley im Namen von American Geophysical Union (AGU).

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Summer of Applied Geophysical Experience (SAGE): Training for our future geoscientists (2015)

Baldridge, W. S., Bedrosian, P. A., Biehler, S., Braile, L. W., Ferguson, J. F., Folsom, M., Jiracek, G. R., Kelley, S. A., McPhee, D. K., Pellerin, L., Snelson, C. M.

Society of Exploration Geophysicists (SEG)

In: Leading Edge

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Publikationsdatum: 2015-10-07

Beschreibung: Energy and natural resources are crucial to the sustainability of worldwide economies, security, and overall well-being. However, the future workforce in the energy and natural-resources sector is at risk, and meeting the challenges of this dwindling workforce requires well-educated geoscientists in exploration and applied geophysics and related geoscience and technology disciplines. Programs such as geophysical field courses that are supported by SEG and industry, in partnership with academic institutions and government laboratories, are important approaches to maintaining and enhancing expertise in exploration geophysics. One example of a geophysical field course devoted to educating our future workforce is the Summer of Applied Geophysical Experience (SAGE), a four-week program based in Santa Fe, New Mexico, designed to actively engage students in all phases of applied geophysical research. SAGE is a unique educational experience that combines teaching and research as a partnership among universities, industry, government agencies, and professional societies. SAGE teaches the principles and applications of refraction and reflection seismology, magnetics, gravity, GPS, heat flow, several electromagnetic (EM) methods, and ground-penetrating radar (GPR) in a field-based, hands-on setting. More than 850 students and qualified professionals have attended SAGE, many of whom have gone on to become leaders in academia, industry, and government. SAGE students are exposed to the exciting challenges that face earth scientists today, and they develop skills that are necessary to address the world's growing energy demands. Examples of SAGE research projects include mapping archaeological sites and tectonic structure and investigating water and geothermal resources in the Rio Grande rift.

Print ISSN: 1070-485X

Digitale ISSN: 1938-3789

Thema: Geologie und Paläontologie

Publiziert von Society of Exploration Geophysicists (SEG)

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