Publication Date:
1993-06-25
Description:
CD4+ T cells play a major role in protective immunity against the blood stage of malaria, but the mechanism of protection is unclear. By adoptive transfer of cloned T cell lines, direct evidence is provided that both TH1 and TH2 subsets of CD4+ T cells can protect mice against Plasmodium chabaudi chabaudi infection. TH1 cells protect by a nitric oxide-dependent mechanism, whereas TH2 cells protect by the enhancement and accelerated production of specific immunoglobulin G1 antibody.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Taylor-Robinson, A W -- Phillips, R S -- Severn, A -- Moncada, S -- Liew, F Y -- Wellcome Trust/United Kingdom -- New York, N.Y. -- Science. 1993 Jun 25;260(5116):1931-4.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Wellcome Laboratories for Experimental Parasitology, University of Glasgow, United Kingdom.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/8100366" target="_blank"〉PubMed〈/a〉
Keywords:
Animals
;
Antibodies, Protozoan/biosynthesis
;
Arginine/analogs & derivatives/pharmacology
;
CD4-Positive T-Lymphocytes/*immunology
;
Cell Line
;
Female
;
Immunoglobulin G/*biosynthesis
;
Lymphocyte Depletion
;
Malaria/*immunology
;
Mice
;
Mice, Inbred Strains
;
Nitrates/blood
;
Nitric Oxide/*metabolism
;
Plasmodium chabaudi/*immunology
;
T-Lymphocyte Subsets/*immunology
;
omega-N-Methylarginine
Print ISSN:
0036-8075
Electronic ISSN:
1095-9203
Topics:
Biology
,
Chemistry and Pharmacology
,
Computer Science
,
Medicine
,
Natural Sciences in General
,
Physics
