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    The role of TH1 and TH2 cells in a rodent malaria infection (1993)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1993-06-25
    Description: CD4+ T cells play a major role in protective immunity against the blood stage of malaria, but the mechanism of protection is unclear. By adoptive transfer of cloned T cell lines, direct evidence is provided that both TH1 and TH2 subsets of CD4+ T cells can protect mice against Plasmodium chabaudi chabaudi infection. TH1 cells protect by a nitric oxide-dependent mechanism, whereas TH2 cells protect by the enhancement and accelerated production of specific immunoglobulin G1 antibody.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Taylor-Robinson, A W -- Phillips, R S -- Severn, A -- Moncada, S -- Liew, F Y -- Wellcome Trust/United Kingdom -- New York, N.Y. -- Science. 1993 Jun 25;260(5116):1931-4.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Wellcome Laboratories for Experimental Parasitology, University of Glasgow, United Kingdom.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/8100366" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; Antibodies, Protozoan/biosynthesis ; Arginine/analogs & derivatives/pharmacology ; CD4-Positive T-Lymphocytes/*immunology ; Cell Line ; Female ; Immunoglobulin G/*biosynthesis ; Lymphocyte Depletion ; Malaria/*immunology ; Mice ; Mice, Inbred Strains ; Nitrates/blood ; Nitric Oxide/*metabolism ; Plasmodium chabaudi/*immunology ; T-Lymphocyte Subsets/*immunology ; omega-N-Methylarginine
    Print ISSN: 0036-8075
    Electronic ISSN: 1095-9203
    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
    Published by American Association for the Advancement of Science (AAAS)
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  • 2
    Electronic Resource
    Electronic Resource
    Predominance of infected reticulocytes in the peripheral blood of CD4+ T-cell-depleted mice chronically infected withPlasmodium chabaudi chabaudi (1994)
    Springer
    Parasitology research 80 (1994), S. 614-619 
    Details
    ISSN: 1432-1955
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology , Medicine
    Notes: Abstract The distribution ofPlasmodium chabaudi chabaudi AS among normocytes and reticulocytes in the peripheral blood of NIH mice undergoing a primary infection was determined from brilliant cresyl blue/Giemsa's stained thin blood films. During the early stages of infection in normal mice, parasites were found exclusively in normocytes. The presence of parasites in reticulocytes was limited to a period of severe immune pressure on the parasites, peak parasitaemia and the ensuing “crisis” phase, at which time the rapid production of new erythrocytes in response to the anaemia in these mice resulted in a high reticulocyte count. Later, during the recrudescence, parasites inhabited normocytes only. Thus, in immunologically competent animals,P. c. chabaudi AS showed no absolute preference for either mature or immature erythrocytes. In marked contrast, in chronically infected CD4+ T-cell-depleted mice, this malaria parasite apparently displayed a pronounced predilection for reticulocytes. During an unremitting parasitaemia of 2.8%–3.9% during days 13–60 post infection, all parasites were found in reticulocytes, even though these comprised only 25% of the total erythrocyte count. The possible reasons for this reversal in preference for the type of erythrocyte inhabited by asexual malaria parasites are discussed.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00933011
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