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  • 1
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    IL-33 clears {beta}-amyloid through innate immunity [Neuroscience] (2016)
    National Academy of Sciences
    Details
    Publication Date: 2016-05-12
    Description: Alzheimer’s disease (AD) is a devastating condition with no known effective treatment. AD is characterized by memory loss as well as impaired locomotor ability, reasoning, and judgment. Emerging evidence suggests that the innate immune response plays a major role in the pathogenesis of AD. In AD, the accumulation of β-amyloid...
    Print ISSN: 0027-8424
    Electronic ISSN: 1091-6490
    Topics: Biology , Medicine , Natural Sciences in General
    Published by National Academy of Sciences
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  • 2
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    The role of TH1 and TH2 cells in a rodent malaria infection (1993)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1993-06-25
    Description: CD4+ T cells play a major role in protective immunity against the blood stage of malaria, but the mechanism of protection is unclear. By adoptive transfer of cloned T cell lines, direct evidence is provided that both TH1 and TH2 subsets of CD4+ T cells can protect mice against Plasmodium chabaudi chabaudi infection. TH1 cells protect by a nitric oxide-dependent mechanism, whereas TH2 cells protect by the enhancement and accelerated production of specific immunoglobulin G1 antibody.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Taylor-Robinson, A W -- Phillips, R S -- Severn, A -- Moncada, S -- Liew, F Y -- Wellcome Trust/United Kingdom -- New York, N.Y. -- Science. 1993 Jun 25;260(5116):1931-4.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Wellcome Laboratories for Experimental Parasitology, University of Glasgow, United Kingdom.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/8100366" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; Antibodies, Protozoan/biosynthesis ; Arginine/analogs & derivatives/pharmacology ; CD4-Positive T-Lymphocytes/*immunology ; Cell Line ; Female ; Immunoglobulin G/*biosynthesis ; Lymphocyte Depletion ; Malaria/*immunology ; Mice ; Mice, Inbred Strains ; Nitrates/blood ; Nitric Oxide/*metabolism ; Plasmodium chabaudi/*immunology ; T-Lymphocyte Subsets/*immunology ; omega-N-Methylarginine
    Print ISSN: 0036-8075
    Electronic ISSN: 1095-9203
    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
    Published by American Association for the Advancement of Science (AAAS)
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  • 3
    Electronic Resource
    Electronic Resource
    Delayed-type hypersensitivity responses to H-Y: Characterization and mapping ofIr genes (1980)
    Springer
    Immunogenetics 11 (1980), S. 255-266 
    Details
    ISSN: 1432-1211
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology , Medicine
    Notes: Abstract This paper examines the delayed-type hypersensitivity (DTH) response to male (H-Y) antigen(s). Female mice of theH−2 b haplotype developed delayed footpad reaction to syngeneic or allogenic male thymus and spleen cells after priming with syngeneic male thymus and spleen cells. The reaction peaks at 24 h, has classical DTH histology and is specific to H-Y antigen as it is not elicited with female cells. Cell transfer studies show that donor/recipient matching at theI−B b subregion is necessary for sucessful transfer of DTH and that the effective primed population is Thy-1+, Lyt-1+, 2−. DTH response to H-Y antigen appears to be confined to mice of theH−2 b haplotype. There appears to be a lack of associative recognition between H-Y antigen and MHC-coded determinants in the effector phase of DTH, and macrophage processing of H-Y seems likely, since nonresponder haplotypes can elicit the DTH response. Studies withH−2 b recombinant mouse strains indicate that the dominantIr gene is located in theI−B region. Female F1 hybrid mice derived from matings of strains not involvingH−2 b haplotype failed to develop DTH to H-Y. In summary, these data imply that a complete correlation exists between DTH to H-Y and the ability to reject male skin graft, suggesting that the effector mechanisms of skin-graft rejection may closely involve DTH cells.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01567792
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  • 4
    Electronic Resource
    Electronic Resource
    An H-11-linked gene has a parallel effect on Leishmania major and L. donovani infections in mice (1985)
    Springer
    Immunogenetics 21 (1985), S. 385-395 
    Details
    ISSN: 1432-1211
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology , Medicine
    Notes: Abstract The courses of visceral infection following intravenous injection of Leishmania donovani amastigotes, or lesion growth following subcutaneous injection of L. major promastigotes, were examined in B10.129(IOM) (H-2 b, H-11 b) mice and compared with disease profiles observed in congenic C57BL/10ScSn(=B10) (H-2 b, H-11 a) and B10.D2/n (H-2 d, H-11 a) mice, and in BALB/mice. Possession of alternative alleles at H-11 and closely linked loci transformed the normal curing/healing phenotype of B 10 mice into a characteristically different noncuring/nonhealing phenotype affecting both visceral and subcutaneous infections in B10.129(10M) mice. In reciprocal radiation bone marrow chimeras made between the congenic B10 and B10.129(10M) strains, both cure and noncure phenotypes were transferable with the donor hematopoietic system. Although it was possible to demonstrate transfer of suppression with T-enriched spleen cells from day 61 L. donovani-infected B10.129(10M) donor mice into 550 rad syngeneic recipients, the pretreatment of mice with sublethal irradiation did not, as in the earlier studies of Scl-controlled L. major nonhealing or H-2-controlled L. donovani noncure phenotypes, have a clear or consistent prophylactic effect. Together with the progressive disease profile observed even for L. donovani at low parasite doses this suggests that, despite their ability to develop initial delayed-type hypersensitivity reactions to parasite antigen early in L. major infection, B10.129(10M) mice possess some inherent defect in ability to mount a cell-mediated response effective at the level of macrophage antileishmanial activity in vivo even when suppressor T cells are not generated. Further elucidation of this characteristically different noncuring/nonhealing phenotype may provide important insight into common events involved in the development of the cell-mediated immune response to both visceral and subcutaneous forms of leishmaniasis.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00430803
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  • 5
    Electronic Resource
    Electronic Resource
    Biology of Nitric Oxide in Neuroimmunoregulation (1994)
    Oxford, UK : Blackwell Publishing Ltd
    Annals of the New York Academy of Sciences 741 (1994), S. 0 
    Details
    ISSN: 1749-6632
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Natural Sciences in General
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1111/j.1749-6632.1994.tb39642.x
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  • 6
    Electronic Resource
    Electronic Resource
    THE INDUCIBLE FORM OF NITRIC OXIDE SYNTHASE (NOS2) ISOLATED FROM MURINE MACROPHAGES MAPS NEAR THE NUDE MUTATION ON MOUSE CHROMOSOME 11 (1994)
    Oxford, UK : Blackwell Publishing Ltd
    International journal of immunogenetics 21 (1994), S. 0 
    Details
    ISSN: 1744-313X
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Biology , Medicine
    Notes: Nitric oxide synthase has been shown to mediate streptozocin-induced diabetes and to act as an antimicrobial agent in murine macrophages. Using a cDNA probe for the inducible form of nitric oxide synthase (Nos2) isolated from murine macrophages we have determined that the gene maps within 1 cM of the nude mutation on mouse Chromosome 11. The position of Nos2 was also mapped relative to the markers 115, Evi 2, Cchlbl (previously unmapped), and Gfap. This map location is discussed relative to map locations for disease susceptibility loci involved in mediating cutaneous leishmaniasis (Sell) and autoimmune type-I diabetes (Idd4).
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1111/j.1744-313X.1994.tb00196.x
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  • 7
    Electronic Resource
    Electronic Resource
    Video cytokine (1993)
    [s.l.] : Nature Publishing Group
    Nature 365 (1993), S. 402-402 
    Details
    ISSN: 1476-4687
    Source: Nature Archives 1869 - 2009
    Topics: Biology , Chemistry and Pharmacology , Medicine , Natural Sciences in General , Physics
    Notes: [Auszug] RESEARCH laboratories rarely indulge in the art of video, but when they do, the result can be as informative and colourful as any good seminar. An unusual collaboration between the pharmaceutical company Boehringer Ingelheim and Dr Greg Bancroft and his team at the London School of Hygiene and ...
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1038/365402a0
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  • 8
    Electronic Resource
    Electronic Resource
    Genetically determined susceptibility to Leishmania tropica infection is expressed by haematopoietic donor cells in mouse radiation chimaeras (1980)
    [s.l.] : Nature Publishing Group
    Nature 288 (1980), S. 161-162 
    Details
    ISSN: 1476-4687
    Source: Nature Archives 1869 - 2009
    Topics: Biology , Chemistry and Pharmacology , Medicine , Natural Sciences in General , Physics
    Notes: [Auszug] Lethally irradiated mice injected with allogeneic bone marrow cells develop not only haematopoietic and lymphoid cells but also macrophages which are predominantly of donor type12'13. When an H-2 incompatibility is involved, mature T lymphocytes must be excluded from the donor cells to avoid the ...
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1038/288161a0
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  • 9
    Electronic Resource
    Electronic Resource
    T cells primed by influenza virion internal components can cooperate in the antibody response to haemagglutinin (1979)
    [s.l.] : Nature Publishing Group
    Nature 280 (1979), S. 147-148 
    Details
    ISSN: 1476-4687
    Source: Nature Archives 1869 - 2009
    Topics: Biology , Chemistry and Pharmacology , Medicine , Natural Sciences in General , Physics
    Notes: [Auszug] Table 1 X31 HAI antibody response of mice after antigen priming Iog2 serum HA titre ± s.e.m. Priming antigen Boosting antigen Day 4 Day 10 __ X31 Virus ^1.58* 2.38 ±0.49 X31 Spikeless Particles X31 Virus 4.98 ±0.93 5.38±1.07 - X31 Monomer ...
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1038/280147a0
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  • 10
    Electronic Resource
    Electronic Resource
    Inhibition of pathogenic effect of effector T cells by specific suppressor T cells during influenza virus infection in mice (1983)
    [s.l.] : Nature Publishing Group
    Nature 304 (1983), S. 541-543 
    Details
    ISSN: 1476-4687
    Source: Nature Archives 1869 - 2009
    Topics: Biology , Chemistry and Pharmacology , Medicine , Natural Sciences in General , Physics
    Notes: [Auszug] Splenic T cells were obtained from inbred CBA/T6T6 mice injected intraperitoneally (i.p.) with 10 mg of purified UV-inactivated PR8 virus 3 weeks previously and cultured in vitro for 5 days with PR8 virus-infected CBA spleen cells as described by Leung and Ada3. These secondary Td cells had minimal ...
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1038/304541a0
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