Publikationsdatum:
2010-10-23
Beschreibung:
The Afrotropical mosquito Anopheles gambiae sensu stricto, a major vector of malaria, is currently undergoing speciation into the M and S molecular forms. These forms have diverged in larval ecology and reproductive behavior through unknown genetic mechanisms, despite considerable levels of hybridization. Previous genome-wide scans using gene-based microarrays uncovered divergence between M and S that was largely confined to gene-poor pericentromeric regions, prompting a speciation-with-ongoing-gene-flow model that implicated only about 3% of the genome near centromeres in the speciation process. Here, based on the complete M and S genome sequences, we report widespread and heterogeneous genomic divergence inconsistent with appreciable levels of interform gene flow, suggesting a more advanced speciation process and greater challenges to identify genes critical to initiating that process.〈br /〉〈br /〉〈a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3674514/" target="_blank"〉〈img src="https://static.pubmed.gov/portal/portal3rc.fcgi/4089621/img/3977009" border="0"〉〈/a〉 〈a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3674514/" target="_blank"〉This paper as free author manuscript - peer-reviewed and accepted for publication〈/a〉〈br /〉〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Lawniczak, M K N -- Emrich, S J -- Holloway, A K -- Regier, A P -- Olson, M -- White, B -- Redmond, S -- Fulton, L -- Appelbaum, E -- Godfrey, J -- Farmer, C -- Chinwalla, A -- Yang, S-P -- Minx, P -- Nelson, J -- Kyung, K -- Walenz, B P -- Garcia-Hernandez, E -- Aguiar, M -- Viswanathan, L D -- Rogers, Y-H -- Strausberg, R L -- Saski, C A -- Lawson, D -- Collins, F H -- Kafatos, F C -- Christophides, G K -- Clifton, S W -- Kirkness, E F -- Besansky, N J -- AI076584/AI/NIAID NIH HHS/ -- BB/C519670/1/Biotechnology and Biological Sciences Research Council/United Kingdom -- BB/E002641/1/Biotechnology and Biological Sciences Research Council/United Kingdom -- R01 AI063508/AI/NIAID NIH HHS/ -- R01 AI076584/AI/NIAID NIH HHS/ -- R01 AI63508/AI/NIAID NIH HHS/ -- U54-HG00379/HG/NHGRI NIH HHS/ -- U54-HG03068/HG/NHGRI NIH HHS/ -- New York, N.Y. -- Science. 2010 Oct 22;330(6003):512-4. doi: 10.1126/science.1195755.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Division of Cell and Molecular Biology, Imperial College London, South Kensington Campus, London SW7 2AZ, UK.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/20966253" target="_blank"〉PubMed〈/a〉
Schlagwort(e):
Animals
;
Anopheles gambiae/classification/*genetics
;
Evolution, Molecular
;
Female
;
Gene Flow
;
*Genetic Speciation
;
*Genome, Insect
;
Male
;
Models, Genetic
;
Polymorphism, Single Nucleotide
Print ISSN:
0036-8075
Digitale ISSN:
1095-9203
Thema:
Biologie
,
Chemie und Pharmazie
,
Informatik
,
Medizin
,
Allgemeine Naturwissenschaft
,
Physik
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