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  • Artikel  (1.250)
  • Column liquid chromatography  (1.216)
  • 04. Solid Earth::04.06. Seismology::04.06.11. Seismic risk
  • Springer  (1.235)
  • INGV  (13)
  • Associazione Nazionale di Ingegneria Sismica  (2)
  • American Institute of Physics
  • Blackwell publishing
  • Wabern : Federal Office of Topography, Swiss Geological Survey
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  • Artikel  (1.250)
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  • 1
    Publikationsdatum: 2020-12-23
    Beschreibung: The Disruption Index is used here for the assessment of urban disruption in the Mt. Etna area after a natural disaster. The first element of the procedure is the definition of the seismic input, which is based on information about the historical seismicity and seismogenic faults. The second element is the computation of the seismic impact on the building stock and infrastructure in the region considered. Information on urban-scale vulnerability was collected and a geographic information system was used to organize the data relating to buildings and network systems (e.g., typologies, schools, strategic structures, lifelines). The central idea underlying the definition of the Disruption Index is the identification and evaluation of the impacts on a target community, considering the physical elements that contribute most to the severe disruption. The results of this study are therefore very useful for earthquake preparedness planning and for the development of strategies to minimize the risks from earthquakes. This study is a product of the European “Urban Disaster Prevention Strategies using Macroseismic Fields and Fault Sources” project (UPStrat-MAFA European project 2013).
    Beschreibung: Published
    Beschreibung: Torino
    Beschreibung: 3T. Pericolosità sismica e contributo alla definizione del rischio
    Beschreibung: open
    Schlagwort(e): Seismic impact ; Disruption index ; Urban system ; Risk measures ; Mt. Etna area (Italy) ; 04. Solid Earth::04.06. Seismology::04.06.11. Seismic risk
    Repository-Name: Istituto Nazionale di Geofisica e Vulcanologia (INGV)
    Materialart: Conference paper
    Standort Signatur Erwartet Verfügbarkeit
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  • 2
    Publikationsdatum: 2017-04-04
    Beschreibung: The paper examines the correlations to obtain rough estimates of the shear wave velocity VS from nonseismic dilatometer tests (DMT) and cone penetration tests (CPT). While the direct measurement of VS is obviously preferable, these correlations may turn out useful in various circumstances. The experimental results at six international research sites suggest that the DMT predictions of VS from the parameters ID (material index), KD (horizontal stress index), MDMT (constrained modulus) are more reliable and consistent than the CPT predictions from qc (cone resistance), presumably because of the availability, by DMT, of the stress history index KD.
    Beschreibung: Published
    Beschreibung: 83-92
    Beschreibung: 3T. Pericolosità sismica e contributo alla definizione del rischio
    Beschreibung: N/A or not JCR
    Beschreibung: restricted
    Schlagwort(e): horizontal stress index ; shear wave velocity ; flat dilatometer test ; cone penetration test ; 04. Solid Earth::04.06. Seismology::04.06.11. Seismic risk
    Repository-Name: Istituto Nazionale di Geofisica e Vulcanologia (INGV)
    Materialart: article
    Standort Signatur Erwartet Verfügbarkeit
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  • 3
    Publikationsdatum: 2017-04-04
    Beschreibung: The aim of this study is a critical revision of historical and recent seismicity of the Salento peninsula (Apulia, Southern Italy), offering an updated evaluation of its seismic hazard currently underestimated. This area is actually included in the least dangerous IV category of the Italian seismic classification. The Salento Peninsula was struck by the February 20, 1743 earthquake, considered as the strongest seismic event of this area. The reassessment of both the macroseismic effects on man-made structures, and the triggered effects in the natural environment has been carried out on the basis of archival documents and recent literature, according to the MCS and the ESI 2007 scale. The main result of our study has been the re-evaluation of the maximum intensity (Imax=XMCS) of the 1743 earthquake, besides new intensity values for some localities along the Apulian coasts.
    Beschreibung: INQUA INGV ISPRA Universitas Studiorum Insubriae
    Beschreibung: Published
    Beschreibung: 317-320
    Beschreibung: 2T. Tettonica attiva
    Beschreibung: N/A or not JCR
    Beschreibung: open
    Schlagwort(e): Salento ; 1743 earthquake ; historical seismicity ; seismically induced effects ; 04. Solid Earth::04.06. Seismology::04.06.11. Seismic risk
    Repository-Name: Istituto Nazionale di Geofisica e Vulcanologia (INGV)
    Materialart: article
    Standort Signatur Erwartet Verfügbarkeit
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  • 4
    Publikationsdatum: 2020-02-24
    Beschreibung: The results of a detailed seismic microzonation study performed at Canazei (Trentino—Northern Italy) are here presented. We investigated the local seismic response of this small village using a Level 3 seismic microzonation, the most accurate according to the Italian Code of Seismic Microzonation. This method consists of gradual steps of knowledge to consider different aspects of the amplification phenomena. A multidisciplinary approach has been performed, including a local geological study, geophysical investigations, geotechnical characterization of lithologies and numerical analyses. The obtained elastic response spectra were compared to the spectra prescribed by the Italian Building Code. Our results show the geologic and geophysical subsoil heterogeneities, responsible for different local seismic responses in terms of acceleration spectra and amplification factors.
    Beschreibung: Published
    Beschreibung: 1085-1089
    Beschreibung: 3T. Pericolosità sismica e contributo alla definizione del rischio
    Beschreibung: reserved
    Schlagwort(e): Seismic microzonation ; Response spectra ; Amplification factor ; Canazei ; 04. Solid Earth::04.06. Seismology::04.06.04. Ground motion ; 04. Solid Earth::04.06. Seismology::04.06.06. Surveys, measurements, and monitoring ; 04. Solid Earth::04.06. Seismology::04.06.11. Seismic risk
    Repository-Name: Istituto Nazionale di Geofisica e Vulcanologia (INGV)
    Materialart: book chapter
    Standort Signatur Erwartet Verfügbarkeit
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  • 5
    Publikationsdatum: 2020-02-24
    Beschreibung: The communication process between the geoscientists and native communities in risk areas can significantly affect disaster prevention and land use planning. In Peru, the problem of disaster prevention is a fundamental policy due to unfamiliarity and deficiency of the associate information on the population. It is possible that talk of disaster prevention it will be an unlikely ideal in a country where most towns have settled on unplanned projects by the constant change and the lack of interest from the authorities in such topics. However, it is anachronistic that the rural communities and towns continue to live without a plan to enable them to improve their quality of life. The correct use of geoscience information in the mass media can help in this work. The characteristics of the enterprise in Peru require more training by professionals in the geosciences and support communication specialists. In this paper, we analyze the problem of communication for disaster prevention in Peru, with the aim of contributing to the articulation of a disaster prevention strategy.
    Beschreibung: Published
    Beschreibung: 81-83
    Beschreibung: 3T. Pericolosità sismica e contributo alla definizione del rischio
    Beschreibung: 4V. Vulcani e ambiente
    Beschreibung: 6A. Monitoraggio ambientale, sicurezza e territorio
    Beschreibung: reserved
    Schlagwort(e): Communication process ; Disaster prevention ; Risk management ; Peru ; Geoethics ; 04. Solid Earth::04.06. Seismology::04.06.11. Seismic risk ; 04. Solid Earth::04.08. Volcanology::04.08.08. Volcanic risk ; 05. General::05.03. Educational, History of Science, Public Issues::05.03.99. General or miscellaneous ; 05. General::05.08. Risk::05.08.99. General or miscellaneous ; 05. General::05.09. Miscellaneous::05.09.99. General or miscellaneous
    Repository-Name: Istituto Nazionale di Geofisica e Vulcanologia (INGV)
    Materialart: book chapter
    Standort Signatur Erwartet Verfügbarkeit
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  • 6
    Publikationsdatum: 2017-04-04
    Beschreibung: Nel settembre del 1884 una gravissima epidemia di colera colpì napoli diffondendosi con estrema virulenza nei quartieri bassi della città.
    Beschreibung: Published
    Beschreibung: 31-39
    Beschreibung: 3T. Pericolosità sismica e contributo alla definizione del rischio
    Beschreibung: N/A or not JCR
    Beschreibung: restricted
    Schlagwort(e): architettura antismica ; Giuseppe Mercalli ; 04. Solid Earth::04.06. Seismology::04.06.05. Historical seismology ; 04. Solid Earth::04.06. Seismology::04.06.11. Seismic risk
    Repository-Name: Istituto Nazionale di Geofisica e Vulcanologia (INGV)
    Materialart: article
    Standort Signatur Erwartet Verfügbarkeit
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  • 7
    Publikationsdatum: 2017-04-04
    Beschreibung: We perform numerical experiments by using a mass–spring fault model subject to an external coseismic stress perturbation due to a remote seismic event happening on another fault, the causative fault. In particular, the aim of this study is to investigate the instantaneous fault interaction and possible triggering that happens when a fault perturbed by a stress change fails before the so–called unperturbed instability. As a realistic example we focus our attention on the instantaneous dynamic triggering phenomena occurred during the 17 June 2000 south Iceland seismic sequence in the South Iceland Seismic Zone (SISZ, Reykjanes Peninsula). The main event (Ms 6.6) was followed by three large events within a few tens of seconds (8, 26 and 30 s, respectively) located in a neighborhood of several tens of km. Among them the 26 s event was the best constrained (Bizzarri and Belardinelli, 2008). In the present study, conditions to simulate the instantaneous dynamic triggering connected to the former three events, have been investigated using the simple 1–D spring–slider analogue model representing a fault governed by the rate– and state–dependent friction laws. In previous studies suitable constitutive parameters of the modeled fault which allow the instantaneous triggering of the three events, have been found (Antonioli et al., 2006) and, furthermore, it was also shown how the dynamics of the 26 s event strongly depends on the assumed constitutive law and stress conditions (Bizzarri and Belardinelli, 2008) by considering the Dieterich–Ruina (DR henceforth) and the Ruina–Dieterich (RD henceforth) governing laws. In this context take place the present study original contribution that is to better understand if the conditions of instantaneous dynamic triggering (focusing on the case of the 26 s triggered event) provide any significant differences if modeled with a different rate– and state–dependent governing equation, the Chester and Higgs law (CH henceforth; see Chester and Higgs, 1992; Bizzarri, 2010b; Bizzarri, 2010c) which accounts for the thermal effect for frictional heating which may occur during seismic sliding.
    Beschreibung: Published
    Beschreibung: 1-20
    Beschreibung: 3.1. Fisica dei terremoti
    Beschreibung: N/A or not JCR
    Beschreibung: open
    Schlagwort(e): Earthquake recourrence ; Hazard ; 04. Solid Earth::04.06. Seismology::04.06.11. Seismic risk
    Repository-Name: Istituto Nazionale di Geofisica e Vulcanologia (INGV)
    Materialart: article
    Standort Signatur Erwartet Verfügbarkeit
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  • 8
    Publikationsdatum: 2017-04-04
    Beschreibung: In questo lavoro sono descritte le attività svolte nell’ambito del Progetto Europeo Strategico RISKNAT riguardanti l’analisi di microzonazione di Sant’Agata Fossili (AL). Sono in particolare descritte tutte le indagini ed analisi numeriche condotte al fine di ottenere una microzonazione sismica di livello 3 secondo quanto previsto nelle recenti linee guida nazionali degli. Al fine inoltre di valutare le ricadute di tipo applicativo di una corretta microzonazione sismica del territorio, sono state realizzate delle simulazioni di scenario adottando come riferimento gli spettri di risposta ottenuti dall’analisi di microzonazione. Le valutazioni di scenario ottenute sono state infine confrontate con le previsioni di scenario realizzabili a priori sulla base dell’adozione degli spettri di risposta definiti nelle Norme Tecniche per le Costruzioni.
    Beschreibung: Published
    Beschreibung: Politecnico di Bari - Campus Universitario
    Beschreibung: 4.1. Metodologie sismologiche per l'ingegneria sismica
    Beschreibung: open
    Schlagwort(e): microzonazione sismica ; rischio sismico ; scenario di danno ; 04. Solid Earth::04.02. Exploration geophysics::04.02.05. Downhole, radioactivity, remote sensing, and other methods ; 04. Solid Earth::04.02. Exploration geophysics::04.02.06. Seismic methods ; 04. Solid Earth::04.06. Seismology::04.06.04. Ground motion ; 04. Solid Earth::04.06. Seismology::04.06.06. Surveys, measurements, and monitoring ; 04. Solid Earth::04.06. Seismology::04.06.09. Waves and wave analysis ; 04. Solid Earth::04.06. Seismology::04.06.11. Seismic risk ; 05. General::05.01. Computational geophysics::05.01.03. Inverse methods
    Repository-Name: Istituto Nazionale di Geofisica e Vulcanologia (INGV)
    Materialart: Conference paper
    Standort Signatur Erwartet Verfügbarkeit
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  • 9
    Publikationsdatum: 2017-04-04
    Beschreibung: Il progetto SEE-GeoForm (Site Effects Evaluation - Geological Form: http://www.seegeoform.it) nasce con l’obiettivo di realizzare uno strumento semplice, potente e completo per la consultazione e la rappresentazione, tramite un WebGIS, di dati geologici, geomorfologici, geotecnici e geofisici relativi all’intero territorio italiano. In questo modo, si vogliono concentrare in un sistema flessibile e intuitivo, dotato di un’unica modalità di accesso e consultazione, una serie di informazioni che attualmente sono disperse in numerosi database mono-tematici consultabili via Internet. Attualmente il WebGIS contiene dati georeferenziati e carte tematiche relative alla pericolosità sismica a differenti scale territoriali e per diverse unità amministrative (regioni, province e comuni). Le informazioni provengono sia da banche dati esistenti che da elaborazioni effettuate “ad hoc” nell’ambito di questo progetto (carte tematiche in scala 1:100.000 del territorio italiano). Per rendere il sistema più flessibile ed aggiornabile è stata sviluppata una piattaforma che utilizza esclusivamente tecnologie “open source”, basate sulle linee guida dell’Open Geospatial Consortium (OGC); in questo modo è stato possibile realizzare alcuni moduli tematici che sono totalmente compatibili con il protocollo standard denominato WMS (Web Map Services) per la consultazione e la visualizzazione spaziale dei dati tramite Internet.
    Beschreibung: Published
    Beschreibung: Politecnico di Bari - Campus Universitario
    Beschreibung: 4.1. Metodologie sismologiche per l'ingegneria sismica
    Beschreibung: 5.5. TTC - Sistema Informativo Territoriale
    Beschreibung: open
    Schlagwort(e): geologia ; pericolosità sismica ; banche dati ; webgis ; 04. Solid Earth::04.06. Seismology::04.06.11. Seismic risk ; 05. General::05.02. Data dissemination::05.02.02. Seismological data ; 05. General::05.09. Miscellaneous::05.09.99. General or miscellaneous
    Repository-Name: Istituto Nazionale di Geofisica e Vulcanologia (INGV)
    Materialart: Conference paper
    Standort Signatur Erwartet Verfügbarkeit
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  • 10
    Publikationsdatum: 2023-06-05
    Beschreibung: A detailed analysis of the earthquake effects on the urban area of Rome has been conducted for the L’Aquila sequence, which occurred in April 2009, by using an on-line macroseismic questionnaire. Intensity residuals calculated using the mainshock and four aftershocks are analyzed in the light of a very accurate and original geological reconstruction of the subsoil of Rome based on a large amount of wells. The aim of this work is to highlight ground motion amplification areas and to find a correlation with the geological settings at a sub-regional scale, putting in evidence the extreme complexity of the phenomenon and the difficulty of making a simplified model. Correlations between amplification areas and both near-surface and deep geology were found. Moreover, the detailed scale of investigation has permitted us to find a correlation between seismic amplification in recent alluvial settings and subsiding zones, and between heard seismic sound and Tiber alluvial sediments.
    Beschreibung: Published
    Beschreibung: 425-443
    Beschreibung: 4.1. Metodologie sismologiche per l'ingegneria sismica
    Beschreibung: JCR Journal
    Beschreibung: open
    Schlagwort(e): Earthquakes ; Intensity residuals ; Urban geosciences ; Macroseismic effects ; Amplification areas ; 04. Solid Earth::04.04. Geology::04.04.09. Structural geology ; 04. Solid Earth::04.06. Seismology::04.06.04. Ground motion ; 04. Solid Earth::04.06. Seismology::04.06.11. Seismic risk
    Repository-Name: Istituto Nazionale di Geofisica e Vulcanologia (INGV)
    Materialart: article
    Standort Signatur Erwartet Verfügbarkeit
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  • 11
    Publikationsdatum: 2020-11-18
    Beschreibung: By analyzing surface latent heat flux (SLHF) data from the NCEP/NCAR Reanalysis Project for the period three months before and after the Sept. 3, 2010 MS 7.1 New Zealand earthquake, an isolated SLHF positive anomaly on Aug. 1, 2010 was found with a high value of about 160 W/m2 to the northeast of the epicenter. Historical data, background pixels, and wavelet transforms of time series were comprehensively analyzed to study the spatiotemporal features of the SLHF anomaly. After removing the influences of wind speed and cloud cover, the key factor leading to local SLHF anomalies is the surface temperature increment. Combined with GPS displacement observations and tectonic settings, we determined that the physical mechanism of the SLHF anomaly could possibly be attributed to hot underground materials related to high-temperature and high-pressure upwelling from the deep crust and mantle along the nearby subduction zone, thereby explaining the local temperature increment to the northeast of the epicenter, as well as in the center of the North Island and the southwest of the South Island. Furthermore, it changed the specific humidity between the ground and surface air, causing the local SLHF increment.
    Beschreibung: Published
    Beschreibung: 3273-3280
    Beschreibung: 1.7. Osservazioni di alta e media atmosfera
    Beschreibung: 1.10. TTC - Telerilevamento
    Beschreibung: 3.1. Fisica dei terremoti
    Beschreibung: JCR Journal
    Beschreibung: open
    Schlagwort(e): remote sensing ; earthquakes ; precursors ; 01. Atmosphere::01.01. Atmosphere::01.01.05. Radiation ; 04. Solid Earth::04.02. Exploration geophysics::04.02.05. Downhole, radioactivity, remote sensing, and other methods ; 04. Solid Earth::04.06. Seismology::04.06.11. Seismic risk
    Repository-Name: Istituto Nazionale di Geofisica e Vulcanologia (INGV)
    Materialart: article
    Standort Signatur Erwartet Verfügbarkeit
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  • 12
    Publikationsdatum: 2017-04-04
    Beschreibung: Having a reliable site conditions estimate is an important step to analyze and predict earthquake ground motions. To provide this information for the Campania-Lucania region (southern Apennines, Italy), in the framework of a collaboration with regional civil protection agency, geologic units shown on 1:250,000 scale geologic map, have been sorted together into four categories based on age and geological similarities. According to the site classification defined in engineering building codes, we have assigned to each site classes, a value or range of values of the average shear-wave velocity to 30 m (Vs30) and of the site dominant period. Thus, we have digitized the category boundaries from the map tracing only the geologic contacts that separate units of different site classes. The accuracy of the site-conditions map is only limited by the number of Vs profiles, used to compute the Vs30, and geologic data available so far. Analyses with new data will allow updates and modifications of this map. Anyhow, the resulting site classification map may be an helpful tool to better characterizing the sites effects for those applications where amplification values at large scale are need, such as ground-shaking maps or seismic hazard maps.
    Beschreibung: Published
    Beschreibung: 27-37
    Beschreibung: 4.2. TTC - Modelli per la stima della pericolosità sismica a scala nazionale
    Beschreibung: JCR Journal
    Beschreibung: open
    Schlagwort(e): Site-conditions map ; site effects ; seismic hazard ; shear-wave velocity ; 04. Solid Earth::04.06. Seismology::04.06.04. Ground motion ; 04. Solid Earth::04.06. Seismology::04.06.11. Seismic risk
    Repository-Name: Istituto Nazionale di Geofisica e Vulcanologia (INGV)
    Materialart: article
    Standort Signatur Erwartet Verfügbarkeit
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  • 13
    Publikationsdatum: 2017-04-04
    Beschreibung: The Irpinia Seismic Network (ISNet) is deployed in Southern Apennines along the active fault system responsible for the 1980, November 23, MS 6.9 Campania-Lucania earthquake. It is comprised of 28 stations and covers an area of about 100x70 km2. Each site is equipped with a 1-g full-scale accelerometer and a short-period velocimeter. Thanks to its design characteristics, i.e. the wide dynamic recording range and the high density of stations, the ISNet network is mainly devoted to estimating in real-time the earthquake location and magnitude from low- to high- magnitude events, and to providing ground-motion parameters to get some insights about the ground shaking expected. Moreover, the availability of high-quality data allows studying the source processes related to the seismogenetic structures in the area. The network layout, the data communication system and protocols and the main instrumental features are described in the paper. Most of the data analysis is performed through the Earthworm software package, that also provides the automatic earthquake locations, while custom software has been developed for real-time computation of the source parameters and shaking maps. Technical details about these procedures are given in the article. The data collected at the ISNet stations are available upon request.
    Beschreibung: Published
    Beschreibung: 1105-1129
    Beschreibung: 4.1. Metodologie sismologiche per l'ingegneria sismica
    Beschreibung: JCR Journal
    Beschreibung: open
    Schlagwort(e): early warning ; real time seismology ; Irpinia region ; 04. Solid Earth::04.06. Seismology::04.06.11. Seismic risk
    Repository-Name: Istituto Nazionale di Geofisica e Vulcanologia (INGV)
    Materialart: article
    Standort Signatur Erwartet Verfügbarkeit
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  • 14
    Publikationsdatum: 2017-04-04
    Beschreibung: A seismic noise recording experiment has been carried out in the Campi Flegrei volcanic area from March 9 to 26, 2009 in the framework of the INGV-DPC 2007-2009 agreement (Project V1 – UNREST). The project aimed at the realization of an integrated method for the definition of the unrest phases at Campi Flegrei. 21 digital three-component seismic stations equipped with broad band seismometers have been added to the existing 11 digital stations already deployed in the area. The preliminary results show a correlation between the seismic noise level and the anthropic activity, whereas the meteorological conditions seem affecting the low frequency seismic noise. These results are important to define the detection thresholds of the seismic signals generated during a possible renewal phase of the volcanic activity.
    Beschreibung: Published
    Beschreibung: 1-21
    Beschreibung: N/A or not JCR
    Beschreibung: open
    Schlagwort(e): Campi Flegrei ; seismic noise ; spectral analysis ; wave polarization ; 04. Solid Earth::04.06. Seismology::04.06.04. Ground motion ; 04. Solid Earth::04.06. Seismology::04.06.06. Surveys, measurements, and monitoring ; 04. Solid Earth::04.06. Seismology::04.06.08. Volcano seismology ; 04. Solid Earth::04.06. Seismology::04.06.09. Waves and wave analysis ; 04. Solid Earth::04.06. Seismology::04.06.10. Instruments and techniques ; 04. Solid Earth::04.06. Seismology::04.06.11. Seismic risk
    Repository-Name: Istituto Nazionale di Geofisica e Vulcanologia (INGV)
    Materialart: article
    Standort Signatur Erwartet Verfügbarkeit
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  • 15
    Publikationsdatum: 2022-05-24
    Beschreibung: National seismic risk maps are an important risk mitigation tool as they can be used for the prioritization of regions within a country where retrofitting of the building stock or other risk mitigation measures should take place. The production of a seismic risk map involves the convolution of seismic hazard data, vulnerability predictions for the building stock and exposure data. The seismic risk maps produced in Italy over the past 10 years are compared in this paper with recent proposals for seismic risk maps based on state-of-the-art seismic hazard data and mechanics-based vulnerability assessment procedures. The aim of the paper is to open the discussion for the way in which future seismic risk maps could be produced, making use of the most up-to-date information in the fields of seismic hazard evaluation and vulnerability assessment.
    Beschreibung: Published
    Beschreibung: 149–180
    Beschreibung: 4.2. TTC - Modelli per la stima della pericolosità sismica a scala nazionale
    Beschreibung: JCR Journal
    Beschreibung: open
    Schlagwort(e): Seismic risk ; Seismic hazard ; 04. Solid Earth::04.06. Seismology::04.06.11. Seismic risk
    Repository-Name: Istituto Nazionale di Geofisica e Vulcanologia (INGV)
    Materialart: article
    Standort Signatur Erwartet Verfügbarkeit
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  • 16
    Publikationsdatum: 2017-04-04
    Beschreibung: National seismic risk maps are an important risk mitigation tool as they can be used for the prioritization of regions within a country where retrofitting of the building stock or other risk mitigation measures should take place. The production of a seismic risk map involves the convolution of seismic hazard data, vulnerability predictions for the building stock and exposure data. The seismic risk maps produced in Italy over the past 10 years are compared in this paper with recent proposals for seismic risk maps based on state-of-the-art seismic hazard data and mechanics-based vulnerability assessment procedures. The aim of the paper is to open the discussion for the way in which future seismic risk maps could be produced, making use of the most up-to-date information in the fields of seismic hazard evaluation and vulnerability assessment.
    Beschreibung: Italian Ministry of Research and Higher Education (MIUR—Ministero dell’Università e della Ricerca) through the financing of the project AIRPLANE (Advancing Interdisciplinary Research PLAtform on volcanoes aNd Earthquakes)
    Beschreibung: In press
    Beschreibung: 4.2. TTC - Scenari e mappe di pericolosità sismica
    Beschreibung: JCR Journal
    Beschreibung: reserved
    Schlagwort(e): Seismic risk ; Seismic hazard ; 04. Solid Earth::04.06. Seismology::04.06.11. Seismic risk
    Repository-Name: Istituto Nazionale di Geofisica e Vulcanologia (INGV)
    Materialart: article
    Standort Signatur Erwartet Verfügbarkeit
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  • 17
    Publikationsdatum: 2017-04-04
    Beschreibung: Le stime probabilistiche della pericolosità sismica sono alla base di qualsiasi politica di prevenzione dei danni da terremoto, sia perché utilizzate per definire le aree prioritarie per interventi di riduzione del rischio sismico, sia perché su di esse si basa la normativa tecnica per le costruzioni. Eppure, nonostante la loro importanza, non esiste una procedura standard universalmente riconosciuta per definire con precisione la pericolosità sismica di un’area.
    Beschreibung: Published
    Beschreibung: Reggio Calabria, Italy
    Beschreibung: 4.2. TTC - Scenari e mappe di pericolosità sismica
    Beschreibung: open
    Schlagwort(e): Seismic hazard ; Italy ; 04. Solid Earth::04.06. Seismology::04.06.11. Seismic risk
    Repository-Name: Istituto Nazionale di Geofisica e Vulcanologia (INGV)
    Materialart: Oral presentation
    Standort Signatur Erwartet Verfügbarkeit
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  • 18
    Publikationsdatum: 2019-11-04
    Beschreibung: In this paper we report the results of several investigations aimed at evaluating ground motion scenarios for the September 26th, 1997 Colfiorito earthquake (Mw 6.0, 09:40 UTC). We model the observed variability of ground motions through synthetic scenarios which simulate an earthquake rupture propagating at constant rupture velocity (2.7 km/s) and the inferred directivity. We discuss the variability of kinematic source parameters, such as the nucleation position and the rupture velocity, and how it influences the predicted ground motions and it does not account for the total standard deviation of the empirical predictive model valid for the region. Finally, we used the results from the scenario studies for the Colfiorito earthquake to integrate the probabilistic and deterministic approaches for seismic hazard assessment.
    Beschreibung: GNDT 2000-2003 S3 Project, DPC-INGV 2004-2006
    Beschreibung: Published
    Beschreibung: 509-525
    Beschreibung: 4.2. TTC - Scenari e mappe di pericolosità sismica
    Beschreibung: JCR Journal
    Beschreibung: open
    Schlagwort(e): ground motion scenario ; 04. Solid Earth::04.06. Seismology::04.06.11. Seismic risk
    Repository-Name: Istituto Nazionale di Geofisica e Vulcanologia (INGV)
    Materialart: article
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  • 19
    Publikationsdatum: 2022-05-24
    Beschreibung: The concerted effort to collect earthquake damage data in Italy over the past 30 years has led to the development of an extensive database from which vulnerability predictions for the Italian building stock can be derived. A methodology to derive empirical vulnerability curves with the aforementioned data is presented herein and the resulting curves have been directly compared with mechanics-based vulnerability curves. However, it has been found that a valid comparison between the empirical and analytical vulnerability curves is not possible mainly due to a number of shortcomings in the database of surveyed buildings. A detailed discussion of the difficulties in deriving vulnerability curves from the current observed damage database is thus also presented.
    Beschreibung: DPC — Dipartimento della Protezione Civile MIUR – Ministero dell’Università e della Ricerca - project AIRPLANE
    Beschreibung: Published
    Beschreibung: 485–504
    Beschreibung: 4.2. TTC - Scenari e mappe di pericolosità sismica
    Beschreibung: JCR Journal
    Beschreibung: reserved
    Schlagwort(e): vulnerability curves ; damage data ; 04. Solid Earth::04.06. Seismology::04.06.11. Seismic risk
    Repository-Name: Istituto Nazionale di Geofisica e Vulcanologia (INGV)
    Materialart: article
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  • 20
    Publikationsdatum: 2021-06-21
    Beschreibung: Earthquake early warning systems (EEWS), based on real-time prediction of ground motion or structural response measures, may play a role in re- ducing vulnerability and/or exposure of buildings and lifelines. Indeed, seismologists have recently developed efficient methods for real-time es- timation of an event’s magnitude and location based on limited informa- tion of the P-waves. Therefore, when an event occurs, estimates of magni- tude and source-to-site distance are available, and the prediction of the structural demand at the site may be performed by Probabilistic Seismic Hazard Analysis (PSHA) and then by Probabilistic Seismic Demand Analysis (PSDA) depending upon EEWS measures. Such an approach contains a higher level of information with respect to traditional seismic risk analysis and may be used for real-time risk management. However, this kind of prediction is performed in very uncertain conditions which may affect the effectiveness of the system and therefore have to be taken into due account. In the present study the performance of the EWWS under development in the Campania region (southern Italy) is assessed by simu- lation. The earthquake localization is formulated in a Voronoi cells ap- proach, while a Bayesian method is used for magnitude estimation. Simu- lation has an empirical basis but requires no recorded signals. Our results, in terms of hazard analysis and false/missed alarm probabilities, lead us to conclude that the PSHA depending upon the EEWS significantly improves seismic risk prediction at the site and is close to what could be produced if magnitude and distance were deterministically known.
    Beschreibung: Published
    Beschreibung: 211-232
    Beschreibung: 4.1. Metodologie sismologiche per l'ingegneria sismica
    Beschreibung: reserved
    Schlagwort(e): Earthquake Early ; Campania Region ; 04. Solid Earth::04.06. Seismology::04.06.03. Earthquake source and dynamics ; 04. Solid Earth::04.06. Seismology::04.06.04. Ground motion ; 04. Solid Earth::04.06. Seismology::04.06.11. Seismic risk
    Repository-Name: Istituto Nazionale di Geofisica e Vulcanologia (INGV)
    Materialart: book chapter
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  • 21
    Publikationsdatum: 2017-04-04
    Beschreibung: For early-warning applications in particular, the reliability and efficiency of rapid scenario generation strongly depend on the availability of reliable strong ground-motion prediction tools. If shake maps are used to represent patterns of potential damage as a consequence of large earthquakes, attenuation relations are used as a tool for predicting peak ground-motion parameters and intensities. One of the limitations in the use of attenuation relations is that these have only rarely been retrieved from data collected in the same tectonic environment in which the prediction has to be performed. As a consequence, strong ground motion can result in underestimations or overestimations with respect to the recorded data. This also holds for Italy, and in particular for the Southern Apennines, due to limitations in the available databases, both in terms of distances and magnitude. Moreover, for “real-time” early-warning applications, it is important to have attenuation models for which the parameters can be easily upgraded when new data are collected, whether this has to be done during the earthquake rupture occurrence or in the post-event, when all the strong motion waveforms are available. Here we present a strong-motion attenuation relation for early-warning applications in the Campania region (Southern Apennines), Italy. The model has a classical analytical formulation, and its coefficients were retrieved from a synthetic strong-motion database created by using a stochastic approach. The input parameters for the simulation technique were obtained through the spectral analysis of waveforms of earthquakes recorded by the Istituto Nazionale di Geofisica e Vulcanologia (INGV) network for a magnitude range Md (1.5,5.0) in the last fifteen years, and they have been extrapolated to cover a larger range. To validate the inferred relation, comparisons with two existing attenuation relations are presented. The results show that the calibration of the attenuation parameters, i.e., geometric spreading, quality factor Q, static stress drop values along with their uncertainties, are the main concern.
    Beschreibung: Published
    Beschreibung: 133-152
    Beschreibung: 4.1. Metodologie sismologiche per l'ingegneria sismica
    Beschreibung: reserved
    Schlagwort(e): A Strong Motion ; Earlywarning ; 04. Solid Earth::04.06. Seismology::04.06.03. Earthquake source and dynamics ; 04. Solid Earth::04.06. Seismology::04.06.04. Ground motion ; 04. Solid Earth::04.06. Seismology::04.06.11. Seismic risk
    Repository-Name: Istituto Nazionale di Geofisica e Vulcanologia (INGV)
    Materialart: book chapter
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  • 22
    Publikationsdatum: 2017-04-04
    Beschreibung: In the framework of an ongoing project financed by the Campania Region, a prototype system for seismic early and post-event warning is being developed and tested, based on a dense, wide dynamic seismic network (ISNet) and under installation in the Apennine belt region. This paper reports the characteristics of the seismic network, focussing on the required technological innovation of the different seismic network components (data-logger, sensors and data communication). To ensure a highly dynamic recording range, each station is equipped with two types of sensors: a strong-motion accelerometer and a velocimeter. Data acquisition at the seismic stations is performed using Osiris-6 model data-loggers made by Agecodagis. Each station is supplied with two (120 W) solar panels and two 130 Ah gel cell batteries, ensuring 72-h autonomy for the seismic and radio communication equipment. The site is also equipped with a GSM/GPRS programmable control/alarm system connected to several environmental sensors (door forcing, solar panel controller, battery, fire, etc) and through which the site status is known in real time. The data are stored locally on the hard-disk and, at the same time, continuously transmitted by the SeedLink protocol to local acquisition/analysis nodes (Local Control Center) via Wireless LAN bridge. At each LCC site runs a linux Earthworm system which stores and manages the acquired data stream. The real-time analysis system will perform event detection and localization based on triggers coming from data-loggers and parametric information coming from the other LCCs. Once an event is detected, the system will performs automatic magnitude and focal mechanism estimations. In the immediate post-event period, the RISSC performs shaking map calculations using parameters from the LCCs and/or data from the event database. The recorded earthquake data are stored into an event database, to be available for distribution and visualization for further off-line analyses. The seismic network will be completed in two stages: • Deployment of 30 seismic stations along the southern Apennine chain (to date almost completed) • Setting up a carrier-class radio communication system for fast and reliable data transmission, and installation of 10 additional seismic stations.
    Beschreibung: Published
    Beschreibung: 325 - 341
    Beschreibung: 4.1. Metodologie sismologiche per l'ingegneria sismica
    Beschreibung: reserved
    Schlagwort(e): Monitoring Infrastructure ; Early-warning Applications ; 04. Solid Earth::04.06. Seismology::04.06.03. Earthquake source and dynamics ; 04. Solid Earth::04.06. Seismology::04.06.04. Ground motion ; 04. Solid Earth::04.06. Seismology::04.06.11. Seismic risk
    Repository-Name: Istituto Nazionale di Geofisica e Vulcanologia (INGV)
    Materialart: book chapter
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  • 23
    Publikationsdatum: 2017-04-04
    Beschreibung: In this article the implementation and potential of the Seismotectonic Information System of the Campania Region (SISCam) are described, in particular an application of this Web-based GIS system to the seismotectonic analysis of the Sannio area (Southern Apennines) is performed. WEB-GIS technologies greatly contribute to both the environmental monitoring and the disaster management of areas affected by high natural risks. Specifically the SISCam system has been developed with the aim of providing easy access and fast diffusion, through Internet technology, of the most significant geological, geophysical, and territorial data relative to the Campania Region. The Sannio area has been selected as our application example because it is among the most active seismic regions in Italy. This portion of the Southern Apennines which was hit by the June 5, 1688 strong earthquake (MW = 6.7, CPTI 1999) and by some low- and moderate-energy seismic sequences (1990–1992, 1997), is characterized by a complex inherited tectonic setting and low-tectonic deformation rates that hide the seismogenic sources position. Since this case study turned out to be complicated, the use of the SIScam WEB-GIS has become indispensable because it allowed us to visualize, integrate and analyze all the data available, in order to obtain an accurate and direct picture of the seismotectonic setting of the area. Moreover, a different approach of data analysis was necessary, due to the lack of up-todate neotectonic and structural data; therefore, the operation of this GIS system enabled us to process and generate some original informative layers, through image analysis, such as new structural lineaments represented on a map of the potential active faults of the area, which has been the final result of our application, as a contribution to new knowledge about the local seismic risk parameters.
    Beschreibung: Published
    Beschreibung: on line first
    Beschreibung: 5.4. TTC - Sistema Informativo Territoriale
    Beschreibung: JCR Journal
    Beschreibung: reserved
    Schlagwort(e): Web-based GIS ; Seismotectonic data ; 04. Solid Earth::04.06. Seismology::04.06.11. Seismic risk ; 04. Solid Earth::04.07. Tectonophysics::04.07.07. Tectonics ; 05. General::05.02. Data dissemination::05.02.02. Seismological data
    Repository-Name: Istituto Nazionale di Geofisica e Vulcanologia (INGV)
    Materialart: article
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  • 24
    Publikationsdatum: 2017-04-04
    Beschreibung: A prototype system for earthquake early warning and rapid shake map evaluation is being developed and tested in southern Italy based on a dense, dynamic seismic network (accelerometers + seismometers) under installation in the Apenninic belt region (Irpinia Seismic Network). It can be classified as a regional Earthquake Early Warning System consisting of a broad-based seismic sensor network covering a portion or the entire area which is threatened by the quake's strike. The real time magnitude estimate will take advantage from the high spatial density of the network in the source region and the broad dynamic range of installed instruments. Based on the offline analysis of high quality strong-motion data bases recorded in Italy, several methods are envisaged, using different observed quantities (peak amplitude, dominant frequency, square velocity integral, …) to be measured on seismograms, as a function of time, both on P and early-S wave signals. Results from the analysis of the Italian strong motion database point out the possibility of using low-pass filtered displacement and velocity peak amplitudes measured in time windows lasting less than 3-4 sec after the first P- or S-wave arrivals. These parameters show they are robustly correlated with moment magnitude. The correlation found of 3Hz low-pass filtered PGV and PGD with magnitude is discussed and interpreted in terms of plausible dynamic models of the earthquake rupture process during its initial stage.
    Beschreibung: Published
    Beschreibung: 45-63
    Beschreibung: 4.1. Metodologie sismologiche per l'ingegneria sismica
    Beschreibung: reserved
    Schlagwort(e): Real-time Estimation ; Magnitude ; Seismic Early Warning ; 04. Solid Earth::04.06. Seismology::04.06.03. Earthquake source and dynamics ; 04. Solid Earth::04.06. Seismology::04.06.04. Ground motion ; 04. Solid Earth::04.06. Seismology::04.06.11. Seismic risk
    Repository-Name: Istituto Nazionale di Geofisica e Vulcanologia (INGV)
    Materialart: book chapter
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  • 25
    Publikationsdatum: 2019-11-04
    Beschreibung: The neotectonics of the islands of Faial, Pico and S. Jorge (Azores) is presented. Preliminary paleoseismology data from trench exposures across three active fault zones (Lomba do Meio, Lagoa do Capitão and Pico do Carvão faults) complement the information. Radiocarbon age constraints of paleoearthquakes suggest clustering of surface rupturing events. Slip rates deduced from paleoseismology analysis range from 0.10 to 0.40 cm/year and validate long-term slip rates obtained by neotectonic studies (using Pleistocene markers). The studied faults allowed a preliminary seismic hazard assessment: magnitudes of the largest paleoearthquakes, determined from slip per event range from Mw = 6.9 to 7.1, and maximum expected magnitudes, estimated from rupture length or rupture area, vary from Mw = 6.4 to 6.8. The former Mw estimates are in closer agreement with the magnitude of the major historic and instrumental seismic events in the archipelago, even though the used empirical relations between magnitude and rupture parameters may not be the most adequate due to the unique tectonic setting of Azores.
    Beschreibung: Published
    Beschreibung: JCR Journal
    Beschreibung: open
    Schlagwort(e): Azores ; neotectonics ; active faulting ; paleoseismology ; seismic hazard ; 04. Solid Earth::04.01. Earth Interior::04.01.01. Composition and state ; 04. Solid Earth::04.07. Tectonophysics::04.07.07. Tectonics ; 04. Solid Earth::04.06. Seismology::04.06.11. Seismic risk
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  • 26
    Publikationsdatum: 2019-11-04
    Beschreibung: A probabilistic approach was applied to map the seismic hazard in Greece and the surrounding region. The procedure does not require any specification of seismic sources or/and seismic zones and allows for the use of the whole seismological record, comprising both historical and instrumental data, available for the region of interest. The new seismic hazard map prepared for Greece and its vicinity specifies a 10% probability of exceedance of the given Peak Ground Acceleration (PGA) values for shallow seismicity and intermediate soil conditions for an exposure time of 50 years. When preparing the map, the new PGA attenuation relation given by Margaris et al. (2001) was employed. The new map shows a spatial distribution of the seismic hazard that corresponds well with the features of shallow seismicity within the examined region. It depicts the level of seismic hazard in which the exceedance of the PGA value of 0.25 g may be expected to occur within limited areas. The highest estimated levels of seismic hazard inside the territory of Greece are found in the Northern Sporades Islands, where PGA values in excess of 0.50 g are reached at individual sites, and in the Zante Island in Western Greece, where PGA values in the range of 0.35 g to 0.40 g are obtained at more numerous localities. High values are also observed in the sea between the Karpathos and Rhodes islands, near the Island of Amorgos (Cyclades Archipelago) and in the Southwestern Peloponnesus. The levels of seismic hazard at the sites of seven Greek cities (Athens, Jannena, Kalamata, Kozani, Larisa, Rhodes and Thessaloniki) were also estimated in terms of probabilities that a given PGA value will be exceeded at least once during a time interval of 1, 50 and 100 years at those sites. These probabilities were based on the maximum horizontal PGA values obtained by applying the design earthquake procedure, and the respective median values obtained were 0.24 g for Athens, 0.28 g for Jannena, 0.30 g for Kalamata, 0.21 g for Kozani, 0.24 g for Larisa, 0.43 g for Rhodes and 0.35 g for Thessaloniki. The probabilities of exceedance of the estimated maximum possible PGA value were also calculated for the cities to illustrate the uncertainty of maximum PGA assessment.
    Beschreibung: Published
    Beschreibung: JCR Journal
    Beschreibung: open
    Schlagwort(e): seismicity of Greece ; probabilistic seismic ; hazard ; peak ground acceleration ; design earthquake procedure ; 04. Solid Earth::04.06. Seismology::04.06.11. Seismic risk
    Repository-Name: Istituto Nazionale di Geofisica e Vulcanologia (INGV)
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  • 27
    Publikationsdatum: 2019-11-04
    Beschreibung: As an alternative to traditional parametric approaches, we suggest nonparametric methods for analyzing temporal data on earthquake occurrences. In particular, the kernel method for estimating the hazard function and the intensity function are presented. One novelty of our approaches is that we take into account the possible dependence of the data to estimate the distribution of time intervals between earthquakes, which has not been considered in most statistics studies on seismicity. Kernel estimation of hazard function has been used to study the occurrence process of cluster centers (main shocks). Kernel intensity estimation, on the other hand, has helped to describe the occurrence process of cluster members (aftershocks). Similar studies in two geographic areas of Spain (Granada and Galicia) have been carried out to illustrate the estimation methods suggested.
    Beschreibung: Published
    Beschreibung: JCR Journal
    Beschreibung: open
    Schlagwort(e): nonparametric estimation ; hazard function ; intensity function ; dependent data ; clustering ; 04. Solid Earth::04.06. Seismology::04.06.10. Instruments and techniques ; 04. Solid Earth::04.06. Seismology::04.06.11. Seismic risk
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  • 28
    Publikationsdatum: 2019-11-04
    Beschreibung: Seismic hazard in terms of probability of exceedance of a given intensity in a given time span,was assessed for 12 sites in Japan.The method does not use any attenuation law.Instead,the dependence of local intensity on epicentral intensity I 0 is calculated directly from the data,using a Bayesian model.According to this model (Meroni et al., 1994),local intensity follows the binomial distribution with parameters (I 0 ,p ).The parameter p is considered as a random variable following the Beta distribution.This manner of Bayesian estimates of p are assessed for various values of epicentral intensity and epicentral distance.In order to apply this model for the assessment of seismic hazard,the area under consideration is divided into seismic sources (zones)of known seismicity.The contribution of each source on the seismic hazard at every site is calculated according to the Bayesian model and the result is the combined effect of all the sources.High probabilities of exceedance were calculated for the sites that are in the central part of the country,with hazard decreasing slightly towards the north and the south parts.
    Beschreibung: Published
    Beschreibung: JCR Journal
    Beschreibung: open
    Schlagwort(e): Bayesian estimation ; local intensity ; random variable p ; probabilities of exceedance ; 04. Solid Earth::04.06. Seismology::04.06.11. Seismic risk
    Repository-Name: Istituto Nazionale di Geofisica e Vulcanologia (INGV)
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  • 29
    Publikationsdatum: 2019-11-04
    Beschreibung: Based on the indicative modelling, the changes in Coulomb failure function (?CFS) suggest that the W-HV segment and the T-P segment could be stable in at least the future 300 years and 190 years respectively, for these periods should be needed to accumulate the stress released by the M 8.2 Wairarapa earthquake, assuming that there is no influence from other sources, the earthquake did not alter the failure threshold, and that failure is a fairly deterministic process. The results also show that the influence on the W-HV segment and T-P segment of the Wellington Fault caused by the 1855, M 8.2 Wairarapa earthquake is significant considering that the average fault rupture recurrence interval on the Wellington Fault is about 500-770 years. With our present understanding of the Wellington and Wairarapa faults, it can be concluded that the 1855 Wairarapa earthquake retarded earthquake occurrence on the W-HV segment and the T-P segment of the Wellington Fault. Thus the seismic hazard in the Wellington region may be over-estimated.
    Beschreibung: Published
    Beschreibung: JCR Journal
    Beschreibung: open
    Schlagwort(e): Wellington region ; changes on Coulombfailure stress ; earthquake hazard ; 04. Solid Earth::04.04. Geology::04.04.01. Earthquake geology and paleoseismology ; 04. Solid Earth::04.07. Tectonophysics::04.07.05. Stress ; 04. Solid Earth::04.06. Seismology::04.06.11. Seismic risk
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  • 30
    Publikationsdatum: 2019-11-04
    Beschreibung: This paper deals with some fundamental considerations regarding the behaviour of geotechnical structures under seismic loading. First a complete definition of the earthquake disaster risk is provided, followed by the importance of performing site-specific hazard analysis. Then some suggestions are provided in regard to adequate assessment of soil parameters, a crucial point to properly analyze the seismic behaviour of geotechnical structures. The core of the paper is centered on a critical review of the analysis methods available for studying geotechnical structures under seismic loadings. All of the available methods can be classified into three main classes, including the pseudo-static, pseudo-dynamic and dynamic approaches, each of which is reviewed for applicability. A more advanced analysis procedure, suitable for a so-called performance-based design approach, is also described in the paper. Finally, the seismic behaviour of the El Infiernillo Dam was investigated. It was shown that coupled elastoplastic dynamic analyses disclose some of the important features of dam behaviour under seismic loading, confirmed by comparing analytical computation and experimental measurements on the dam body during and after a past earthquake.
    Beschreibung: Published
    Beschreibung: JCR Journal
    Beschreibung: open
    Schlagwort(e): seismic design ; soil dynamics ; case histories ; 04. Solid Earth::04.06. Seismology::04.06.11. Seismic risk
    Repository-Name: Istituto Nazionale di Geofisica e Vulcanologia (INGV)
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  • 31
    Publikationsdatum: 2021-03-01
    Beschreibung: On September 6, 2002, aML =5.6 earthquake, occurring some tens of kilometres offshore from the Northern Sicilian coast (Southern Tyrrhenian Sea), slightly damaged the city of Palermo and surroundings (degree 6 in the European Macroseismic Scale 1998). The macroseismic investigation of the shock and a detailed study of effects of the main earthquakes which affected Palermo in the past have been performed in order to evaluate the seismic response of the city. Moreover, the comparison of the recent event, which is instrumentally constrained, with historical earthquakes allows us to infer new insights on the seismogenic sources of the area, that seem located offshore in the Tyrrhenian sea. In the last 500 years, Palermo has never been completely destroyed but has suffered effects estimated between intensities 6 and 8 EMS-98 many times (1693, 1726, 1751, 1823, 1940, 1968, 2002). The damage scenarios of the analysed events have shown that damage distribution is strongly conditioned by soil response in the different parts of the city and by a high building vulnerability, mainly in the historical centre and in the south-eastern zone of the modern city. As a matter of fact, Palermo has always suffered greater effects than those reported for other nearby localities. The hazard assessment obtained using observed site intensities has shown that the probability of occurrence for intensity 8 (the strongest intensity observed in Palermo) exceeds 99% for 550 years, while the estimated mean return period is 152 ± 40 years. These results, in connection with building vulnerability due to the urban expansion before the introduction of seismic code, suggest that the city is exposed to a relatively high seismic risk.
    Beschreibung: Published
    Beschreibung: 525-543
    Beschreibung: partially_open
    Schlagwort(e): intensity ; damage ; earthquakes ; Italy ; macroseismics ; Palermo ; seismic hazard ; vulnerability ; 04. Solid Earth::04.06. Seismology::04.06.11. Seismic risk
    Repository-Name: Istituto Nazionale di Geofisica e Vulcanologia (INGV)
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  • 32
    Publikationsdatum: 2017-04-04
    Beschreibung: An anisotropic attenuation law, based on an anisotropic characterization of intensity distribution for seismogenic zones, is proposed. This approach, that distinguishes itself for its consistency to the observed data, initially reconfigured by filtering procedures, is particularly suitable for seismic hazard evaluation.
    Beschreibung: Published
    Beschreibung: 707-714
    Beschreibung: partially_open
    Schlagwort(e): Attenuation law ; virtual intensity distribution ; seismic hazard ; 04. Solid Earth::04.06. Seismology::04.06.11. Seismic risk
    Repository-Name: Istituto Nazionale di Geofisica e Vulcanologia (INGV)
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  • 33
    Publikationsdatum: 2017-04-04
    Beschreibung: A modelling of the observed macroseismic intensity of historical and instrumental earthquakes in southern Spain is proposed, with the aim of determining the macroseismic parameters for seismic hazard evaluation in a region in which the characterization of intensity distribution of seismic events shows different levels of difficulty referable to the complex faults system of the area in study. The adopted procedure allows an analytical determination of epicenters and principal attenuation directions of earthquakes with a double level of verification with reference to the maximum shaking area and structural lineaments of the region, respectively. The analyses, carried out on a suitable number of events, highlight, therefore, some elements for a preliminary characterization of a seismic zonation on the basis of the consistency between seismic intensity distribution of earthquakes and corresponding structural framework.
    Beschreibung: Published
    Beschreibung: 747-760
    Beschreibung: partially_open
    Schlagwort(e): Attenuation directions ; southern Spain ; macroseismic intensity ; virtual intensity ; 04. Solid Earth::04.07. Tectonophysics::04.07.07. Tectonics ; 04. Solid Earth::04.06. Seismology::04.06.11. Seismic risk
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  • 34
    Publikationsdatum: 2017-04-04
    Beschreibung: The anisotropic modelling of intensity distribution, affected by the construction of macroseismic planes, allows an analysis of the influence of each point of observed intensity on the analytical determination of epicenter and of the principal attenuation directions. Such a procedure is a vital aid in the cases in which the observed intensity points, that, for location or joined intensity level, are not consistent with an anisotropic model of intensity attenuation. A suitable filtering on intensity levels associated with the points of the intensity map, for a better modelling of observed intensity distribution, is proposed with the aim of a better seismic hazard evaluation
    Beschreibung: Published
    Beschreibung: 683-697
    Beschreibung: partially_open
    Schlagwort(e): Macroseismicity ; observed intensity filtering ; macroseismic planes ; 04. Solid Earth::04.06. Seismology::04.06.11. Seismic risk
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  • 35
    Digitale Medien
    Digitale Medien
    Springer
    Chromatographia 49 (1999), S. 543-546 
    ISSN: 1612-1112
    Schlagwort(e): Column liquid chromatography ; MS-MS detection ; Electrospray-Ionization (ESI) ; Beer ; Ochratoxin
    Quelle: Springer Online Journal Archives 1860-2000
    Thema: Chemie und Pharmazie
    Notizen: Summary Ochratoxin A (OTA) is a nephrotoxic and nephrocacinogenic mycotoxin commonly produced by several ubiquitousAspergillus andPenicillium species. OTA is found predominantly in cereals and derived products, and therefore OTA may be transferred into beer from contaminated grain. Thirty-five samples of German beers were analyzed: OTA was extracted with toluene and purified by solid phase extraction using silica cartridges. OTA was determined by high-performance liquid chromatography with fluorescence detection. Since of fluorescence detection is not specific in this instance, the beer samples were also analyzed by high-performance liquid chromatography electrospray ionization-tandem mass spectrometry (HPLC-ESI-MS/MS). OTA levels in the range of 0.1–0.2 μg L−1 were found in 9 beer samples, 21 samples contained trace amounts of OTA (〈0.1 μg L−1) and in 5 samples no OTA was detectable.
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  • 36
    ISSN: 1612-1112
    Schlagwort(e): Column liquid chromatography ; Solid phase extraction ; Doxorubicin ; Cell culture media ; Human plasma ; Fluorescence detection
    Quelle: Springer Online Journal Archives 1860-2000
    Thema: Chemie und Pharmazie
    Notizen: Summary Doxorubicin is an antineoplastic antibiotic isolated fromStreptomyces peucetius var.cesius clinically used in the treatment of tumors such as lung or breast, Hodgkin's disease and various types of leukemias. The main goal of this study was to develop a simple and sensitive HPLC method with fluorescence detection for the quantitation of doxorubicin in cell culture media collected during an in vitro studies and in human plasma. Solid phase extraction (C2 silica) was applied. The experiment established five-point standard curve (1 ng mL−1 to 100 ng mL−1). The standard curves prepared in blank cell tissue media were linear over the range of doxorubicin assayed and had a mean correlation coefficient of 0.9973±9.43×10−4 and slope 0.02545±1.85×10−3. The standard curves prepared in human plasma were linear and had mean correlation coefficient of 0.997 and slope 0.01885±5.19×10−4. The limit of quantitation for doxorubicin in both specimens was arbitrarily established to be 1 ng mL−1. Intra-day variabilities were determined using 3–4 replicates of control solutions of doxorubicin (3 ng mL−1 and 30 ng mL−1) in blank plasma and cell culture media. Inter-day variabilities were determined over a four day period analyzing replicates of controls. All precision and accuracy values fell within the acceptable range.
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  • 37
    ISSN: 1612-1112
    Schlagwort(e): Column liquid chromatography ; Capillary zone electrophoresis ; Electrospray ionization-mass spectrometry ; Human serum albumin
    Quelle: Springer Online Journal Archives 1860-2000
    Thema: Chemie und Pharmazie
    Notizen: Summary Human serum albumin (HSA) is one of the most abundant human proteins and has been shown to be heterogeneous. A RP-HPLC method has been developed to separate HSA components in commercially available preparations. Separations were carried out on Aquapore RP-300, C8 columns using gradient elution with a combination of acetonitrile/water mobile phases containing 0.05% trifluoroacetic acid as ion-pairing agent. Optimum resolution was attained on narrow-bore columns using a stepwise, linear gradient that incorporated a shallow intermediate step of 0.20%/min in Mobile Phase B. Under similar elution conditions, separations carried out on standard-size columns showed the expected decrease in resolution due to increased peak widths. A comparative analysis of three commercial products highlighted qualitative and quantitative differences. Capillary zone electrophoresis was used for the analysis of collected RP-HPLC fractions. Results indicated that while the HPLC separation was incomplete, one of the major HPLC peaks was primarily composed of one of the three main components typically separated by CZE. ESI-MS was used to characterize the two major RP-HPLC fractions and also showed that the HPLC separation was incomplete. The MaxEnt transform of the HPLC peaks was consistent with components all being HSA and closely related derivatives.
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  • 38
    ISSN: 1612-1112
    Schlagwort(e): Column liquid chromatography ; Amino acids ; FMOC derivatives ; Oligopeptides
    Quelle: Springer Online Journal Archives 1860-2000
    Thema: Chemie und Pharmazie
    Notizen: Summary One classical method for quantitation of amino acids in proteins is hydrolysis of the proteins and determination of the free amino acids. Although the drastic experimental conditions necessary for complete hydrolysis always cause degradation of some of the amino acids, if mild hydrolysis conditions are used, a mixture of amino acids and oligopeptides is obtained. If these conditions are adequately tuned, the oligopeptides are almost exclusively dipeptides. For this reason we have initiated a study to find a derivatizing agent suitable for the analysis of amino acids and dipeptides by an absolute method of quantitation already tested for amino acids. FMOC-Cl was found to be a suitable derivatizing agent for this purpose.
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  • 39
    Digitale Medien
    Digitale Medien
    Springer
    Chromatographia 49 (1999), S. 369-373 
    ISSN: 1612-1112
    Schlagwort(e): Column liquid chromatography ; Sep-Pak CN cartridge ; Oxytetracycline ; Sulphadimidine ; Meat and eggs
    Quelle: Springer Online Journal Archives 1860-2000
    Thema: Chemie und Pharmazie
    Notizen: Summary A rapid method for the simultaneous determination/identification of residual oxytetracycline (OTC) and sulphadimidine (SDD) in meats (beef, pork, chicken) and eggs by high-performance liquid chromatography (HPLC) was developed. The extraction of OTC and SDD was performed using a Sep-Pak® CN cartridge. The extracts contained OTC/SDD analytes when examined by HPLC using a LiChrospher® 100 RP-8 end-capped column and a mobile phase of acetonitrile-acetic acid-water (28:4:68, v/v/v) with a photodiode array detector. The average recoveries from spiked samples (0.1 μg g−1 and 1.0 μg g−1) were in excess of 80.2% with coefficients of variation between 1.5 and 5.0%. The limits of detection for OTC and SDD were 0.05 and 0.02 μg g−1, respectively.
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  • 40
    ISSN: 1612-1112
    Schlagwort(e): Column liquid chromatography ; Evaporative light-scattering detection ; MALDI-TOF ; Polyethylene glycols
    Quelle: Springer Online Journal Archives 1860-2000
    Thema: Chemie und Pharmazie
    Notizen: Summary Polyethylene glycols (PEGs) of nominal molecular weight (M) 200, 400, 600, 1000, 1500, 3000, 4000 and 6000 were chosen as model compounds and subjected to reversed-phase high performance liquid chromatography (RP-HPLC) on an octadecasilyl silica gel (C18) stationary phase using a binary gradient composed of acetonitrile and water and evaporative light scattering detection (ELSD). Satisfactory resolution of oligomers up to M of 3000 was accomplished; the higher M samples PEG-4000 and PEG-6000 could not be further resolved into the constituent oligomers and therefore, M=4000 marks the upper limit of oligomer resolution. Despite some peak overlapping as a consequence of the more or less broad oligomer distribution, individual types of PEG samples can be distinguished from each other by their characteristic chromatographic fingerprint patterns, as shown with a mixture consisting of PEG-400, PEG-1000, PEG-3000, PEG-4000 and PEG-6000. For this reason, the method is well-suited for characterization of samples containing PEGs widely differing in M. In addition, matrix assisted laser desorption ionization time of flight mass spectroscopy (MALDI-TOF/MS) performed with PEG-600, PEG-1000 and PEG-3000 revealed that the optimum degree of oligomer resolution has been achieved by use of the present method.
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  • 41
    ISSN: 1612-1112
    Schlagwort(e): Column liquid chromatography ; Chiral stationary phases ; Crown ether derivatives ; Amino compounds
    Quelle: Springer Online Journal Archives 1860-2000
    Thema: Chemie und Pharmazie
    Notizen: Summary The enantiomers of primary amino compounds have previously been resolved on a chiral stationary phase (CSP) CSP-18C6I, prepared by immobilizing (+)-18-crown-6 tetracarboxylic acid. In this study related chiral stationary phases were prepared in an effort to broaden the scope of CSP18C6I. CSP-18C6II, synthesized to investigate the effect of spacer length, resolved the enantiomers of 2-amino-1,2-diphenylethanol and 1-(1-naphthyl)ethylamine (1-NEA) (hydrophobic amino compounds) with the largerk values and smaller α values than on CSP-18C6I, probably because of the greater hydrophobicity of CSP-18C6II. Use of CSP-18C6III, synthesized by modification of carboxylic acid functionality of CSP-18C6II by introduction of another chiral moiety,S-1-NEA, resulted in larger α values for 2-amino-1-phenylethanol and 2-amino-1-phenylpropanol than on CSP-18C6II, but the enantiomers of 1-NEA were not resolved, because of steric hindrance between 1-NEA and the chiral moiety. The amide derivativeN-3,5-dinitrobenzoyl-1-(α-naphthyl)ethylamine (DNN) as π-acceptor (3,5-dinitrobenzoyl function) or π-donor (naphthylethylamide function), and no primary amino functionality, was resolved on CSP-18C6III. The mechanism of separation of the enantiomers of DNN was assumed to be the π−π interaction between the 3,5-dinitrobenzoyl function (π-acceptor) of DNN and theS-1-NEA moiety (π-donor) of CSP-18C6III.
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  • 42
    ISSN: 1612-1112
    Schlagwort(e): Column liquid chromatography ; Alcohols ; Pre-column fluorescence derivatization
    Quelle: Springer Online Journal Archives 1860-2000
    Thema: Chemie und Pharmazie
    Notizen: Summary A sensitive LC method for the determination of alcohols, using fluorescent condensation agent carbazole-9-N-acetylbenzne-disulfonate(CABS), has been developed. A mixture of alcohols and triethylamine catalyst in dichloromethane or chloroform is treated with CABS to give quantitative yields of esters. Emission maximum for the derivatized alcohols is 365 nm (λex 335 nm). The labeled derivatives are very stable, no significant decomposition is observed after heating in 40% at 40°C for 24 h. The method, in conjunction with a multigradient program, offers baseline resolution of common alcohol derivatives on a reversed-phase C18 column. Studies on derivatization conditions indicate that primary and secondary alcohols react very fast with CABS in the presence of triethylamine in dichloromethane or chloroform to give the corresponding fluorescent derivatives. This method is more convenient and more efficient than previous methods which require prior conversion of carboxylic acids to acyl chlorides. The separation of alcohol derivatives has good reproducibility and the rsd's (n=5) for 50 pmol of each alcohol are 4%. Detection limits are at the fmol level.
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  • 43
    Digitale Medien
    Digitale Medien
    Springer
    Chromatographia 49 (1999), S. 42-46 
    ISSN: 1612-1112
    Schlagwort(e): Column liquid chromatography ; Chiral resolution ; Jasmonic acid ; Plant growth regulators ; Amine conjugates
    Quelle: Springer Online Journal Archives 1860-2000
    Thema: Chemie und Pharmazie
    Notizen: Summary Racemic jasmonic acid (3R,7R/3S,7S)-(±)-JA) was chemically conjugated with different biogenic amines originating from aliphatic and aromatic α-amino acids by decarboxylation. The resulting isomeric compounds were subjected to reversed-phase high-performance liquid chromatography (HPLC) and to HPLC on the chiral stationary phases Chiralpak AS and Nucleodex β-PM. Under reversed-phase conditions, all the homologous amine derivatives tested could be separated from each other except the JA-conjugates containing 2-phenyl-ethylamine and 3-methylbutylamine. On both chiral supports the (3R,7R)-(−)-JA conjugates eluted earlier than those of the enantiomeric counterpart (3S,7S)-(+)-JA. On Chiralpak AS all the isomers studied could be separated to baseline with a mobile phase containingn-hexane and 2-propanol. The calculated resolution factors were between 1.80 and 4.17. The pairs of isomers were also chromatographed on the cyclodextrin stationary phase Nucleodex β-PM with methanol-triethylammonium acetate buffer as mobile phase. Under these conditions resolution factors were between 0.74 and 1.29. The individual isomers were chiroptically characterized by measurement of their circular dichroism.
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  • 44
    ISSN: 1612-1112
    Schlagwort(e): Column liquid chromatography ; Micellar electrokinetic chromatography (MEKC) ; Oral contraceptives ; Ethinylestradiol ; Gestodene
    Quelle: Springer Online Journal Archives 1860-2000
    Thema: Chemie und Pharmazie
    Notizen: Summary A micellar electrokinetic chromatographic method is presented which permits quantification of ethinylestradiol and gestodene in pharmaceutical products. Separation was carried out at 25°C and 25 KV, using a 20 mM borate buffer (pH 9.2), 15 mM sodium dodecylsulfate in 30% acetonitrile-water (v/v). Under these conditions analyses were carried out in 7 min. Four different oral contraceptives were analysed and the results compared favourably with those of a reference liquid chromatographic method.
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  • 45
    ISSN: 1612-1112
    Schlagwort(e): Column liquid chromatography ; Zirconium oxide ceramics ; X-ray fluorescence ; Neutron activation
    Quelle: Springer Online Journal Archives 1860-2000
    Thema: Chemie und Pharmazie
    Notizen: Summary Lanthania-and yttria-stabilized zirconium oxide ceramics have been examined using High Performance Liquid Chromatography (HPLC), thermal neutron activation (NA) and X-ray Fluorescence (XRF) analyses and thus determine the stabilizer content. Ceramic powders with the composition ZrO2:x mol % La2O3 (x=5, 10, 15, 20 and 33) and ZrO2:x mol % Y2O3 (x=10, 15, 20 and 25) were prepared by the citrate and the co-precipitation techniques, respectively. The lanthanum content was determined by HPLC (x=5.09, 9.78, 14.98, 19.81 and 25.94) and NA (x=5.15, 10.32, 17.25, 21.08 and 27.97) analyses, the yttrium content by HPLC (x=8.5, 13.5, 17.9 and 22.1) and XRF (x=9.9, 15.8, 20.1 and 24.9) analyses. An experimental sequence, based on continuous dilution of ceramic powder solutions, is proposed for preparing samples for HPLC measurements. A swimming pool nuclear reactor is used for NA analysis. The quantitative determinations of yttrium and lanthanum doping levels obtained using those techniques are described.
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  • 46
    ISSN: 1612-1112
    Schlagwort(e): Column liquid chromatography ; α-Chymotrypsin immobilized on silica ; In situ immobilization process ; Structural chiral separations
    Quelle: Springer Online Journal Archives 1860-2000
    Thema: Chemie und Pharmazie
    Notizen: Summary α-Chymotrypsin was immobilized on an epoxide derivatized silica gel by anin situ immobilization process. Several racemates were resolved by a structural recognition mechanism. The immobilization process and the stability of this α-chymotrypsin stationary phase have been studied. The mobile phase parameters including the ionic strength, pH and the effects of organic modifiers have been also investigated. The retention, efficiency and stereoselectivity of the solutes appear to be related to their molecular structure, hydrophobicity and electrostatic interactions. These relationships determine the recognition mechanism and the position of each enantiomer in the active site.
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  • 47
    ISSN: 1612-1112
    Schlagwort(e): Column liquid chromatography ; Enantiomer separation ; Chiral-AGP column ; Idrapril ; Temperature effect
    Quelle: Springer Online Journal Archives 1860-2000
    Thema: Chemie und Pharmazie
    Notizen: Summary A direct liquid-chromatographic method has been developed for the stereoselective analysis of idrapril and its stereoisomers on a chiral α1 glycoprotein (AGP) column. The influence of flow-rate, temperature, and mobile phase composition on retention and selectivity was evaluated to find the optimum conditions for chiral separation.
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  • 48
    ISSN: 1612-1112
    Schlagwort(e): Column liquid chromatography ; Polyfluoroalkyl-coated silica ; 29Si CP/MAS NMR ; Polyaromatic compounds ; Fluorinated compounds
    Quelle: Springer Online Journal Archives 1860-2000
    Thema: Chemie und Pharmazie
    Notizen: Summary The conditions for reaction of the branched polyfluoroalkylsilane D3CL with silica gel have been examined. From elemental analyses and29Si NMR spectra it was found that the surface coverage and endcapping of D3CL-coated silica gel (Fluofix®) were the same as for ODS packings. The separation behavior of these phases was compared that of a variety of other packings. For polyaromatic compounds and benzene derivatives Fluofix worked in the reversed-phase mode and its retention characteristics were similar to those of C1 or CN packings. For fluorinated compound the retention characteristics of the phases is similar to those of ODS although with MeOH-water and MeCN-water mobile phases the pressure loss was lower for the fluorinated phases than for ODS.
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  • 49
    Digitale Medien
    Digitale Medien
    Springer
    Chromatographia 49 (1999), S. 699-702 
    ISSN: 1612-1112
    Schlagwort(e): Column liquid chromatography ; Anion-exchange chromatography ; High ph elvents ; Monosaccharides ; Carbopac PA-100
    Quelle: Springer Online Journal Archives 1860-2000
    Thema: Chemie und Pharmazie
    Notizen: Summary We have studied the elution behaviour of six common monosaccharides, fucose, galactosamine, glucosamine, galactose, glucose and mannose, on the CarboPac PA-100 column. The relative elution positions of galactose, glucose and mannose were dependent on the sodium hydroxide concentrations, a phenomenon which was likely to be the result of differential ionisation of the hydroxyl groups at ring positions two and four. The optimal resolution of the monosaccharides studied was achieved by elution with 30 mM sodium hydroxide with no appreciable loss in sensitivity at this low concentration.
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  • 50
    Digitale Medien
    Digitale Medien
    Springer
    Chromatographia 49 (1999), S. 253-255 
    ISSN: 1612-1112
    Schlagwort(e): Column liquid chromatography ; Meropenem in human plasma ; Solid phase extraction
    Quelle: Springer Online Journal Archives 1860-2000
    Thema: Chemie und Pharmazie
    Notizen: Summary This paper describes an HPLC method for the determination of meropenem in human plasma. The method uses solid phase extraction (SPE) of the samples and has good sensitivity, precision and accuracy. The limit of quantification in plasma samples is 0.02 μg mL−1. Calibration curves were linear over a large dynamic range, namely within 0.02–50 μg mL−1. The method was applied to the determination of meropenem levels in patients receiving meropenem, as a single dose or at steady state.
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  • 51
    Digitale Medien
    Digitale Medien
    Springer
    Chromatographia 49 (1999), S. 12-16 
    ISSN: 1612-1112
    Schlagwort(e): Column liquid chromatography ; Fatty alcohol sulfates ; Alkyl polyglycosides ; Trace analysis ; Steam distillation
    Quelle: Springer Online Journal Archives 1860-2000
    Thema: Chemie und Pharmazie
    Notizen: Summary Acid catalyzed hydrolysis of fatty alcohol sulfates under reflux condition or by microwave heating is compared. Microwave hydrolysis turned out to be faster and more convenient to use. The combination of reflux hydrolysis of fatty alcohol sulfates or alkyl polyglycosides and the simultaneous steam distillation of the generated fatty alcohols gives a very powerful sample preparation and enrichment method for fatty alcohol sulfates and alkyl polyglycosides. The preconcentrated fatty alcohols are derivatized and detected via fluorescence detection. The applicability of the method is demonstrated by the analysis of fatty alcohol sulfates in cosmetics and in river water as matrices spiked with approximately 4 ppb fatty alcohol sulfates.
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  • 52
    Digitale Medien
    Digitale Medien
    Springer
    Chromatographia 49 (1999), S. 17-20 
    ISSN: 1612-1112
    Schlagwort(e): Column liquid chromatography ; DAD and MS detection ; Liquid-solid extraction ; Catechin derivatives ; Myricetin derivatives
    Quelle: Springer Online Journal Archives 1860-2000
    Thema: Chemie und Pharmazie
    Notizen: Summary A liquid-solid extraction and purification procedure (LSE) was developed to identify and quantify polyphenols in the leaf tissue ofMyrtus communis L. Identification and quantitation of individual compounds was performed using HPTLC, HPLC-DAD and HPLC-MS analysis. Leaves ofMyrtus communis L. contain small amounts of phenolic acids (caffeic, ellagic and gallic acids) and quercetin derivatives (quercetin 3-O-galactoside and quercetin 3-O-rhamnoside), whereas catechin derivatives (epigallocatechin, epigallocatechin 3-O-gallate, epicatechin 3-O-gallate) and myricetin derivatives (myricetin 3-O-galactoside, myricetin 3-O-rhamnoside) are present in large amounts. This is the first report on the occurrence of galloyl-derivatives of catechin and gallo-catechin inMyrtus communis L. leaves.
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  • 53
    ISSN: 1612-1112
    Schlagwort(e): Column liquid chromatography ; Glycolytic enzymes ; p-Hydroxymercuribenzoate ; 203Hg-labelledp-hydroxymercuribenzoate
    Quelle: Springer Online Journal Archives 1860-2000
    Thema: Chemie und Pharmazie
    Notizen: Summary The use of hydrophobic-interaction chromatography (HIC) is proposed for the simultaneous determination of more than one thiol-protein after formation of the corresponding mercury mercaptides withp-hydroxymercuribenzoate (PHMB). The new chromatographic procedure, based on the HIC separation of the modified proteins from each other and from excess organomercury reagent has been successfully applied to the quantitative determination of phosphoglucose isomerase (PGI) and phosphoglucose mutase (PGM) in crude PGI powder, and of L-lactate dehydrogenase, PGM and aldolase in crude pyruvate kinase from rabbit muscle. The suitability of203Hg-labelled PHMB has been tested in the analysis of mixtures, which give barely distinguishable UV-peaks owing to the presence of other non-thiol components in the sample. For this purpose glyceraldehyde 3-phosphate dehydrogenase (GAPDHy) and PGIy from bakers yeast have been considered. Results obtained in experiments performed by both procedures are reported.
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  • 54
    Digitale Medien
    Digitale Medien
    Springer
    Chromatographia 49 (1999), S. 61-64 
    ISSN: 1612-1112
    Schlagwort(e): Column liquid chromatography ; Chiral stationary phases ; Benzophenone imine derivatives ; Amino acid esters ; Enantiomer separation
    Quelle: Springer Online Journal Archives 1860-2000
    Thema: Chemie und Pharmazie
    Notizen: Summary The liquid-chromatographic separation of the enantiomers of amino acid esters as benzophenone Schiff-base derivatives on polysaccharide-derived chiral stationary phases (CSPs) is described. The performance of Chiralcel OF was superior to that of the other CSPs for resolution of benzophenone imine derivatives of amino acid ethyl and methyl esters. The enantiomers of most of the amino acid esters examined as their benzophenone imine derivatives were resolved to baseline on Chiralcel OF. The L-(−) enantiomers of all the analytes were preferentially retained on Chiralcel OF. The resolution of several imine derivatives of amino acid esters was investigated, as was the effect of eluent composition on the resolution of amino acid ethyl esters as their benzophenone imine derivatives.
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  • 55
    ISSN: 1612-1112
    Schlagwort(e): Column liquid chromatography ; Amperometric detection ; Clozapine ; Desmethylclozapine ; Drug monitoring
    Quelle: Springer Online Journal Archives 1860-2000
    Thema: Chemie und Pharmazie
    Notizen: Summary A high-performance liquid chromatographic method with amperometric detection has been developed for the determination of levels of clozapine (CLZ) and its active metabolite N-desmethylclozapine (DMC) in human plasma. The analysis was performed on a 5 μm C8 reversed phase column (150×4.6 mm i.d.), with acetonitrile-phosphate buffer (pH 3.5), as the mobile phase. The detection voltage was +800 mV and the cell and column temperature were 50°C. Linear responses were obtained between 2 ng mL−1 and 100 ng mL−1. Absolute recovery for both clozapine and desmethylclozapine exceeded 88% and the detection limit was 1 ng mL−1. Repeatability, intermediate precision and accuracy were satisfactory. The method, which is rapid, sensitive and selective, has been applied to therapeutic drug monitoring in schizophrenic patients following administration of Leponex® tablets. In 21 patients in steady state at a mean daily clozapine dosage of 358 mg (ranging from 150 to 500 mg day−1), clozapine levels averaged 379 ng mL−1 (ranging from 102 to 818 ng mL−1) and DMC levels averaged 233 ng mL−1 (ranging from 70 to 540 ng mL−1). The method requires only a very small amount of plasma (100 μL), and thus it is suitable for pharmacokinetic studies, as well as for therapeutic drug monitoring.
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  • 56
    ISSN: 1612-1112
    Schlagwort(e): Column liquid chromatography ; Cyclodextrin additives ; Fluorescence agents
    Quelle: Springer Online Journal Archives 1860-2000
    Thema: Chemie und Pharmazie
    Notizen: Summary We report four new derivatization agents, acridone-N-acetic acid (ARC), carbazole-9-ylacetic acid (CRA), carbazole-9-ylpropionic acid (CRP), and 2-methyl-2-carbazole-9-ylacetic acid (MCRA), with strong fluorescence emission which has low dependence on solvent polarity. The emission maxima for ARC, CRA, CRP, and MCRA were 430 nm (λex 404 nm), 368 nm (λex 335 nm), 356 nm (λex 340 nm) and 360 nm (λex 330 nm), respectively. The effects of mobile-phase composition, pH, and temperature on the liquid chromatographic retention behavior of the four fluorescence agents were investigated. An experimental model was established for calculating the inclusion constants of cyclodextrin (CD) complexes in the dynamic state, using β-cyclodextrin (β-CD) and hydroxypropyl-β-cyclodextrin (HP-β-CD) as examples, and different mobilephase compositions. On the basis of the model, the inclusion constants of the solutes in pure water (K fw) were determined by extrapolation. The thermodynamic parameters (ΔH o and ΔS o) and dissociation constantsK am for the solutes in this chromatographic system were obtained by means of capacity factor (k) values using a corresponding model formulation.
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  • 57
    ISSN: 1612-1112
    Schlagwort(e): Column liquid chromatography ; Interaction of mobile and stationary phases ; Linear solvation energy relationships ; Triethylamine
    Quelle: Springer Online Journal Archives 1860-2000
    Thema: Chemie und Pharmazie
    Notizen: Summary The effect of triethylamine (TEA) in the mobile phase on the RPLC retention behavior of small organic solutes has been studied on a conventional polymeric octadecylsilica (ODS) and on a horizontally polymerized ODS. Retention factors for a set of solutes were measured on the two phases with methanol-water mobile phases containing triethylamine at different concentrations and analyzed by use of linear solvation energy relationships (LSER). Variation of the resulting LSER coefficients—v (hydrophobicity),r (polarizability),s (dipolarity),b (hydrogen-bond (HB) donating acidity), anda (HB accepting strength)—were examined to see how TEA affects the intermolecular interaction properties of the mobile and stationary phases and hence the retention of the solutes. Addition of TEA to the mobile phase changes the interaction properties of both conventionally polymerized and horizontally polymerized ODS; the effect is greater for the conventional phase. The HB donating acidity (b) of conventional polymeric ODS is significantly reduced by addition of TEA. For the mobile phases studied the magnitudes of theb andv coefficients for the horizontally polymerized ODS phase are greater than for the conventional phase. The different interaction properties of the two polymeric phases arise mainly as a result of differential adsorption of TEA, because of the very different amounts of surface silanol groups present on the two phases.
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  • 58
    ISSN: 1612-1112
    Schlagwort(e): Column liquid chromatography ; p-tert-Butyl-calix[4]arene-bonded silica ; Nuclear magnetic resonance spectrometry ; PAHs ; Nucleosides bases
    Quelle: Springer Online Journal Archives 1860-2000
    Thema: Chemie und Pharmazie
    Notizen: Summary A new method is proposed for preparation of ap-tert-butyl-calix[4]arene-bonded silica stationary phase. The chemically modifiedp-tert-butyl-calix[4]arene is attached to silica gel via the silane coupling reagent γ-(ethylenediamino)-propyl-triethoxyl-silane. The bonded phase has been characterized by29Si and13C cross polarization/magic angle spinning solid-state nuclear magnetic spectrometry. The retention behavior of polycyclic aromatic hydrocarbons (PAHs), nucleosides and bases has been investigated on the bonded phase in the reversed-phase mode.
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  • 59
    Digitale Medien
    Digitale Medien
    Springer
    Chromatographia 49 (1999), S. 671-677 
    ISSN: 1612-1112
    Schlagwort(e): Column liquid chromatography ; Microwave hydrolysis ; Microcystin ; Nodularin ; D- and L-selective amino acid determination
    Quelle: Springer Online Journal Archives 1860-2000
    Thema: Chemie und Pharmazie
    Notizen: Summary Microwave radiation has been successfully used for hydrolysis of the hepatotoxic cyclic peptides microcystins and nodularin. Set-up of the microwave device and the operating conditions for microwave hydrolysis were optimized. Results of the microwave hydrolysis were compared with results from conventional hydrolysis for 24 h at 110°C. Microwave hydrolysis of microcystins and nodularin for as little as 10 min at 160°C results in complete cleavage of peptide bonds and high recoveries of amino acids. Enantioselective determination of amino acids was achieved by use of a previously described HPLC method after pre-column derivatization withortho-phthaldialdehyde and the chiral thiolN-iso-butyryl-cysteine.
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  • 60
    ISSN: 1612-1112
    Schlagwort(e): Column liquid chromatography ; Hydroxypropyl-β-cyclodextrin ; Imidazole derivatives ; Retention mechanisms ; Enthalpy-entropy compensation
    Quelle: Springer Online Journal Archives 1860-2000
    Thema: Chemie und Pharmazie
    Notizen: Summary Two different methods have been used to investigate the retention mechanism of a series of imidazole derivatives in reversed-phase liquid chromatography (RPLC) over a range of column temperatures and with different concentrations of hydroxypropyl-β-cyclodextrin (HP-β-CD) in the mobile phase. The first approach was the separate study of each factor affecting the retention mechanism; the second method was the simultaneous variation of all these factors. Changes in Van't Hoff plots as a function of HP-β-CD concentration were examined. Enthalpy and entropy were determined for two physicochemical processes: (i) solute transfer from the mobile phase to the stationary phase, and (ii) solute complexation by HP-β-CD. These thermodynamic data showed that the mechanism of retention of the solute was dependent on the concentration of HP-β-CD in the mobile phase. For a HP-β-CD concentration,C, greater than to 4 mM, from 28°C to a critical temperature,T *, solute retention was entropy-dominated because of inclusion of the solute in the HP-β-CD cavity. AboveT * retention was enthalpy-dominated, because of interaction of the solute with the RP18 stationary phase. At firstT * increased asC was increased up to a critical value,C **; it the remained relatively constant because of auto-association of the HP-β-CD molecules in the mobile phase. Enthalpy-entropy compensation revealed that HP-β-CD-solute complexation had a greater effect on retention than RP18 stationary phase-solute interaction. This confirms that the main parameter determining retention in RPLC is the distribution of the solute in the mobile phase, and that interactions with the stationary phase play a minor role.
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  • 61
    ISSN: 1612-1112
    Schlagwort(e): Column liquid chromatography ; Non-aqueous reversed-phase liquid chromatography ; Evaporative light-scattering detection ; Octadecyl grafted silica ; Ceramides
    Quelle: Springer Online Journal Archives 1860-2000
    Thema: Chemie und Pharmazie
    Notizen: Summary This paper describes the development of a chromatographic system for analysis of commercial ceramides structurally similar to those found in the stratum corneum. The ceramides used in this study contain different amine based (phytosphingosine, sphingosine and dihydrosphingosine) and fatty acids of different chain lengths and with different functional groups (hydroxylated and unsaturated). Non-aqueous reversed-phase (NARP) liquid chromatography with evaporative light-scattering detection (ELSD) were the techniques chosen in accordance with the nature of the ceramides. The eluent strength and the potential selectivity of different organic solvents were investigated. On a C18-bonded silica, the most promising chromatographic conditions employed a gradient from ACN-THF, 95∶5, to ACN-THF-PrOH, 35∶5∶60, in 15 min with a constant concentration of TEA (10 mM) and a stoichiometric amount of formic acid.
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  • 62
    Digitale Medien
    Digitale Medien
    Springer
    Chromatographia 49 (1999), S. 281-284 
    ISSN: 1612-1112
    Schlagwort(e): Column liquid chromatography ; Glucosinolates ; Rapseed-mustard ; Brassica
    Quelle: Springer Online Journal Archives 1860-2000
    Thema: Chemie und Pharmazie
    Notizen: Summary A simple, economical and efficient HPLC method has been developed for the separation and determination of the individual glucosinolates in rapessed and mustard. The method involves single-step extraction of glucosinolates with boiling water and separation of the individual glucosinolates on a Novapack RP-18 column (3.9 mm ×150mm) with 0.2 M ammonium sulphate as mobile phase. Peaks were monitored at 229 nm. All major glucosinolates could be eluted within 10 min. The method proved effective for routine analysis of glucosinolates.
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  • 63
    Digitale Medien
    Digitale Medien
    Springer
    Chromatographia 49 (1999), S. 535-538 
    ISSN: 1612-1112
    Schlagwort(e): Column liquid chromatography ; Solid phase extraction ; Herbicides in soil ; Flupoxam
    Quelle: Springer Online Journal Archives 1860-2000
    Thema: Chemie und Pharmazie
    Notizen: Summary High-performance liquid chromatography with UV detection was used to determine the residues of flupoxam (a new herbicide) in soils. Soil samples were extracted with aqueous methanol. The soil extracts were cleaned up and concentrated using two solid phase extraction columns: a polymeric stationary phase based on a polystyrene-divinylbenzene resin (Lichrolut EN) and alumina. Recovery experiments were performed at ppb levels in spiked soil samples. The recovery was 76±1.7% for flupoxam in the range 5–100 μg kg−1 of soil. Limit of determination was 3 μg kg−1.
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  • 64
    ISSN: 1612-1112
    Schlagwort(e): Column liquid chromatography ; α-Chymotrypsin-CSP ; Enzymatic chiral separations ; Loadability evaluation
    Quelle: Springer Online Journal Archives 1860-2000
    Thema: Chemie und Pharmazie
    Notizen: Summary Several racemates has been resolved according to an enzymatic recognition mechanism on an α-chymotrypsin chiral stationary phase. The loadability of the ACHT-CSP has been evaluated both in buffered and non-buffered mobile phases under the enzymatic process and compared with the loading capacity obtained by the structural recognition process.
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  • 65
    ISSN: 1612-1112
    Schlagwort(e): Column liquid chromatography ; Enantioseparations ; Amylose phenylcarbamate phase ; Glycidyl sulfides ; Glycidyl selenides
    Quelle: Springer Online Journal Archives 1860-2000
    Thema: Chemie und Pharmazie
    Notizen: Summary The resolution of the enantiomers of a series of glycidyl sulfides and glycidyl selenides has been examined on a chiral stationary phase prepared by coating aminopropylated silica gel with amylose tris-(phenylcarbamate). Most of the enantiomers of glycidyl monosulfides and monoselenides could be resolved satisfactorily but those of the disulfides could not. The effects of solute structure and of the concentration of 2-propanol in the mobile phase on retention and resolution were investigated.
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  • 66
    ISSN: 1612-1112
    Schlagwort(e): Column liquid chromatography ; Cis-diamminedichloroplatinum (II) ; Transdiamminedichloroplatinum (II) ; Amminetri-chloroplatinate ; 4-Methyl-2-thiouracil
    Quelle: Springer Online Journal Archives 1860-2000
    Thema: Chemie und Pharmazie
    Notizen: Summary We have developed a simple, rapid, selective and sensitive method for detecting the antitumour agent cis-diamminedichloroplatinum (II) (cisplatin) (CDDP) and its toxic impurities trans-diamminedichloroplatinum (II) (transplatin) (TDDP) amminetri-chloroplatinat (ATCP) anion using HPLC in one run. By using 4-methyl-2-thiouracil (MTU) as a derivatizing agent, new compounds have been formed from the Pt compounds and separated on a μ-Bondapak C18 column with isocratic elution and detection at 315 nm. Reactant concentration, methanol content, pH and the reaction time on yield of derivatives were investigated and the optimum conditions for the detection response were defined. The derivatives of each of the three platinum compounds formed in an acetate buffer solution containing 40% (v/v) methanol and 0.9% KCl solution at pH 3.7 and ambient temperature were only stable for one hour.
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  • 67
    Digitale Medien
    Digitale Medien
    Springer
    Chromatographia 49 (1999), S. 306-308 
    ISSN: 1612-1112
    Schlagwort(e): Column liquid chromatography ; Digoxin and digoxigenin ; Temperature effects ; Pore size effects
    Quelle: Springer Online Journal Archives 1860-2000
    Thema: Chemie und Pharmazie
    Notizen: Summary Increased retention of digoxin has been observed at elevated temperatures on both 10 nm and 30 nm porediamter, RP-18 packing. This result is the opposite effect compared with the decreased retention under the same conditions with digoxin aglycon-digoxigenin. Rotation around the C−C σ-bonds in the digoxin molecule is presumed; the rod-like molecules of the newlyobtained digoxin penetrate stationary phase pores more easily thus increasing retention.
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  • 68
    Digitale Medien
    Digitale Medien
    Springer
    Chromatographia 49 (1999), S. 338-342 
    ISSN: 1612-1112
    Schlagwort(e): Column liquid chromatography ; Ion chromatography ; Monovalent anions determination ; Potentiometric detection ; Ion selective PVC-matrix electrode
    Quelle: Springer Online Journal Archives 1860-2000
    Thema: Chemie und Pharmazie
    Notizen: Summary An all solid-state contact tubular PVC-matrix membrane electrode has been applied for potentiometric detection of inorganic and organic monovalent anions using phosphate and hydrogen phosphate eluents at low concentrations. This is a “monovalent detection method” as the selectivity of the electrode towards monovalent anions results in some other anions being undetected unless the concentration of those other anions is higher than 10−3 mol dm−3 in the sample solution injected. It takes only eight minutes to complete the separation with a good resolution. Theoretical and practical considerations are discussed, and in particular, sensitivity, linearity, detection limit and dynamic behaviour are presented. The use of an all solid-state contact bromide-selective electrode as a detector offers so far the best simultaneous sensitivity toward all anions when compared with other detection methods. Determination of Cl− and NO3 − ions in river, rain and drinking water samples without any further sample preconcentration has been successfully achieved. The detection limit is sub-ppb for most of anions in a 20 μL injection volume.
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  • 69
    ISSN: 1612-1112
    Schlagwort(e): Column liquid chromatography ; Evaporative light scatering detection ; APCI mass spectrometry ; Triacylglycerols
    Quelle: Springer Online Journal Archives 1860-2000
    Thema: Chemie und Pharmazie
    Notizen: Summary Short- and long-chain triacylglycerols (SLCT) are a family of lipids prepared by chemical or enzymatic interesterification of triacetin, tripropionin and/or tributyrin, and long-chain (C16!18) hydrogenated vegetable oils. In this study, a normal-phase cyanopropyl high-performance liquid chromatographic (HPLC) method was developed for the separation and quantification of SLCT. The method is capable of separating SLCT mixtures, free fatty acids and the neutral lipid classes of saturated long-chain triacylglycerols, diacylglycerols and monoacylglycerols. To characterize the specific SLCT classes, a normal-phase HPLC procedure using a non-modified silica column was developed to separate the SLCT into individual isomers based on total carbon number and position of fatty acids on the glycerol backbone. Online coupling with a mass detector (LC/MS) allowed the identification of the individual triacylglycerol structures.
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  • 70
    Digitale Medien
    Digitale Medien
    Springer
    Chromatographia 49 (1999), S. 424-430 
    ISSN: 1612-1112
    Schlagwort(e): Column liquid chromatography ; Octadecyl titania ; Surface hydrosilation ; Solid-state NMR C7
    Quelle: Springer Online Journal Archives 1860-2000
    Thema: Chemie und Pharmazie
    Notizen: Summary The structure of a C18 phase based on titania (C18-A), synthesized by the method of solution polymerization, is investigated by diffuse reflectance infrared Fourier transform (DRIFT) and solid-state nuclear magnetic resonance (NMR) spectroscopy. The findings are compared with the results of a second C18 phase based on titania (C18-B) which was synthesized by the method of surface hydrosilation. The dynamic behavior of both phases is examined by1H MAS NMR detection of spinlattice relaxation times in the rotating frame (T1pH) and conventional spin-lattice relaxation times (T1). Due to a smaller ligand density, phase C18-A appears to be a somewhat more mobile than phase C18-B. The chromatographic capability of the phase C18-A is demonstrated by the separation of samples containing benzene derivates or anilines. The elution order is analogous to the phase C18-B, but for both test mixtures the polarity of the mobile phase has to be increased. Phase C18-A is classified as being polymeric by the Sander and Wise test, whereas phase C18-B shows intermediate retention behavior.
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  • 71
    ISSN: 1612-1112
    Schlagwort(e): Column liquid chromatography ; NMR spectroscopy and mass spectrometry ; Plant products ; Silene otites
    Quelle: Springer Online Journal Archives 1860-2000
    Thema: Chemie und Pharmazie
    Notizen: Summary HPLC coupled in parallel to nuclear magnetic resonance (NMR) and mass spectrometry (MS) has been used to obtain1H NMR and mass spectra of a number of ecdysteroids present in an extract of the plantSilene otites. Reversed phase gradient chromatography was performed using a D20-acetonitrile-based solvent system. NMR and mass spectra were obtained for integristerone A, 20-hydroxyecdysone, 2-deoxy-20-hydroxyecdysone and 2-deoxyecdysone to provide structural confirmation using continuous and stopped flow HPLC-NMR. The combined HPLC-NMR-MS system described here provided a more comprehensive analysis of the ecdysteroids present in the extract than HPLC-NMR alone.
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  • 72
    ISSN: 1612-1112
    Schlagwort(e): Column liquid chromatography ; O-alkyl, O-(1-methylthioethylideneamino) phosphoramidates ; Quantitative structure-retention relationship (QSRR) ; Reversed-phase LC
    Quelle: Springer Online Journal Archives 1860-2000
    Thema: Chemie und Pharmazie
    Notizen: Summary By using factor analysis, cluster analysis and multiple linear regression methods, two parameters, FHF and ECCR, were selected from eight solute-related structure parameters as showing the best correlation with retention data. The relationship between the retention data (k) and these two structure parameters were established for ten O-alkyl, O-(1-methylthioethylideneamino) phosphoramidate compounds under the experimental conditions studied. Retention data (k) for six other compounds that have a high correlation with structure parameters were predicted using these QSRR equations. The system was evaluated by comparing the experimentalk values with the predicted ones. Good agreement was obtained between the experimental and predictedk values.
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  • 73
    Digitale Medien
    Digitale Medien
    Springer
    Chromatographia 47 (1998), S. 25-34 
    ISSN: 1612-1112
    Schlagwort(e): Column liquid chromatography ; Solid Phase Extraction ; RP-HPLC gradient analysis ; Taxus Cell Cultures ; Taxol and Taxanes
    Quelle: Springer Online Journal Archives 1860-2000
    Thema: Chemie und Pharmazie
    Notizen: Summary Solid phase extraction (SPE) methods are studied for the sample pretreatment for HPLC analysis ofTaxus cell suspension cultures. Various types of SPE materials were tested for the extraction of both the taxane standards and samples of various origin. Comparison between the different cartridges and the different elution solvents are made in terms of extraction recovery and sample clean-up. Selective elution of the taxanes is achieved by a gradient elution scheme.
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  • 74
    Digitale Medien
    Digitale Medien
    Springer
    Chromatographia 47 (1998), S. 77-80 
    ISSN: 1612-1112
    Schlagwort(e): Column liquid chromatography ; Ion chromatography ; Stability constants ; Ionic strength ; Heavy metals ; Tartaric acid
    Quelle: Springer Online Journal Archives 1860-2000
    Thema: Chemie und Pharmazie
    Notizen: Summary Ion chromatography and potentiometry were used for the determination of the stability constants Pb, Zn, Co, Ni, Mn tartrate complexes at different ionic strengths. An extrapolation function based on the Debye-Hückel equation was applied to obtain the thermodynamic stability constants.
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  • 75
    ISSN: 1612-1112
    Schlagwort(e): Column liquid chromatography ; Ion-pair LC ; Plasma ; 2,4-Toluendiamine ; 2,6-Toluendiamine
    Quelle: Springer Online Journal Archives 1860-2000
    Thema: Chemie und Pharmazie
    Notizen: Summary An ion-pair HPLC method is presented for the determination in plasma of 2,4- and 2,6-toluendiamine (TDA), known carcinogens. The chromatographic conditions consisted in isocratic elution on a reversed phase C18 column with 5 mM octanesulfonic acid in methanol-water, 45∶55, as mobile phase. UV detection was performed at 235 nm. Samples were analyzed after a simple single step liquid-liquid extraction and the method was validated by measurement of precision (interassay and intraassay), sensitivity, specificity, linearity, and recovery. The detection limit for both TDAs in plasma was 20 ng mL−1. The correlation coefficients based on the intrassay calibration curve were 0.998 and 0.997 for 2,6- and 2,4-TDA, respectively. The intraassay accuracy, expressed in terms of recovery, was found to be up to 89.91% and 97.05% for 2,6- and 2,4-TDA, respectively.
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  • 76
    ISSN: 1612-1112
    Schlagwort(e): Column liquid chromatography ; Enantiomer separation ; Voriconazole (UK-109,496) ; Effect of organic mobile-phase modifier
    Quelle: Springer Online Journal Archives 1860-2000
    Thema: Chemie und Pharmazie
    Notizen: Summary Coupled achiral-chiral high-performance liquid chromatography (HPLC) with an achiral amino-based column coupled with a chiral amylose-based column has been used for qualitative and quantitative determination of the potential chiral and achiral impurities of Voriconazole (UK-109,496), a new antifungal agent with two stereogenic centres. The effect of the organic mobile-phase modifier, ethanol, was studied. The assay response was linearly dependent on concentration over the range 1.2–40.4 μg for Voriconazole and 2.5–104.0 ng for the impurities. The limit of detection was 2.5 ng for each analyte.
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  • 77
    Digitale Medien
    Digitale Medien
    Springer
    Chromatographia 47 (1998), S. 655-658 
    ISSN: 1612-1112
    Schlagwort(e): Column liquid chromatography ; Ion chromatography ; Titania packings ; Inorganic anions and cations
    Quelle: Springer Online Journal Archives 1860-2000
    Thema: Chemie und Pharmazie
    Notizen: Summary The ion-exchange retention behavior of titania synthesized in our laboratory was investigated by ion chromatography of inorganic anions and cations. Dilute acetic acid-sodium acetate and bicine-sodium hydroxide buffers were used as mobile phases with no use of suppresor. We observed that the titania, although poor at separating monovalent anions expcept nitrite ion in this experiment, was both an anion and a cation exchanger, and selectively retained fluoride and carbonate ions. We concluded that because of its specific retention properties there were possibilites of using this amphoteric exchanger for simultaneous analysis of anions and cations, and of using it as a selective packing material for ion chromatography.
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  • 78
    Digitale Medien
    Digitale Medien
    Springer
    Chromatographia 47 (1998), S. 667-672 
    ISSN: 1612-1112
    Schlagwort(e): Column liquid chromatography ; Porous graphitic carbon ; Optimization ; Morphine and metabolites
    Quelle: Springer Online Journal Archives 1860-2000
    Thema: Chemie und Pharmazie
    Notizen: Summary The chromatographic behaviour of a series of morphine-based opiates has been investigated using a porous graphitic carbon packing material at acid and alkaline pH. The effects of mobile phase pH, mobile phase organic percentage, column temperature and ionpairing agents were studied. All six opiates were separated within a close retention window despite large differences in measured lipophilicities of the individual opiates. The retention order was not related to the log P values of the opiates and strong retention of the fully ionised compounds was observed, particularly those with acidic functional groups. The effect of pH on the retention of the compounds indicated that the degree of ionisation of the individual compounds was important in the separation mechanism, suggesting that hydrophobic interactions were present in addition to the polar retentive effects observed above. The strong retention of the ionised glucuronide and sulphate conjugates of morphine is a particularly useful feature of the porous graphitic carbon packing material which has general applicability to the analysis of polar or ionised drug metabolites.
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  • 79
    ISSN: 1612-1112
    Schlagwort(e): Column liquid chromatography ; Amperometric detection ; Solid-phase extraction ; Plasma ; Clozapine
    Quelle: Springer Online Journal Archives 1860-2000
    Thema: Chemie und Pharmazie
    Notizen: Summary A sensitive and selective high-performance liquid chromatographic method has been developed for monitoring clozapine levels in human plasma. Chromatography was performed on a reversed-phase column (C8, 150 mm×4.6 mm i.d., 5 μm) with acetonitrile-aqueous sodium acetate solution, 88∶12 (v/v), as mobile phase; the flow rate was 1 mL min−1. Clozapine oxidation at +800 mV was detected amperometrically. Response was linearly dependent on concentration over the range 50–1500 ng mL−1 clozapine in plasma. Sample preparation by solid-phase extraction before HPLC analysis gave high extraction yield (94%). The accuracy and precision of the method were both very good (recovery: 97%;RSD〈3.3%).
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  • 80
    Digitale Medien
    Digitale Medien
    Springer
    Chromatographia 47 (1998), S. 299-304 
    ISSN: 1612-1112
    Schlagwort(e): Column liquid chromatography ; Plasma samples ; Direct injection ; Restricted-access media ; Column-switching
    Quelle: Springer Online Journal Archives 1860-2000
    Thema: Chemie und Pharmazie
    Notizen: Summary A new restricted access media (RAM) type of precolumn, Bio Trap 500 C18, for direct injection of plasma samples in column-switching systems was evaluated with respect to the elution of plasma proteins in different mobile phases, the loading capacity of plasma samples, the chromatographic behavior during plasma injections and protein contamination of the packing and sealings. More than 95% of plasma proteins could be excluded from the precolumn within three minutes for all selected mobile phases. Quantitative analyte recoveries could be obtained by injecting plasma samples ranging from 5 to 500 μL with the analyte mass〉150 ng onto a BioTrap 500 C18 column (20×4 mm I.D.). One precolumn tolerated about 15 mL of plasma injection without out noticeable change in retention and pressure. Clogging of the precolumn was encountered (≥45 mL of plasma) due mainly to the adsorption of proteins on the packing. The performance of the analytical column (Kromasil C18) was also examined. The column efficiency decreased by 60% after processing 45 mL plasma in total.
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  • 81
    Digitale Medien
    Digitale Medien
    Springer
    Chromatographia 47 (1998), S. 373-382 
    ISSN: 1612-1112
    Schlagwort(e): Column liquid chromatography ; Polyaromatic hydrocarbons ; Pitch
    Quelle: Springer Online Journal Archives 1860-2000
    Thema: Chemie und Pharmazie
    Notizen: Summary A new high performance liquid chromatography method for the characterisation of toluene-soluble fractions of pitches has been developed. Although a chromatographic system typical of size exclusion chromatography was used, results indicate that, for these structurally complex samples, separation does not follow the usual discrimination by molecular size. A differentiation between several classes of polyaromatic hydrocarbons is achieved instead. Data are reported on the analysis of individual standard polyaromatic hydrocarbons, showing that four different elution ranges can be observed: three ofcata-condensed compounds (Cata1, Cata2 and Cata3) and one ofperi-condensed compounds (Peri). Results are reported proving the capacity of this high performance liquid chromatography method to distinguish between pitches of different origin and nature. It is also effective for the study of the chemical reactions occurring during heat treatment.
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  • 82
    ISSN: 1612-1112
    Schlagwort(e): Column liquid chromatography ; Opium alkaloids ; Papaver somniferum L.
    Quelle: Springer Online Journal Archives 1860-2000
    Thema: Chemie und Pharmazie
    Notizen: Summary A reversed phase HPLC method for the separation of the five major alkaloids fromPapaver somniferum L., morphine, codeine, thebaine, papaverine and noscapine, has been developed and validated. By use of a basedeactivated silica-based stationary phase excellent peak shape was achieved for each substance. The five alkaloids were quantified by internal standardization within 20 min and with good precision. The method is applicable to opium and to poppy straw.
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  • 83
    ISSN: 1612-1112
    Schlagwort(e): Column liquid chromatography ; Carbofuran pesticides ; On-line analysis of milk
    Quelle: Springer Online Journal Archives 1860-2000
    Thema: Chemie und Pharmazie
    Notizen: Summary A method has been developed for extraction and determination of carbofuran in milk. The method involved direct injection of raw milk on to a human serum albumin dimethyloctyl-silica gel (HSA-C8) column and the use of 80:20 (v/v) 0.01 M phosphate buffer pH 5.5-acetonitrile as mobile phase. UV spectrophotometric detection was performed at 220 nm. Identification was based on retention time. Quantification was performed by automatic peak-area determination and was calibrated by use of an external standard.
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  • 84
    Digitale Medien
    Digitale Medien
    Springer
    Chromatographia 48 (1998), S. 17-19 
    ISSN: 1612-1112
    Schlagwort(e): Column liquid chromatography ; Dibromomannitol in plasma ; Pharmacokinetics
    Quelle: Springer Online Journal Archives 1860-2000
    Thema: Chemie und Pharmazie
    Notizen: Summary Myelobromol 1,6-dibromo-1,6-dideoxy-D-mannitol (dibromomannitol, DBM) is a bifunctional alkylating agent that has been in clinical use since 1963. It is currently included at high dose in preconditioning regimen for bone marrow transplantation (BMT) and is a main-stay of treatment for polycythaemia vera. A high-performance liquid chromatographic method was developed for the determination of DBM in the plasma. The basis of the assay is a derivatization with sodium-diethyldithiocarbamate at 42°C in the presence of 1-bromo-1-deoxy-3,6-anhydro-galactitol as internal standard (IS). The analysis was carried out on a 250×4mm Hypersil 5 CPS column equipped with a 20×4 mm Hypersil 10 CPS precolumn. The eluent consisted of heptane:isopropyl-alcohol: glacial acetic acid=600:76:80 w/w. The flow rate was 1.2 mL min−1. UV detection was performed at 254 nm. The calibration graph was linear in the concentration range of 2.5–260 μM of DBM in plasma. The limit of detection was 1.0 μM. The precision and accuracy of the method was between the good laboratory practice (GLP) required limits.
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  • 85
    Digitale Medien
    Digitale Medien
    Springer
    Chromatographia 48 (1998), S. 37-42 
    ISSN: 1612-1112
    Schlagwort(e): Column liquid chromatography ; Biologically active amines ; Polyamines ; Cereal and Cereal products
    Quelle: Springer Online Journal Archives 1860-2000
    Thema: Chemie und Pharmazie
    Notizen: Summary Biologically active amines (putreanine sulphate, N-acetyl putrescine, putrescine, cadaverine, histamine, agmatine, N-acetyl spermidine, spermidine, spermine) were separated and quantified in cereal flour and cereal products by a liquid chromatographic method. The method consists of the separation of ion pairs formed between biologically active amines and octanesulphonic acid on a reversed-phase column, postcolumn derivatization with o-phtalaldehyde-2-mercapthoethanol and spectrofluorometric detection. Results of the reliability study were satisfactory. The method was linear for each amine at 1–10 mg L−1. Putrescine and spermidine were the only amines always detected in cereal flour and cereal products, ranging from 2.45 to 47.83 mg kg−1 for putrescine and 3.27 to 37.14 mg kg−1 for spermidine. The most important differences among types of samples were found in polyamine derivatives.
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  • 86
    ISSN: 1612-1112
    Schlagwort(e): Column liquid chromatography ; Normal- and reversed-phase LC ; Fumagillin in fish samples
    Quelle: Springer Online Journal Archives 1860-2000
    Thema: Chemie und Pharmazie
    Notizen: Summary Fumagillin is an antibiotic agent mostly used in the veterinary profession. A normal-phase liquid chromatographic method was developed for the determination of this drug in fish matrices. A hexane-dichloromethanedioxan-2-PrOH-acetic acid (43:43:9:5:0.1 v/v %) eluent was used on a Perkin Elmer silica gel column. For validation of the process a reversed-phase HPLC method was also developed (eluent: acetonitrile-water-bicyclohyxylamine 70:30:0.05 v/v %, with Spherisorb ODS, as stationary phase). Recovery is about 100% and the limit of detection is 5 ng g−1 for meat samples.
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  • 87
    Digitale Medien
    Digitale Medien
    Springer
    Chromatographia 48 (1998), S. 59-64 
    ISSN: 1612-1112
    Schlagwort(e): Column liquid chromatography ; Buckminsterfullerene ; Hydrogenation ; Separation technique
    Quelle: Springer Online Journal Archives 1860-2000
    Thema: Chemie und Pharmazie
    Notizen: Summary The effect of composition and flow rate of the mobile phase on the HPLC separation of hydrogenated buckminsterfullerene (C60Hn n=2–38) was investigated on BuckySep column. Toluene was used as the basic solvent and hexane, heptane, cyclohexane, THF, acetonitrile, acetone, ethanol and 2-propanol as co-solvents. The fraction of co-solvents was varied 10–80%, and the flow rate 1–0.1 mL min−1. Toluene-acetonitrile 65∶35 and toluene-acetone 50∶50 provided the best separation. Under the best conditions complete separation of C60H2 and almost complete separation of the four most abundant isomers of C60H4 were achieved. Separation of derivatives with higher hydrogen content was very poor.
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  • 88
    Digitale Medien
    Digitale Medien
    Springer
    Chromatographia 47 (1998), S. 440-442 
    ISSN: 1612-1112
    Schlagwort(e): Column liquid chromatography ; Preparative scale separations ; Chiral stationary phase ; Enantiomer separation ; Morphanthridine analog
    Quelle: Springer Online Journal Archives 1860-2000
    Thema: Chemie und Pharmazie
    Notizen: Summary The preparative chromatographic enantioseparation of a chiral morphoanthridine analog has been performed on an analytical column using amylose-tris(3,5-dimethylphenylcarbamate) as chiral stationary phase. The racemate (100 mg) was resolved to baseline within 15 min. This paper describes the development of the method, estimation of the capacity of the chiral stationary phase and discussed the potential of the chromatography if performed under preparative conditions. From the results and calculations presented it seems likely that the resolution of 70 tons year−1 could easily be achieved on 30 kg of stationary phase with a mobile-phase consumption of only 720 L day−1.
    Materialart: Digitale Medien
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  • 89
    Digitale Medien
    Digitale Medien
    Springer
    Chromatographia 47 (1998), S. 449-450 
    ISSN: 1612-1112
    Schlagwort(e): Column liquid chromatography ; Chitin stationary phase ; Marrubiin ; Analgesic activity
    Quelle: Springer Online Journal Archives 1860-2000
    Thema: Chemie und Pharmazie
    Notizen: Summary Marrubiin is the main active compound isolated fromM. vulgare, a medicinal plant used in folk medicine to cure several diseases. The present study shows that chitin, an abundant natural polymer, may be successfully in chromatography column to separate marrubiin from complex mixtures. The experimental procedure described here represents an efficient and rapid method to obtain such compound in high yield.
    Materialart: Digitale Medien
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  • 90
    ISSN: 1612-1112
    Schlagwort(e): Column liquid chromatography ; Affinity chromatography ; Molecular imprinting ; Molecular recognition ; Combinatorial libraries
    Quelle: Springer Online Journal Archives 1860-2000
    Thema: Chemie und Pharmazie
    Notizen: Summary Molecular imprinting is an attractive method for producing highly selective adsorbents, and several new and potentially useful applications based on molecularly imprinted polymers (MIPs) have been described in recent years. In this article, we highlight some of the areas where these materials have found application, and also describe some new fields of application where the selectivities of imprinted materials can be gainfully employed, for example as binding matrices in the screening of combinatorial libraries, and as auxiliary agents in enzymatic syntheses.
    Materialart: Digitale Medien
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  • 91
    ISSN: 1612-1112
    Schlagwort(e): Column liquid chromatography ; Fermentation ; Microdialysis sampling ; Monosaccharides and ethanol ; On-line monitoring ; Biosensors
    Quelle: Springer Online Journal Archives 1860-2000
    Thema: Chemie und Pharmazie
    Notizen: Summary Two amperometric biosensors were used as detection units in liquid chromatography for on-line monitoring of the production of fuel ethanol during a fermentation. Sampling was performed with a microdialysis probe, and the dialysate was introduced into a liquid chromatographic system providing separation of the substrates and the product: three monosaccharides and ethanol. The analytes were detected by two carbon paste electrodes based on pyranose oxidase and alcohol oxidase, respectively, co-immobilised with horseradish peroxidase, operating in parallel at −50 mVvs. Ag/AgCl. The measured linear ranges of the biosensors by direct injection into the LC system were for glucose 0.3–2.5 g L−1, xylose 0.5–6.7 g L−1, galactose 0.5–6.7 g L−1, and ethanol 1.6–11.7 g L−1, respectively. Injection of standard solutions were required to monitor the stability of the biosensors. Due to the strict selectivity of the biosensors, no interference from other compounds in the broth was encountered from other compounds in the broth was encountered in the quantification. The fermentation process was monitored for 16 h. The on-line results were compared with off-line measurements.
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  • 92
    ISSN: 1612-1112
    Schlagwort(e): Column liquid chromatography ; Cisapride in plasma ; Pharmacokinetics
    Quelle: Springer Online Journal Archives 1860-2000
    Thema: Chemie und Pharmazie
    Notizen: Summary An HPLC method has been developed for the quantification of cisapride in plasma for pharmacokinetic studies. Clebopride was used as internal standard. Plasma samples were extracted at alkaline pH withtert-butyl methyl ether. The organic phase was then extracted with sulphuric acid to eliminate endogenous interferences, and cisapride and the internal standard were then extracted at alkaline pH intotert-butyl methyl ether. After evaporation oftert-butyl methyl ether, the residue was analysed by HPLC. Chromatography was performed at 20°C on a 250mm×4mm i.d. reversed-phase column selective for basic compounds. The isocratic mobile phase was 48∶52 (v/v) acetonitrile-water containing 0.05 M potassium dihydrogen phosphate and 0.04 M triethylamine, adjusted to pH 5.5; the flow rate was 1 mL min−1. Cisapride and the internal standard were detected by ultraviolet monitoring at 276 nm. The calibration graph was linear for quantities of cisapride from 1 to 200 ng mL−1. Intra- and inter-day precision (CV) did not exceed 13.98%. The limit of quantitation (LOQ) was 0.68 ng mL−1 for human plasma. The applicability of the method has been demonstrated in a pharmacokinetic study of normal volunteers who received 10 mg cisapride orally.
    Materialart: Digitale Medien
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  • 93
    Digitale Medien
    Digitale Medien
    Springer
    Chromatographia 47 (1998), S. 285-290 
    ISSN: 1612-1112
    Schlagwort(e): Column liquid chromatography ; Enantiomeric separation ; β-Cyclodextrins ; Methylenedioxylated amphetamines ; Ecstasy
    Quelle: Springer Online Journal Archives 1860-2000
    Thema: Chemie und Pharmazie
    Notizen: Summary Native and derivatized β-cyclodextrins such as chiral stationary phases (CSP) were used for the simultaneous enantiomeric separation of four methylenedioxylated amphetamines (MDA, MDMA, MDEA and MBDB) by liquid chromatography. Fluorimetric detection was used in order to enhance sensitivity and selectivity. The mobile phase was, optimised by studying the influence of pH, triethylamine concentration, organic solvent type, column temperature and flow rate of the mobile phase. This method was validated by determining linearity, precision, accuracy, limits of detection and quantification, and was applied to the stereoselective analysis of illicit tablets (23 samples) and of human whole blood samples (spiked samples and two post-mortem cases). Whereas no significant deviation from a racemic ratio was observed in the tablets contents, the analysis of blood samples showed an enantioselective metabolism of MDMA.
    Materialart: Digitale Medien
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  • 94
    ISSN: 1612-1112
    Schlagwort(e): Column liquid chromatography ; Aminopropyl-silica sorbent ; Continuous cleanup/preconcentration ; Hydroxyvitamin D3 metabolites ; Flow injection analysis
    Quelle: Springer Online Journal Archives 1860-2000
    Thema: Chemie und Pharmazie
    Notizen: Summary A new procedure for continuous cleanup and concentration of hydroxyvitamin D3 metabolites prior to their separation by HPLC and UV-detection is reported. The process is based on the use of aminopropyl-silica as solid-phase sorbent as an alternative to the use of nonpolar sorbents. The improvement thus achieved has been tested by comparing the results with those obtained using octadecyl-C18 as non-polar sorbent. The comparison has been based on the calibration graphs (linear range, detection and quantitation limits), precision and multiple standard addition method.
    Materialart: Digitale Medien
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  • 95
    ISSN: 1612-1112
    Schlagwort(e): Column liquid chromatography ; Coulometric detection ; Mandelic acids ; Phenylglycols ; Urine
    Quelle: Springer Online Journal Archives 1860-2000
    Thema: Chemie und Pharmazie
    Notizen: Summary A method has been developed for the quantification of urinary 3,4-dihydroxymandelic acid (DOMA), 4-hydroxy-3-methoxymandelic acid (VMA), 3,4-dihydroxyphenylglycol (DHPG), and 4-hydroxy-3-methoxyphenyglycol (MHPG). Separation and determination of these compounds in biological samples was previously thought to be very difficult. In this work the separation has been achieved by reversed-phase high-performance liquid chromatography with step-wise gradient elution with three mobile phases. The conditions for coulometric detection have been optimized for effective determination of these compounds. In analysis of a sample of human urine, after a simple deproteinization proceudre, DOMA, VMA, DHPG, and MHPG were separated from interferences and quantified successfully; the average levels of these compounds in six different samples were 33.87±1.03, 1202±41.3, 31.3±1.92, and 80.6±2.15 μg (24 h)−1, respectively. Their precursors E, MN, DOPA, DA, NE, DOPAC, HVA, 3MT, and NMN, and the indolamine 5HT and its metabolite 5HIAA (a list of abbreviations is given at the end of the paper) can also be determined simultaneously in the same chromatographic run. The overlapping peak of DHPG was resolved by deconvolution.
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  • 96
    ISSN: 1612-1112
    Schlagwort(e): Column liquid chromatography ; Optimization ; Mixture design ; Special cubic polynomial model ; Pareto-optimality ; Overlapping resolution mapping (ORM)
    Quelle: Springer Online Journal Archives 1860-2000
    Thema: Chemie und Pharmazie
    Notizen: Summary A systematic approach, using a mixture-design statistical technique, has been developed for selecting the optimum mobile phase for the separation of fat-soluble vitamins in reversed-phase high-performance liquid chromatography. A quaternary mixture of methanol, acetonitrile, tetrahydrofuran and water was used as mobile phase. Retention time and peak width were recorded in ten runs augmented with five replicates and the data were subsequently fitted to special cubic polynomial models. The resulting mathematical equations enabled prediction of resolution over the entire parameter space. Contour plots of minimum effective resolution and maximum retention time as a function of mobile phase composition are presented and discussed. Visual inspection of these plots provides an overview of the quality of the separation and the analysis time required for each possible mobile-phase composition with n the parameter space. It is demonstrated that the methodology followed was an important tool which enabled the taking of informed decisions necessary for selection of the optimum mobile phase for a chromatographic separation. A combination ofR S minimum andt R maximum as optimization criteria in a multicriteria decision-making plot using pareto-optimality concept is discussed. This combination enabled visual demonstration of the compromise between separation quality and the economics of analysis time. Our methodology has been compared with the common used technique of ‘overlapping resolution mapping’.
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  • 97
    Digitale Medien
    Digitale Medien
    Springer
    Chromatographia 47 (1998), S. 457-464 
    ISSN: 1612-1112
    Schlagwort(e): Column liquid chromatography ; Imprinted polymer ; Non-covalent imprinting ; Selectivity and capacity ; Association constant
    Quelle: Springer Online Journal Archives 1860-2000
    Thema: Chemie und Pharmazie
    Notizen: Summary Imprinted polymers as stationary phases for HPLC separations have been the subject of extensive investigations in recent years. In order to aid the rational design of synthetic protocols for the preparation of imprinted polymers, a series of calculations were made to assess the equilibrium concentration of templatemonomer complexes as a function of association constant (K) for the functional groups involved in the interactions and initial concentrations of reactants. This data was then used to predict the selectivity of polymers prepared under different reaction conditions and the model was tested using an experimentally determined value ofK and separation factors taken from the literature.
    Materialart: Digitale Medien
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  • 98
    Digitale Medien
    Digitale Medien
    Springer
    Chromatographia 48 (1998), S. 431-435 
    ISSN: 1612-1112
    Schlagwort(e): Column liquid chromatography ; N-(dansyl)-dl-amino acids ; Human serum albumin ; Chiral discrimination ; Optimization
    Quelle: Springer Online Journal Archives 1860-2000
    Thema: Chemie und Pharmazie
    Notizen: Summary The effect of perchlorate anion as mobile phase modifier on the separation factor, α, forN-(dansyl)-dl-norvaline andN-(dansyl)-dl-tryptophan on a human serum albumin (HSA) column was studied by varying the concentration,c, of the chaotropic agent and the column temperatureT. Gibbs-Helmholtz parameters Δ(ΔH) and Δ(ΔS) between thed andl enantiomers were determined from linear van't Hoff plots of lnα against 1/T. Thermodynamic results indicated that the enhancement of the separation factor observed asc was increased was enthalpically controlled owing to stereoselective H-bonding interactions. Such behavior was used to optimize the chromatographic conditions for separation ofN-(dansyl)-amino acids on HSA.
    Materialart: Digitale Medien
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  • 99
    ISSN: 1612-1112
    Schlagwort(e): Column liquid chromatography ; Solid phase extraction ; Sample treatment optimisation ; Taguchi method ; Albendazole metabolites ; Milk samples
    Quelle: Springer Online Journal Archives 1860-2000
    Thema: Chemie und Pharmazie
    Notizen: Summary Reversed phase HPLC methods for the determination of two metabolites of albendazole in cow's milk are described. Albendazole is an anthelmintic agent used both in veterinary and human practice. Its main metabolites are albendazole-sulfoxide and albendazole-sulfone. The separation of the two metabolites was performed on a μ-Bondapak C-18 column using an acetonitrile/methanol/phosphate buffer as mobile phase, with detection at 290 nm. For the sample preparation of the milk samples we used solid phase extraction. A new sample treatment optimisation procedure is also presented for the sample preparation method. Since sample preparation is a critical step in the analysis of residues in biological samples, the second part of our publication describes an optimisation using Taguchi's methodology that increased recovery, accuracy and reliability. After optimisation of the sample preparation, the limit of detection was 10 ng mL−1 milk and the recovery was 70–80% in the concentration range of 30–1000 ng mL−1 milk for both metabolities.
    Materialart: Digitale Medien
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  • 100
    ISSN: 1612-1112
    Schlagwort(e): Column liquid chromatography ; Ketotifen analysis ; Stability indicating analysis ; Aqueous and oil-based formulations
    Quelle: Springer Online Journal Archives 1860-2000
    Thema: Chemie und Pharmazie
    Notizen: Summary A simple and specific high-performance liquid chromatographic (HPLC) method for the analysis of ketotifen in aqueous solutions and silicon oil suspensions is described. The HPLC system is based on a reversed phase μBondapak C18 (30×0.39 cm) column with a mobile phase of phosphate buffer (0.001 M, pH 7.4):methanol: acetonitrile: trimethylamine (29.8:45:25:0.2, by volume) at a flow-rate of 1 mL min−1. The eluent was monitored by UV absorption at 299 nm. Silicon oil-based samples were extracted with HCl (0.05 M) using imipramine as internal standard. The recovery of ketotifen and imipramine was greater than 80%. The calibration curves for both assays were linear over the ranges examined, yielding correlation coefficients greater than 0.997. The assay was shown to be stability indicating by subjecting solutions of ketotifen in phosphate buffer to heat, oxidative stress and irradiation with ultraviolet light (254 and 369 nm)for up to 8 h. The methodology was also shown to be applicable for the analysis of ketotifen in simple aqueous based formulations, in suspension in silicon oil and for the analysis of samples derived fromin vitro skin transfer experiments.
    Materialart: Digitale Medien
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