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  • Haplorhini  (40)
  • Cats  (37)
  • American Association for the Advancement of Science (AAAS)  (77)
  • Nature Publishing Group
  • 1975-1979  (77)
  • 1940-1944
Collection
Keywords
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  • American Association for the Advancement of Science (AAAS)  (77)
  • Nature Publishing Group
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Year
  • 1
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    Pituitary-brain vascular relations: a new paradigm (1979)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1979-04-06
    Description: Vascular casts of the pituitary gland have demonstrated a paucity of veins extending from the adenohypophysis to the systemic circulation and have suggested that some adenohypophyseal venous blood returns to the neurohypophysis. The neurohypophyseal capillary bed may function as a vascular switch and in this article a series of 14 questions are proposed regarding the vascular dynamics of the pituitary. Together these questions raise the larger question, namely, whether pituitary hormones are transported directly to the brain to modify brain function?〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Bergland, R M -- Page, R B -- New York, N.Y. -- Science. 1979 Apr 6;204(4388):18-24.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/373118" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; Arteriovenous Anastomosis/anatomy & histology ; Capillaries/anatomy & histology ; Cats ; *Cerebrovascular Circulation ; Dogs ; Humans ; Hypothalamo-Hypophyseal System/blood supply ; Pituitary Gland/*blood supply ; Pituitary Gland, Anterior/blood supply ; Rats ; Species Specificity
    Print ISSN: 0036-8075
    Electronic ISSN: 1095-9203
    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
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  • 2
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    Visual resolution and receptive field size: examination of two kinds of cat retinal ganglion cell (1979)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1979-09-07
    Description: Intraocular recordings from brisk-sustained and brisk-transient ganglion cells in the cat's retina revealed a systematic increase in center size and decrease in spatial cut-off frequency with increasing distance from the area centralis. At any one eccentricity sizes of the centers of sustained and transient cells did not overlap, and the variation in cut-off frequency for each class was constrained to about one-half octave.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Cleland, B G -- Harding, T H -- Tulunay-Keesey, U -- New York, N.Y. -- Science. 1979 Sep 7;205(4410):1015-7.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/472720" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; Cats ; Evoked Potentials ; Ganglia/physiology ; Retina/cytology/*physiology ; Vision, Ocular/*physiology ; *Visual Fields
    Print ISSN: 0036-8075
    Electronic ISSN: 1095-9203
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  • 3
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    Enchancement of luminance flicker by color-opponent mechanisms (1979)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1979-08-10
    Description: Color-opponent ganglion cells in the monkey retina respond to luminance flicker at high temporal frequencies. Color opponency, which makes these cells so selective of wavelength at low temporal frequencies, is progressively lost at high frequencies. This loss is due to a frequency-dependent phase shift between the responses of spectrally different center and surround mechanisms in the receptive field of each of these cells. Center and surround responses, which are antagonistic at low temporal frequencies, become synergistic at high ones, making these cells most responsive at high frequencies to those wavelengths to which they are least responsive at low frequencies. This phenomenon can explain the differences between chromatic and luminance flicker in human vision.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Gouras, P -- Zrenner, E -- New York, N.Y. -- Science. 1979 Aug 10;205(4406):587-9.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/109925" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; *Color ; Ganglia/*physiology ; Haplorhini ; Light ; Retina/*physiology ; *Vision, Ocular
    Print ISSN: 0036-8075
    Electronic ISSN: 1095-9203
    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
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  • 4
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    Cerebellar plasticity: modification of Purkinje cell structure by differential rearing in monkeys (1979)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1979-10-12
    Description: Dendritic branching in Purkinje and granule cells and the diameters of Purkinje cell somas were compared in several cerebellar areas of monkeys reared in isolation, with social experience, or in a large colony. In the colony-reared monkeys, spiny branchlets of Purkinje cells were more extensive in the paraflocculus and the nodulus than they were in the other two groups. Granule cell dendritic branching in the paraflocculus and nodulus did not differ across groups. In addition, Purkinje cell somas were larger in the uvula and the nodulus of the colony animals than in the other groups. These data indicate that the social and physical environment during development influences the morphology of cerebellar Purkinje cells.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Floeter, M K -- Greenough, W T -- New York, N.Y. -- Science. 1979 Oct 12;206(4415):227-9.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/113873" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; Behavior, Animal/*physiology ; Cerebellum/*growth & development ; Dendrites/ultrastructure ; Environment ; Haplorhini ; Macaca fascicularis ; Movement ; Purkinje Cells/*cytology
    Print ISSN: 0036-8075
    Electronic ISSN: 1095-9203
    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
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  • 5
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    Structure of physiologically identified X and Y cells in the cat's lateral geniculate nucleus (1979)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1979-06-08
    Description: Horseradish peroxidase injected into 18 single, physiologically identified geniculate X and Y cells permitted a detailed morphological correlate to be determined for the physiological properties of each neuron. Class 1 morphological characteristics were associated with Y cells, class 3 with X cells, and class 2 structural traits were seen in both physiological types.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Friedlander, M J -- Lin, C S -- Sherman, S M -- New York, N.Y. -- Science. 1979 Jun 8;204(4397):1114-7.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/451559" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; Cats ; Geniculate Bodies/*cytology/physiology ; Horseradish Peroxidase ; Interneurons/cytology
    Print ISSN: 0036-8075
    Electronic ISSN: 1095-9203
    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
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  • 6
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    Cortical plasticity in monocularly deprived immobilized kittens depends on eye movement (1979)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1979-11-30
    Description: A marked reduction of binocular cells in striate cortex is found if 4-week-old kittens are visually stimulated monocularly while anesthetized and held in a stereotaxic apparatus. If the kittens are paralyzed and artificially respirated, changes are not found unless an eye is moved mechanically. It appears that eye movement and visual stimulation are necessary conditions for deactivation of binocular connections, but neither is sufficient to induce such changes alone.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Freeman, R D -- Bonds, A B -- New York, N.Y. -- Science. 1979 Nov 30;206(4422):1093-5.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/493996" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; Cats ; Evoked Potentials ; *Eye Movements ; Functional Laterality ; Immobilization ; Paralysis/physiopathology ; Visual Cortex/*growth & development/physiology ; Visual Pathways/*growth & development
    Print ISSN: 0036-8075
    Electronic ISSN: 1095-9203
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  • 7
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    Muscle fiber regeneration after transplantation: prediction of structure and physiology from electromyograms (1979)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1979-06-08
    Description: Digitized electromyographic activity of transplanted extensor digitorum longus (EDL) muscles in cats differs from that of control EDL and anterior tibialis muscles lying adjacent to transplanted EDL muscles. In autotransplanted muscles, the cross-sectional area of the fibers shows a negative correlation with mean spike frequency and a positive correlation with mean amplitude. The mean frequency-amplitude products correlate with isometric tetanic tensions.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Gorniak, G C -- Gans, C -- Faulkner, J A -- New York, N.Y. -- Science. 1979 Jun 8;204(4397):1085-7.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/451552" target="_blank"〉PubMed〈/a〉
    Keywords: Action Potentials ; Animals ; Cats ; Electrodes ; Electromyography/methods ; Muscles/cytology/physiology/*transplantation ; *Regeneration ; Transplantation, Autologous
    Print ISSN: 0036-8075
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  • 8
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    Alteration of cortical orientation selectivity: importance of asymmetric input (1979)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1979-06-08
    Description: Rearing cats so that each of the two eyes sees stripes of a different orientation alters the orientation preference of visual cortex cells. This result can be obtained by rearing the cats in striped cylinders or with goggles attached to their faces, but a tighter control of orientation preference is achieved by the goggles.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Gordon, B -- Presson, J -- Packwood, J -- Scheer, R -- New York, N.Y. -- Science. 1979 Jun 8;204(4397):1109-11.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/451557" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; Cats ; Functional Laterality ; Orientation/*physiology ; Visual Cortex/cytology/*growth & development/physiology ; Visual Perception/*physiology
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  • 9
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    Tissue perfusion rate determined from the decay of oxygen-15 activity after photon activation in situ (1979)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1979-06-15
    Description: Rates of cerebral perfusion were obtained from measurements of the disappearance (wash-out) of oxygen-15 after in situ tissue activation with 45-million-volt x-rays. In an anesthetized cat, typical values were 90 milliliters per minute per 100 grams of tissue, with 55 percent wash-out. In a specific radiotherapy patient, the value was 65 milliliters per minute per 100 grams of tissue, with 63 percent wash-out of oxygen-15 through incorporation into tissue water.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Hughes, W L -- Nussbaum, G H -- Connolly, R -- Emami, B -- Reilly, P -- New York, N.Y. -- Science. 1979 Jun 15;204(4398):1215-7.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/451567" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; Brain/*blood supply ; Cats ; Humans ; Neoplasms/blood supply ; Oxygen/*blood/radiation effects ; Oxygen Radioisotopes ; *Regional Blood Flow ; X-Rays
    Print ISSN: 0036-8075
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  • 10
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    Sex hormones and brain development (1979)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1979-09-07
    Description: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Kolata, G B -- New York, N.Y. -- Science. 1979 Sep 7;205(4410):985-7.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/112680" target="_blank"〉PubMed〈/a〉
    Keywords: Adrenocortical Hyperfunction/physiopathology ; Animals ; Behavior/*physiology ; Behavior, Animal/physiology ; Brain/*growth & development ; Female ; Gonadal Steroid Hormones/*physiology ; Haplorhini ; Humans ; Male ; Preoptic Area/growth & development ; Rats ; Receptors, Estrogen/metabolism ; Sex Differentiation ; Testosterone/metabolism
    Print ISSN: 0036-8075
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    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
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  • 11
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    Lateral geniculate nucleus in dark-reared cats: loss of Y cells without changes in cell size (1979)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1979-03-30
    Description: In cats reared in the dark from birth until 4 months of age, the dorsal lateral geniculate nucleus contained few normal Y cells in either the binocular or monocular segments. Although most of the neurons appeared to be normal X cells unaffected by light deprivation, many cells with abnormal receptive field and response charcteristics were encountered. These effects were permanent, since 1 to 2 years of normal visual experience following initial light deprivation did not lead to any functional recovery. The sizes of cell bodies in cats reared in the dark were similar to those of normal animals, an indication that changes in geniculate cell physiology need not be related to changes in cell size.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Kratz, K E -- Sherman, S M -- Kalil, R -- New York, N.Y. -- Science. 1979 Mar 30;203(4387):1353-5.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/424758" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; Cats ; Darkness ; Functional Laterality ; Geniculate Bodies/*cytology/growth & development ; *Vision, Ocular ; Visual Pathways/cytology/*growth & development
    Print ISSN: 0036-8075
    Electronic ISSN: 1095-9203
    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
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  • 12
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    Reversal potential for noradrenaline-induced hyperpolarization of spinal motoneurons (1979)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1979-07-27
    Description: By using two separate electrodes with tips inside a single feline motoneuron, current-voltage characteristics were studied during extracellular iontophoresis of noradrenaline. The usually observed hyperpolarization was accompanied by an increase in membrane resistance and became larger with polarizing and smaller with depolarizing currents. During large depolarizing current injections, the noradrenaline-induced potential reversed its direction, usually at a membrane potential of about -20 millivolts. These data are compatible with the concept that noradrenaline hyperpolarizes nerve cells by decreasing resting membrane conductances to sodium and potassium ions. The observation could also be explained by a nonspecific decrease in ion permeability that is associated with a hyperpolarization due to sodium pump activation.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Marshall, K C -- Engberg, I -- New York, N.Y. -- Science. 1979 Jul 27;205(4404):422-4.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/451613" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; Cats ; Membrane Potentials/drug effects ; Neurons/drug effects/*physiology ; Norepinephrine/*pharmacology ; Potassium/metabolism ; Sodium/metabolism ; Spinal Cord/drug effects/*physiology
    Print ISSN: 0036-8075
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  • 13
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    Functional organization of lateral geniculate cells following removal of visual cortex in the newborn kitten (1979)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1979-11-09
    Description: When the visual cortex of a newborn kitten is removed, most neurons in the dorsal lateral geniculate nucleus degenerate, but a small population of large cells is spared. Electrophysiological recording revealed that detailed visual topography in the nucleus is abnormal and that single cells have unusually large receptive fields. These results suggest that optic axons deprived of their normal synaptic targets rearrange their connections to converge on local surviving neurons.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Murphy, E H -- Kalil, R -- New York, N.Y. -- Science. 1979 Nov 9;206(4419):713-6.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/493978" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; Animals, Newborn/anatomy & histology ; Cats ; Functional Laterality ; Geniculate Bodies/*cytology ; Nerve Degeneration ; Visual Cortex/*cytology ; Visual Pathways/*cytology/growth & development
    Print ISSN: 0036-8075
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    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
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  • 14
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    Thalamic and cortical afferents differentiate anterior from posterior cingulate cortex in the monkey (1979)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1979-04-13
    Description: The anterior cingulate cortex receives thalamic afferents mainly from the midline and intralaminar nuclei rather than the anterior thalamic nuclei. In contrast, the posterior cingulate cortex receives afferents primarily from the anterior thalamic nuclei and from extensive cortical areas in the frontal, parietal, and temporal lobes. These contrasting afferents may provide a structural basis for pain-related functions of the anterior cingulate cortex.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Vogt, B A -- Rosene, D L -- Pandya, D N -- New York, N.Y. -- Science. 1979 Apr 13;204(4389):205-7.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/107587" target="_blank"〉PubMed〈/a〉
    Keywords: Afferent Pathways/cytology ; Animals ; Brain Mapping ; Cerebral Cortex/*cytology ; Gyrus Cinguli/*cytology/physiology ; Haplorhini ; Horseradish Peroxidase ; Macaca mulatta ; Thalamic Nuclei/*cytology
    Print ISSN: 0036-8075
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  • 15
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    Species-specific perceptual processing of vocal sounds by monkeys (1979)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1979-05-25
    Description: Monkeys of four species were trained to discriminate between sets of natural tonal calls of Japanese macaques (Macaca fuscata) by the position of a frequency-inflection peak or by initial pitch. The Japanese macaques consistently performed best on peak position and the other species on pitch. The results imply special strategies for perceptional processing of vocal sounds and suggest parallels with human speech perception.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Zoloth, S R -- Petersen, M R -- Beecher, M D -- Green, S -- Marler, P -- Moody, D B -- Stebbins, W -- New York, N.Y. -- Science. 1979 May 25;204(4395):870-3.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/108805" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; Auditory Perception/*physiology ; Haplorhini ; Macaca/*physiology ; Species Specificity ; Speech Perception/*physiology ; Vocalization, Animal/*physiology
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  • 16
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    Orientation anisotropy of visual stimuli in rhesus monkey: a behavior study (1979)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1979-08-03
    Description: The contrast sensitivity of the rhesus monkey was tested, according to a modified reaction-time paradigm, for sine-wave grating targets at different orientations. The monkey possesses an oblique effect slightly larger than that of humans. A reaction time analysis showed the oblique effect to be a suprathreshold as well as a threshold phenomenon. The presence of this effect further strengthens the use of the monkey as a model for the human visual system.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Boltz, R L -- Harwerth, R S -- Smith, E L 3rd -- R01 EY001139/EY/NEI NIH HHS/ -- New York, N.Y. -- Science. 1979 Aug 3;205(4405):511-3.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/109923" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; Behavior, Animal ; Haplorhini ; Humans ; Macaca mulatta ; Species Specificity ; *Visual Perception
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  • 17
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    Target velocity signals of visual tracking in vermal Purkinje cells of the monkey (1979)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1979-08-17
    Description: Discharges of Purkinje cells were recorded from the vermis, lobules VI and VII, of a monkey trained to track a visual target. When the monkey tracked a sinusoidally oscillating target, cellular activity changes in phase with the velocity signal of the eye movement. When the monkey fixated a stationary point, almost identical modulation in activity occurred, reflecting the velocity signal of the motion of the retinal image of the target. The data suggest that the vermis participates in the control of smooth pursuit eye movements by providing the oculomotor system with the actual target velocity information which is the sum of eye velocity and retinal image velocity signals.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Kase, M -- Noda, H -- Suzuki, D A -- Miller, D C -- New York, N.Y. -- Science. 1979 Aug 17;205(4407):717-20.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/111350" target="_blank"〉PubMed〈/a〉
    Keywords: Action Potentials ; Animals ; *Eye Movements ; Haplorhini ; Motion Perception/physiology ; Proprioception ; Purkinje Cells/*physiology ; Visual Perception/*physiology
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  • 18
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    Subicular input from temporal cortex in the rhesus monkey (1979)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1979-08-10
    Description: The subicular cortices of the primate hippocampal formation form a physical and connectional link between the cortex of the temporal lobe and the hippocampus. Their direct connections with all classes of cortex in the temporal lobe except primary sensory cortex underscore the pivotal role of these areas in the potential interplay between the hippocampal formation and the association cortices.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Van Hoesen, G W -- Rosene, D L -- Mesulam, M M -- New York, N.Y. -- Science. 1979 Aug 10;205(4406):608-10.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/109926" target="_blank"〉PubMed〈/a〉
    Keywords: Amino Acids/metabolism ; Animals ; Haplorhini ; Hippocampus/anatomy & histology/*physiology ; Macaca mulatta ; Temporal Lobe/anatomy & histology/*physiology
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  • 19
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    Physostigmine and recent memory: effects in young and aged nonhuman primates (1979)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1979-11-30
    Description: The effect of physostigmine on recent memory was evaluated in young and aged rhesus monkeys. All aged monkeys had previously shown impaired memory. The performance of the young monkeys treated with physostigmine was similar to that recently reported for young humans--no effects at low doses, some improvement at a restricted range of doses, and deficits at the highest dose. Although the aged subjects also improved at the same general doses, their overall response as a group was much more variable than that of the younger subjects. The performance of some aged monkeys was impaired by low doses that did not affect young monkeys. Continued improvement was observed in some aged monkeys at the highest dose, which typically impaired young monkeys. These variable effects across aged subjects suggest that physostigmine cannot easily or reliably be used as an agent for treating geriatric cognition. Nevertheless, the differential age-related effects suggest that appropriate manipulation of the cholinergic system may eventually be developed to alleviate some of the cognitive impairments suffered by aged subjects.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Bartus, R T -- New York, N.Y. -- Science. 1979 Nov 30;206(4422):1087-9.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/227061" target="_blank"〉PubMed〈/a〉
    Keywords: Acetylcholine/physiology ; Aging ; Animals ; Cognition/physiology ; Female ; Haplorhini ; Humans ; Male ; Memory/*drug effects ; Memory Disorders/drug therapy ; Memory, Short-Term/drug effects ; Physostigmine/*pharmacology/therapeutic use ; Synaptic Transmission
    Print ISSN: 0036-8075
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    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
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  • 20
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    Response of cat inferior colliculus neurons to binaural beat stimuli: possible mechanisms for sound localization (1979)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1979-11-02
    Description: The interaural phase sensitivity of neurons was studied through the use of binaural beat stimuli. The response of most cells was phase-locked to the beat frequency, which provides a possible neural correlate to the human sensation of binaural beats. In addition, this stimulus allowed the direction and rate of interaural phase change to be varied. Some neurons in our sample responded selectively to manipulations of these two variables, which suggests a sensitivity to direction or speed of movement.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Kuwada, S -- Yin, T C -- Wickesberg, R E -- New York, N.Y. -- Science. 1979 Nov 2;206(4418):586-8.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/493964" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; Auditory Perception/*physiology ; Cats ; Evoked Potentials ; Inferior Colliculi/*physiology ; Motion Perception/physiology ; Orientation/*physiology ; Periodicity
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  • 21
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    Beta-adrenergic-sensitive adenylate cyclase in secretory cells of choroid plexus (1979)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1979-05-25
    Description: Biochemical evidence supporting the sympathetic control of cerebrospinal fluid production has been obtained through identification of a specific beta-adrenergic-sensitive adenylate cyclase in the choroid plexus. The enzyme, which is localized in the secretory epithelium, is activated by low concentrations of isoproterenol and norepinephrine and appears separate from beta-adrenergic-sensitive adenylate cyclase present in cerebral blood vessels.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Nathanson, J A -- New York, N.Y. -- Science. 1979 May 25;204(4395):843-4.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/220707" target="_blank"〉PubMed〈/a〉
    Keywords: Adenylyl Cyclases/*metabolism ; Animals ; Cats ; Cattle ; Cerebrospinal Fluid/metabolism ; Cerebrovascular Circulation ; Choroid Plexus/*enzymology/metabolism ; Dogs ; Enzyme Activation/drug effects ; Epithelium/enzymology ; Isoproterenol/pharmacology ; Rabbits ; Receptors, Adrenergic/*metabolism ; Receptors, Adrenergic, beta/*metabolism
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  • 22
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    Inhibition of gonadotropin by delta9-tetrahydrocannabinol:mediation by steroid receptors? (1979)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1979-04-20
    Description: Competition assays for estradiol receptors in cytosol preparations of uteri from rhesus monkeys and humans showed that delta9-tetrahydrocannabinol (THC) does not compete with estradiol for intracellular estrogen recptors. Although isotopically labeled THC bound to macromolecules in uterine cytosol from the rhesus monkey, the binding was not displaced by unlabeled THC, diethylstilbestrol, estradiol, progesterone, cortisol, or 5 alpha-dihydrostestosterone. Scatchard analyses indicated that high-affinity saturable binding of THC to cytosol did not occur. Thus the inhibitory effect of THC on gonadotropin and steroid secretion in primates is not mediated by the interaction of THC with intracellular steroid hormone receptors.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Smith, R G -- Besch, N F -- Besch, P K -- Smith, C G -- New York, N.Y. -- Science. 1979 Apr 20;204(4390):325-7.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/107589" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; Binding, Competitive ; Cytosol/metabolism ; Diethylstilbestrol/metabolism ; Dronabinol/*pharmacology ; Estradiol/metabolism ; Female ; Haplorhini ; Humans ; Receptors, Estrogen/*drug effects/metabolism ; Steroids/metabolism ; Uterus/*metabolism
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  • 23
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    Localization of the neurally mediated arrhythmogenic properties of digitalis (1979)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1979-04-20
    Description: Available evidence suggests that the propensity of digitalis glycosides to produce cardiac arrhythmias is due in part to their neuroexictatory effects. We have performed experiments in cats which support the existence of a neurogenic component in the etiology of digitalis-induced ventricular arrhythmias. Our data further indicate that the locus of this neural effect lies within an area of the medulla 2 millimeters above to 2 millimeters below the obex. These findings, when considered with the effects of polar cardiac glycosides that do not cross the blood-brain barrier, suggest that the area postrema may be the site of neural activation.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Somberg, J C -- Smith, T W -- New York, N.Y. -- Science. 1979 Apr 20;204(4390):321-3.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/219481" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; Arrhythmias, Cardiac/*chemically induced ; Brain Stem/*physiology ; Cats ; Digitalis Glycosides/*pharmacology/toxicity ; Dose-Response Relationship, Drug ; Heart/*drug effects/innervation ; Myocardium/*metabolism ; Sodium-Potassium-Exchanging ATPase/metabolism ; Spinal Cord/physiology ; Vagus Nerve/physiology
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  • 24
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    Plasticity: the mirror of experience (1979)
    American Association for the Advancement of Science (AAAS)
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    Publication Date: 1979-01-05
    Description: A simple avoidance training procedure during early development produces massive neural traces in visual and somatic cortices of kittens reared in a normal environment. A preponderance of cells in these areas had response preferences for the stimuli used during training. Furthermore, some of these cells exhibited properties never found in normal animals not receiving such training. It appears that, even in an environment in which many other stimuli are present, some early experiences powerfully affect brain development and the way in which other experiences exert their effect.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Spinelli, D N -- Jensen, F E -- New York, N.Y. -- Science. 1979 Jan 5;203(4375):75-8.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/758683" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; Avoidance Learning/physiology ; Cats ; Environment ; Functional Laterality ; Memory/physiology ; Orientation/physiology ; Somatosensory Cortex/*growth & development/physiology ; Visual Cortex/*growth & development/physiology
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  • 25
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    Isolation and characterization of an endogenous type C virus of rhesus monkeys (1979)
    American Association for the Advancement of Science (AAAS)
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    Publication Date: 1979-05-25
    Description: A type C retrovirus was isolated from a continuous cell line established from a spontaneous esophageal carcinoma of a rhesus monkey (Macaca mulata) by prolonged cocultivation with canine cells. A DNA transcript of the viral RNA hybridized to a high level and kinetic analysis indicated the presence of multiple copies of the viral genome in rhesus monkey DNA, showing that the virus is endogenous in this species. The rhesus monkey virus closely resembles, in several respects, an endogenous type C virus previously isolated from stumptailed macques (Macaca arctoides), aa species closely related to rhesus monkeys.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Rabin, H -- Benton, C V -- Tainsky, M A -- Rice, N R -- Gilden, R V -- New York, N.Y. -- Science. 1979 May 25;204(4395):841-2.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/87013" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; Haplorhini ; Macaca/*microbiology ; Macaca mulatta/*microbiology ; Nucleic Acid Hybridization ; RNA, Viral/analysis ; RNA-Directed DNA Polymerase/metabolism ; Retroviridae/enzymology/*isolation & purification/ultrastructure ; Viral Proteins/analysis/immunology
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  • 26
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    Inhibitory, GABAergic nerve terminals decrease at sites of focal epilepsy (1979)
    American Association for the Advancement of Science (AAAS)
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    Publication Date: 1979-07-13
    Description: Using an immunocytochemical method for the localization of the gamma-aminobutyric acid (GABA) synthesizing enzyme, glutamic acid decarboxylase (GAD), we have observed GABAergic nerve terminals distributed throughout all layers of normal monkey sensorimotor cortex. These terminals displayed ultrastructural characteristics that suggested that they arose from aspinous and sparsely spinous stellate neurons. In monkeys (Macaca mulatta and M. fascicularis) made epileptic by cortical application of alumina gel, a highly significant numerical decrease of GAD-positive nerve terminals occurred at sites of seizure foci indicating a functional loss of GABAergic inhibitory synapses. A loss of such inhibition at seizure foci could lead to epileptic activity of cortical pyramidal neurons.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Ribak, C E -- Harris, A B -- Vaughn, J E -- Roberts, E -- New York, N.Y. -- Science. 1979 Jul 13;205(4402):211-4.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/109922" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; Carboxy-Lyases/*metabolism ; Cerebral Cortex/*metabolism ; Epilepsies, Partial/*physiopathology ; Glutamate Decarboxylase/*metabolism ; Glutamates/metabolism ; Haplorhini ; Macaca fascicularis ; Macaca mulatta ; Motor Cortex/metabolism ; Nerve Endings/enzymology ; gamma-Aminobutyric Acid/metabolism
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  • 27
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    Effects of frontal eye field and superior colliculus ablations on eye movements (1979)
    American Association for the Advancement of Science (AAAS)
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    Publication Date: 1979-11-02
    Description: Two parallel neural pathways are primarily responsible for the control of saccadic eye movements--one mediated through the frontal eye fields and the other through the superior colliculus. When both pathways are disrupted, control of saccadic eye movements is lost. Disruption of either pathway alone produces only subtle deficits.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Schiller, P H -- True, S D -- Conway, J L -- New York, N.Y. -- Science. 1979 Nov 2;206(4418):590-2.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/115091" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; Brain Mapping ; *Eye Movements ; Frontal Lobe/*physiology ; Haplorhini ; Neural Pathways/physiology ; Reflex/physiology ; Saccades ; Superior Colliculi/*physiology ; Vestibule, Labyrinth/physiology
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  • 28
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    Behavior maintained by termination of a schedule of self-administered cocaine (1979)
    American Association for the Advancement of Science (AAAS)
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    Publication Date: 1979-06-15
    Description: Squirrel monkeys self-administered cocaine by pressing a lever while under a variable-interval schedule of reinforcement. At the same time, they terminated the availability of self-administered cocaine by pressing a second lever while under a fixed-interval schedule of reinforcement. The maintenance of behavior by schedule drug injections and by termination of scheduled drug injections, usually considered to be processes associated with different classes of drugs, can occur simultaneously when behavior is controlled by different contingencies associated with a single drug.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Spealman, R D -- New York, N.Y. -- Science. 1979 Jun 15;204(4398):1231-3.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/109920" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; Behavior, Animal/*drug effects ; Cocaine/*pharmacology ; Disease Models, Animal ; Haplorhini ; Humans ; Male ; Reinforcement (Psychology) ; Saimiri ; Self Administration/psychology ; Substance-Related Disorders/physiopathology
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  • 29
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    Long-term amphetamine treatment decreases brain serotonin metabolism: implications for theories of schizophrenia (1979)
    American Association for the Advancement of Science (AAAS)
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    Publication Date: 1979-09-21
    Description: Long-term amphetamine administration to cats (a mean of 8.75 milligrams per kilogram twice daily for 10 days) produced large decreases (40 to 67 percent in serotonin and its major metabolite, 5-hydroxyindoleacetic acid, in all brain regions examined. This treatment also produced several behaviors that are dependent on depressed central serotonergic neurotransmission, and which normally are elicited exclusively by hallucinogenic drugs. Short-term amphetamine administration (15 mg/kg) did not produce these behaviors and resulted in small decreases in brain serotonin and no change in 5-hydroxyindoleacetic acid. These data are discussed in the context of monoamine theories of schizophrenia.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Trulson, M E -- Jacobs, B L -- New York, N.Y. -- Science. 1979 Sep 21;205(4412):1295-7.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/572992" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; Behavior, Animal/drug effects ; Brain/*metabolism ; Brain Chemistry/*drug effects ; Cats ; Dextroamphetamine/*pharmacology ; Disease Models, Animal ; Female ; Humans ; Hydroxyindoleacetic Acid/metabolism ; Schizophrenia/*physiopathology ; Serotonin/*metabolism ; Time Factors
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  • 30
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    Primate olfactory behavior (1979)
    American Association for the Advancement of Science (AAAS)
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    Publication Date: 1979-03-16
    Description: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉New York, N.Y. -- Science. 1979 Mar 16;203(4385):1139-40.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/106469" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; Behavior, Animal/*physiology ; Haplorhini ; Macaca mulatta/physiology ; Male ; Pheromones ; Smell/*physiology
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  • 31
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    Cognitive deficit caused by regional depletion of dopamine in prefrontal cortex of rhesus monkey (1979)
    American Association for the Advancement of Science (AAAS)
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    Publication Date: 1979-08-31
    Description: Depletion of dopamine in a circumscribed area of association cortex in rhesus monkeys produces an impairment in spatial delayed alternation performance nearly as severe as that caused by surgical ablation of the same area. This behavioral deficit can be pharmacologically reversed with dopamine agonists such as L-dopa and apomorphine. These data provide direct evidence that dopamine plays an important role in a specific cortical function.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Brozoski, T J -- Brown, R M -- Rosvold, H E -- Goldman, P S -- New York, N.Y. -- Science. 1979 Aug 31;205(4409):929-32.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/112679" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; Apomorphine/pharmacology ; Behavior, Animal/drug effects/physiology ; Cerebral Cortex/*physiology ; Cognition/drug effects/*physiology ; Dihydroxyphenylalanine/analogs & derivatives/pharmacology ; Dopamine/*physiology ; Dose-Response Relationship, Drug ; Haplorhini ; Levodopa/pharmacology ; Macaca mulatta ; Norepinephrine/physiology
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  • 32
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    Conditioned inhibition: selective response of single units (1979)
    American Association for the Advancement of Science (AAAS)
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    Publication Date: 1979-05-04
    Description: Single cell activity and local field potentials in parastriate cortex of cats and rabbits were studied during a Pavlovian discrimination procedure. Cell activity was selectively modified; conditioned changes occurred in response either to the reinforced stimulus or to the unreinforced one, but not to both. Cells exhibiting conditioned alteration in response to the unreinforced stimulus are thought to participate in specialized circuits mediating conditioned inhibition.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉de Toledo-Morrell, L -- Hoeppner, T J -- Morrell, F -- New York, N.Y. -- Science. 1979 May 4;204(4392):528-30.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/432660" target="_blank"〉PubMed〈/a〉
    Keywords: Action Potentials ; Animals ; Cats ; Cerebral Cortex/physiology ; Conditioning (Psychology)/*physiology ; Neural Inhibition ; Rabbits ; Reinforcement (Psychology) ; Visual Cortex/*physiology ; Visual Perception/*physiology
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  • 33
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    The central origin of efferent pathways in the carotid sinus nerve of the cat (1979)
    American Association for the Advancement of Science (AAAS)
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    Publication Date: 1979-09-07
    Description: The application of horseradish peroxidase to the central cut end of the carotid sinus nerve of the cat produced retrograde labeling of neurons in the ipsilateral medulla in the region of the nucleus ambiguus at anterior-posterior coordinates -8 to -10.5. These data coupled with previous electrophysiological observations suggest that the nucleus ambiguus may be the origin of an efferent inhibitory pathway to the carotid body.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉deGroat, W C -- Nadelhaft, I -- Morgan, C -- Schauble, T -- New York, N.Y. -- Science. 1979 Sep 7;205(4410):1017-8.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/472721" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; Carotid Sinus/cytology/*innervation ; Cats ; Efferent Pathways/cytology ; Glossopharyngeal Nerve/cytology ; Horseradish Peroxidase ; Medulla Oblongata/cytology ; Neural Inhibition
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  • 34
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    GABA receptor control of parasympathetic outflow to heart: characterization and brainstem localization (1979)
    American Association for the Advancement of Science (AAAS)
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    Publication Date: 1979-06-08
    Description: Blockade of gamma-aminobutyric acid (GABA) receptor function by direct microinjection of the GABA receptor antagonist bicuculline into the nucleus ambiguus of the brainstem produced a marked, dose-related depression of heart rate and blood pressure which was mediated by the vagus nerve. This effect was not obtained in other regions of the brainstem and was reversed by the GABA receptor agonist muscimol. These data indicate that the nucleus ambiguus may be the site of a GABA receptor-mediated inhibition of vagal outflow.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉DiMicco, J A -- Gale, K -- Hamilton, B -- Gillis, R A -- New York, N.Y. -- Science. 1979 Jun 8;204(4397):1106-9.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/451556" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; Bicuculline/pharmacology ; Blood Pressure/drug effects ; Brain Stem/*physiology ; Cats ; Heart/*innervation ; Heart Rate/drug effects ; Isoniazid/pharmacology ; Muscimol/pharmacology ; Receptors, Drug/*physiology ; Vagus Nerve/*physiology ; gamma-Aminobutyric Acid/*physiology
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  • 35
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    Eye movements initiate visual-motor development in the cat (1979)
    American Association for the Advancement of Science (AAAS)
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    Publication Date: 1979-06-22
    Description: Visually naive kittens turn their eyes toward visual targets but lack other visual-motor coordinations. Light-reared animals were able to mediate guided behaviors with an immobilized eye, but animals with the eye immobilized before initial exposure to a lighted environment were not. Eye movement is implied to play an essential role in visual-motor development.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Hein, A -- Vital-Durand, F -- Salinger, W -- Diamond, R -- New York, N.Y. -- Science. 1979 Jun 22;204(4399):1321-2.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/313076" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; Behavior, Animal/physiology ; Cats ; Darkness ; *Eye Movements ; Functional Laterality ; Locomotion ; *Movement ; Vestibule, Labyrinth/physiology ; Visual Pathways/*growth & development ; Visual Perception/physiology
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    Agent orange furor continues to build (1979)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1979-08-24
    Description: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Holden, C -- New York, N.Y. -- Science. 1979 Aug 24;205(4408):770-2.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/111351" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; Defoliants, Chemical/*poisoning ; Dioxins/*poisoning ; Haplorhini ; Herbicides/*poisoning ; Humans ; Male ; *Military Medicine ; Vietnam
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  • 37
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    Phase resetting and annihilation of pacemaker activity in cardiac tissue (1979)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1979-11-09
    Description: Spontaneous rhythmic activity in isolated cardiac pacemaker cells can be terminated by a brief, subthreshold, depolarizing or hyperpolarizing perturbation of the proper magnitude applied at a specific point in the pacemaker cycle. Evidence is provided in support of a topological theory of the existence of a "singular" point in cardiac oscillators.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Jalife, J -- Antzelevitch, C -- New York, N.Y. -- Science. 1979 Nov 9;206(4419):695-7.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/493975" target="_blank"〉PubMed〈/a〉
    Keywords: Action Potentials ; Animals ; Cats ; Cattle ; Dogs ; Evaluation Studies as Topic ; Heart Conduction System/*physiology ; Membrane Potentials ; *Periodicity ; Purkinje Fibers/*physiology ; Sinoatrial Node/*physiology
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    Choline excites cortical neurons (1979)
    American Association for the Advancement of Science (AAAS)
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    Publication Date: 1979-12-14
    Description: In cats under halothane or methoxyflurane, iontophoretic applications of choline are only eight times weaker than applications of acetylcholine in evoking firing of neurons in the sensorimotor region of the cerebral cortex. The action of choline is suppressed by atropine but not by two agents that block choline uptake (hemicholinium-3 and triethylcholine), and is not potentiated by an anticholinesterase (physostigmine). Choline therefore appears to excite cortical neurons by a direct action, which may be a significant component of its beneficial therapeutic effects.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Krnjevic, K -- Reinhardt, W -- New York, N.Y. -- Science. 1979 Dec 14;206(4424):1321-3.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/515735" target="_blank"〉PubMed〈/a〉
    Keywords: Acetylcholine/pharmacology ; Action Potentials/drug effects ; Animals ; Cats ; Cerebral Cortex/*drug effects ; Choline/*pharmacology ; Drug Synergism ; Evoked Potentials ; Glutamates/pharmacology ; Hemicholinium 3/pharmacology ; Motor Cortex/physiology ; Physostigmine/pharmacology ; Receptors, Muscarinic/drug effects ; Stimulation, Chemical
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  • 39
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    Dissociations between the effects of LSD on behavior and raphe unit activity in freely moving cats (1979)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1979-08-03
    Description: The hypothesis that the action of hallucinogenic drugs is mediated by a depression of the activity of brain serotonergic (raphe) neurons was tested by examining the behavioral effects of d-lysergic acid diethylamide (LSD) while studying the activity of raphe neurons in freely moving cats. Although the results provide general support for the hypothesis, there were several important dissociations. (i) Low doses of LSD produced only small decreases in raphe unit activity but significant behavoiral changes; (ii) LSD-induced behavioral changes outlasted the depression of raphe unit activity; and (iii) raphe neurons were at least as responsive to LSD during tolerance as they were in the nontolerant condition.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Trulson, M E -- Jacobs, B L -- New York, N.Y. -- Science. 1979 Aug 3;205(4405):515-8.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/451617" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; Behavior, Animal/*drug effects ; Brain Stem/*physiology ; Cats ; Lysergic Acid Diethylamide/*pharmacology ; Neurons/drug effects/*physiology ; Raphe Nuclei/drug effects/*physiology
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  • 40
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    Electromagnetic muscle stretch strongly excites sensorimotor cortex neurons in behaving primates (1979)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1979-02-02
    Description: Responses of single units in primary motor and sensory cortex of behaving primates to electromagnetic stretch of the muscle flexor carpi ulnaris are comparable in latency and intensity to responses to wrist extension. Thus, muscle stretch appears to be a major factor in cortical response to limb displacement during performance and probably has an important role in motor control at the cortical level.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Wolpaw, J R -- New York, N.Y. -- Science. 1979 Feb 2;203(4379):465-7.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/104385" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; Arm ; Cerebral Cortex/*physiology ; Electromagnetic Phenomena ; Haplorhini ; Macaca mulatta ; Motor Cortex/*physiology ; *Movement ; Muscles/*innervation ; Neurons/physiology ; Proprioception
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  • 41
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    Generation of unidirectionally propagated action potentials in a peripheral nerve by brief stimuli (1979)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1979-12-14
    Description: Single, unidirectionally propagated action potentials can be elicited in peripheral nerves by electrical stimuli of short duration. Propagation in one direction is blocked anodically by means of a quasi-trapezoidal stimulus wave form and a modified tripolar electrode configuration. Propagation in the other direction proceeds unhindered. This technique may be applicable to collision blocking of motor nerves for neural prostheses.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉van den Honert, C -- Mortimer, J T -- New York, N.Y. -- Science. 1979 Dec 14;206(4424):1311-2.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/515733" target="_blank"〉PubMed〈/a〉
    Keywords: *Action Potentials ; Animals ; Cats ; Electric Stimulation ; Electrodes ; Nerve Block/methods ; Peripheral Nerves/*physiology ; Sciatic Nerve/physiology
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  • 42
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    Pontine reticular formation neurons and motor activity (1978)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1978-01-13
    Description: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Cohen, B -- New York, N.Y. -- Science. 1978 Jan 13;199(4325):207-8.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/619453" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; Cats ; Eye Movements ; Humans ; Motor Neurons/*physiology ; Reticular Formation/*physiology
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  • 43
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    Functional plasticity in the immature striate cortex of the monkey shown by the [14C]deoxyglucose method (1978)
    American Association for the Advancement of Science (AAAS)
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    Publication Date: 1978-04-28
    Description: Autoradiographic representation of the local rates of cerebral glucose utilization and local cerebral functional activity by means of the [14C]deoxyglucose technique reveals the existence of the ocular dominance columns in the striate cortex of the monkey in the first day of life. In contrast to the stability of these columns in more mature brain, monocular deprivation for 3 months from the first day of life results in their complete disappearance and a reversion of the autoradiographic pattern to that seen in animals with normal binocular vision. These results are consistent with a reorganization of the representation of the visual fields of the two eyes in the striate cortex and provide additional evidence of the plasticity of the striate cortex of the monkey in early life.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Des Rosiers, M H -- Sakurada, O -- Jehle, J -- Shinohara, M -- Kennedy, C -- Sokoloff, L -- New York, N.Y. -- Science. 1978 Apr 28;200(4340):447-9.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/417397" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; Animals, Newborn/physiology ; Brain Mapping ; Cell Differentiation ; Deoxy Sugars/*metabolism ; Deoxyglucose/*metabolism ; Female ; Haplorhini ; Male ; Vision, Ocular ; Visual Cortex/*cytology/physiology ; Visual Pathways/*cytology/physiology
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  • 44
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    Physiological basis of anisometropic amblyopia (1978)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1978-07-21
    Description: In the visual cortex of kittens that have received their only visual experience while wearing a high-power lens before one eye, most neurons are dominated by input from the normal eye. Moreover, contrast sensitivity and resolving power are lower for stimulation through the originally defocused eye, mimicking psychophysical results from human anisometropic amblyopes.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Eggers, H M -- Blakemore, C -- New York, N.Y. -- Science. 1978 Jul 21;201(4352):264-7.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/663654" target="_blank"〉PubMed〈/a〉
    Keywords: Amblyopia/*physiopathology ; Animals ; Brain Mapping ; Cats ; Disease Models, Animal ; Orientation/physiology ; Refractive Errors/*physiopathology ; Visual Cortex/*physiopathology ; Visual Pathways/physiopathology
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  • 45
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    Thermoregulation is impaired in an environment without circadian time cues (1978)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1978-02-17
    Description: Squirrel monkeys synchronized to a 24-hour light-dark cycle show a prominent circadian rhythm in body temperature which is regulated against mild environmental cold exposures throughout the 24-hour day. However, cold exposures produce significant decreases in core body temperature when the circadian rhythms of the animal are free-running in the absence of environmental time cues. Effective thermoregulation appears to require the precise internal synchronization of the circadian timekeeping system.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Fuller, C A -- Sulzman, F M -- Moore-Ede, M C -- New York, N.Y. -- Science. 1978 Feb 17;199(4330):794-6.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/414356" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; *Body Temperature Regulation ; *Circadian Rhythm ; Cold Temperature ; Cues ; *Environment ; Environmental Exposure ; Haplorhini ; Homeostasis ; Male ; Saimiri ; Time Factors
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  • 46
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    Neuronal plasticity in primate telencephalon: anomalous projections induced by prenatal removal of frontal cortex (1978)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1978-11-17
    Description: When the dorsolateral prefrontal cortex in one hemisphere of a rhesus monkey is resected 6 weeks before birth and the fetus survives to postnatal ages, neurons of the corresponding cortex in the intact hemisphere issue a greatly expanded projection to the contralateral caudate nucleus in addition to a normal projection to the ipsilateral caudate. The enhancement of the crossed prefronto-caudate pathway after prenatal neurosurgery provides direct evidence for lesion-induced neuronal rearrangement in the primate telencephalon.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Goldman, P S -- New York, N.Y. -- Science. 1978 Nov 17;202(4369):768-70.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/102031" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; Axons/ultrastructure ; Brain/embryology/growth & development ; Brain Mapping ; Cell Differentiation ; Cerebral Cortex/*cytology ; Haplorhini ; Macaca mulatta ; Neural Pathways/*cytology ; Synapses/*ultrastructure
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  • 47
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    Evoked response correlate of symbol and significate (1978)
    American Association for the Advancement of Science (AAAS)
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    Publication Date: 1978-07-14
    Description: Changing the source and intensity of the auditory signal to six trained cats responding to meaningful auditory stimuli permits exogenous and endogenous processes in the auditory evoked potential to be separated. For short-latency exogenous processes, latency and amplitude depend on the parameters of the physical stimulus. However, the amplitude and shape of longer-latency endogenous processes are essentially independent of the location and intensity of the signal source and seem to be invariant concomitants of the significance of the signal.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Grastyan, E -- John, E R -- Bartlett, F -- New York, N.Y. -- Science. 1978 Jul 14;201(4351):169-71.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/663648" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; Auditory Perception/*physiology ; Cats ; Conditioning (Psychology)/physiology ; Discrimination (Psychology)/*physiology ; *Evoked Potentials ; Geniculate Bodies/*physiology ; Memory/physiology
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  • 48
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    Hypophysial responses to continuous and intermittent delivery of hypopthalamic gonadotropin-releasing hormone (1978)
    American Association for the Advancement of Science (AAAS)
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    Publication Date: 1978-11-10
    Description: In rhesus monkeys with hypothalamic lesions that abolish gonadotropic hormone release by the pituitary gland, the constant infusion of exogenous gonadotropin-releasing hormone (GnRH) fails to restore sustained gonadotropin secretion. In marked contrast, intermittent administration of the synthetic decapeptide once per hour, the physiological frequency of gonadotropin release in the monkeys, reestablishes pituitary gonadotropin secretion. This phenomenon is attributable to the pattern of GnRH delivery rather than to the amounts of this hormone to which the cells of the pituitary are exposed. Moreover, the initiation of continuous GnRH administration in animals with lesions and in which gonadotropin secretion is reestablished by intermittent GnRH replacement can result in a "desensitization" or "down regulation" of the processes responsible for gonadotropin release.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Belchetz, P E -- Plant, T M -- Nakai, Y -- Keogh, E J -- Knobil, E -- New York, N.Y. -- Science. 1978 Nov 10;202(4368):631-3.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/100883" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; Castration ; Dose-Response Relationship, Drug ; Drug Administration Schedule ; Female ; Follicle Stimulating Hormone/*secretion ; Gonadotropin-Releasing Hormone/administration & dosage/*pharmacology ; Haplorhini ; Luteinizing Hormone/*secretion ; Macaca mulatta ; Pituitary Gland, Anterior/*drug effects/secretion
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    Transient synapses in the embryonic primate spinal cord (1978)
    American Association for the Advancement of Science (AAAS)
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    Publication Date: 1978-12-15
    Description: Electron microscopic and tritiated thymidine autoradiographic analysis of the embryonic spinal cord in the rhesus monkey reveals considerable rearrangement of cellular and synaptic relationships in the posterior (sensory) quadrant during early developmental stages. This remodeling involves the death of an entire population of neurons that received synapses from sensory afferent axons and the possible relocation of these afferents upon subsequently generated viable substantia gelatinosa neurons.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Knyihar, E -- Csillik, B -- Rakic, P -- New York, N.Y. -- Science. 1978 Dec 15;202(4373):1206-9.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/103200" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; Axons/ultrastructure ; Cell Survival ; Dendrites/ultrastructure ; Gestational Age ; Haplorhini ; Macaca mulatta ; Spinal Cord/*embryology/ultrastructure ; Synapses/ultrastructure
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  • 50
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    Neural lateralization of species-specific vocalizations by Japanese macaques (Macaca fuscata) (1978)
    American Association for the Advancement of Science (AAAS)
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    Publication Date: 1978-10-20
    Description: Five Japanese macaques and five other Old World monkeys were trained to discriminate among field-recorded Japanese macaque vocalizations. One task required discrimination of a communicatively relevant acoustic feature ("peak"), and a second required discrimination of an orthogonal feature of the same vocalizations ("pitch"). The Japanese animals more proficiently discriminated the peak feature when stimuli were presented to the right ear (primarily left cerebral hemisphere), as opposed to the left ear (primarily right hemisphere). In discriminating the pitch feature, the Japanese animals either showed (i) a left-ear processing advantage or (ii) no ear advantage. The comparison animals, with one exception, showed no ear advantage in processing either feature of the vocalizations. The results suggest that Japanese macaques engage left-hemisphere processors for the analysis of communicatively significant sounds that are analogous to the lateralized mechanisms used by humans listening to speech.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Petersen, M R -- Beecher, M D -- Zoloth, S R -- Moody, D B -- Stebbins, W C -- New York, N.Y. -- Science. 1978 Oct 20;202(4365):324-7.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/99817" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; Auditory Perception/*physiology ; Discrimination Learning/physiology ; Female ; *Functional Laterality ; Haplorhini ; Macaca/*physiology ; Male ; Species Specificity ; Vocalization, Animal/*physiology
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    Terminal arbors of axons that have formed abnormal connections (1978)
    American Association for the Advancement of Science (AAAS)
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    Publication Date: 1978-08-18
    Description: Ther terminal arbors of individual retinogeniculate axons that have been induced to grow into an inappropriate geniculate layer have been revealed for light and electron microscopic study by being filled with horseradish peroxidase. After a unilateral ocular enucleation in kittens, single axons from the surviving eye show terminal arbors not only within their own geniculate layers but also in the denervated layers. The new, abnormal arbors arise from the terminal segments of arbors that lie within the nondenervated layer and make patterns of synaptic contacts that appear normal.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Robson, J A -- Mason, C A -- Guillery, R W -- New York, N.Y. -- Science. 1978 Aug 18;201(4356):635-7.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/675248" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; Axons/*ultrastructure ; Cats ; Eye/innervation ; Geniculate Bodies/*ultrastructure ; Synapses/*ultrastructure ; Visual Pathways/*ultrastructure
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  • 52
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    Potency in male rhesus monkeys: effects of continuously receptive females (1978)
    American Association for the Advancement of Science (AAAS)
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    Publication Date: 1978-04-28
    Description: Ejaculations decreased and mount latencies increased when intact males were paired regularly over a 3.5-year period (3180 tests) with ovariectomized females made constantly receptive by daily injections of estradiol. The deterioration in potency was abruptly and completely reversed by substituting a group of new but similarly treated females for the original ones.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Michael, R P -- Zumpe, D -- New York, N.Y. -- Science. 1978 Apr 28;200(4340):451-3.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/417398" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; Ejaculation ; Female ; Haplorhini ; Macaca/*physiology ; Macaca mulatta/*physiology ; Male ; Pair Bond ; Periodicity ; Seasons ; Sexual Behavior, Animal/*physiology ; Testosterone/blood ; Time Factors
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    Is pump stimulation associated with positive inotropy of the heart? (1978)
    American Association for the Advancement of Science (AAAS)
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    Publication Date: 1978-06-16
    Description: A purified sodium and potassium dependent adenosinetriphosphatase isolated from cat heart was not stimulated by any concentration of ouabain that produced positive inotropy of cat papilliary muscle. Only inhibition of enzyme activity was observed. Concentrations of ouabain used ranged from 3.3 x 10(-10) molar to 5 x 10(-7) molar and produced an increased force of contraction without any evidence of toxicity. The results are inconsistent with a concept that stimulation of sodium pump activity is associated with positive inotropy.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Michael, L -- Pitts, B J -- Schwartz, A -- New York, N.Y. -- Science. 1978 Jun 16;200(4347):1287-9.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/149369" target="_blank"〉PubMed〈/a〉
    Keywords: Adenosine Triphosphatases/*antagonists & inhibitors ; Animals ; Biological Transport, Active/drug effects ; Cats ; Dose-Response Relationship, Drug ; In Vitro Techniques ; Myocardial Contraction/*drug effects ; Myocardium/*enzymology ; Ouabain/*pharmacology ; Potassium/metabolism ; Sodium/metabolism
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    delta9-tetrahydrocannabinol: antiaggressive effects in mice, rats, and squirrel monkeys (1978)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1978-03-31
    Description: delta9-Tetrahydrocannabinol, the most active constituent of marihuana, decreased species-specific attack behavior in mice, rats, and squirrel monkeys at doses (0.25 to 2.0 milligram per kilogram of body weight) that have no effects on other elements of the behavioral repertoire. Aggressive behavior was engendered in all three species by confronting a resident animal with an intruder conspecific. The present results contrast with the widely held belief that marihuana increases aggressive behavior.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Miczek, K A -- New York, N.Y. -- Science. 1978 Mar 31;199(4336):1459-61.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/415367" target="_blank"〉PubMed〈/a〉
    Keywords: Aggression/*drug effects ; Animals ; Behavior, Animal/*drug effects ; Depression, Chemical ; Dose-Response Relationship, Drug ; Dronabinol/*pharmacology ; Female ; Haplorhini ; Humans ; Male ; Mice ; Motor Activity/drug effects ; Rats ; Saimiri ; Territoriality
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    Dyskinesias evoked in monkeys by weekly administration of haloperidol (1978)
    American Association for the Advancement of Science (AAAS)
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    Publication Date: 1978-05-19
    Description: In two cebus (Cebus albifrons) monkeys given weekly oral doses of 0.25 milligram of haloperidol per kilogram, movement disorders appeared 1 to 8 hours after drug administration following the tenth weekly dose. These disorders included oral movements, peculiar postures, writhing, and stretching. Such reactions faded in intensity after the next two doses. Increasing the dose to 0.5 milligram per kilogram has elicited the disorders reliably after each weekly dose for almost 2 years. Similar reactions also developed in a squirrel monkey (Saimiri sciurea) treated weekly with haloperidol and in a third cebus monkey previously maintained for a year on a regimen of 0.25 milligram of haloperidol per kilogram on 5 days per week. These findings suggest an experimental model for determining the etiology of drug-induced movement disorders. They also suggest an unrecognized clinical problem.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Weiss, B -- Santelli, S -- New York, N.Y. -- Science. 1978 May 19;200(4343):799-801.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/417399" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; *Disease Models, Animal ; Dyskinesia, Drug-Induced/*etiology ; *Haloperidol/administration & dosage ; Haplorhini ; Time Factors
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    Chronic focal epileptiform discharges induced by injection of iron into rat and cat cortex (1978)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1978-06-30
    Description: A single injection of 5 or 10 microliters of ferrous or ferric chloride into rat or cat sensorimotor cortex resulted in chronic recurrent focal paroxysmal electroencephalographic discharges as well as behavioral convulsions and electrical seizures. Recurrent focal epileptiform discharge caused by cortical injection of iron salts suggests that the development of human posttraumatic epilepsy may depend, in part, on the neurochemical alterations induced by the principal metallic ions found in whole blood.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Willmore, L J -- Sypert, G W -- Munson, J V -- Hurd, R W -- New York, N.Y. -- Science. 1978 Jun 30;200(4349):1501-3.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/96527" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; Cats ; Cerebral Cortex/*drug effects/physiopathology ; *Disease Models, Animal ; Electrophysiology ; Epilepsies, Partial/*chemically induced ; Ferric Compounds ; Ferrous Compounds ; *Iron ; Rats ; Seizures/*chemically induced/physiopathology
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    Opiate receptors for behavioral analgesia resemble those related to the depression of spinal nociceptive neurons (1978)
    American Association for the Advancement of Science (AAAS)
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    Publication Date: 1978-03-17
    Description: With naloxone as antagonist, a dose-ratio analysis of the depression by morphine of nociceptive neurons in the spinal cord reveals that this opiate depression of single unit activity has the same pharmacological properties as observed with morphine analgesia. This suggests that the opiate receptor, mediating the observed cellular depression, and those mediating analgesia are presumably the same.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Yaksh, T L -- New York, N.Y. -- Science. 1978 Mar 17;199(4334):1231-3.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/204008" target="_blank"〉PubMed〈/a〉
    Keywords: Action Potentials/drug effects ; Animals ; Cats ; Decerebrate State ; Dose-Response Relationship, Drug ; Morphine/*pharmacology ; Naloxone/*pharmacology ; Nerve Fibers/physiology ; Nociceptors/*drug effects/physiology ; Receptors, Opioid/*physiology ; Spinal Cord/physiology
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    Interaction of critical periods in the visual cortex of kittens (1978)
    American Association for the Advancement of Science (AAAS)
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    Publication Date: 1978-02-03
    Description: The critical period for modifying the preferred direction in cat cortical units occurs earlier than that for monocular deprivation. The independence of the effects of these two types of deprivation from each other was tested by rearing six kittens with both reverse suture and reversed directional deprivation. The kittens were placed in a drum rotating in one direction with one eye open at ages 2 1/2 to 5 weeks; the drum rotation was reversed and the other eye opened when they were 5 to 12 weeks old. Recordings were then made in the visual cortex. The results were the sum of the effects of reverse suture and reversal of directional deprivation: most cells were driven by the eye that was open second, and most unidirectional cells preferred the direction to which the animals were exposed first. Consequently, many unidirectional cells preferred the first direction but were driven by the eye open second--a combination that the animal never saw during rearing. There was also an effect of ocular deprivation on directional properties and vice versa: reverse suture reduced the overall percentage of unidirectional cells, just as directional deprivation has been shown to affect the ocular dominance histogram. This result suggests that the same cells may be affected by both forms of deprivation.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Daw, N W -- Berman, N E -- Ariel, M -- New York, N.Y. -- Science. 1978 Feb 3;199(4328):565-7.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/622560" target="_blank"〉PubMed〈/a〉
    Keywords: Age Factors ; Animals ; Cats ; Cell Differentiation ; Functional Laterality ; Motion Perception/physiology ; *Vision, Ocular ; Visual Cortex/cytology/*growth & development ; Visual Pathways/growth & development ; Visual Perception/physiology
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    Anosmia in male rhesus monkeys does not alter copulatory activity with cycling females (1978)
    American Association for the Advancement of Science (AAAS)
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    Publication Date: 1978-03-10
    Description: Three adult male rhesus monkeys were tested daily with intact adult female partners over the course of four or five mentstrual cycles. The males were made permanently anosmic by chemical ablation of the olfactory epithelium after the second or fourth cycle was completed. All males continued to display typical cycles of copulation with their partners after the anosmia procedures, with the shortest latencies to ejaculation occurring during the periovulatory phase of the partner's ovulatory cycle. Hence, female attractivity and cyclic copulatory performance of rhesus monkeys are not dependent upon olfactory signals.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Goldfoot, D A -- Essock-Vitale, S M -- Asa, C S -- Thornton, J E -- Leshner, A I -- New York, N.Y. -- Science. 1978 Mar 10;199(4333):1095-6.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/415362" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; Copulation/*physiology ; Female ; Haplorhini ; Macaca/*physiology ; Macaca mulatta/*physiology ; Male ; Menstruation ; *Odors ; Olfaction Disorders ; Vasectomy
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    Vasectomy increases the severity of diet-induced atherosclerosis in Macaca fascicularis (1978)
    American Association for the Advancement of Science (AAAS)
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    Publication Date: 1978-08-11
    Description: Diet-induced atherosclerosis developed more extensively in vasectomized cynomolgus monkeys (Macaca fascicularis) than in sham-vasectomized control monkeys fed the same diet. The effect was most pronounced in the abdominal aortas, carotid arteries, distal segments of the coronary arteries, and intracranial cerebral arteries. Antibodies to sperm developed in all vasectomized monkeys, and complement and immunoglobulins were associated with atherosclerotic plaques in some of the vasectomized animals. The immunological response to sperm antigens that often accompanies vasectomy may exacerbate atherosclerosis.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Alexander, N J -- Clarkson, T B -- New York, N.Y. -- Science. 1978 Aug 11;201(4355):538-41.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/96532" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; Arteries/immunology/pathology ; Arteriosclerosis/*etiology/immunology/pathology ; Autoantibodies ; Cholesterol/metabolism ; Cholesterol Esters/metabolism ; Diet, Atherogenic ; Haplorhini ; Macaca fascicularis ; Male ; Spermatozoa/immunology ; Vasectomy/*adverse effects
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    Choice behavior in rhesus monkeys: cocaine versus food (1978)
    American Association for the Advancement of Science (AAAS)
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    Publication Date: 1978-08-11
    Description: Rhesus monkeys were allowed to choose between intravenous injections of cocaine and food reinforcement for lever pressing. A choice trial was available every 15 minutes continuously for 8 days. The animals chose cocaine almost exclusively, which resulted in high cocaine intake, decreased food intake, weight loss, and marked behavioral toxicity. The study provides evidence of the reinforcing efficacy of cocaine.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Aigner, T G -- Balster, R L -- New York, N.Y. -- Science. 1978 Aug 11;201(4355):534-5.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/96531" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; Behavior, Animal/drug effects ; Body Weight ; Choice Behavior/*drug effects ; Cocaine/*pharmacology ; Decision Making/*drug effects ; Feeding Behavior/*drug effects ; Haplorhini ; Macaca mulatta ; Male ; Posture ; *Reinforcement (Psychology)
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    Primate infant's effects on mother's future reproduction (1978)
    American Association for the Advancement of Science (AAAS)
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    Publication Date: 1978-09-15
    Description: Female savanna baboons (Papio cynocephalus) had a longer postpartum amenorrhea and thereafter cycled longer before conceiving if their previous infant survived than if that infant died. Among mothers of surviving infants, differences in maternal care produced differences in age of weaning and age of independence but did not result in differences in interbirth intervals.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Altmann, J -- Altmann, S A -- Hausfater, G -- New York, N.Y. -- Science. 1978 Sep 15;201(4360):1028-30.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/98844" target="_blank"〉PubMed〈/a〉
    Keywords: Amenorrhea ; Animals ; Female ; Haplorhini ; Maternal Behavior ; Papio/*physiology ; *Postpartum Period ; Pregnancy ; *Reproduction ; Time Factors ; Weaning
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    Primate neurobiology: neurosurgery with fetuses (1978)
    American Association for the Advancement of Science (AAAS)
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    Publication Date: 1978-03-03
    Description: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Kolata, G B -- New York, N.Y. -- Science. 1978 Mar 3;199(4332):960-1.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/414357" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; Brain/embryology/surgery ; Eye/embryology/innervation ; Fetus/*surgery ; Haplorhini ; Nervous System/*embryology ; Neural Pathways/embryology ; *Neurosurgery ; Neurosurgical Procedures ; Primates/*embryology/surgery ; Research ; Visual Cortex/embryology/surgery
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    Enhancement of conditioned arterial pressure responses in cats after brainstem lesions (1978)
    American Association for the Advancement of Science (AAAS)
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    Publication Date: 1978-07-07
    Description: Cats were classically conditioned after the baroreceptor reflexes were abolished by bilateral placement of electrolytic lesions in the nucleus tractus solitarii. The conditioned increases in arterial pressure were more than five times larger than the responses obtained in similarly trained controls. This finding suggests that the baroreceptor reflexes actively inhibit conditioned increases of arterial pressure.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Nathan, M A -- Tucker, L W -- Serverini, W H -- Reis, D J -- New York, N.Y. -- Science. 1978 Jul 7;201(4350):71-3.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/663640" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; *Blood Pressure ; Cats ; Conditioning, Classical/physiology ; Disease Models, Animal ; Female ; Heart Rate ; Hypertension/physiopathology ; Male ; Medulla Oblongata/*physiology ; Pressoreceptors/*physiology ; Reflex/physiology
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    Frequency discrimination following the selective destruction of cochlear inner and outer hair cells (1978)
    American Association for the Advancement of Science (AAAS)
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    Publication Date: 1978-03-24
    Description: Frequency discrimination was measured behaviorally before and after drug-induced lesions of cochlear hair cells in the cat. Discrimination was unaffected by complete loss of outer hair cells provided that at least 50% of inner hair cells were intact. Thus, inner hair cells are important for frequency discrimination, and they can function normally in this regard without the influence of outer hair cells.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Nienhuys, T G -- Clark, G M -- New York, N.Y. -- Science. 1978 Mar 24;199(4335):1356-7.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/628846" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; Auditory Threshold/physiology ; Behavior, Animal/physiology ; Cats ; Cochlea/ultrastructure ; Hair Cells, Auditory/drug effects/*physiology ; Kanamycin/pharmacology ; Mechanoreceptors/*physiology ; *Pitch Discrimination
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    Processes controlling arm movements in monkeys (1978)
    American Association for the Advancement of Science (AAAS)
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    Publication Date: 1978-09-29
    Description: The experiments identify some of the processes underlying arm movements in rhesus monkeys. Three monkeys were trained to point to a target with the hand and forearm and to hold that position for about 1 second to obtain a reward. Forearm movements were performed without sight of the arm before and after bilateral dorsal rhizotomy. In both intact and deafferented animals, we unexpectedly displaced the forearm prior to movement initiation and observed that the arm moved accurately to the target. These results are relevant to the question of what is being controlled by motor commands. The controlled variable appears to be an equilibrium point between agonist and antagonist muscles. The findings suggest that the feedback system plays a major role in updating and adjusting the central programs subserving the execution of learned motor patterns.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Polit, A -- Bizzi, E -- New York, N.Y. -- Science. 1978 Sep 29;201(4362):1235-7.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/99813" target="_blank"〉PubMed〈/a〉
    Keywords: Afferent Pathways/physiology ; Animals ; Arm/*physiology ; Feedback ; Haplorhini ; Macaca mulatta ; *Movement ; *Proprioception ; Visual Perception/physiology
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    Measurement of regional substrate utilization rates by emission tomography (1978)
    American Association for the Advancement of Science (AAAS)
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    Publication Date: 1978-03-03
    Description: Emission tomography can be used to monitor, in vivo and regionally, the utilization of metabolic substrates labeled with positron-emitting radioisotopes produced by a cyclotron. The concept was validated by measuring brain glucose utilization with carbon--11-labeled glucose in rhesus monkeys.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Raichle, M E -- Welch, M J -- Grubb, R L Jr -- Higgins, C S -- Ter-Pogossian, M M -- Larson, K B -- New York, N.Y. -- Science. 1978 Mar 3;199(4332):986-7.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/414358" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; Brain/*metabolism/radionuclide imaging ; Carbon Radioisotopes ; Glucose/*metabolism ; Haplorhini ; Macaca mulatta ; Tomography/*utilization ; Tomography, X-Ray Computed/utilization
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    Ponto-geniculo-occipital (PGO) burst neurons: correlative evidence for neuronal generators of PGO waves (1978)
    American Association for the Advancement of Science (AAAS)
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    Publication Date: 1978-07-21
    Description: A newly discovered class of neurons, ponto-geniculo-occipital (PGO) burst neurons, has PGO wave relationships of phase-leading, stereotyped discharge bursts, and the highest reported discharge specificity and coherence; these neurons thus fulfill correlative criteria for output generator neurons for PGO waves. The PGO burst neurons are recorded in a discrete dorsal brainstem area in apposition to the brachium conjunctivum.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉McCarley, R W -- Nelson, J P -- Hobson, J A -- New York, N.Y. -- Science. 1978 Jul 21;201(4352):269-72.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/663656" target="_blank"〉PubMed〈/a〉
    Keywords: Action Potentials ; Animals ; Brain Mapping ; Brain Stem/cytology/*physiology ; Cats ; Geniculate Bodies/*physiology ; Neural Conduction ; Neural Pathways/physiology ; Occipital Lobe/*physiology ; Pons/*physiology ; Sleep/physiology
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    Highly reiterated sequences of SIMIANSIMIANSIMIANSIMIANSIMIAN (1978)
    American Association for the Advancement of Science (AAAS)
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    Publication Date: 1978-04-28
    Description: A 172-base pair segment of DNA that is repeated several million times in the genome of the African green monkey has been characterized. Sequence analysis revealed that the many repeats of this complex unit are not all identical but represent a set of closely related segments: Sequence divergence occurs at various positions in the segment in a nonrandom manner. The uncloned segment obtained from monkey DNA is compared with a cloned segment of the same DNA which was recombined into the genome of simian virus 40 during permissive infection.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Rosenberg, H -- Singer, M -- Rosenberg, M -- New York, N.Y. -- Science. 1978 Apr 28;200(4340):394-402.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/205944" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; Base Sequence ; Biological Evolution ; Cell Line ; Cercopithecus/*genetics ; Cercopithecus aethiops/*genetics ; DNA/*genetics ; DNA Restriction Enzymes ; DNA, Recombinant ; Haplorhini ; Molecular Weight ; Recombination, Genetic ; Simian virus 40/genetics
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    Environmental hydrocarbons produce degeneration in cat hypothalamus and optic tract (1978)
    American Association for the Advancement of Science (AAAS)
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    Publication Date: 1978-01-13
    Description: 2,5-Hexanedione, the principal neurotoxic metabolite of the industrial solvents n-hexane and methyl n-butyl ketone causes axonal degeneration in the mammillary body and visual nuclei of cats. Prolonged, low-level exposure to hydrocarbons in the environment may cause premature deterioration in areas of the human brain vital for perception and behavior.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Schaumburg, H H -- Spencer, P S -- New York, N.Y. -- Science. 1978 Jan 13;199(4325):199-200.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/413192" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; Axons/pathology ; Cats ; Environmental Pollutants/*toxicity ; Geniculate Bodies/drug effects ; Hexanones/*toxicity ; Ketones/*toxicity ; Mammillary Bodies/*drug effects/pathology ; Nerve Degeneration/*drug effects ; Superior Colliculi/pathology ; Visual Pathways/*drug effects/pathology
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    Spinothalamic tract neurons in the substantia gelatinosa (1978)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1978-12-01
    Description: The substantia gelatinosa of the mammalian spinal cord is generally believed to be a closed system; that is its neurons are thought to project only to the substantia gelatinosa of the same or the contralateral side. Experiments in monkeys, using injections of the marker enzyme horseradish peroxidase, show that at least some neurons of the substantia gelatinosa project to the thalamus and thus belong to the spinothalamic tract. Such neurons include two cell types intrinsic to the gelatinosa, the central cells and the limitrophe cells of Cajal.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Willis, W D -- Leonard, R B -- Kenshalo, D R Jr -- New York, N.Y. -- Science. 1978 Dec 1;202(4371):986-8.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/102034" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; Diencephalon/*cytology ; Haplorhini ; Macaca fascicularis ; Spinal Cord/*cytology ; Spinothalamic Tracts/*cytology ; Substantia Gelatinosa/*cytology
    Print ISSN: 0036-8075
    Electronic ISSN: 1095-9203
    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
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    Ultradian cortisol rhythms in monkeys: synchronized or not synchronized? (1978)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1978-12-01
    Description: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Kronauer, R E -- Moore-Ede, M C -- Menser, M S -- New York, N.Y. -- Science. 1978 Dec 1;202(4371):1001-2.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/102033" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; Haplorhini ; Hydrocortisone/*blood ; Light ; Macaca mulatta/blood ; *Periodicity
    Print ISSN: 0036-8075
    Electronic ISSN: 1095-9203
    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
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    Intracellular analysis of trigeminal motoneuron activity during sleep in the cat (1978)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1978-01-13
    Description: Intracellular recordings were made from trigeminal motoneurons of normally respiring, unanesthetized cats during naturally occurring sleep. The transition from quiet to active sleep was accompanied by tonic motoneuron hyperpolarization. Stimulation of the reticular formation induced a depolarizing potential in trigeminal motoneurons during quiet sleep and a hyperpolarizing potential during active sleep. The results provide a synaptic explanation for the phenomenon of reticular response reversal and insights into the basic mechanisms controlling motor activity during the sleep states.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Nakamura, Y -- Goldberg, L J -- Chandler, S H -- Chase, M H -- New York, N.Y. -- Science. 1978 Jan 13;199(4325):204-7.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/202025" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; Cats ; Electric Stimulation ; Membrane Potentials ; Motor Neurons/*physiology ; Reflex ; Reticular Formation/*physiology ; Sleep/*physiology ; Sleep, REM/physiology ; Synapses/physiology ; Trigeminal Nerve/*physiology
    Print ISSN: 0036-8075
    Electronic ISSN: 1095-9203
    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
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    Prostacyclin: a potentially valuable agent for preserving myocardial tissue in acute myocardial ischemia (1978)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1978-04-07
    Description: Prostacyclin, a potent, naturally occurring prostaglandin exerts a variety of cardiovascular and cellular actions of potential value in acute myocardial ischemia. These properties include the reduction of systemic blood pressure without changing heart rate, the lowering of coronary vascular and total peripheral resistance, the inhibition of platelet aggregation and the concomitant formation of thromboxane B2, and the reduction of the release of lysosomal enzymes.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Lefer, A M -- Ogletree, M L -- Smith, J B -- Silver, M J -- Nicolaou, K C -- Barnette, W E -- Gasic, G P -- New York, N.Y. -- Science. 1978 Apr 7;200(4337):52-4.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/345441" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; Blood Pressure/drug effects ; Cats ; Coronary Circulation/drug effects ; Coronary Disease/drug therapy ; Epoprostenol/*pharmacology/therapeutic use ; Heart Rate/drug effects ; Hemodynamics/*drug effects ; In Vitro Techniques ; Lysosomes/drug effects/enzymology ; Myocardial Contraction/drug effects ; Platelet Aggregation/drug effects ; Prostaglandins/*pharmacology ; Thromboxanes/blood ; Vascular Resistance/drug effects
    Print ISSN: 0036-8075
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    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
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    Localization of primate calls by old world monkeys (1978)
    American Association for the Advancement of Science (AAAS)
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    Publication Date: 1978-08-25
    Description: Monkeys (Macaca) were trained by operant conditioning techniques to report the minimum detectable change in location of a sound in space, and were tested with a series of recorded coo or clear call vocalizations. Acuity of localization varied from approximately 4 degrees to 15 degrees and was a function of the magnitude of the change in pitch (frequency modulation) of the different clear calls.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Brown, C H -- Beecher, M D -- Moody, D B -- Stebbins, W C -- New York, N.Y. -- Science. 1978 Aug 25;201(4357):753-4.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/97785" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; Auditory Perception/*physiology ; Haplorhini ; Macaca/*physiology ; Orientation/*physiology ; Pitch Discrimination/physiology ; Vocalization, Animal/*physiology
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    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
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    Eye movements of monkeys during learning-set formation (1978)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1978-03-24
    Description: Eye movements of stump-tailed monkeys were measured during learning of a long series of two-choice pattern discrimination problems. The amount of scanning per trial (shifts in visual fixation from one pattern to the other) and the duration of individual fixations on the patterns increased during the course of learning-set formation and (except for the amount of scanning by some animals) remained high during the prolonged training following learning-set formation. Some of the changes in eye movements were different from those seen during the learning of single discrimination problems, a difference that possibly reflects cognitive processes specific to the learning-set task.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Schrier, A M -- Povar, M L -- New York, N.Y. -- Science. 1978 Mar 24;199(4335):1362-4.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/415365" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; Discrimination Learning/*physiology ; *Eye Movements ; Haplorhini ; Macaca ; Time Factors
    Print ISSN: 0036-8075
    Electronic ISSN: 1095-9203
    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
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    Vaccination of experimental monkeys against Plasmodium falciparum: a possible safe adjuvant (1978)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1978-09-29
    Description: Owl monkeys (Aotus trivirgatus griseimembra) were effectively immunized against a human malaria parasite, Plasmodium falciparum. Two injections of antigen, primarily mature segmenters with fully developed merozoites, mixed with adjuvant (6-O-stearoyl-N-acetylmuramyl-L-alanyl-D-isoglutamine and liposomes) were administered intramuscularly at a 4-week interval. Approximately 2 weeks after the second vaccination, the monkeys were challenged with the homologous strain of P. falciparum. All immunized monkeys survived the challenge. The substitution of Freund's complete adjuvant is an encouraging step toward the development of an effective and safe vaccine for human malaria.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Siddiqui, W A -- Taylor, D W -- Kan, S C -- Kramer, K -- Richmond-Crum, S M -- Kotani, S -- Shiba, T -- Kusumoto, S -- New York, N.Y. -- Science. 1978 Sep 29;201(4362):1237-9.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/99814" target="_blank"〉PubMed〈/a〉
    Keywords: Acetylmuramyl-Alanyl-Isoglutamine/*immunology ; *Adjuvants, Immunologic ; Animals ; Glycopeptides/*immunology ; Haplorhini ; Liposomes ; Malaria/*prevention & control ; Plasmodium falciparum/*immunology ; *Vaccination
    Print ISSN: 0036-8075
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    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
    Published by American Association for the Advancement of Science (AAAS)
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