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  • Male  (628)
  • Female  (577)
  • United States  (383)
  • American Association for the Advancement of Science (AAAS)  (1,265)
  • Springer  (4)
  • American Chemical Society
  • International Union of Crystallography (IUCr)
  • 1980-1984  (1,269)
Collection
Keywords
Publisher
  • American Association for the Advancement of Science (AAAS)  (1,265)
  • Springer  (4)
  • American Chemical Society
  • International Union of Crystallography (IUCr)
Years
Year
  • 1
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    Scientists and Congress Battle over NIH. Biomedical lobbyists resist tighter control, but to no avail (1980)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1980-09-26
    Description: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉New York, N.Y. -- Science. 1980 Sep 26;209(4464):1497-8.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/7433971" target="_blank"〉PubMed〈/a〉
    Keywords: Budgets ; Legislation as Topic ; *National Institutes of Health (U.S.) ; United States
    Print ISSN: 0036-8075
    Electronic ISSN: 1095-9203
    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
    Published by American Association for the Advancement of Science (AAAS)
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  • 2
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    Human sleep: its duration and organization depend on its circadian phase (1980)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1980-12-12
    Description: Two- to threefold variations in sleep length were observed in 12 subjects living on self-selected schedules in an environment free of time cues. The duration of polygraphically recorded sleep episodes was highly correlated with the circadian phase of the body temperature rhythm at bedtime and not with the length of prior wakefulness. Furthermore, the rate of REM (rapid eye movement) sleep accumulation , REM latency, bedtime selection, and self-rated alertness assessments were also correlated with the body temperature rhythm.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Czeisler, C A -- Weitzman, E d -- Moore-Ede, M C -- Zimmerman, J C -- Knauer, R S -- AG-00792/AG/NIA NIH HHS/ -- GM-07365/GM/NIGMS NIH HHS/ -- MH-28460/MH/NIMH NIH HHS/ -- New York, N.Y. -- Science. 1980 Dec 12;210(4475):1264-7.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/7434029" target="_blank"〉PubMed〈/a〉
    Keywords: Adult ; Body Temperature ; *Circadian Rhythm ; Humans ; Male ; Middle Aged ; Sleep/*physiology ; Sleep, REM/physiology ; Wakefulness
    Print ISSN: 0036-8075
    Electronic ISSN: 1095-9203
    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
    Published by American Association for the Advancement of Science (AAAS)
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  • 3
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    Amino acid acylation: a mechanism of nitrogen excretion in inborn errors of urea synthesis (1980)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1980-02-08
    Description: Treatment of a patient deficient in carbamyl phosphate synthetase with benzoate or phenylacetic acid resulted in an increase in urinary nitrogen, which could be accounted for by the respective amino acid acylation product, hippurate or phenylacetylgultamine. Benzoate treatment of four hyperammonemic comatose patients led to clinical improvement and a return of plasma ammonium levels toward normal.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Brusilow, S -- Tinker, J -- Batshaw, M L -- New York, N.Y. -- Science. 1980 Feb 8;207(4431):659-61.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/6243418" target="_blank"〉PubMed〈/a〉
    Keywords: Adolescent ; Amino Acid Metabolism, Inborn Errors/*drug therapy ; Amino Acids/blood ; Ammonia/blood ; Benzoates/*therapeutic use ; Carbamoyl-Phosphate Synthase (Ammonia)/*deficiency ; Child ; Female ; Glutamine/metabolism ; Glycine/metabolism ; Hippurates/urine ; Humans ; Infant ; Male ; Nitrogen/blood ; *Ornithine Carbamoyltransferase Deficiency Disease ; Phenylacetates/*therapeutic use ; Phosphotransferases/*deficiency
    Print ISSN: 0036-8075
    Electronic ISSN: 1095-9203
    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
    Published by American Association for the Advancement of Science (AAAS)
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  • 4
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    Immunofluorescence of NADPH-cytochrome c (P-450) reductase in rat and minipig tissues injected with phenobarbital (1980)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1980-06-27
    Description: The enzyme NADPH-cytochrome c (P-450) reductase was identified by indirect immunofluorescence in hepatocytes, bronchioles, and proximal tubules of liver, lung, and kidney, respectively, of rats and minipigs that had been injected with phenobarbital or saline. The distribution of this component of the cytochrome P-450-mediated microsomal system may be relevant to sites of drug toxicity and carcinogenesis.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Dees, J H -- Coe, L D -- Yasukochi, Y -- Masters, B S -- New York, N.Y. -- Science. 1980 Jun 27;208(4451):1473-5.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/6770464" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; Fluorescent Antibody Technique ; Kidney/drug effects/*enzymology ; Liver/drug effects/*enzymology ; Lung/drug effects/*enzymology ; Male ; NADPH-Ferrihemoprotein Reductase/*metabolism ; Organ Specificity ; Phenobarbital/*pharmacology ; Rats
    Print ISSN: 0036-8075
    Electronic ISSN: 1095-9203
    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
    Published by American Association for the Advancement of Science (AAAS)
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  • 5
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    Automated information retrieval in science and technology (1980)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1980-04-04
    Description: The rapid advances in computer and communication technology in the 1970's have enabled large interactive scientific and technical information retrieval systems to be implemented. Major search services today offer on-line access to millions of bibliographic citations and an increasing number of "electronic handbooks." In addition, development of knowledge bases is well under way. Despite the impressive speed and flexibility of interactive retrieval systems, their impact has been lessened by limited awareness of their existence, uneven quality of retrieval, inadequate linkages among data bases, and reliance on specially trained intermediaries.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Doszkocs, T E -- Rapp, B A -- Schoolman, H M -- New York, N.Y. -- Science. 1980 Apr 4;208(4439):25-30.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/6987735" target="_blank"〉PubMed〈/a〉
    Keywords: *Computers ; History, 20th Century ; *Information Systems ; MEDLARS/history ; *National Library of Medicine (U.S.) ; *Science ; *Technology ; United States
    Print ISSN: 0036-8075
    Electronic ISSN: 1095-9203
    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
    Published by American Association for the Advancement of Science (AAAS)
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  • 6
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    Fetal exposure to narcotics: neonatal sleep as a measure of nervous system disturbance (1980)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1980-08-01
    Description: Newborn infants, chronically exposed in utero to low doses of methadone with or without concomitant heroin, display more rapid eye movement sleep and less quiet sleep than control infants, while babies fetally exposed to both opiates and nonopiates have less organization of sleep states. Other perinatal factors, such as birth weight and gestational age, are related more to the amount of fetal drug exposure than to the type.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Dinges, D F -- Davis, M M -- Glass, P -- New York, N.Y. -- Science. 1980 Aug 1;209(4456):619-21.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/7190326" target="_blank"〉PubMed〈/a〉
    Keywords: Birth Weight ; Female ; Heroin/*adverse effects ; Heroin Dependence/drug therapy ; Humans ; Infant, Newborn ; Infant, Newborn, Diseases/*chemically induced ; Maternal-Fetal Exchange ; Methadone/*adverse effects/therapeutic use ; Nervous System Diseases/*chemically induced ; Pregnancy ; Sleep/*drug effects ; Substance-Related Disorders
    Print ISSN: 0036-8075
    Electronic ISSN: 1095-9203
    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
    Published by American Association for the Advancement of Science (AAAS)
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  • 7
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    Radioactive wastes from biomedical institutions (1980)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1980-03-21
    Description: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Eisenbud, M -- New York, N.Y. -- Science. 1980 Mar 21;207(4437):1299.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/7355289" target="_blank"〉PubMed〈/a〉
    Keywords: Hospitals ; Laboratories ; Medical Waste ; *Radioactive Waste ; United States
    Print ISSN: 0036-8075
    Electronic ISSN: 1095-9203
    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
    Published by American Association for the Advancement of Science (AAAS)
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  • 8
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    L-Ornithine decarboxylase:an essential role in early mammalian embryogenesis (1980)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1980-05-02
    Description: The highly selective, enzyme-activated, irreversible inhibitor of L-ornithine decarboxylase, DL-alpha-difluoromethylornithine, suppresses the increase in uterine L-ornithine decarboxylase activity associated with early embryogenesis in the mouse and arrests embryonic development at that stage. Contragestational effects were confirmed in the rat and rabbit. An increase in L-ornithine decarboxylase activity that leads to a rapid increase in putrescine concentration appears to be essential during a critical period after implantation for continued mammalian embryonal growth.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Fozard, J R -- Part, M L -- Prakash, N J -- Grove, J -- Schechter, P J -- Sjoerdsma, A -- Koch-Weser, J -- New York, N.Y. -- Science. 1980 May 2;208(4443):505-8.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/6768132" target="_blank"〉PubMed〈/a〉
    Keywords: Adenosylmethionine Decarboxylase/metabolism ; Animals ; Carboxy-Lyases/*physiology ; Eflornithine ; Embryo, Mammalian/drug effects/*physiology ; Female ; Gestational Age ; Mice ; Ornithine/*analogs & derivatives/pharmacology ; Ornithine Decarboxylase/*physiology ; Ornithine Decarboxylase Inhibitors ; Polyamines/metabolism ; Pregnancy ; Rabbits ; Rats ; Uterus/drug effects/*metabolism
    Print ISSN: 0036-8075
    Electronic ISSN: 1095-9203
    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
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  • 9
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    Bioactive conformation of luteinizing hormone-releasing hormone: evidence from a conformationally constrained analog (1980)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1980-11-07
    Description: An analog of luteinizing hormone-releasing hormone containing a gamma-lactam as a conformational constraint has been prepared with the use of a novel cyclization of a methionine sulfonium salt. The analog is more active as a luteinizing hormone-releasing hormone agonist that the parent hormone, and provides evidence for a bioactive conformation containing a beta-turn.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Freidinger, R M -- Veber, D F -- Perlow, D S -- Brooks, J R -- Saperstein, R -- New York, N.Y. -- Science. 1980 Nov 7;210(4470):656-8.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/7001627" target="_blank"〉PubMed〈/a〉
    Keywords: Amino Acid Sequence ; Animals ; Biological Assay ; Cells, Cultured ; Female ; *Gonadotropin-Releasing Hormone/analogs & derivatives ; Hydrogen Bonding ; Lactams ; Protein Conformation ; Rats ; Structure-Activity Relationship
    Print ISSN: 0036-8075
    Electronic ISSN: 1095-9203
    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
    Published by American Association for the Advancement of Science (AAAS)
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  • 10
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    Reorganization of the axon membrane in demyelinated peripheral nerve fibers: morphological evidence (1980)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1980-11-07
    Description: Cytochemical staining of demyelinated peripheral axons revealed two types of axon membrane organization, one of which suggests that the demyelinated axolemma acquires a high density of sodium channels. Ferric ion-ferrocyanide stain was confined to a restricted region of axon membrane at the beginning of a demyelinated segment or was distributed throughout the demyelinated segment of axon. The latter pattern represents one possible morphological correlate of continuous conduction through a demyelinated segment and suggests a reorganization of the axolemma after demyelination.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Foster, R E -- Whalen, C C -- Waxman, S G -- NS-15320/NS/NINDS NIH HHS/ -- New York, N.Y. -- Science. 1980 Nov 7;210(4470):661-3.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/6159685" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; Demyelinating Diseases/metabolism/*pathology ; Disease Models, Animal ; Ion Channels/*metabolism ; Male ; Neural Conduction ; Neurilemma/*metabolism/pathology ; Rats ; Staining and Labeling
    Print ISSN: 0036-8075
    Electronic ISSN: 1095-9203
    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
    Published by American Association for the Advancement of Science (AAAS)
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